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A/Prof. Filip Braet

Position
Deputy Director & Biomedical Scientist, Australian Centre for Microscopy & Microanalysis (ACMM)

Contact
Email: filip.braet@sydney.edu.au
Ph: + 61 2 9351 7619
Fax: + 61 2 9351 7682

Qualifications
BClinChem, BBioMedSc, MBioMedSc, PhD BioMedSc

Background
A/Prof. Braet is Deputy Director and Biomedical Scientist of the Australian Centre for Microscopy & Microanalysis. He has 15 years experience as a research cell biologist and histologist, specialising in the use of microscopy and fine-structure techniques to explore structure–function relationships. Following undergraduate, honours and masters studies in medical technology and biomedical sciences, he began a doctorate on the ultrastructure of the liver endothelium in 1992 at the Free University of Brussels (Belgium). In 2002, he was appointed a Visiting Professor of Life Sciences at his alma mater; a year later, he joined the Department for Molecular Biomedical Research, University Ghent.

A/Prof. Braet has over 85 ISI-indexed publications and an h-index of 20. He has presented 76 international talks, contributed eight invited review papers about his work and received several visiting scholarships and hold several academic adjunct positions. His research was awarded the Scholar in Vascular Biology by the State University of New York, the Ignace Vanderschueren Prize for Biomedicine by the Free University of Brussels, and the Japan Association for the Advancement of Medical Equipment. He serves on different editorial boards of journals in the field of microscopy, gastroenterology, microanatomy and nanotechnology

Research Interests
A/Prof. Braet’s research covers the areas of structural biology, cancer biology, cell membrane biology, nanobiology and chemical biology, and his recent work focuses on the development and application of targeted drug delivery approaches for colorectal cancer.

Our team seek to understand the spatial and temporal mechanisms involved in the onset and progress of colorectal cancer by using state-of-the-art multidimensional microscopy and correlative imaging techniques. In this way, novel ultrastructural information over micrometre-to-nanometre scales can be gathered to underpin the development of new immunotherapeutic strategies.

Other related work focuses on the development of 3-D simulation models of the colorectal tumour’s in-vivo microenvironment in relevant organoid and animal models.

Available projects for students

  • X-Ray Micro-Computed Imaging of Bioreactor Liver Tissue
  • Identifying Membrane-Related Biomolecular Signalling Pathways in Colorectal Cancer Cells

Selected Publications

  1. Su Y, Nykanen M, Jahn KA, Whan R, Cantrill L, Soon LL, Ratinac KR, Braet F. Multi-dimensional correlative imaging of subcellular events: combining the strengths of light and electron microscopy. Biophys Rev 2010:2;121-135
  2. Su Y, Whan R, Empsen C, Soon L, Braet F. Multidimensional live cell imaging of cancer-mediated events. In: Méndez-Vilas A, D'az J, eds. Modern Research and Educational Topics in Microscopy (Vol IV). Badajoz, Formatex Press, 2010:1-12
  3. Braet F, Soon L, Vekemans K, Thordarson P, Spector I. Actin-binding drugs: An elegant tool to dissect subcellular processes in endothelial and cancer cells. In: Protein reviews, Volume 8 – Actin-binding proteins and disease. dos Remedios C, Chhabra D, eds. New York: Springer, 2008:37-49.
  4. Braet F, Soon L, Kelly TF, Larson J, Ringer SP. Some new advances and challenges in biological and biomedical materials characterisation. In: Kumar CSSR, ed. Nanotechnologies for the Life Sciences Vol 3 - Nanosystem Characterization Tools in the Life Sciences. Weinheim – Berlin: Wiley-VCH Verlag GmbH & Co. KgaA, 2006:292-318.
  5. Braet F, Wisse E. Imaging surface and submembranous structures in living cells with the atomic force microscope: notes and tricks. In: Braga PC, Ricci D, eds. Atomic Force Microscopy: Methods and Protocols in Biomedical Applications. Totowa, NJ: Humana Press Inc., 2004:201-216.
  6. Braet F, Luo D, Spector I, Vermijlen D, Wisse E. Endothelial and pit cells. In: Arias I, Boyer JL, Fausto N, Jakoby WB, Schachter DA, Schafritz DA, eds. The liver: Biology and Pathobiology, 4th ed. New York: Raven Press, 2001:437-453.
  7. Wisse E, Braet F, Dianzhong L, Vermijlen D, Eddouks M, Empsen C, Spapen H, De Zanger RB. Sinusoidal liver cells. In: Bircher J, Benhamou JP, McIntyre N, Rizzetto M, Rodés J, eds. Oxford Textbook of Clinical Hepatology, Volume 1. New York: Oxford University Press, 1999:33-49.