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Ellie Kable

Position
Laboratory Manager

Contact
Email:
Ph: + 61 2 9351 7566
Fax: + 61 2 9351 7682


Qualifications
M.Sc. University of Queensland, Dept. Biochemistry, (Part time 1984-1987). Thesis title: "Redox Agents and Glutathione Metabolism in Human Melanoma." Masters Qualifying, (Honours equivalent), University of Queensland, Dept. Biochemistry, 1982. B.Sc., Griffith University, School of Science, 1979-1981. Double Major in Biological Chemistry and Biology.

Background
During her career Ellie has engaged in a cross-disciplinary research career in the biological/physical sciences. Initially she engaged in medical research projects which included Vitamin B12 metablolism and a research masters thesis on cancer chemotherapy of melanomas. She then worked for 3 years in a biophysics laboratory at Cornell University (USA) in a technical capacity. It is here that Ellie gained early confocal microscopy knowledge. She did a short stint in London studying cytomeglovirus using confocal microscopy and on coming back to Australia returned to the medical research studying the role of calcium in hypertension using live cell microscopy techniques. Since joining the Australian Centre for Microscopy & Micronanalysis Ellie has worked in a teaching and research capacity with the confocal and light microscopy as her expertise.

Role
Ellie's role is to manage the Centre’s laboratories for successful delivery of Centre's research services, research programs and research training. To enable and, where possible, develop new research and teaching programs in microscopy and analysis and to manage their implementation. Provide training and support for both staff and users of the Facility and to provide strategic support to the Director on matters concerning microscopy and analysis, particularly in terms of integration of laboratory activities at Sydney with those at other nodes of the AMMRF.

Research interests
Her research interests are in the application of optical microscopy to living systems. This has led her to learn about a variety of very new techniques, including non-linear microscopy, fluorescence resonance energy transfer (FRET) and fluorescence lifetime imaging (FLIM). Although her position does not allow very much time for independent research, Ellie has been involved with a variety of collaborative projects with Department of Pharmacy, Biochemistry, Pharmacology, Physics, Centenary Institute, University of NSW and the University of Armidale.

Publications
View Ellie’s publications listing on Google Scholar

  • Katharina Gaus, Enrico Gratton, Eleanor P W Kable, Allan S Jones, Ingrid Gelissen, Leonard Kritharides and Wendy Jessup. Visualizing lipid structure and raft domains in living cells with two-photon microscopy. PNAS. 100, 15554-15559, 2003.
  • Dong Fu, Mary Bebawy, Eleanor P W Kable and Basil D Roufogalis. Dynamic and intracellular trafficking of p-glycoprotein-EGFP fusion protien: Implications in multidrug resistance in cancer. Int. J. Cancer,109, 174-181 (2004).
  • G. Cox, E. Kable, A. Jones, I. Fraser, F. Manconi and M.D. Gorell, 3-Dimensional Imaging of Collagen using Second Harmonic Generation, J. Structural Biology, 141, 53-62 (2003).
  • G.R. Monteith, E.P.W. Kable, S. Chen and B.D. Roufogalis, Plasma Membrane Calcium Pump-mediated Calcium Efflux and Bulk Cytosolic Free Calcium in Cultured Aortic Smooth Muscle Cells from Spontaneously Hypertensive and Wistar-Kyoto Normotensive Rats, J. Hypertension, 14, 435-442 (1996).
  • S. Chandra, E.P.W. Kable, G.H.Morrison and W.W.Webb, Calcium Sequestration in the Golgi Apparatus of Cultured Mammalian Cells Revealed by Laser Scanning Confocal Microscopy and Ion Microscopy, Journal of Cell Science, 100, 747-752 (1991).
  • E.P.W. Kable and P.G. Parsons, Potency, Selectivity and Cell Cycle Dependence of Redox Agents in Human Tumour Cells in Vitro, Biochemical Pharmacology, 37, 1711-1715 (1988).

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