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Dr Lilian Soon

Position
Lecturer, Structural Biology

Contact
Email:
Ph: + 61 2 9351 5322
Fax: + 61 2 9351 7682

Qualifications
PhD 1997 - The University of Adelaide.

Background
2009-present Senior Lecturer, Structural Cell Biology, Australia Centre for Microscopy & Microanalysis, NANO-MNRF.
2005-2008 Lecturer, Structural Cell Biology, Australian Key Centre for Microscopy and Microanalysis, NANO-MNRF.
2003-2005 Senior Associate Research Scientist, laboratory. Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, USA.
2001-2003 Associate Research Scientist. Department of Pulmonary and Critical Care, New York University, NY, USA.
1997-2001 Postdoctoral Research Fellow. Laboratory of Cellular and Molecular Biology, NCI, National Institutes of Health, Bethesda, MD, USA


Research interests
Dr. Soon’s research interests include cell migration processes on two-dimensional and within three-dimensional matrices. She has discovered a novel invasion strategy that involves physical cell traction mechanisms regulated by N-WASp, and the secretion of proteases to facilitate migration. In addition, Dr. Soon’s work on environmentally-regulated metastasis suppressor genes that function in secondary tumour formation, has potential for therapeutic applications in breast cancers. Her current and past research grants include:

  • ARC Discovery DP0881012, A New Model for 3D Migration involving claw structures and metalloproteinases, 2009 - 2011.
    NHMRC 402510, NHMRC New Investigator Project Grant, Mechanisms of Motility and Metastasis in Breast Cancer, 2007 - 2009.

Selected publications

View Lilian’s publications listing on PubMed
  1. Soon L.L., Tachtsidis, A., Fok, S., Williams, E.D., Newgreen, D.F. and Thompson, E.W. The continuum of epithelial mesenchymal transition – implication of hybrid states for migration and survival in development and cancer. In Cancer Metastasis: Biological Basis and Therapeutics. DR Welch and DC Lyden, eds. (Cambridge Press) –invited review, Accepted Oct 2009. In Press
  2. Soon, L.L., Vallotton, P. Selected applications of graph-based tracking methods for cancer research. In: Computational Biology. In: Applied Bioinformatics and Biostatistics in Cancer Research. VIII. 2010. 8:193-203
  3. Fok, S., P. Domachuk, G. Rosengarten, N. Krause, F. Braet, B. J. Eggleton, and L. L. Soon. 2008. Planar microfluidic chamber for generation of stable and steep chemoattractant gradients. Biophysical Journal 95:1523-1530.
  4. Soon, L. L. 2007. A discourse on cancer cell chemotaxis: Where to from here? IUBMB Life 59:60-67.
  5. Lapidus, K., J. Wyckoff, G. Mouneimne, M. Lorenz, L. L. Soon, J. S. Condeelis, and R. H. Singer. 2007. ZBP1 enhances cell polarity and reduces chemotaxis. Journal of Cell Science 120:3173-3178.
  6. Mouneimne, G., L. L. Soon, V. DesMarais, M. Sidani, X. Y. Song, S. C. Yip, M. Ghosh, R. Eddy, J. M. Backer, and J. Condeelis. 2004. Phospholipase C and cofilin are required for carcinoma cell directionality in response to EGF stimulation. Journal of Cell Biology 166:697-708.
  7. DesMarais, V., H. Yamaguchi, M. Oser, L. L. Soon, G. Mouneimne, C. Sarmiento, R. Eddy, and J. Condeelis. 2009. N-WASP and Cortactin Are Involved In Invadopodium-Dependent Chemotaxis to EGF In Breast Tumor Cells. Cell Motility and the Cytoskeleton 66:303-316.

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