Dr Lilian Soon
Lecturer, Structural Biology
Ph: + 61 2 9351 5322
Fax: + 61 2 9351 7682
PhD 1997 - The University of Adelaide.
2009-present Senior Lecturer, Structural Cell Biology, Australia Centre for Microscopy & Microanalysis, NANO-MNRF.
2005-2008 Lecturer, Structural Cell Biology, Australian Key Centre for Microscopy and Microanalysis, NANO-MNRF.
2003-2005 Senior Associate Research Scientist, laboratory. Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, USA.
2001-2003 Associate Research Scientist. Department of Pulmonary and Critical Care, New York University, NY, USA.
1997-2001 Postdoctoral Research Fellow. Laboratory of Cellular and Molecular Biology, NCI, National Institutes of Health, Bethesda, MD, USA
Dr. Soon’s research interests include cell migration processes on two-dimensional and within three-dimensional matrices. She has discovered a novel invasion strategy that involves physical cell traction mechanisms regulated by N-WASp, and the secretion of proteases to facilitate migration. In addition, Dr. Soon’s work on environmentally-regulated metastasis suppressor genes that function in secondary tumour formation, has potential for therapeutic applications in breast cancers. Her current and past research grants include:
- ARC Discovery DP0881012, A New Model for 3D Migration involving claw structures and metalloproteinases, 2009 - 2011.
NHMRC 402510, NHMRC New Investigator Project Grant, Mechanisms of Motility and Metastasis in Breast Cancer, 2007 - 2009.
|View Lilian’s publications listing on PubMed|
- Soon L.L., Tachtsidis, A., Fok, S., Williams, E.D., Newgreen, D.F. and Thompson, E.W. The continuum of epithelial mesenchymal transition – implication of hybrid states for migration and survival in development and cancer. In Cancer Metastasis: Biological Basis and Therapeutics. DR Welch and DC Lyden, eds. (Cambridge Press) –invited review, Accepted Oct 2009. In Press
- Soon, L.L., Vallotton, P. Selected applications of graph-based tracking methods for cancer research. In: Computational Biology. In: Applied Bioinformatics and Biostatistics in Cancer Research. VIII. 2010. 8:193-203
- Fok, S., P. Domachuk, G. Rosengarten, N. Krause, F. Braet, B. J. Eggleton, and L. L. Soon. 2008. Planar microfluidic chamber for generation of stable and steep chemoattractant gradients. Biophysical Journal 95:1523-1530.
- Soon, L. L. 2007. A discourse on cancer cell chemotaxis: Where to from here? IUBMB Life 59:60-67.
- Lapidus, K., J. Wyckoff, G. Mouneimne, M. Lorenz, L. L. Soon, J. S. Condeelis, and R. H. Singer. 2007. ZBP1 enhances cell polarity and reduces chemotaxis. Journal of Cell Science 120:3173-3178.
- Mouneimne, G., L. L. Soon, V. DesMarais, M. Sidani, X. Y. Song, S. C. Yip, M. Ghosh, R. Eddy, J. M. Backer, and J. Condeelis. 2004. Phospholipase C and cofilin are required for carcinoma cell directionality in response to EGF stimulation. Journal of Cell Biology 166:697-708.
- DesMarais, V., H. Yamaguchi, M. Oser, L. L. Soon, G. Mouneimne, C. Sarmiento, R. Eddy, and J. Condeelis. 2009. N-WASP and Cortactin Are Involved In Invadopodium-Dependent Chemotaxis to EGF In Breast Tumor Cells. Cell Motility and the Cytoskeleton 66:303-316.