Dr Chong Mei Dong

Summary

I am interested in cereal genetics, functional genomics and molecular biology. I have a passion for utilising genomics tools and gene technologies for crop improvement.

Research interests

My research interests include cloning and functional study of genes, association study of genes with traits, and application of modern biotechnologies for wheat breeding and improvement. One of my current projects is using TILLING technology for wheat breeding. TILLING (Targeting Induced Local Lesions IN Genomes) combines traditional chemical mutagenesis with high-throughput PCR-based mutation detection. As a non-transgenic approach, TILLING generates useful mutations that can be used in wheat breeding.

Background

Chong Mei Dong has an undergraduate and a master degree from Fudan University, Shanghai, China. Her PhD research was on the study of wheat cell cycle genes and their regulations during plant development at the Australian National University. Her post doctoral research was on meiosis and chromosome pairing in wheat at University of Adelaide. She joined the University of Sydney in 2002 as a research fellow in Plant Breeding Institute Cobbitty, working on non-transgenic gene modification methods for wheat breeding including oligonucleotide-directed gene repair and TILLING.

Recent publications

  • Dong C and Yu B. (2011) Mutation Surveyor: an in silico tool for sequencing analysis. In Methods in Molecular Biology: In Silico Tools for Gene Discovery (eds. BYu and M J Hinchcliffe), Humana Press. DOI: 10.1007/978-1-61779-176-5_14
  • Dong C, Vincent K and Sharp P. (2009) Simultaneous mutation detection of three homoeologous genes in wheat by High Resolution Melting analysis and Mutation Surveyor®. BMC Plant Biology 9:143 (highly accessed). DOI: 10.1186/1471-2229-9-143
  • Zhang P, McIntosh RA, Hoxha S and Dong C. (2009) Wheat stripe rust resistance genes Yr5 and Yr7 are allelic. Theor Appl Genet 120:25–29. DOI: 10.1007/s00122-009-1156-5
  • Dong C, Dalton-Morgan C, Vincent K and Sharp P. (2009) A modified TILLING method for wheat breeding. The Plant Genome 2:39-47. DOI: 10.3835/plantgenome2008.10.0012
  • Dong C and Sharp P. (2007) Oligonucleotide-directed gene repair: promises and limitations for plant gene modification. Transgenic Plant Journal 1: 10-16.
  • Dong C, Beetham P, Vincent K and Sharp P. (2006) Oligonucleotide-directed gene repair in wheat using a transient plasmid gene repair assay system. Plant Cell Reports 25: 457-465.
  • Dong C, Thomas S, Becker D, Lörz H, Whitford R, Sutton T, Able JA and Langridge P. (2005) WM5: isolation and characterization of a gene expressed during early meiosis and shoot meristem development in wheat. Functional Plant Biology 32: 249-258.
  • Sutton T, Whitford R, Baumann U, Dong C, Able JA and Langridge P. (2003) The Ph2 pairing homoeologous locus of wheat (Triticum aestivum): identification of candidate meiotic genes using a comparative genetics approach. The Plant Journal 36: 443-456.
  • Dong C, Whitford R and Langridge P. (2002) A DNA mismatch repair gene links to the Ph2 locus in Wheat”. Genome 45: 116-124.

Contact

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