Associate Professor Lars Ittner

Associate Professor
Brain & Mind Research Institute, Sydney Medical School

M02 - Mallet Street Campus
The University of Sydney
NSW 2006 Australia

T:+61 2 9351 0845
F:+61 2 9351 0731
E:

Teaching areas

Neuroanatomy

Current national competitive grants*

2012

Novel mechanisms underlying the spreading of Tau pathology in Alzheimers disease and other Tauopathies
Ittner L, Kril J
NHMRC Project Grants ($513,675 over 3 years)

2011

Senior Research Fellowship B
Ittner L
NHMRC Career Award: Research Fellowship ($630,505 over 5 years)

Selective vunerability in alzheimer's disease and related disorders: Mechanism of tau pathology
Goetz J, Ittner L
National Health and Medical Research Council Project Grant ($1,026,728 over 4 years)

2010

Combinatorial transgenesis to dissect tauopathies
Goetz J, Ittner L
ARC Discovery Project ($555,000 over 3 years)

Biological functions of the TAR DNA binding protein 43
Ittner L, Goetz J, Haass N
ARC Discovery Project ($480,000 over 3 years)

* Grants administered through the University of Sydney

Keywords

Aging; Alzheimer's disease; Dementia; Stroke

Publications

2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006

2012

  
  • Götz, J., Ittner, A., Ittner, L. (2012), Tau-targeted treatment strategies in Alzheimer's disease. British journal of pharmacology. 165(5), 1246-59. [Abstract]

2011

  
  • Götz, J., Eckert, A., Matamales, M., Ittner, L., Liu, X. (2011), Modes of Aβ toxicity in Alzheimer's disease. Cellular and molecular life sciences : CMLS. 68(20), 3359-75. [Abstract]
  • Ittner, A., Ke, Y., Eersel, J., Gladbach, A., Götz, J., Ittner, L. (2011), Brief update on different roles of tau in neurodegeneration. IUBMB Life. 63(7), 495-502. [Abstract]
  • Ittner, L., Götz, J. (2011), Amyloid-β and tau - a toxic pas de deux in Alzheimer's disease. Nature reviews. Neuroscience. 12(2), 65-72. [Abstract]
  • Liu, X., Dobbie, M., Tunningley, R., Whittle, B., Zhang, Y., Ittner, L., Götz, J. (2011), ENU Mutagenesis Screen to Establish Motor Phenotypes in Wild-Type Mice and Modifiers of a Pre-Existing Motor Phenotype in Tau Mutant Mice. Journal of Biomedicine & Biotechnology. 2011, 130947. [Abstract]
  • Lim, Y., Grimm, A., Giese, M., Mensah-Nyagan, A., Villafranca, J., Ittner, L., Eckert, A., Götz, J. (2011), Inhibition of the mitochondrial enzyme ABAD restores the amyloid-β-mediated deregulation of estradiol. PLoS One. 6(12), e28887. [Abstract]
  • Gotz, J., Ittner, L., Gotz, N., Lam, H., Nicholas, H. (2011), Invertebrate and Vertebrate Models of Tauopathies. In: Animal Models for Neurodegenerative Disease. (pp.69-85).Cambridge: RSC Publishing.
  • van Eersel, J., Ke, Y., Gladbach, A., Bi, M., Götz, J., Kril, J., Ittner, L. (2011), Cytoplasmic Accumulation and Aggregation of TDP-43 upon Proteasome Inhibition in Cultured Neurons. PloS one. 6(7), e22850. [Abstract]
  • Bi, M., Ittner, A., Ke, Y., Götz, J., Ittner, L. (2011), Tau-Targeted Immunization Impedes Progression of Neurofibrillary Histopathology in Aged P301L Tau Transgenic Mice. PLoS One. 6(12), e26860. [Abstract]

2010

  
  • Götz, J., Gladbach, A., Pennanen, L., van Eersel, J., Schild, A., David, D., Ittner, L. (2010), Animal models reveal role for tau phosphorylation in human disease. Biochimica et biophysica acta. 1802(10), 860-71. [Abstract]
  • Ittner, L., Ke, Y., Delerue, F., Bi, M., Gladbach, A., van Eersel, J., Wölfing, H., Chieng, B., Christie, M., Napier, I., Eckert, A., Staufenbiel, M., Hardeman, E., Götz, J. (2010), Dendritic Function of Tau Mediates Amyloid-beta Toxicity in Alzheimer's Disease Mouse Models. Cell. 142(3), 387-97. [Abstract]
  • van Eersel, J., Ke, Y., Liu, X., Delerue, F., Kril, J., Götz, J., Ittner, L. (2010), Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models. Proceedings of the National Academy of Sciences of the United States of America. 107(31), 13888-93. [Abstract]
  • Krupka, N., Strappe, P., Götz, J., Ittner, L. (2010), Gateway-compatible lentiviral transfer vectors for ubiquitin promoter driven expression of fluorescent fusion proteins. Plasmid. 63(3), 155-160. [Abstract]
  • Lim, Y., Rhein, V., Baysang, G., Meier, F., Poljak, A., J Raftery, M., Guilhaus, M., Ittner, L., Eckert, A., Götz, J. (2010), Abeta and human amylin share a common toxicity pathway via mitochondrial dysfunction. Proteomics. 10(8), 1621-33. [Abstract]
  • Götz, J., Lim, Y., Ke, Y., Eckert, A., Ittner, L. (2010), Dissecting toxicity of tau and beta-amyloid. Neurodegenerative Diseases. 7(1-3), 10-12. [Abstract]
  • Schonrock, N., Ke, Y., Humphreys, D., Staufenbiel, M., Ittner, L., Preiss, T., Götz, J. (2010), Neuronal MicroRNA Deregulation in Response to Alzheimer's Disease Amyloid-beta. PLoS One. 5(6), e11070. [Abstract]

2009

  
  • Rhein, V., Song, X., Wiesner, A., Ittner, L., Baysang, G., Meier, F., Ozmen, L., Bluethmann, H., Dröse, S., Brandt, U., Savaskan, E., Czech, C., Götz, J., Eckert, A. (2009), Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice. Proceedings of the National Academy of Sciences of the United States of America. 106(47), 20057-20062. [Abstract]
  • van Eersel, J., Bi, M., Ke, Y., Hodges, J., Xuereb, J., Gregory, G., Halliday, G., Götz, J., Kril, J., Ittner, L. (2009), Phosphorylation of soluble tau differs in Pick's disease and Alzheimer's disease brains. Journal of neural transmission (Vienna, Austria : 1996). 116(10), 1243-51. [Abstract]
  • Ittner, L., Ke, Y., Gotz, J. (2009), Phosphorylated tau interacts with c-JUN N-terminal kinase (JNK) interacting protein 1 (JIP1) in Alzheimer's disease. The Journal of biological chemistry. 284(31), 20909-16. [Abstract]
  • G��tz, J., Ittner, L., Lim, Y. (2009), Response to the comment 'Iron, type 2 diabetes mellitus, and Alzheimer's disease' to our Visions and Reflections article 'Common features between diabetes mellitus and Alzheimer's disease'. Cellular and Molecular Life Sciences. 66(17), 2945. [Abstract]
  • Götz, J., Ittner, L., Lim, Y. (2009), Common features between diabetes mellitus and Alzheimer's disease. Cellular and molecular life sciences. 66(8), 1321-1325. [Abstract]
  • Scarf, A., Ittner, L., Kassiou, M. (2009), The translocator protein (18 kDa): central nervous system disease and drug design. Journal of Medicinal Chemistry. 52(3), 581-592. [Abstract]
  • Deters, N., Ittner, L., Götz, J. (2009), Substrate-specific reduction of PP2A activity exaggerates tau pathology. Biochemical and biophysical research communications. 379(2), 400-405. [Abstract]
  • Fath, T., Ke, Y., Gunning, P., Götz, J., Ittner, L. (2009), Primary support cultures of hippocampal and substantia nigra neurons. Nature protocols. 4(1), 78-85. [Abstract]
  • Ke, Y., Delerue, F., Gladbach, A., Götz, J., Ittner, L. (2009), Experimental Diabetes Mellitus Exacerbates Tau Pathology in a Transgenic Mouse Model of Alzheimer's Disease. PLoS One. 4(11), e7917. [Abstract]
  • Götz, J., Schonrock, N., Vissel, B., Ittner, L. (2009), Alzheimer's Disease Selective Vulnerability and Modelling in Transgenic Mice. Journal of Alzheimer's disease : JAD. 18(2), 243-51. [Abstract]

2008

  
  • Götz, J., Ittner, L., Schonrock, N., Cappai, R. (2008), An update on the toxicity of Abeta in Alzheimer's disease. Neuropsychiatric disease and treatment. 4(6), 1033-1042. [Abstract]
  • Ittner, L., Fath, T., Ke, Y., Bi, M., van Eersel, J., Li, K., Gunning, P., Götz, J. (2008), Parkinsonism and impaired axonal transport in a mouse model of frontotemporal dementia. Proceedings of the National Academy of Sciences of the United States of America. 105(41), 15997-6002. [Abstract]
  • Götz, J., Ittner, L., Fändrich, M., Schonrock, N. (2008), Is tau aggregation toxic or protective: a sensible question in the absence of sensitive methods?. Journal of Alzheimer's disease. 14(4), 423-9. [Abstract]
  • Götz, J., Ittner, L. (2008), Animal models of Alzheimer's disease and frontotemporal dementia. Nature Reviews. Neuroscience. 9(7), 532-544. [Abstract]
  • Deters, N., Ittner, L., Götz, J. (2008), Divergent phosphorylation pattern of tau in P301L tau transgenic mice. The European Journal of Neuroscience. 28(1), 137-147. [Abstract]
  • Lim, Y., Ittner, L., Lim, Y., Götz, J. (2008), Human but not rat amylin shares neurotoxic properties with Abeta42 in long-term hippocampal and cortical cultures. FEBS letters. 582(15), 2188-94. [Abstract]
  • Falk, S., Wurdak, H., Ittner, L., Ille, F., Sumara, G., Schmid, M., Draganova, K., Lang, K., Paratore, C., Leveen, P., Suter, U., Karlsson, S., Born, W., Ricci, R., Götz, M., Sommer, L. (2008), Brain area-specific effect of TGF-beta signaling on Wnt-dependent neural stem cell expansion. Cell Stem Cell. 2(5), 472-483. [Abstract]
  • Götz, J., David, D., Hoerndli, F., Ke, Y., Schonrock, N., Wiesner, A., Fath, T., Bokhari, L., Lim, Y., Deters, N., Ittner, L. (2008), Functional genomics dissects pathomechanisms in tauopathies: mitosis failure and unfolded protein response. Neuro-Degenerative Diseases. 5(3-4), 179-181. [Abstract]
  • Ittner, L., Schwerdtfeger, K., Kunz, T., Muff, R., Husmann, K., Grimm, C., Hafezi, F., Lang, K., Kurrer, M., Götz, J., Born, W., Fischer, J. (2008), Transgenic mice with ocular overexpression of an adrenomedullin receptor reflect human acute angle-closure glaucoma. Clinical science. 114(1), 49-58. [Abstract]

2007

  
  • Kunz, T., Scott, M., Ittner, L., Fischer, J., Born, W., Vogel, J. (2007), Calcitonin gene-related peptide-evoked sustained tachycardia in calcitonin receptor-like receptor transgenic mice is mediated by sympathetic activity. American Journal of Physiology: Heart and Circulatory Physiology. 293(4), H2155-H160. [Abstract]
  • Kunz, T., Mueller-Steiner, S., Schwerdtfeger, K., Kleinert, P., Troxler, H., Kelm, J., Ittner, L., Fischer, J., Born, W. (2007), Interaction of receptor-activity-modifying protein1 with tubulin. Biochimica et biophysica acta. 1770(8), 1145-1150. [Abstract]
  • Ille, F., Atanasoski, S., Falk, S., Ittner, L., Märki, D., Büchmann-Møller, S., Wurdak, H., Suter, U., Taketo, M., Sommer, L. (2007), Wnt/BMP signal integration regulates the balance between proliferation and differentiation of neuroepithelial cells in the dorsal spinal cord. Developmental Biology. 304(1), 394-408. [Abstract]
  • Ittner, L., Götz, J. (2007), Pronuclear injection for the production of transgenic mice. Nature protocols. 2(5), 1206-1215. [Abstract]
  • Götz, J., Deters, N., Doldissen, A., Bokhari, L., Ke, Y., Wiesner, A., Schonrock, N., Ittner, L. (2007), A decade of tau transgenic animal models and beyond. Brain pathology (Zurich, Switzerland). 17(1), 91-103. [Abstract]
  • Stanescu, D., Iseli, H., Schwerdtfeger, K., Ittner, L., Remé, C., Hafezi, F. (2007), Continuous expression of the homeobox gene Pax6 in the ageing human retina. Eye. 21(1), 90-93. [Abstract]

2006

  
  • Wurdak, H., Ittner, L., Sommer, L. (2006), DiGeorge syndrome and pharyngeal apparatus development. BioEssays. 28(11), 1078-1086. [Abstract]
  • Schild, A., Schmidt, K., Lim, Y., Ke, Y., Ittner, L., Hemmings, B., Götz, J. (2006), Altered levels of PP2A regulatory B/PR55 isoforms indicate role in neuronal differentiation. International journal of developmental neuroscience. 24(7), 437-443. [Abstract]
  • Kelm, J., Djonov, V., Hoerstrup, S., Guenter, C., Ittner, L., Greve, F., Hierlemann, A., Sanchez-Bustamante, C., Perriard, J., Ehler, E., Fussenegger, M. (2006), Tissue-transplant fusion and vascularization of myocardial microtissues and macrotissues implanted into chicken embryos and rats. Tissue Engineering. 12(9), 2541-2553. [Abstract]
  • Schild, A., Ittner, L., Götz, J. (2006), Altered phosphorylation of cytoskeletal proteins in mutant protein phosphatase 2A transgenic mice. Biochemical and biophysical research communications. 343(4), 1171-1178. [Abstract]
  • Schild, A., Isenmann, S., Tanimoto, N., Tonagel, F., Seeliger, M., Ittner, L., Kretz, A., Ogris, E., Götz, J. (2006), Impaired development of the Harderian gland in mutant protein phosphatase 2A transgenic mice. Mechanisms of development. 123(5), 362-371. [Abstract]
  • Kelm, J., Ittner, L., Born, W., Djonov, V., Fussenegger, M. (2006), Self-assembly of sensory neurons into ganglia-like microtissues. Journal of Biotechnology. 121(1), 86-101. [Abstract]
  • Goetz, J., David, D., Ittner, L. (2006), Impact of beta-amyloid on the tau pathology in tau transgenic mouse and tissue culture models. In: Abeta Peptide and Alzheimer's Disease: Celebrating a Century of Research. (pp.198-215).United Kingdom: Springer.