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Publications list for Professor Juergen Goetz

2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003

2010

  
  • Lim, Y., Rhein, V., Baysang, G., Meier, F., Poljak, A., J Raftery, M., Guilhaus, M., Ittner, L., Eckert, A., G��tz, J. Abeta and human amylin share a common toxicity pathway via mitochondrial dysfunction. Proteomics. 2010; 10:1621-33. [Abstract]
  • G��tz, J., Lim, Y., Ke, Y., Eckert, A., Ittner, L. Dissecting toxicity of tau and beta-amyloid. Neurodegenerative Diseases. 2010; 7:10-12. [Abstract]

2009

  
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  • Rhein, V., Song, X., Wiesner, A., Ittner, L., Baysang, G., Meier, F., Ozmen, L., Bluethmann, H., Dröse, S., Brandt, U., Savaskan, E., Czech, C., Götz, J., Eckert, A. Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice. Proceedings of the National Academy of Sciences of the United States of America. 2009; 106:20057-20062. [Abstract]
  • G��tz, J., Schonrock, N., Vissel, B., Ittner, L. Alzheimer's Disease Selective Vulnerability and Modelling in Transgenic Mice. Journal of Alzheimer's disease : JAD. 2009; 18:243-51. [Abstract]
  • van Eersel, J., Bi, M., Ke, Y., Hodges, J., Xuereb, J., Gregory, G., Halliday, G., Götz, J., Kril, J., Ittner, L. Phosphorylation of soluble tau differs in Pick's disease and Alzheimer's disease brains. Journal of neural transmission (Vienna, Austria : 1996). 2009; 116:1243-51. [Abstract]
  • Götz, J., Gladbach, A., Pennanen, L., van Eersel, J., Schild, A., David, D., Ittner, L. Animal models reveal role for tau phosphorylation in human disease. Biochimica et biophysica acta. 2009. [Abstract]
  • Ittner, L., Ke, Y., Gotz, J. Phosphorylated tau interacts with c-JUN N-terminal kinase (JNK) interacting protein 1 (JIP1) in Alzheimer's disease. The Journal of biological chemistry. 2009; 284:20909-16. [Abstract]
  • G��tz, J., Ittner, L., Lim, Y. Response to the comment 'Iron, type 2 diabetes mellitus, and Alzheimer's disease' to our Visions and Reflections article 'Common features between diabetes mellitus and Alzheimer's disease'. Cellular and Molecular Life Sciences. 2009; 66:2945. [Abstract]
  • Götz, J., Ittner, L., Lim, Y. Common features between diabetes mellitus and Alzheimer's disease. Cellular and molecular life sciences. 2009; 66:1321-1325. [Abstract]
  • Deters, N., Ittner, L., Götz, J. Substrate-specific reduction of PP2A activity exaggerates tau pathology. Biochemical and biophysical research communications. 2009; 379:400-405. [Abstract]
  • Fath, T., Ke, Y., Gunning, P., Götz, J., Ittner, L. Primary support cultures of hippocampal and substantia nigra neurons. Nature protocols. 2009; 4:78-85. [Abstract]
  • Ke, Y., Delerue, F., Gladbach, A., G��tz, J., Ittner, L. Experimental Diabetes Mellitus Exacerbates Tau Pathology in a Transgenic Mouse Model of Alzheimer's Disease. PLoS One. 2009; 4:e7917. [Abstract]

2008

  
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  • G��tz, J., Ittner, L., Schonrock, N., Cappai, R. An update on the toxicity of Abeta in Alzheimer's disease. Neuropsychiatric disease and treatment. 2008; 4:1033-1042. [Abstract]
  • Eckert, A., Hauptmann, S., Scherping, I., Meinhardt, J., Rhein, V., Dröse, S., Brandt, U., Fändrich, M., Müller, W., Götz, J. Oligomeric and fibrillar species of beta-amyloid (A beta 42) both impair mitochondrial function in P301L tau transgenic mice. Journal of molecular medicine. 2008; 86:1255-67. [Abstract]
  • Ittner, L., Fath, T., Ke, Y., Bi, M., van Eersel, J., Li, K., Gunning, P., Götz, J. Parkinsonism and impaired axonal transport in a mouse model of frontotemporal dementia. Proceedings of the National Academy of Sciences of the United States of America. 2008; 105:15997-6002. [Abstract]
  • Einfeld, S., Götz, J., Holsinger, R. Pathogenetic mechanisms in Down Syndrome. Journal of intellectual disability research. 2008; 52:813. [Abstract]
  • Pienaar, I., Daniels, W., Götz, J. Neuroproteomics as a promising tool in Parkinson's disease research. Journal of neural transmission. 2008; 115:1413-30. [Abstract]
  • Götz, J., Ittner, L., Fändrich, M., Schonrock, N. Is tau aggregation toxic or protective: a sensible question in the absence of sensitive methods?. Journal of Alzheimer's disease. 2008; 14:423-9. [Abstract]
  • Götz, J., Ittner, L. Animal models of Alzheimer's disease and frontotemporal dementia. Nature Reviews. Neuroscience. 2008; 9:532-544. [Abstract]
  • Deters, N., Ittner, L., Götz, J. Divergent phosphorylation pattern of tau in P301L tau transgenic mice. The European Journal of Neuroscience. 2008; 28:137-147. [Abstract]
  • Lim, Y., Ittner, L., Lim, Y., Götz, J. Human but not rat amylin shares neurotoxic properties with Abeta42 in long-term hippocampal and cortical cultures. FEBS letters. 2008; 582:2188-94. [Abstract]
  • Baur, K., Rauer, M., Richter, K., Pagenstecher, A., Götz, J., Hausmann, J., Staeheli, P. Antiviral CD8 T cells recognize borna disease virus antigen transgenically expressed in either neurons or astrocytes. Journal of Virology. 2008; 82:3099-3108. [Abstract]
  • Götz, J., David, D., Hoerndli, F., Ke, Y., Schonrock, N., Wiesner, A., Fath, T., Bokhari, L., Lim, Y., Deters, N., Ittner, L. Functional genomics dissects pathomechanisms in tauopathies: mitosis failure and unfolded protein response. Neuro-Degenerative Diseases. 2008; 5:179-181. [Abstract]
  • Eckert, A., Hauptmann, S., Scherping, I., Rhein, V., Müller-Spahn, F., Götz, J., Müller, W. Soluble beta-amyloid leads to mitochondrial defects in amyloid precursor protein and tau transgenic mice. Neuro-degenerative diseases. 2008; 5:157-9. [Abstract]
  • Ittner, L., Schwerdtfeger, K., Kunz, T., Muff, R., Husmann, K., Grimm, C., Hafezi, F., Lang, K., Kurrer, M., Götz, J., Born, W., Fischer, J. Transgenic mice with ocular overexpression of an adrenomedullin receptor reflect human acute angle-closure glaucoma. Clinical science. 2008; 114:49-58. [Abstract]

2007

  
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  • Habicht, G., Haupt, C., Friedrich, R., Hortschansky, P., Sachse, C., Meinhardt, J., Wieligmann, K., Gellermann, G., Brodhun, M., Götz, J., Halbhuber, K., Röcken, C., Horn, U., Fändrich, M. Directed selection of a conformational antibody domain that prevents mature amyloid fibril formation by stabilizing Abeta protofibrils. Proceedings of the National Academy of Sciences of the United States of America. 2007; 104:19232-7. [Abstract]
  • Hoerndli, F., Pelech, S., Papassotiropoulos, A., Götz, J. Abeta treatment and P301L tau expression in an Alzheimer's disease tissue culture model act synergistically to promote aberrant cell cycle re-entry. The European journal of neuroscience. 2007; 26:60-72. [Abstract]
  • Goetz, J., Chen, F. Glyoxalase I and Alzheimer's disease. In: Research Progress in Alzheimer's Disease and Dementia. Vol.1. United States: Nova Science Publishers 2007. p. 0.
  • Götz, J., Deters, N., Doldissen, A., Bokhari, L., Ke, Y., Wiesner, A., Schonrock, N., Ittner, L. A decade of tau transgenic animal models and beyond. Brain pathology (Zurich, Switzerland). 2007; 17:91-103. [Abstract]
  • Burke, D., Hickie, I., Breakspear, M., Gotz, J. Possibilities for the prevention and treatment of cognitive impairment and dementia. British Journal of Psychiatry. 2007; 190:371-372. [Abstract]
  • Ittner, L., Götz, J. Pronuclear injection for the production of transgenic mice. Nature protocols. 2007; 2:1206-1215. [Abstract]

2006

  
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  • David, D., Ittner, L., Gehrig, P., Nergenau, D., Shepherd, C., Halliday, G., Götz, J. beta-Amyloid treatment of two complementary P301L tau-expressing Alzheimer's disease models reveals similar deregulated cellular processes. Proteomics. 2006; 6:6566-77. [Abstract]
  • Schild, A., Schmidt, K., Lim, Y., Ke, Y., Ittner, L., Hemmings, B., Götz, J. Altered levels of PP2A regulatory B/PR55 isoforms indicate role in neuronal differentiation. International journal of developmental neuroscience. 2006; 24:437-443. [Abstract]
  • Götz, J., Ittner, L., Schonrock, N. Alzheimer's disease and frontotemporal dementia: prospects of a tailored therapy?. The Medical journal of Australia. 2006; 185:381-384. [Abstract]
  • Gotz, J. Transgenic animal models of Alzheimer's disease. European Neuropsychopharmacology. 2006; 16:S197-S197. [Abstract]
  • Götz, J., Ittner, L., Kins, S. Do axonal defects in tau and amyloid precursor protein transgenic animals model axonopathy in Alzheimer's disease?. Journal of neurochemistry. 2006; 98:993-1006. [Abstract]
  • Pennanen, L., Wolfer, D., Nitsch, R., Götz, J. Impaired spatial reference memory and increased exploratory behavior in P301L tau transgenic mice. Genes, brain, and behavior. 2006; 5:369-379. [Abstract]
  • Schild, A., Ittner, L., Götz, J. Altered phosphorylation of cytoskeletal proteins in mutant protein phosphatase 2A transgenic mice. Biochemical and biophysical research communications. 2006; 343:1171-1178. [Abstract]
  • Schild, A., Isenmann, S., Tanimoto, N., Tonagel, F., Seeliger, M., Ittner, L., Kretz, A., Ogris, E., Götz, J. Impaired development of the Harderian gland in mutant protein phosphatase 2A transgenic mice. Mechanisms of development. 2006; 123:362-371. [Abstract]
  • Kulic, L., Kurosinski, P., Chen, F., Tracy, J., Mohajeri, M., Li, H., Nitsch, R., Götz, J. Active immunization trial in Abeta(42)-injected P301L tau transgenic mice. Neurobiology of disease. 2006; 22:50-6. [Abstract]
  • Tam, C., Husmann, K., Clark, N., Clark, J., Lazar, Z., Ittner, L., Götz, J., Douglas, G., Grant, A., Sugden, D., Poston, L., Poston, R., McFadzean, I., Marber, M., Fischer, J., Born, W., Brain, S. Enhanced vascular responses to adrenomedullin in mice overexpressing receptor-activity-modifying protein 2. Circulation research. 2006; 98:262-70. [Abstract]
  • Pei, J., An, W., Zhou, X., Nishimura, T., Norberg, J., Benedikz, E., Gotz, J., Winblad, B. P70S6 kinase mediates tau phosphorylation and synthesis. Febs Letters. 2006; 580:107-114. [Abstract]
  • Goetz, J., David, D., Ittner, L. Impact of beta-amyloid on the tau pathology in tau transgenic mouse and tissue culture models. In: Abeta Peptide and Alzheimer's Disease: Celebrating a Century of Research. United Kingdom: Springer 2006. p. 198-215.

2005

  
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  • Pennanen, L., Götz, J. Different tau epitopes define Abeta42-mediated tau insolubility. Biochemical and biophysical research communications. 2005; 337:1097-101. [Abstract]
  • David, D., Hauptmann, S., Scherping, I., Schuessel, K., Keil, U., Rizzu, P., Ravid, R., Dröse, S., Brandt, U., Müller, W., Eckert, A., Götz, J. Proteomic and functional analyses reveal a mitochondrial dysfunction in P301L tau transgenic mice. The Journal of biological chemistry. 2005; 280:23802-23814. [Abstract]
  • Hoerndli, F., David, D., Götz, J. Functional Genomics meets neurodegenerative disorders. Part II: application and data integration. Progress in neurobiology. 2005; 76:169-88. [Abstract]
  • David, D., Hoerndli, F., Götz, J. Functional Genomics meets neurodegenerative disorders Part I: transcriptomic and proteomic technology. Progress in neurobiology. 2005; 76:153-68. [Abstract]
  • Goetz, J., Ittner, L., David, D. Role of the protein tau in Alzheimer's disease. Drug discovery today. Disease mechanisms. 2005; 2:395-400.

2004

  
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  • Hoerndli, F., Toigo, M., Schild, A., Götz, J., Day, P. Reference genes identified in SH-SY5Y cells using custom-made gene arrays with validation by quantitative polymerase chain reaction. Analytical biochemistry. 2004; 335:30-41. [Abstract]
  • Götz, J., Schild, A., Hoerndli, F., Pennanen, L. Amyloid-induced neurofibrillary tangle formation in Alzheimer's disease: insight from transgenic mouse and tissue-culture models. International journal of developmental neuroscience. 2004; 22:453-465. [Abstract]
  • Chen, F., David, D., Ferrari, A., Götz, J. Posttranslational modifications of tau--role in human tauopathies and modeling in transgenic animals. Current drug targets. 2004; 5:503-515. [Abstract]
  • Götz, J., Streffer, J., David, D., Schild, A., Hoerndli, F., Pennanen, L., Kurosinski, P., Chen, F. Transgenic animal models of Alzheimer's disease and related disorders: histopathology, behavior and therapy. Molecular psychiatry. 2004; 9:664-683. [Abstract]
  • Chen, F., Wollmer, M., Hoerndli, F., Münch, G., Kuhla, B., Rogaev, E., Tsolaki, M., Papassotiropoulos, A., Götz, J. Role for glyoxalase I in Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 2004; 101:7687-7692. [Abstract]
  • Pennanen, L., Welzl, H., D'Adamo, P., Nitsch, R., Götz, J. Accelerated extinction of conditioned taste aversion in P301L tau transgenic mice. Neurobiology of disease. 2004; 15:500-509. [Abstract]
  • Rauer, M., Götz, J., Schuppli, D., Staeheli, P., Hausmann, J. Transgenic mice expressing the nucleoprotein of Borna disease virus in either neurons or astrocytes: decreased susceptibility to homotypic infection and disease. Journal of virology. 2004; 78:3621-3632. [Abstract]
  • Martens, E., Stevens, I., Janssens, V., Vermeesch, J., Götz, J., Goris, J., Van Hoof, C. Genomic organisation, chromosomal localisation tissue distribution and developmental regulation of the PR61/B' regulatory subunits of protein phosphatase 2A in mice. Journal of molecular biology. 2004; 336:971-986. [Abstract]

2003

  
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  • Ferrari, A., Hoerndli, F., Baechi, T., Nitsch, R., Götz, J. beta-Amyloid induces paired helical filament-like tau filaments in tissue culture. The Journal of biological chemistry. 2003; 278:40162-8. [Abstract]
  • Kins, S., Kurosinski, P., Nitsch, R., Götz, J. Activation of the ERK and JNK signaling pathways caused by neuron-specific inhibition of PP2A in transgenic mice. The American journal of pathology. 2003; 163:833-843. [Abstract]
  • Flechsig, E., Hegyi, I., Leimeroth, R., Zuniga, A., Rossi, D., Cozzio, A., Schwarz, P., Rülicke, T., Götz, J., Aguzzi, A., Weissmann, C. Expression of truncated PrP targeted to Purkinje cells of PrP knockout mice causes Purkinje cell death and ataxia. The EMBO journal. 2003; 22:3095-3101. [Abstract]
  • Streffer, J., Papassotiropoulos, A., Kurosinski, P., Signorell, A., Wollmer, M., Tsolaki, M., Iakovidou, V., Hörndli, F., Bosset, J., Götz, J., Nitsch, R., Hock, C. Saitohin gene is not associated with Alzheimer's disease. Journal of neurology, neurosurgery, and psychiatry. 2003; 74:362-363. [Abstract]
  • Chen, F., Ferrari, A., Schild, A., Kurosinski, P., David, D., Hoerndli, F., Pennanen, L., Kins, S., van Dorpe, J., Nitsch, R., Goetz, J. Amyloid-induced neurofibrillary tangle formation. In: Alzheimer's disease and related disorders: Research Advances. United States: Ana Aslan International Academy of Aging 2003. p. 343-354.
  • Götz, J., Schild, A. Transgenic and knockout models of PP2A. Methods in enzymology. 2003; 366:390-403. [Abstract]