You are here: Home / Our research / Clinical Research Unit 

Associate Professor Simon Lewis

Associate Professor
Brain & Mind Research Institute, Sydney Medical School

M02 - Mallet Street Campus
The University of Sydney
NSW 2006 Australia

T:+61 2 9351 0702
F:+61 2 9351 0855
E:

Biographical details

Dr Simon Lewis is an NHMRC Practitioner Fellow who works as a Consultant Neurologist at the Royal Prince Alfred Hospital and is Associate Professor in Cognitive Neuroscience at the University of Sydney. He is the Director of the Parkinson's Disease Research Clinic at the Brain & Mind Research Institute and heads the NSW Movement Disorders Brain Donor program. He has published over 50 peer review papers, 2 books and 2 book chapters and has attracted funding from the NHMRC, ARC and Michael J Fox Foundation to support his research interests targeting quality of life in PD. In addition to this research, he sits on the Council of Parkinson's NSW. He recently led the nationwide 'DASH to the InfoLine' campaign aiming to raise awareness and reduce stigma in PD and is now heading the first trial to evaluate community based Parkinson's nurse specialists in Australia.

Back to Top

Current national competitive grants*

2012

Make up your mind! - Dissociating the roles of orbitofrontal cortex and striatum in human decision making
Hornberger M, Hodges J, Lewis S
ARC Discovery Project ($794,339 over 4 years)

2011

Practitioner Fellowship 1
Lewis S
NHMRC Career Award: Practitioner Fellowship ($428,865 over 5 years)

* Grants administered through the University of Sydney

Back to Top

Keywords

Neurosciences; Cognitive disorders; Neuroimaging; Parkinson's disease; Dementia

Back to Top

International links

United States. (Mt Sinai, New York) A/Prof Steven Moore.

Back to Top

Publications

2013 | 2012 | 2011 | 2010 | 2009 | 2007

2013

  
  • Shine, J., Naismith, S., Palavra, N., Lewis, S., Moore, S., Dilda, V., Morris, T. (2013), Attentional set-shifting deficits correlate with the severity of freezing of gait in Parkinson's disease. Parkinsonism & Related Disorders. , 388-390. [Abstract]
  • Shine, J., Naismith, S., Lewis, S. (2013), The differential yet concurrent contributions of motor, cognitive and affective disturbance to freezing of gait in Parkinson's disease. Clinical Neurology and Neurosurgery. 115(5), 542-545. [Abstract]
  • Shine, J., Matar, E., Ward, P., Bolitho, S., Pearson, M., Naismith, S., Lewis, S. (2013), Differential neural activation patterns in patients with Parkinson's disease and freezing of gait in response to concurrent cognitive and motor load. PloS One. 8(1), e52602. [Abstract]

2012

  
Back to Top
  • Lewis, S., Shine, J., Duffy, S., Halliday, G., Naismith, S. (2012), Anterior cingulate integrity: Executive and neuropsychiatric features in Parkinson's disease. Movement Disorders. 27(10), 1262-1267. [Abstract]
  • Handojoseno, A., Shine, J., Nguyen, T., Tran, Y., Lewis, S., Nguyen, H. (2012), The detection of Freezing of Gait in Parkinson's disease patients using EEG signals based on Wavelet decomposition. United States: IEEE, . [Abstract]
  • Tsang, R., Diamond, K., Mowszowski, L., Lewis, S., Naismith, S. (2012), Using informant reports to detect cognitive decline in mild cognitive impairment. International Psychogeriatrics. 24(6), 967-973. [Abstract]
  • Morris, T., Cho, C., Dilda, V., Shine, J., Naismith, S., Lewis, S., Moore, S. (2012), A comparison of clinical and objective measures of freezing of gait in Parkinson's disease. Parkinsonism & Related Disorders. 18(5), 572-577. [Abstract]
  • Shine, J., Halliday, G., Carlos, M., Naismith, S., Lewis, S. (2012), Investigating visual misperceptions in Parkinson's disease: A novel behavioral paradigm. Movement Disorders. 27(4), 500-505. [Abstract]
  • Naismith, S., Mowszowski, L., Ward, P., Diamond, K., Paradise, M., Kaur, M., Lewis, S., Hickie, I., Hermens, D. (2012), Reduced temporal mismatch negativity in late-life depression: An event-related potential index of cognitive deficit and functional disability?. Journal of Affective Disorders. 138(1-2), 71-78. [Abstract]
  • Mowszowski, L., Hermens, D., Diamond, K., Norrie, L., Hickie, I., Lewis, S., Naismith, S. (2012), Reduced Mismatch Negativity in Mild Cognitive Impairment: Associations with Neuropsychological Performance. Journal of Alzheimer's Disease. 30(1), 209-219. [Abstract]
  • Shine, J., Moore, S., Bolitho, S., Morris, T., Dilda, V., Naismith, S., Lewis, S. (2012), Assessing the utility of Freezing of Gait Questionnaires in Parkinson's Disease. Parkinsonism & related disorders. 18(1), 25-9. [Abstract]

2011

  
Back to Top
  • Shine, J., Halliday, G., Naismith, S., Lewis, S. (2011), Visual misperceptions and hallucinations in Parkinson's disease: Dysfunction of attentional control networks?. Movement disorders : official journal of the Movement Disorder Society. 26, 2154-9. [Abstract]
  • Shine, J., Naismith, S., Lewis, S. (2011), The pathophysiological mechanisms underlying freezing of gait in Parkinson's Disease. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. 18(9), 1154-7. [Abstract]
  • Zhong, G., Naismith, S., Rogers, N., Lewis, S. (2011), Sleep-wake disturbances in common neurodegenerative diseases: A closer look at selected aspects of the neural circuitry. Journal of the neurological sciences. 307(1-2), 9-14. [Abstract]
  • Abbott, L., Naismith, S., Lewis, S. (2011), Parkinson's disease in general practice: Assessing knowledge, confidence and the potential role of education. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. 18(8), 1044-7. [Abstract]
  • Naismith, S., Terpening, Z., Shine, J., Lewis, S. (2011), Neuropsychological functioning in Parkinson's disease: Differential relationships with self-reported sleep-wake disturbances. Movement disorders : official journal of the Movement Disorder Society. 26(8), 1537-41. [Abstract]
  • Naismith, S., Rogers, N., Lewis, S., Terpening, Z., Ip, T., Diamond, K., Norrie, L., Hickie, I. (2011), Sleep disturbance relates to neuropsychological functioning in late-life depression. Journal of affective disorders. 132(1-2), 139-45. [Abstract]
  • Lewis, S. (2011), Commentary: An evaluation of mechanisms underlying the influence of step cues on gait in Parkinson's disease. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. 18(6), 803. [Abstract]
  • Shine, J., Ward, P., Naismith, S., Pearson, M., Lewis, S. (2011), Utilising functional MRI (fMRI) to explore the freezing phenomenon in Parkinson's disease. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. 18(6), 807-10. [Abstract]
  • Hardy, T., Garsia, R., Halmagyi, G., Lewis, S., Harrisberg, B., Fulham, M., Barnett, M. (2011), Tumour necrosis factor (TNF) inhibitor therapy in Susac's syndrome. Journal of the neurological sciences. 302(1-2), 126-8. [Abstract]
  • Naismith, S., Lewis, S. (2011), "DASH" symptoms in patients with Parkinson's disease: red flags for early cognitive decline. Journal of Clinical Neuroscience. 18(3), 352-355. [Abstract]
  • Naismith, S., Diamond, K., Carter, P., Norrie, L., Redoblado-Hodge, M., Lewis, S., Hickie, I. (2011), Enhancing Memory in Late-Life Depression: The Effects of a Combined Psychoeducation and Cognitive Training Program. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. 19(3), 240-8. [Abstract]
  • Naismith, S., Rogers, N., Lewis, S., Diamond, K., Terpening, Z., Norrie, L., Hickie, I. (2011), Sleep disturbance in mild cognitive impairment: Differential effects of current and remitted depression. Acta Neuropsychiatrica. 23(4), 167-172.
  • Hurelbrink, C., Lewis, S. (2011), Pathological considerations in the treatment of Parkinson's disease: More than just a wiring diagram. Clinical neurology and neurosurgery. 113(1), 1-6. [Abstract]
  • Naismith, S., Lewis, S., Rogers, N. (2011), Sleep-wake changes and cognition in neurodegenerative disease. Progress in Brain Research. 190, 21-52. [Abstract]
  • Komadina, N., Terpening, Z., Huang, Y., Halliday, G., Naismith, S., Lewis, S. (2011), Utility and Limitations of Addenbrooke's Cognitive Examination-Revised for Detecting Mild Cognitive Impairment in Parkinson's Disease. Dementia and geriatric cognitive disorders. 31(5), 349-57. [Abstract]
  • Naismith, S., Pereira, M., Shine, J., Lewis, S. (2011), How well do caregivers detect mild cognitive change in Parkinson's disease?. Movement disorders : official journal of the Movement Disorder Society. 26, 161-4. [Abstract]

2010

  
Back to Top
  • Naismith, S., Lewis, S. (2010), A novel paradigm for modelling freezing of gait in Parkinson's disease. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. 17(8), 984-7. [Abstract]
  • Naismith, S., Shine, J., Lewis, S. (2010), The specific contributions of set-shifting to freezing of gait in Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. 25(8), 1000-4. [Abstract]
  • Gunn, D., Naismith, S., Lewis, S. (2010), Sleep disturbances in Parkinson disease and their potential role in heterogeneity. Journal of Geriatric Psychiatry and Neurology. 23(2), 131-7. [Abstract]
  • Naismith, S., Rogers, N., Hickie, I., Mackenzie, J., Norrie, L., Lewis, S. (2010), Sleep Well, Think Well: Sleep-Wake Disturbance in Mild Cognitive Impairment. Journal of geriatric psychiatry and neurology. 23(2), 123-30. [Abstract]
  • Naismith, S., Rogers, N., Mackenzie, J., Hickie, I., Lewis, S. (2010), The relationship between actigraphically defined sleep disturbance and REM sleep behaviour disorder in Parkinson's Disease. Clinical neurology and neurosurgery. 112(5), 420-3. [Abstract]
  • Naismith, S., Redoblado-Hodge, M., Lewis, S., Scott, E., Hickie, I. (2010), Cognitive training in affective disorders improves memory: A preliminary study using the NEAR approach. Journal of Affective Disorders. 121(3), 258-262. [Abstract]
  • Ahmed, R., Green, T., Halmagyi, G., Lewis, S. (2010), A new model for neurology care in the emergency department. The Medical Journal of Australia. 192(1), 30-32. [Abstract]
  • Lewis, S., Naismith, S. (2010), DASH to the InfoLine: Promoting a healthy brain and mind in Parkinson’s Disease. Australia: LifeBlood.
  • Naismith, S., Hickie, I., Lewis, S. (2010), The role of mild depression in sleep disturbance and quality of life in Parkinson's disease. The Journal of Neuropsychiatry and Clinical Neurosciences. 22(4), 384-389. [Abstract]

2009

  
Back to Top
  • Parratt, K., Allan, M., Lewis, S., Dalmau, J., Halmagyi, G., Spies, J. (2009), Acute psychiatric illness in a young woman: an unusual form of encephalitis. The Medical Journal of Australia. 191(5), 284-286. [Abstract]
  • Naismith, S., Norrie, L., Lewis, S., Rogers, N., Scott, E., Hickie, I. (2009), Does sleep disturbance mediate neuropsychological functioning in older people with depression?. Journal of Affective Disorders. 116(1-2), 139-143. [Abstract]
  • Lewis, S., Barker, R. (2009), A pathophysiological model of freezing of gait in Parkinson's disease. Parkinsonism & related disorders. 15(5), 333-8. [Abstract]
  • Lewis, S., Barker, R. (2009), Understanding the dopaminergic deficits in Parkinson's disease: insights into disease heterogeneity. Journal of clinical neuroscience. 16(5), 620-625. [Abstract]
  • Clatworthy, P., Lewis, S., Brichard, L., Hong, Y., Izquierdo, D., Clark, L., Cools, R., Aigbirhio, F., Baron, J., Fryer, T., Robbins, T. (2009), Dopamine release in dissociable striatal subregions predicts the different effects of oral methylphenidate on reversal learning and spatial working memory. The Journal of Neuroscience. 29(15), 4690-4696. [Abstract]
  • Lewis, S. (2009), Parkinson's Disease: New approaches to treatment, non-drug management, and how to monitor response or side effects of medications. Geriatric Medicine in General Practice. 1, 18-20.
  • Lewis, S. (2009), Parkinson’s Disease: New approaches to treatment, non-drug management, and how to monitor response or side effects of medications. Geriatric Medicine in General Practice. 1, 18-20.
  • Alkhalil, M., Lewis, S., Hawker, M., Dick, D. (2009), Persistent unilateral mydriasis and headache. BMJ case reports. 2009, bcr11.2008.1260. [Abstract]

2007

  
Back to Top
  • Stacpoole, S., McGuigan, C., Lewis, S., Phadke, R., Stevens, J., Choi, D., Kapoor, R. (2007), Spinal claudication due to myxopapillary ependymoma. Practical Neurology. 7(6), 394-396. [Abstract]
  • Goris, A., Williams-Gray, C., Clark, G., Foltynie, T., Lewis, S., Brown, J., Ban, M., Spillantini, M., Compston, A., Burn, D., Chinnery, P., Barker, R., Sawcer, S. (2007), Tau and alpha-synuclein in susceptibility to, and dementia in, Parkinson's disease. Annals of neurology. 62(2), 145-153. [Abstract]
  • Cools, R., Lewis, S., Clark, L., Barker, R., Robbins, T. (2007), L-DOPA disrupts activity in the nucleus accumbens during reversal learning in Parkinson's disease. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 32(1), 180-189. [Abstract]