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Dr Damian Holsinger

Lecturer in Neuroscience
Biomedical Sciences, School of Medical Sciences

M02 - Mallet Street Campus
The University of Sydney
NSW 2006 Australia

T:+61 2 9351 9324 (or 0876)
F:+61 2 9351 9520
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Biographical details

Damian Holsinger began investigating molecular mechanisms underlying Alzheimer's disease in 1997. In 2002 he made the seminal discovery that levels of the pivotal AD-related enzyme, BACE1, were increased in the brain of patients (Annals of Neurology, 51:783-786). These findings have been widely accepted in the field (250 citations) and have led to a concentrated focus on this enzyme as a therapeutic avenue for the treatment of Alzheimer?s disease. In 2006, Damian accepted a position as Lecturer in Neuroscience at The University of Sydney and founded the Laboratory of Molecular Neuroscience at the Brain & Mind Research Institute in 2007. He continues to investigate molecular mechanisms underlying neurodegenerative diseases with a particular focus on BACE1.

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Research interests

Research interests surround the understanding of mechanisms by which complex neurological disorders arise and methods of treating these diseases.

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Keywords

Dementia; Cell biology; Molecular biology; Alzheimer's disease; Ageing

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Publications

2013 | 2012 | 2010 | 2009 | 2008

2013

  
  • Holsinger, R., Goense, N., Bohorquez, J., Strappe, P. (2013), Splice variants of the Alzheimer's disease beta-secretase, BACE1. Neurogenetics. 14(1), 1-9. [Abstract]
  • Buljan, V., Holsinger, D., Hambly, B., Banati, R., Ivanova, E. (2013), Intrinsic microtubule GTP-cap dynamics in semi-confined systems: kinetochore-microtubule interface. Journal of Biological Physics. 39(1), 81-98.

2012

  
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  • Holsinger, R., Brown, R., Richmond, R., Kay-Lambkin, F., Law, J., Kirby, A., Chan, D. (2012), Prevalence of the long-allele genotype of the serotonin transporter-linked gene in female centenarians. Journal of the American Geriatrics Society. 60(9), 1786-1788. [Abstract]

2010

  
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  • George, A., Gordon, L., Beissbarth, T., Koukoulas, I., Holsinger, R., Perreau, V., Cappai, R., Tan, S., Masters, C., Scott, H., Li, Q. (2010), A Serial Analysis of Gene Expression Profile of the Alzheimer's Disease Tg2576 Mouse Model. Neurotoxicity research. 17(4), 360-79. [Abstract]

2009

  
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  • Kassiou, M., Banati, R., Holsinger, R., Meikle, S. (2009), Challenges in molecular imaging of Parkinson's disease: A brief overview. Brain research bulletin. 78(0), 105-8. [Abstract]

2008

  
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  • Einfeld, S., Götz, J., Holsinger, R. (2008), Pathogenetic mechanisms in Down Syndrome. Journal of intellectual disability research. 52(10), 813. [Abstract]