Skip to main content
Centres and institutes_

Microscopy

One of the world’s largest, most comprehensive microscopy facilities

The Brain and Mind Centre’s microscopy facilities provide researchers with access to sophisticated technology to observe diseases of the brain and mind at a micro level. 

The microscopy facility based at the Brain and Mind Centre forms part of Sydney Microscopy & Microanalysis, the University of Sydney’s largest core facility, run by the Australian Centre for Microscopy & Microanalysis. This cross-disciplinary microscopy research facility is one of the largest and most comprehensive in the world, and it provides our researchers with technical expertise and access to world-class instrumentation.

Microscopes available at the Brain and Mind Centre

  • Zeiss 710 LSM confocal/multiphoton microscope
    • Specifically designed to deeply observe living organisms, to create 3-D time lapse records of cells interacting with each other or pathological diseased states.
    • It can also be used to observe fluorescently-labelled tissue sections to a very high magnification and resolution.
  • Olympus VS-120 slide scanner
    • This scanner allows researchers to observe labelled tissues on slides, using five channel fluorescence, dark field, Differential Interference Contrast (DIC) and transmitted light modalities.
    • Researchers can acquire immuno-fluorescently labelled tissues, or typical staining procedures including DAB and H & E stained tissue.
    • The system has a robotic arm that can be used in conjunction with two 50-slide racks, allowing up to 100 slides to be put under the microscope objective, one slide at a time. These are then scanned in a fully automated fashion.
  • Zeiss Axio Observer Z1 Live Cell Imaging System
    • Set up to visualise and acquire long term (or very fast) images, to show cell migration, wound healing, and cell proliferation over time.
    • This inverted microscopy system has a specially designed atmospheric chamber which is thermos-controlled to 37C and pumped with gasses to keep the cells being observed alive and happy for extended periods of time.
    • The system is equipped with five objectives (10x, 20x, 40x, 63x and 100x), four channel fluorescence and transilluminated light, allowing for observation of a wide variety of cells.

  • Imaging Desktops
    • We also have two very high-end imaging desktops which run a variety of imaging programs including Virtual-Slide-Scanner analysis software, Huygens, Fiji and Matlab.