Dr Andrew Hoy

Research Fellow
Physiology, School of Medical Sciences
Bosch Institute

F13 - Anderson Stuart Building
The University of Sydney
NSW 2006 Australia

T: 02 9351 2514
E:
Curriculum vitae

Biographical details

Research interests

Research conducted by my laboratory is focused on the regulation of lipid metabolism, predominantly fatty acid storage and utilisation, and how this may be perturbed in chronic disease states such as cancer, obesity and insulin resistance. For example, investigations are underway to understand the relationship between lipid and glucose metabolism and insulin action. A role for dysregulation of lipid metabolism, which results in accumulation metabolically active lipid intermediates, has been shown to interfere with insulin signalling. Investigations into the relationship between the main site of fatty acid storage, the lipid droplet, and the mitochondria and how this maybe hormonally regulating are ongoing. Finally, understanding the potential role for altered fatty acid metabolism in cancer is another stream of research.

Current Laboratory Members:

  • Miss Seher Balaban - PhD Student

  • Mr Harrison Shtein -MPhil Student

  • Mr Tim Nguyen -MPhil Student

  • Miss Lisa Lee - BSc Hons Student

  • Mr Mark Schreuder - visiting MSc Student (University of Utrecht)

PhD and Masters' project opportunities

Research opportunities in metabolism

Publications

2013 | 2012 | 2011 | 2010 | 2009 | 2008

2013

   
  • Kim, M., Lee, K., Iseli, T., Hoy, A., George, J., Grewal, T., Roufogalis, B. (2013), Compound K modulates fatty acid-induced lipid droplet formation and expression of proteins involved in lipid metabolism in hepatocytes. Liver International. 33, 1583-1593. [Abstract]
  • Peoples, G., Hoy, A., Henry, R., McLennan, P. (2013), Autologous pump-perfused rat hind limb preparation for investigating muscle function and metabolism in vivo. Microcirculation. 20(6), 511-523. [Abstract]
  • Bell-Anderson, K., Funnell, A., Williams, H., Jusoh, H., Scully, T., Lim, W., Burdach, J., Mak, K., Knights, A., Hoy, A., Nicholas, H., Sainsbury, A., Turner, N., Pearson, R., Crossley, M. (2013), Loss of Kruppel-like Factor 3 (KLF3/BKLF) leads to upregulation of the insulin-sensitizing factor adipolin (FAM132A/CTRP12/C1qdc2). Diabetes. 62(8), 2728-2737. [Abstract]

2012

   
  • Watt, M., Barnett, A., Bruce, C., Schenk, S., Horowitz, J., Hoy, A. (2012), Regulation of plasma ceramide levels with fatty acid oversupply: evidence that the liver detects and secretes de novo synthesised ceramide. Diabetologia. 55(10), 2741-2746. [Abstract]
  • Watt, M., Hoy, A. (2012), Lipid metabolism in skeletal muscle: generation of adaptive and maladaptive intracellular signals for cellular function. American Journal of Physiology: Endocrinology and Metabolism. 302(11), E1315-E1328. [Abstract]
  • Watt, M., Hoy, A., Muoio, D., Coleman, R. (2012), Distinct roles of specific fatty acids in cellular processes: implications for interpreting and reporting experiments. American Journal of Physiology: Endocrinology and Metabolism. 302(1), E1-E3. [Abstract]

2011

   
  • Wright, L., Brandon, A., Hoy, A., Forsberg, G., Lelliott, C., Reznick, J., Löfgren, L., Oscarsson, J., Strömstedt, M., Cooney, G., Turner, N. (2011), Amelioration of lipid-induced insulin resistance in rat skeletal muscle by overexpression of Pgc-1? involves reductions in long-chain acyl-CoA levels and oxidative stress. Diabetologia. 54(6), 1417-26. [Abstract]
  • Brandon, A., Hoy, A., Wright, L., Turner, N., Hegarty, B., Iseli, T., Julia Xu, X., Cooney, G., Saha, A., Ruderman, N., Kraegen, E. (2011), The evolution of insulin resistance in muscle of the glucose infused rat. Archives of Biochemistry and Biophysics. 509(2), 133-141. [Abstract]
  • Hoy, A., Bruce, C., Turpin, S., Morris, A., Febbraio, M., Watt, M. (2011), Adipose triglyceride lipase-null mice are resistant to high-fat diet-induced insulin resistance despite reduced energy expenditure and ectopic lipid accumulation. Endocrinology. 152(1), 48-58. [Abstract]
  • Turpin, S., Hoy, A., Brown, R., Rudaz, C., Honeyman, J., Matzaris, M., Watt, M. (2011), Adipose triacylglycerol lipase is a major regulator of hepatic lipid metabolism but not insulin sensitivity in mice. Diabetologia. 54(1), 146-156. [Abstract]

2010

   
  • Hoehn, K., Turner, N., Swarbrick, M., Wilks, D., Preston, E., Phua, Y., Joshi, H., Furler, S., Larance, M., Hegarty, B., Leslie, S., Pickford, R., Hoy, A., Kraegen, E., James, D., Cooney, G. (2010), Acute or chronic upregulation of mitochondrial fatty acid oxidation has no net effect on whole-body energy expenditure or adiposity. Cell Metabolism. 11(1), 70-76. [Abstract]

2009

   
  • Hoehn, K., Salmon, A., Hohnen-Behrens, C., Turner, N., Hoy, A., Maghzal, G., Stocker, R., Van Remmen, H., Kraegen, E., Cooney, G., Richardson, A., James, D. (2009), Insulin resistance is a cellular antioxidant defense mechanism. Proceedings of the National Academy of Sciences of the United States of America. 106(42), 17787-17792. [Abstract]
  • Hoy, A., Peoples, G., McLennan, P. (2009), The effect of vasoconstrictors on oxygen consumption in resting and contracting skeletal muscle of the autologous pump-perfused rat hindlimb. Journal of Physiology and Pharmacology. 60(3), 155-160. [Abstract]
  • Hoy, A., Brandon, A., Turner, N., Watt, M., Bruce, C., Cooney, G., Kraegen, E. (2009), Lipid and insulin infusion-induced skeletal muscle insulin resistance is likely due to metabolic feedback and not changes in IRS-1, Akt, or AS160 phosphorylation. American Journal of Physiology: Endocrinology and Metabolism. 297(1), E67-E75. [Abstract]
  • Bruce, C., Hoy, A., Turner, N., Watt, M., Allen, T., Carpenter, K., Cooney, G., Febbraio, M., Kraegen, E. (2009), Overexpression of carnitine palmitoyltransferase-1 in skeletal muscle is sufficient to enhance fatty acid oxidation and improve high-fat diet-induced insulin resistance. Diabetes. 58(3), 550-558. [Abstract]
  • Hoy, A., Watt, M. (2009), Lipid Partitioning and Insulin Sensitivity: Lessons learnt from Genetic Models. Asia-Pacific Journal of Endocrinology. 1(1), 35-47.

2008

   
  • Hoy, A., Turner, N. (2008), New insight into the mechanism by which acute physical exercise ameliorates insulin resistance. Journal of Physiology. 586(9), 2251-2252. [Abstract]