Dr Chris Jolly

Research Fellow
Medicine, Central Clinical School
Centenary Institute of Cancer Medicine & Cell Biology

C39 - Royal Prince Alfred Hospital
The University of Sydney
NSW 2006 Australia

T: 02 95656188
F: 02 9565 6101
E:
W: Related website

Biographical details

Research interests

My group studies antibody mutation in activated B cells, which is initiated by the DNA editing enzyme "AID". B cells mutate their antibody genes at extremely high rates during infections, to rapidly optimise the ability of the antibodies they make to neutralise the infecting pathogen. "Off-target" mutation of oncogenes by AID underlies most adult B cell cancers, so we seek to understand why AID-induced DNA damage leads to mutation, when similar DNA damage is generally repaired faithfully.

Teaching areas

B cell development. Antibody gene rearrangement and mutation.

Publications

2012 | 2010 | 2008

2012

   
  • Chan, T., Wood, K., Hermes, J., Butt, D., Jolly, C., Basten, A., Brink, R. (2012), Elimination of Germinal Center-Derived Self-Reactive B Cells Is Governed by the Location and Concentration of Self-Antigen. Immunity. 37(5), 893-904. [Abstract]
  • Sharbeen, G., Yee, C., Smith, A., Jolly, C. (2012), Ectopic restriction of DNA repair reveals that UNG2 excises AID-induced uracils predominantly or exclusively during G1 phase. The Journal of Experimental Medicine. 209(5), 965-974. [Abstract]

2010

   
  • Sharbeen, G., Cook, A., Lau, K., Raftery, J., Yee, C., Jolly, C. (2010), Incorporation of dUTP does not mediate mutation of A:T base pairs in Ig genes in vivo. Nucleic Acids Research. 38(22), 8120-8130. [Abstract]

2008

   
  • Jolly, C., Cook, A., Manis, J. (2008), Fixing DNA breaks during class switch recombination. The Journal of Experimental Medicine. 205(3), 509-513. [Abstract]