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Professor Cristobal Dos Remedios

Professor
Anatomy & Histology, School of Medical Sciences
Bosch Institute

F13 - Anderson Stuart Building
The University of Sydney
NSW 2006 Australia

T: +61 2 9351 3209
F: +61 2 9351 6546
E:
W: Related website

Research interests

Molecular basis of human heart failure

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Keywords

Inflammation; Melanoma and skin cancer; Proteomics; Autoimmunity; Cardiovascular diseases

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International links

United States. (Harvard Medical School) working with Prof Paul Allen.
United States. (William Pu, PhD Department of Cardiology, Children''s Hospital Enders 13,300 Longwood Ave., Boston, MA 02115) Research collaboration involving the role of splicing variants of cardiac proteins in human heart failure.
United Kingdom. (Dr Michael Gray, Epithelial Research Group, Institute for Cell and Molecular Biosciences, University Medical School, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4HH) Research collaboration involving the role of a protein kinase called sgk1 in human heart failure..
United Kingdom. (Paul Riley PhD, Molecular Medicine Unit, UCL-Institute of Child Health, 30 Guilford Street, London, WC1N 1EH) Research collaboration involving hypertrophic cardiomyopathy (HOCM) myectomy heart samples to study transcriptional/microRNA regulation of sarcomeric gene expression in human heart failure..
United Kingdom. (Elizabeth Ehler PhD., Kings College London BHF Research Excellence Centre, The Randall Division of Cell and Molecular Biophysics, New Hunts House, Guys Campus, London SE1 1UL) Research collaboration involving measurement of expression levels of a muscle-specific isoform of the formin (FHOD3) in the human heart and its role in myofibril maintenance.
Japan. (Shin''ichi Ishiwata, Ph.D., Professor of Biophysics, Department of Physics, School of Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo, 169-8555) Awarded a JSRS Travel grant to visit in September 2008. In 2009 we commenced a collaborative, working on SPontaneous Oscilatory Contractions (SPOCs) as a method of quantifying functional deficits in end-stage failing human cardiomyocytes..
United Kingdom. (Ayesha De Souza, PhD, Department of Cardiac & Vascular Sciences, St. George''s Hospital, University of London, Cranmer Terrace Tooting, London, SW17 0RE) Research collaboration involving proteomic and metabolomic analysis of failing human left atria to reveal the molecular mechanism underlying atrial fibrillation..
United States. (Lilehei Heart Inst, Division of Cardiology, University of Minnesota) Collaboration with Prof Jennifer Hall working on transcriptomics of failing human hearts.
United Kingdom. (Jonathan C. Kentish, MA, PhD Cardiovascular Division,King''s College London Rayne Institute, St. Thomas''s Hospital, London SE1 7EH) Collaborating involving a study of normal passive viscoelasticity but abnormal myofibrillar contractile function in patients with obstructive hypertrophic cardiomyopathy..
United States. (Johns Hopkins University Medical School, Division of Cardiology, Biological Chemistry and Biomedical Engineering) Working with Prof Jennifer Van Eyk on proteomics of failing human hearts.
Ireland. (Michael J. Dunn, PhD, UCD Conway Institute of Biomolecular and Biomedical Research, School of Medicine and Medical Science, University College Dublin, Dublin 4) Research collaboration involving the protective effect of phosphorylated Hsp27 in human coronary arteries through actin stabilisation.
United States. (Harvard Children's Hospital, Cardiology) Collaboration with Dr Bill Pu working on microRNAs and human heart failure.
France. (Inserm U915, Institut du Thorax, Nantes Faculte de Medecine) Research collaboration between Dr Marja Steenman, my laboratory and a graduate student, Maurizio Stefani..
United States. (Bernhard Kuhn, MD, PhD, Harvard Children''s Hospital, 61 Binney Street, Enders 1329, Boston MA 02115) Research collaboration with this laboratory involving a study of growth, proliferation and regeneration in the human heart from infancy to senescence..
Netherlands. (Institute for Cardiovascular Research. Free University Amsterdam) Collaboration with Jolanda Van Der Velden and others in her laboratory.
United States. (Director, Long QT Syndrome Clinic and Windland Smith Rice Sudden Death Genomics Laboratory Mayo Clinic) Research collaboration into molecular changes in hypertrophic cardiomyopathy in human hearts.
China. (Professor Xiyun Yan, National Key Laboratory of Biomolecules,Institute of Biophysics, Chinese Academy of Sciences Datun Road No.15, Beijing 100101) Research collaboration involving the use of a monoclonal anti-CD146 antibody to identify the role of CD146 in human heart failure..
Sweden. (University of Uppsala, HPR Research Group, Rudbeck Laboratory, Dag Hammarskjold 20 S-751-85, Uppsala) Research collaboration with Prof Fredrik Ponten involving the use of tissue microarrays of failing and non-failing human hearts..
Netherlands. (D.Dooijes, PhD., Clinical Molecular Geneticist Department of of Clinical Genetics, Erasmus Medical College, Dr. Molewaterplein 50, 3015GE, ROTTERDAM) Collaboration involving the genotyping og familial heart failure in man..
Ireland. (University College Dublin) Working with Prof. Michael Dunn.
Germany. (Dr. Wolfgang A. Linke, Department of Cardiovascular Physiology, Institute of Physiology, Faculty of Medicine Ruhr University Bochum. D-44780 Bochum) Collaboration with Dr Wolfgang Linke on the role of protein kinase G in modulating the passive stiffness of phosphorylated titin, a giant protein component of the cardiomyocyte..
United States. (Anne M. Murphy MD, The Johns Hopkins University Medical School, 720 Rutland Avenue Ross Bldg. 1144, Baltimore, MD 21205) Research collaboration involving mutations in cardiac troponin I in failing and non-failing human left ventricles..
United Kingdom. (Imperial College London) Collaborating with Prof Steve Marston on molecular defects in failing human cardiac proteins, particularly the proteins that regulate contraction in the heart..

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Publications

2012 | 2011 | 2010 | 2009 | 2008 | 2007

2012

   
  • Li, A., Ponten, F., dos Remedios, C. (2012), The interactome of LIM domain proteins: the contributions of LIM domain proteins to heart failure and heart development. Proteomics. 12(2), 203-225. [Abstract]
  • van Dijk, S., Paalberends, E., Najafi, A., Michels, M., Sadayappan, S., Carrier, L., Boontje, N., Kuster, D., van Slegtenhorst, M., Dooijes, D., dos Remedios, C., ten Cate, F., Stienen, G., van der Velden, J. (2012), Contractile dysfunction irrespective of the mutant protein in human hypertrophic cardiomyopathy with normal systolic function. Circulation. Heart Failure. 5(1), 36-46. [Abstract]

2011

   
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  • Changsirivathanathamrong, D., Wang, Y., Rajbhandari, D., Maghzal, G., Mak, W., Woolfe, C., Duflou, J., Gebski, V., Dos Remedios, C., Celermajer, D., Stocker, R. (2011), Tryptophan metabolism to kynurenine is a potential novel contributor to hypotension in human sepsis. Critical Care Medicine. 39(12), 2678-2683. [Abstract]
  • Wijnker, P., Boknik, P., Gergs, U., Müller, F., Neumann, J., dos Remedios, C., Schmitz, W., Sindermann, J., Stienen, G., van der Velden, J., Kirchhefer, U. (2011), Protein phosphatase 2A affects myofilament contractility in non-failing but not in failing human myocardium. Journal of Muscle Research and Cell Motility. 32(3), 221-233. [Abstract]
  • Polden, J., McManus, C., Dos Remedios, C., Dunn, M. (2011), A 2-D gel reference map of the basic human heart proteome. Proteomics. 11(17), 3582-3586. [Abstract]
  • Bilek, M., Bax, D., Kondyurin, A., Yin, Y., Nosworthy, N., Fisher, K., Waterhouse, A., Weiss, A., Dos Remedios, C., McKenzie, D. (2011), Free radical functionalization of surfaces to prevent adverse responses to biomedical devices. Proceedings of the National Academy of Sciences of the United States of America. 108(35), 14405-10. [Abstract]
  • Foreman, A., Phillips, L., Kanellis, V., Hammoudeh, D., Naumann, C., Wong, H., Chisari, R., Hibbert, D., Lee, G., Patra, R., Julli, M., Chapman, J., Cooke, A., Dos Remedios, C. (2011), A DNA-based assay for toxic chemicals in wastewater. Environmental toxicology and chemistry / SETAC. 30(8), 1810-8. [Abstract]
  • Maeder, M., Khammy, O., dos Remedios, C., Kaye, D. (2011), Myocardial and systemic iron depletion in heart failure implications for anemia accompanying heart failure. Journal of the American College of Cardiology. 58(5), 474-480. [Abstract]
  • Morales, M., dos Remedios, C. (2011), Biophysical educational experiment: science and goodwill in Latin America and Africa. Biophysical Reviews. 3, 101–106.
  • Wolfe, J., Ishiwata, S., Braet, F., Whan, R., Su, Y., Lal, S., dos Remedios, C. (2011), SPontaneous Oscillatory Contraction (SPOC): auto-oscillations observed in striated muscle at partial activation. Biophysical Reviews. 3(2), 53-62.
  • Hirsh, S., Nosworthy, N., Kondyurin, A., dos Remedios, C., McKenzie, D., Bilek, M. (2011), Linker-free covalent thermophilic β-glucosidase functionalized polymeric surfaces. Journal of Materials Chemistry. 21(44), 17832–17841.

2010

   
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  • Iskratsch, T., Lange, S., Dwyer, J., Kho, A., dos Remedios, C., Ehler, E. (2010), Formin follows function: a muscle-specific isoform of FHOD3 is regulated by CK2 phosphorylation and promotes myofibril maintenance. The Journal of Cell Biology. 191(6), 1159-1172. [Abstract]
  • Hamdani, N., Borbély, A., Veenstra, S., Kooij, V., Vrydag, W., Zaremba, R., Dos Remedios, C., Niessen, H., Michel, M., Paulus, W., Stienen, G., van der Velden, J. (2010), More severe cellular phenotype in human idiopathic dilated cardiomyopathy compared to ischemic heart disease. Journal of Muscle Research and Cell Motility. 31(4), 289-301. [Abstract]
  • Hoskins, A., Jacques, A., Bardswell, S., McKenna, W., Tsang, V., Dos Remedios, C., Ehler, E., Adams, K., Jalilzadeh, S., Avkiran, M., Watkins, H., Redwood, C., Marston, S., Kentish, J. (2010), Normal passive viscoelasticity but abnormal myofibrillar force generation in human hypertrophic cardiomyopathy. Journal of molecular and cellular cardiology. 49(5), 737-45. [Abstract]
  • Hirsh, S., Bilek, M., Nosworthy, N., Kondyurin, A., Dos Remedios, C., McKenzie, D. (2010), A Comparison of Covalent Immobilization and Physical Adsorption of a Cellulase Enzyme Mixture. Langmuir : the ACS journal of surfaces and colloids. 26(17), 14380-8. [Abstract]
  • Robinson, A., Dunn, M., McCormack, A., dos Remedios, C., Rose, M. (2010), Protective effect of phosphorylated Hsp27 in coronary arteries through actin stabilization. Journal of Molecular and Cellular Cardiology. 49(3), 370-379. [Abstract]
  • Kooij, V., Saes, M., Jaquet, K., Zaremba, R., Foster, D., Murphy, A., Dos Remedios, C., van der Velden, J., Stienen, G. (2010), Effect of troponin I Ser23/24 phosphorylation on Ca2+-sensitivity in human myocardium depends on the phosphorylation background. Journal of Molecular and Cellular Cardiology. 48(5), 954-963. [Abstract]
  • Lu, Z., Xu, X., Hu, X., Lee, S., Traverse, J., Zhu, G., Fassett, J., Tao, Y., Zhang, P., dos Remedios, C., Pritzker, M., Hall, J., Garry, D., Chen, Y. (2010), Oxidative stress regulates left ventricular PDE5 expression in the failing heart. Circulation. 121(13), 1474-83. [Abstract]
  • Kong, S., Hu, Y., Ho, J., Ikeda, S., Polster, S., John, R., Hall, J., Bisping, E., Pieske, B., dos Remedios, C., Pu, W. (2010), Heart failure-associated changes in RNA splicing of sarcomere genes. Circulation: Cardiovascular Genetics. 3(2), 138-146. [Abstract]
  • Kooij, V., Boontje, N., Zaremba, R., Jaquet, K., Dos Remedios, C., Stienen, G., van der Velden, J. (2010), Protein kinase C alpha and epsilon phosphorylation of troponin and myosin binding protein C reduce Ca(2+) sensitivity in human myocardium. Basic research in cardiology. 105(2), 289-300. [Abstract]
  • Mohamed, A., Lal, S., Ho, J., Brown, A., Lui, R., Nguyen, L., Yong, A., Su, Y., Braet, P., Dyer, W., Junius, F., Cumming, R., Freedman, S., Kritharides, L., dos Remedios, C. (2010), How to interrogate the cellular immune system in patients with ischemic heart disease. In: Myocardial ischemia: Causes, symptoms and treatment. (pp.195-216).United States: Nova Publishers.
  • Lal, S., Dos Remedios, C. (2010), Is There a Connection between Ablation of Atrial Fibrillation and Reduced Apoptosis?. Cardiology. 117, 161-2. [Abstract]
  • Kwok, D., Tong, L., Yeung, C., dos Remedios, C., Chu, P. (2010), Hybrid plasma surface modification and ion implantation of biopolymers. Surface and Coatings Technology. 204(18-19), 2892-2897.
  • Ho, J., Lin, M., Adelstein, S., dos Remedios, C. (2010), Customising an antibody leukocyte capture microarray for systemic lupus erythematosus: Beyond biomarker discovery. Proteomics - Clinical Applications. 4(2), 179-189.

2009

   
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  • van Dijk, S., Holewijn, R., Tebeest, A., Dos Remedios, C., Stienen, G., van der Velden, J. (2009), A piece of the human heart: variance of protein phosphorylation in left ventricular samples from end-stage primary cardiomyopathy patients. Journal of muscle research and cell motility. 30(7-8), 299-302. [Abstract]
  • Lal, S., Brown, A., Nguyen, L., Braet, F., Dyer, W., Dos Remedios, C. (2009), Using antibody arrays to detect microparticles from acute coronary syndrome patients based on CD antigen expression. Molecular & cellular proteomics : MCP. 8(4), 799-804. [Abstract]
  • van Dijk, S., Dooijes, D., dos Remedios, C., Michels, M., Lamers, J., Winegrad, S., Schlossarek, S., Carrier, L., ten Cate, F., Stienen, G., van der Velden, J. (2009), Cardiac myosin-binding protein C mutations and hypertrophic cardiomyopathy: haploinsufficiency, deranged phosphorylation, and cardiomyocyte dysfunction. Circulation. 119(11), 1473-1483. [Abstract]
  • Krüger, M., Kötter, S., Grützner, A., Lang, P., Andresen, C., Redfield, M., Butt, E., Dos Remedios, C., Linke, W. (2009), Protein Kinase G Modulates Human Myocardial Passive Stiffness by Phosphorylation of the Titin Springs. Circulation research. 104(1), 87-94. [Abstract]
  • Messer, A., Gallon, C., McKenna, W., Dos Remedios, C., Marston, S. (2009), The use of phosphate-affinity SDS-PAGE to measure the cardiac troponin I phosphorylation site distribution in human heart muscle. Proteomics Clinical Applications. 3, 1371-1382. [Abstract]
  • Ho, J., Stefani, M., dos Remedios, C., Charleston, M. (2009), A model selection approach to discover age-dependent gene expression patterns using quantile regression models. BMC Genomics. 10(Suppl 3), S16. [Abstract]
  • Estigoy, C., Ponten, F., Odeberg, J., Herbert, B., Guilhaus, M., Charleston, M., Ho, J., Cameron, D., dos Remedios, C. (2009), Intercalated discs: multiple proteins perform multiple functions in non-failing and failing human hearts. Biophysical Reviews. 1(1), 43-49.

2008

   
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  • Fermin, D., Barac, A., Lee, S., Polster, S., Hannenhalli, S., Bergemann, T., Grindle, S., Dyke, D., Pagani, F., Miller, L., Tan, S., Dos Remedios, C., Cappola, T., Margulies, K., Hall, J. (2008), Sex and age dimorphism of myocardial gene expression in nonischemic human heart failure. Circulation: Cardiovascular genetics. 1(2), 117-125. [Abstract]
  • Martinez-Neira, R., Dos Remedios, C., Mackay, I. (2008), An actin-myosin functional assay for analysis of smooth muscle (anti-microfilament) autoantibodies in human plasma. Journal of immunological methods. 338(1-2), 63-6. [Abstract]
  • Ho, J., Stefani, M., Dos Remedios, C., Charleston, M. (2008), Differential variability analysis of gene expression and its application to human diseases. Bioinformatics. 24(13), i390-i398. [Abstract]
  • Gan, B., Nosworthy, N., McKenzie, D., Dos Remedios, C., Bilek, M. (2008), Plasma immersion ion implantation treatment of polyethylene for enhanced binding of active horseradish peroxidase. Journal of biomedical materials research. Part A. 85(0), 605-10. [Abstract]
  • Hamdani, N., Kooij, V., van Dijk, S., Merkus, D., Paulus, W., Remedios, C., Duncker, D., Stienen, G., van der Velden, J. (2008), Sarcomeric dysfunction in heart failure. Cardiovascular Research. 77(4), 649-658. [Abstract]
  • Ho, J., Koundinya, R., Caetano, T., dos Remedios, C., Charleston, M. (2008), Inferring differential leukocyte activity from antibody microarrays using a latent variable model. Genome informatics. International Conference on Genome Informatics. 21, 126-137. [Abstract]
  • dos Remedios, C., Chhabra, D. (2008), Foreword. In: Actin-binding proteins and disease. (pp.v-vii).United Kingdom: Springer.
  • dos Remedios, C., Nosworthy, N. (2008), The role of PIP2 in actin, actin-binding proteins and disease. In: Actin-binding proteins and disease. (pp.290-297).United Kingdom: Springer.
  • Lui, P., Brown, A., Wu, B., Velauthen, C., Lin, M., Thompson, J., Braet, F., Dyer, W., Macdonald, P., Hayward, C., Adelstein, S., dos Remedios, C. (2008), Use of antibody microarrays in the analysis of inflammation, autoimmunity, viral infection, and cancer metastases. In: Clinical Proteomics: From Diagnosis to Therapy. (pp.571-592).United States: John Wiley & Sons.
  • Hamdani, N., de Waard, M., Messer, A., Boontje, N., Kooij, V., van Dijk, S., Versteilen, A., Lamberts, R., Merkus, D., Dos Remedios, C., Duncker, D., Borbely, A., Papp, Z., Paulus, W., Stienen, G., Marston, S., van der Velden, J. (2008), Myofilament dysfunction in cardiac disease from mice to men. Journal of muscle research and cell motility. 29(6-8), 189-201. [Abstract]
  • Stefani, M., Tsubakihara, M., Allen, P., Macdonald, P., dos Remedios, C. (2008), Actin and its binding proteins in heart failure. In: Actin-binding proteins and disease. (pp.318-334).United Kingdom: Springer.
  • dos Remedios, C., Chhabra, D. (2008), Actin-Binding Proteins and Disease. United Kingdom: Springer.
  • Chhabra, D., dos Remedios, C. (2008), Actin: an overview of its structure and function. In: Actin-binding proteins and disease. (pp.1-16).United Kingdom: Springer.
  • Brown, A., Lattimore, J., McGrady, M., Sullivan, D., Dyer, W., Braet, F., dos Remedios, C. (2008), Stable and unstable angina: Identifying novel markers on circulating leukocytes. PROTEOMICS - Clinical Applications. 2(1), 90-98.

2007

   
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  • Dos Remedios, C. (2007), New and Notable: The regulation of muscle contraction: As in life, it keeps getting more complex. Biophysical journal. 93(12), 4097-8. [Abstract]
  • Nicolau, D., Solana, G., Kekic, M., Fulga, F., Mahanivong, C., Wright, J., dos Remedios, C. (2007), Surface hydrophobicity modulates the operation of actomyosin-based dynamic nanodevices. Langmuir : the ACS journal of surfaces and colloids. 23(21), 10846-10854. [Abstract]
  • Ho, J., Nosworthy, N., Bilek, M., Gan, B., McKenzie, D., Chu, P., dos Remedios, C. (2007), Plasma-Treated Polyethylene Surfaces for Improved Binding of Active Protein. Plasma Processes and Polymers. 4(5), 583-590.
  • Zaremba, R., Merkus, D., Hamdani, N., Lamers, J., Paulus, W., dos Remedios, C., Duncker, D., Stienen, G., van der Velden, J. (2007), Quantitative analysis of myofilament protein phosphorylation in small cardiac biopsies. Proteomics - Clinical Applications. 1, 1285 - 1290.