Professor Desi Richardson

Professor & NHMRC Senior Principal Research Fellow
Pathology, School of Medical Sciences
Bosch Institute

D06 - Blackburn Building
The University of Sydney
NSW 2006 Australia

T: +61 2 9036 6548
F: +61 2 9351 3429

Research interests

Professor Richardson’s major contributions to cancer research are focussed on understanding the role of iron in cancer cell proliferation and the development of novel anti-tumour agents known as iron chelators. Indeed, these studies have resulted in highly promising and potent anti-cancer drugs and are subject of a suite of active national patents.

Current national competitive grants*


Investigating the Cellular Response to Iron-Depletion: The Trilogy of ASK1, Thioredoxin and Ribonucleotide Reductase
Richardson D, Hawkins C, Suryo Rahmanto Y, Lovejoy D, Ponka P
NHMRC Project Grants ($533,675 over 3 years)

Pharmacology of potential anti-tumour agents: Iron and copper chelators of the ApT, BpT and DpT classes
Richardson D, Lovejoy D, Brunk U
NHMRC Project Grants ($624,685 over 3 years)


Development of iron complexes for the treatment of Friedreich's Ataxia
Richardson D, Ponka P
Muscular Dystrophy Association (USA) Research Support ($450,000 over 3 years)

* Grants administered through the University of Sydney


Iron chelators; Cells and cell physiology


2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009


  • Krishan, S., Richardson, D., Sahni, S. (2015), Adenosine Monophosphate Activated Kinase (AMPK) and its Key Role in Catabolism: Structure, Regulation, Biological Activity and Pharmacological Activation. Molecular pharmacology. 87(3), 363-377. [Abstract]


  • Sahni, S., Krishan, S., Palanimuthu, D., Richardson, D. (2014), The use of iron chelators in biocidal compositions: evaluation of patent, WO2014059417A1. Expert Opinion on Therapeutic Patents. 25(3), 367-372. [Abstract]
  • Fang, B., Kovacevic, Z., Park, K., Kalinowski, D., Jansson, P., Lane, D., Sahni, S., Richardson, D. (2014), Molecular Functions of the Iron-Regulated Metastasis Suppressor, NDRG1, and its Potential as a Molecular Target for Cancer Therapy. Biochimica et Biophysica Acta. 1845(1), 1-19. [Abstract]
  • Ellis, S., Kalinowski, D., Leotta, L., Huang, M., Jelfs, P., Sintchenko, V., Richardson, D., Triccas, J. (2014), Potent Anti-Mycobacterial Activity of the Pyridoxal Isonicotinoyl Hydrazone Analogue, 2-Pyridylcarboxaldehyde Isonicotinoyl Hydrazone: A Lipophilic Transport Vehicle for Isonicotinic Acid Hydrazide. Molecular Pharmacology. 85(2), 269-278. [Abstract]
  • Anzovino, A., Lane, D., Huang, M., Richardson, D. (2014), Fixing frataxin: "ironing out" the metabolic defect in friedreich's ataxia. British Journal of Pharmacology. 171(8), 2174-2190. [Abstract]
  • Gutierrez, E., Richardson, D., Jansson, P. (2014), The Anti-Cancer Agent, Dp44mT, Overcomes Pro-Survival Autophagy by Two Mechanisms: Persistent Induction of Autophagosome Synthesis and Impairment of Lysosomal Integrity. The Journal of Biological Chemistry. 289(48), 33568-33589. [Abstract]
  • Lane, D., Richardson, D. (2014), Chaperone turns gatekeeper: PCBP2 and DMT1 form an iron-transport pipeline. The Biochemical Journal. 462(1), e1-e3. [Abstract]
  • Lukmantara, A., Kalinowski, D., Kumar, N., Richardson, D. (2014), Synthesis and biological evaluation of 2-benzoylpyridine thiosemicarbazones in a dimeric system: Structure-activity relationship studies on their anti-proliferative and iron chelation efficacy. Journal of Inorganic Biochemistry. 141(C), 43-54. [Abstract]
  • Ataie-Kachoie, P., Pourgholami, M., Richardson, D., Morris, D. (2014), Gene of the month: Interleukin 6 (IL-6). Journal of Clinical Pathology. 67(11), 932-937. [Abstract]
  • Jin, R., Liu, W., Menezes, S., Yue, F., Zheng, M., Kovacevic, Z., Richardson, D. (2014), The metastasis suppressor NDRG1 modulates the phosphorylation and nuclear translocation of ß-catenin through mechanisms involving FRAT1 and PAK4. Journal of Cell Science. 127(Pt 14), 3116-3130. [Abstract]
  • Lane, D., Richardson, D. (2014), The Active Role of Vitamin C in Mammalian Iron Metabolism: Much More Than Just Enhanced Iron Absorption!. Free Radical Biology & Medicine. 75(C), 69-83. [Abstract]
  • Lok, H., Sahni, S., Richardson, V., Kalinowski, D., Kovacevic, Z., Lane, D., Richardson, D. (2014), Glutathione S-Transferase and MRP1 Form an Integrated System Involved in the Storage and Transport of Dinitrosyl-Dithiolato Iron Complexes in Cells. Free Radical Biology & Medicine. 75(C), 14-29. [Abstract]
  • Filak, L., Kalinowski, D., Bauer, T., Richardson, D., Arion, V. (2014), Effect of the piperazine unit and metal-binding site position on the solubility and anti-proliferative activity of ruthenium(II)- and osmium(II)- arene complexes of isomeric indolo[3,2-c]quinoline-piperazine hybrids. Inorganic Chemistry. 53(13), 6934-43. [Abstract]
  • Sahni, S., Krishan, S., Richardson, D. (2014), NDRG1 as a molecular target to inhibit the epithelial-mesenchymal transition: the case for developing inhibitors of metastasis. Future Medicinal Chemistry. 6, 1241-1244. [Abstract]
  • Krishan, S., Richardson, D., Sahni, S. (2014), AMP kinase (PRKAA1). Journal of Clinical Pathology. 67(9), 758-763. [Abstract]
  • Sahni, S., Merlot, A., Krishan, S., Jansson, P., Richardson, D. (2014), Gene of the month: BECN1. Journal of Clinical Pathology. 67(8), 656-660. [Abstract]
  • Stariat, J., Suprunova, V., Roh, J., Sestak, V., Eisner, T., Filipsky, T., Mladenka, P., Nobilis, M., Simunek, T., Klimes, J., Kalinowski, D., Richardson, D., Kovarikova, P. (2014), Simultaneous determination of the novel thiosemicarbazone anti-cancer agent, Bp4eT, and its main phase I metabolites in plasma: application to a pilot pharmacokinetic study in rats. Biomedical Chromatography. 28(5), 621-629. [Abstract]
  • Sahni, S., Bae, D., Lane, D., Kovacevic, Z., Kalinowski, D., Jansson, P., Richardson, D. (2014), The metastasis suppressor, N-myc downstream-regulated gene 1 (NDRG1), inhibits stress-induced autophagy in cancer cells. Journal of Biological Chemistry. 289(14), 9692-9709. [Abstract]
  • Lane, D., Mills, T., Shafie, N., Merlot, A., Saleh Moussa, R., Kalinowski, D., Kovacevic, Z., Richardson, D. (2014), Expanding horizons in iron chelation and the treatment of cancer: Role of iron in the regulation of ER stress and the epithelial-mesenchymal transition. Biochimica et Biophysica Acta. 1845(2), 166-181. [Abstract]
  • Lane, D., Merlot, A., Richardson, D. (2014), The lure of a LYR: The logistics of iron sulfur cluster delivery. Cell Metabolism. 19(3), 348-350. [Abstract]
  • Basha, M., Rodríguez, C., Richardson, D., Martínez, M., Bernhardt, P. (2014), Kinetic studies on the oxidation of oxyhemoglobin by biologically active iron thiosemicarbazone complexes: relevance to iron-chelator-induced methemoglobinemia. Journal of Biological Inorganic Chemistry. 19(3), 349-357. [Abstract]
  • Lane, D., Richardson, D. (2014), Can we target the α2-macroglobulin-hepcidin interaction to treat pathologic hypoferremia?. Future Medicinal Chemistry. 6(1), 13-16. [Abstract]
  • Merlot, A., Kalinowski, D., Richardson, D. (2014), Unraveling the mysteries of serum albumin-more than just a serum protein. Frontiers in Physiology. 5, 299. [Abstract]
  • Potůčková, E., Hru¿ková, K., Bure¿, J., Kovaříková, P., Spirková, I., Pravdíková, K., Kolbabová, L., Hergeselová, T., Ha¿ková, P., Jansov, H., Macháček, M., Jirkovská, A., Richardson, V., Lane, D., Kalinowski, D., Richardson, D., Vávrová, K., Simůnek, T. (2014), Structure-Activity Relationships of Novel Salicylaldehyde Isonicotinoyl Hydrazone (SIH) Analogs: Iron Chelation, Anti-Oxidant and Cytotoxic Properties. PloS One. 9(11), e112059. [Abstract]
  • Merlot, A., Richardson, D. (2014), Receptor Recognition and Lysosomal Targeting to Enhance Cytotoxicity of Novel Anti-Cancer Agents that Bind Iron and Copper. Vitamins & Minerals. 3, e125.
  • Serda, M., Kalinowski, D., Rasko, N., Potůčková, E., Mrozek-Wilczkiewicz, A., Musiol, R., Małecki, J., Sajewicz, M., Ratuszna, A., Muchowicz, A., Gołąb, J., Simůnek, T., Richardson, D., Polanski, J. (2014), Exploring the Anti-Cancer Activity of Novel Thiosemicarbazones Generated through the Combination of Retro-Fragments: Dissection of Critical Structure-Activity Relationships. PloS One. 9(10), e110291. [Abstract]
  • Potuckova, E., Jansova, H., Machacek, M., Vavrova, A., Haskova, P., Tichotova, L., Richardson, V., Kalinowski, D., Richardson, D., Simunek, T. (2014), Quantitative analysis of the anti-proliferative activity of combinations of selected iron-chelating agents and clinically used anti-neoplastic drugs. PloS One. 9(2), e88754. [Abstract]


  • Stefani, C., Jansson, P., Gutierrez, E., Bernhardt, P., Richardson, D., Kalinowski, D. (2013), Alkyl Substituted 2'-Benzoylpyridine Thiosemicarbazone Chelators with Potent and Selective Anti-Neoplastic Activity: Novel Ligands that Limit Methemoglobin Formation. Journal of Medicinal Chemistry. 56(1), 357-370. [Abstract]
  • Lukmantara, A., Kalinowski, D., Kumar, N., Richardson, D. (2013), Synthesis and biological evaluation of substituted 2-benzoylpyridine thiosemicarbazones: Novel structure-activity relationships underpinning their anti-proliferative and chelation efficacy. Bioorganic & Medicinal Chemistry Letters. 23(4), 967-974. [Abstract]
  • Walcourt, A., Kurantsin-Mills, J., Kwagyan, J., Adenuga, B., Kalinowski, D., Lovejoy, D., Lane, D., Richardson, D. (2013), Anti-plasmodial activity of aroylhydrazone and thiosemicarbazone iron chelators: effect on erythrocyte membrane integrity, parasite development and the intracellular labile iron pool. Journal of Inorganic Biochemistry. 129, 43-51. [Abstract]
  • Sun, J., Zhang, D., Zheng, Y., Zhao, Q., Zheng, M., Kovacevic, Z., Richardson, D. (2013), Targeting the Metastasis Suppressor, NDRG1, Using Novel Iron Chelators: Regulation of Stress Fiber-Mediated Tumor Cell Migration via Modulation of the ROCK1/pMLC2 Signaling Pathway. Molecular Pharmacology. 83(2), 454-469. [Abstract]
  • Lui, G., Obeidy, P., Ford, S., Tselepis, C., Sharp, D., Jansson, P., Kalinowski, D., Kovacevic, Z., Lovejoy, D., Richardson, D. (2013), The Iron Chelator, Deferasirox, as a Novel Strategy for Cancer Treatment: Oral Activity Against Human Lung Tumor Xenografts and Molecular Mechanism of Action. Molecular Pharmacology. 83(1), 179-190. [Abstract]
  • Merlot, A., Pantarat, N., Menezes, S., Sahni, S., Richardson, D., Kalinowski, D. (2013), Cellular Uptake of the Anti-Tumor and Anti-Metastatic Agent, Dp44mT, Occurs via a Saturable, Temperature-Dependent Mechanism Consistent with Carrier/Receptor-Mediated Transport. Molecular Pharmacology. 84(6), 911-924. [Abstract]
  • Yamagishi, T., Sahni, S., Sharp, D., Arvind, A., Jansson, P., Richardson, D. (2013), P-Glycoprotein Mediates Drug Resistance via a Novel Mechanism Involving Lysosomal Sequestration. The Journal of Biological Chemistry. 288(44), 31761-31771. [Abstract]
  • Stacy, A., Jansson, P., Richardson, D. (2013), Molecular Pharmacology of ABCG2 and its Role in Chemoresistance. Molecular Pharmacology. 84(5), 655-669. [Abstract]
  • Lukmantara, A., Kalinowski, D., Kumar, N., Richardson, D. (2013), Structure-activity studies of 4-phenyl-substituted 2'-benzoylpyridine thiosemicarbazones with potent and selective anti-tumour activity. Organic & Biomolecular Chemistry. 11(37), 6414-6425. [Abstract]
  • Lane, D., Huang, M., Ting, S., Sivagurunathan, S., Richardson, D. (2013), Biochemistry of cardiomyopathy in the mitochondrial disease Friedreich's ataxia. The Biochemical Journal. 453(3), 321-336. [Abstract]
  • Huang, M., Sivagurunathan, S., Ting, S., Jansson, P., Austin, C., Kelly, M., Semsarian, C., Zhang, D., Richardson, D. (2013), Molecular and Functional Alterations in a Mouse Cardiac Model of Friedreich Ataxia: Activation of the Integrated Stress Response, eIF2α Phosphorylation, and the Induction of Downstream Targets. The American Journal of Pathology. 183(3), 745-757. [Abstract]
  • Huang, M., Austin, C., Sari, M., Suryo Rahmanto, Y., Ponka, P., Vyoral, D., Richardson, D. (2013), Hepcidin Bound to α2-Macroglobulin Reduces Ferroportin-1 Expression and Enhances its Activity at Reducing Serum Iron Levels. The Journal of Biological Chemistry. 288(35), 25450-25465. [Abstract]
  • Sun, J., Zhang, D., Bae, D., Sahni, S., Jansson, P., Zheng, Y., Zhao, Q., Yue, F., Zheng, M., Kovacevic, Z., Richardson, D. (2013), Metastasis suppressor, NDRG1, mediates its activity through signaling pathways and molecular motors. Carcinogenesis. 34(9), 1943-1954. [Abstract]
  • Bae, D., Jansson, P., Huang, M., Kovacevic, Z., Kalinowski, D., Lee, C., Sahni, S., Richardson, D. (2013), The role of NDRG1 in the pathology and potential treatment of human cancers. Journal of Clinical Pathology. 66(11), 911-917. [Abstract]
  • Lane, D., Huang, M., Richardson, D. (2013), Hepcidin, show some self-control! How the hormone of iron metabolism regulates its own expression. The Biochemical Journal. 452(2), e3-5. [Abstract]
  • Merlot, A., Kalinowski, D., Richardson, D. (2013), Novel Chelators for Cancer Treatment: Where Are We Now?. Antioxidants & Redox Signaling. 18(8), 973-1006. [Abstract]
  • Kovacevic, Z., Chikhani, S., Lui, G., Sivagurunathan, S., Richardson, D. (2013), The Iron-Regulated Metastasis Suppressor NDRG1 Targets NEDD4L, PTEN, and SMAD4 and Inhibits the PI3K and Ras Signaling Pathways. Antioxidants & Redox Signaling. 18(8), 874-887. [Abstract]
  • Ghalayini, M., Dong, Q., Richardson, D., Assinder, S. (2013), Proteolytic cleavage and truncation of NDRG1 in human prostate cancer cells, but not normal prostate epithelial cells. Bioscience Reports. 33(3), e00042. [Abstract]
  • Bambang, I., Lee, Y., Richardson, D., Zhang, D. (2013), Endoplasmic reticulum protein 29 regulates epithelial cell integrity during the mesenchymal-epithelial transition in breast cancer cells. Oncogene. 32(10), 1240-1251. [Abstract]
  • Hua, S., Yao, M., Vignarajan, S., Witting, P., Hejazi, L., Gong, Z., Teng, Y., Niknami, M., Assinder, S., Richardson, D., Dong, Q. (2013), Cytosolic phospholipase A2alpha sustains pAKT, pERK and AR levels in PTEN-null/mutated prostate cancer cells. Biochimica et Biophysica Acta. 1831(6), 1146-1157. [Abstract]
  • Ford, S., Obeidy, P., Lovejoy, D., Bedford, M., Nichols, L., Chadwick, C., Tucker, O., Lui, G., Kalinowski, D., Jansson, P., Iqbal, T., Alderson, D., Richardson, D., Tselepis, C. (2013), Deferasirox (ICL670A) effectively inhibits oesophageal cancer growth in vitro and in vivo. British Journal of Pharmacology. 168(6), 1316-1328. [Abstract]
  • Lane, D., Chikhani, S., Richardson, V., Richardson, D. (2013), Transferrin iron uptake is stimulated by ascorbate via an intracellular reductive mechanism. Biochimica et Biophysica Acta. 1833(6), 1527-1541. [Abstract]
  • Stariat, J., Kovaſíková, P., Kučera, R., KlimeÅ¡, J., Kalinowski, D., Richardson, D., Ketola, R. (2013), Identification of in vitro metabolites of the novel anti-tumor thiosemicarbazone, DpC, using ultra-high performance liquid chromatography-quadrupole-time-of-flight mass spectrometry. Analytical and Bioanalytical Chemistry. 405(5), 1651-1661. [Abstract]
  • Dixon, K., Lui, G., Kovacevic, Z., Zhang, D., Yao, M., Chen, Z., Dong, Q., Assinder, S., Richardson, D. (2013), Dp44mT targets the AKT, TGF-β and ERK pathways via the metastasis suppressor NDRG1 in normal prostate epithelial cells and prostate cancer cells. British Journal of Cancer. 108(2), 409-419. [Abstract]
  • Lane, D., Saletta, F., Suryo Rahmanto, Y., Kovacevic, Z., Richardson, D. (2013), N-myc Downstream Regulated 1 (NDRG1) Is Regulated by Eukaryotic Initiation Factor 3a (eIF3a) during Cellular Stress Caused by Iron Depletion. PloS One. 8(2), e57273. [Abstract]
  • Kalinowski, D., Jansson, P., Kovacevic, Z., Richardson, D. (2013), The redox-active, anti-cancer drug Dp44mT inhibits T-cell activation and CD25 through a copper-dependent mechanism. Redox Report. 18(2), 48-50. [Abstract]
  • Richardson, A., Kovacevic, Z., Richardson, D. (2013), Iron chelation: inhibition of key signaling pathways in the induction of the epithelial mesenchymal transition in pancreatic cancer and other tumors. Critical Reviews in Oncogenesis. 18(5), 409-434. [Abstract]


  • Whitnall, M., Rahmanto, Y., Huang, M., Saletta, F., Lok, H., Gutiérrez, L., Lázaro, F., Fleming, A., St Pierre, T., Mikhael, M., Ponka, P., Richardson, D. (2012), Identification of nonferritin mitochondrial iron deposits in a mouse model of Friedreich ataxia. Proceedings of the National Academy of Sciences. 109(50), 20590-20595. [Abstract]
  • Debebe, Z., Nekhai, S., Ashenafi, M., Lovejoy, D., Kalinowski, D., Gordeuk, V., Byrnes, W., Richardson, D., Karla, P. (2012), Development of a sensitive HPLC method to measure in vitro permeability of E- and Z-isomeric forms of thiosemicarbazones in Caco-2 monolayers. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 906, 25-32. [Abstract]
  • Serda, M., Kalinowski, D., Mrozek-Wilczkiewicz, A., Musiol, R., Szurko, A., Ratuszna, A., Pantarat, N., Kovacevic, Z., Merlot, A., Richardson, D., Polanski, J. (2012), Synthesis and characterization of quinoline-based thiosemicarbazones and correlation of cellular iron-binding efficacy to anti-tumor efficacy. Bioorganic & Medicinal Chemistry Letters. 22(17), 5527-5531. [Abstract]
  • Lovejoy, D., Sharp, D., Seebacher, N., Obeidy, P., Prichard, T., Stefani, C., Basha, M., Sharpe, P., Jansson, P., Kalinowski, D., Bernhardt, P., Richardson, D. (2012), Novel Second-Generation Di-2-Pyridylketone Thiosemicarbazones Show Synergism with Standard Chemotherapeutics and Demonstrate Potent Activity against Lung Cancer Xenografts after Oral and Intravenous Administration in Vivo. Journal of Medicinal Chemistry. 55(16), 7230-7244. [Abstract]
  • Li, C., L��nn, M., Xu, X., Maghzal, G., Frazer, D., Thomas, S., Halliwell, B., Richardson, D., Anderson, G., Stocker, R. (2012), Sustained expression of heme oxygenase-1 alters iron homeostasis in nonerythroid cells. Free Radical Biology & Medicine. 53(2), 366-374. [Abstract]
  • Basha, M., Chartres, J., Pantarat, N., Ali, M., Mirza, A., Kalinowski, D., Richardson, D., Bernhardt, P. (2012), Heterocyclic dithiocarbazate iron chelators: Fe coordination chemistry and biological activity. Dalton Transactions. 41(21), 6536-6548. [Abstract]
  • Yu, Y., Gutierrez, E., Kovacevic, Z., Saletta, F., Obeidy, P., Rahmanto, Y., Richardson, D. (2012), Iron chelators for the treatment of cancer. Current Medicinal Chemistry. 19(17), 2689-2702. [Abstract]
  • Chen, Z., Zhang, D., Yue, F., Zheng, M., Kovacevic, Z., Richardson, D. (2012), The iron chelators Dp44mT and DFO inhibit TGF-?-induced epithelial-mesenchymal transition via up-regulation of N-Myc downstream-regulated gene 1 (NDRG1). The Journal of Biological Chemistry. 287(21), 17016-17028. [Abstract]
  • Quach, P., Gutierrez, E., Basha, M., Kalinowski, D., Sharpe, P., Lovejoy, D., Bernhardt, P., Jansson, P., Richardson, D. (2012), Methemoglobin Formation by 3-AP, Dp44mT and Other Anti-Cancer Thiosemicarbazones: Identification of Novel Thiosemicarbazones and Therapeutics that Prevent this Effect. Molecular Pharmacology. 82(1), 105-114. [Abstract]
  • Stariat, J., Sestak, V., Vavrova, K., Nobilis, M., Kollarova, Z., Klimes, J., Kalinowski, D., Richardson, D., Kovarikova, P. (2012), LC-MS/MS identification of the principal in vitro and in vivo phase I metabolites of the novel thiosemicarbazone anti-cancer drug, Bp4eT. Analytical and bioanalytical chemistry. 403(1), 309-321. [Abstract]
  • Suryo Rahmanto, Y., Kalinowski, D., Lane, D., Lok, H., Richardson, V., Richardson, D. (2012), Nitrogen Monoxide (NO) Storage and Transport by Dinitrosyl-Dithiol-Iron Complexes: Long-Lived NO that is Trafficked by Interacting Proteins. The Journal of Biological Chemistry. 287(10), 6960-6968. [Abstract]
  • Suryo Rahmanto, Y., Bal, S., Loh, K., Yu, Y., Richardson, D. (2012), Melanotransferrin: Search for a function. Biochimica et Biophysica Acta. 1820(3), 237-243. [Abstract]
  • Gao, D., Bambang, I., Putti, T., Lee, Y., Richardson, D., Zhang, D. (2012), ERp29 induces breast cancer cell growth arrest and survival through modulation of activation of p38 and upregulation of ER stress protein p58(IPK). Laboratory Investigation. 92(2), 200-213. [Abstract]
  • Lok, H., Suryo Rahmanto, Y., Hawkins, C., Kalinowski, D., Morrow, C., Townsend, A., Ponka, P., Richardson, D. (2012), Nitric oxide storage and transport in cells is mediated by glutathione-S-transferase P1-1 and Multidrug Resistant Protein 1 via Dinitrosyl iron complexes. Journal of Biological Chemistry. 287(1), 607-618. [Abstract]
  • Kovacevic, Z., Richardson, D. (2012), Targeting Iron in Cancer Cells: A New Strategy to Inhibit Metastatic Progression. Vitamins & Trace Elements. 1(3), 1000e114.
  • Correnti, C., Richardson, V., Sia, A., Bandaranayake, A., Ruiz, M., Suryo Rahmanto, Y., KovačeviÄ¿, ., Clifton, M., Holmes, M., Kaiser, B., Barasch, J., Raymond, K., Richardson, D., Strong, R. (2012), Siderocalin/Lcn2/NGAL/24p3 does not drive apoptosis through gentisic acid mediated iron withdrawal in hematopoietic cell lines. PLoS One. 7(8), e43696. [Abstract]
  • Yu, Y., Rahmanto, Y., Richardson, D. (2012), Bp44mT: An Orally-Active Iron Chelator of the Thiosemicarbazone Class with Potent Anti-Tumour Efficacy. British journal of pharmacology. 165(1), 148-66. [Abstract]
  • Brychtova, K., Dvorakova, L., Opatrilova, R., Raich, I., Kacerova, S., Placek, L., Kalinowski, D., Richardson, D., Jampilek, J. (2012), Investigation of substituted 6-aminohexanoates as skin penetration enhancers. Bioorganic & Medicinal Chemistry. 20(1), 86-95. [Abstract]


  • Huang, M., Lane, D., Richardson, D. (2011), Mitochondrial Mayhem: The Mitochondrion as a Modulator of Iron Metabolism and Its Role in Disease. Antioxidants & redox signaling. 15(12), 3003-19. [Abstract]
  • Saletta, F., Kovacevic, Z., Richardson, D. (2011), Research Spotlight: Iron chelation: deciphering novel molecular targets for cancer therapy. The tip of the iceberg of a web of iron-regulated molecules. Future Medicinal Chemistry. 3(16), 1983-1986. [Abstract]
  • Saletta, F., Suryo Rahmanto, Y., Siafakas, A., Richardson, D. (2011), Cellular iron-depletion and the mechanisms involved in the iron-dependent regulation of the growth arrest and DNA damage family of genes. The Journal of biological chemistry. 286(41), 35396-406. [Abstract]
  • Stefani, C., Punnia-Moorthy, G., Lovejoy, D., Jansson, P., Kalinowski, D., Sharpe, P., Bernhardt, P., Richardson, D. (2011), Halogenated 2'-Benzoylpyridine Thiosemicarbazone (XBpT) Chelators with Potent and Selective Anti-Neoplastic Activity: Relationship to Intracellular Redox Activity. Journal of medicinal chemistry. 54(19), 6936-48. [Abstract]
  • Kovacevic, Z., Chikhani, S., Lovejoy, D., Richardson, D. (2011), Novel thiosemicarbazone iron chelators induce up-regulation and phosphorylation of the metastasis suppressor, NDRG1: A new strategy for the treatment of pancreatic cancer. Molecular pharmacology. 80(4), 598-609. [Abstract]
  • Lovejoy, D., Jansson, P., Brunk, U., Wong, J., Ponka, P., Richardson, D. (2011), Antitumor Activity of Metal-Chelating Compound Dp44mT Is Mediated by Formation of a Redox-Active Copper Complex That Accumulates in Lysosomes. Cancer research. 71(17), 5871-80. [Abstract]
  • Yu, Y., Suryo Rahmanto, Y., Hawkins, C., Richardson, D. (2011), The Potent and Novel Thiosemicarbazone Chelators, Dp44mT and Bp44mT, Affect Crucial Thiol Systems Required for Ribonucleotide Reductase Activity. Molecular pharmacology. 79(6), 921-31. [Abstract]
  • Kovacevic, Z., Sivagurunathan, S., Mangs, H., Chikhani, S., Zhang, D., Richardson, D. (2011), The metastasis suppressor, N-MYC downstream regulated gene 1 (NDRG1), UP-regulates P21 VIA P53-independent mechanisms. Carcinogenesis. 32(5), 732-40. [Abstract]
  • Yu, Y., Richardson, D. (2011), Cellular Iron Depletion Stimulates the JNK and p38 MAPK Signaling Transduction Pathways, Dissociation of ASK1-Thioredoxin, and Activation of ASK1. Journal of Biological Chemistry. 286(17), 15413-15427. [Abstract]
  • Kovacevic, Z., Yu, Y., Richardson, D. (2011), Chelators to the rescue: different horses for different courses!. Chemical Research in Toxicology. 24(3), 279-282. [Abstract]
  • Debebe, Z., Ammosova, T., Breuer, D., Lovejoy, D., Kalinowski, D., Karla, P., Kumar, K., Jerebtsova, M., Ray, P., Kashanchi, F., Gordeuk, V., Richardson, D., Nekhai, S. (2011), Iron chelators of the di-2-pyridylketone thiosemicarbazone and 2-benzoylpyridine thiosemicarbazone series inhibit HIV-1 transcription: identification of novel cellular targets--iron, cyclin-dependent kinase (CDK) 2, and CDK9. Molecular Pharmacology. 79(1), 185-196. [Abstract]
  • Kovacevic, Z., Kalinowski, D., Lovejoy, D., Yu, Y., Rahmanto, Y., Sharpe, P., Bernhardt, P., Richardson, D. (2011), The Medicinal Chemistry of Novel Iron Chelators for the Treatment of Cancer. Current topics in medicinal chemistry. 11(5), 483-99. [Abstract]
  • Sharpe, P., Richardson, D., Kalinowski, D., Bernhardt, P. (2011), Synthetic and natural products as iron chelators. Current Topics in Medicinal Chemistry. 11(5), 591-607. [Abstract]
  • Zhang, D., Richardson, D. (2011), Endoplasmic Reticulum Protein 29 (ERp29): The emerging role in cancer. The international journal of biochemistry & cell biology. 43(1), 33-6. [Abstract]
  • Bernhardt, P., Richardson, D. (2011), Metal chelation. Current Topics in Medicinal Chemistry. 11, 482. [Abstract]


  • Saletta, F., Rahmanto, Y., Richardson, D. (2010), The Translational Regulator eIF3a: The Tricky eIF3 Subunit!. Biochimica et biophysica acta. 1806(2), 275-86. [Abstract]
  • Jansson, P., Hawkins, C., Lovejoy, D., Richardson, D. (2010), The iron complex of Dp44mT is redox-active and induces hydroxyl radical formation: An EPR study. Journal of inorganic biochemistry. 104(11), 1224-8. [Abstract]
  • Merlot, A., Pantarat, N., Lovejoy, D., Kalinowski, D., Richardson, D. (2010), Membrane Transport and Intracellular Sequestration of Novel Thiosemicarbazone Chelators for the Treatment of Cancer. Molecular pharmacology. 78(4), 675-84. [Abstract]
  • Jansson, P., Sharpe, P., Bernhardt, P., Richardson, D. (2010), Novel Thiosemicarbazones of the ApT and DpT Series and Their Copper Complexes: Identification of Pronounced Redox Activity and Characterization of Their Antitumor Activity. Journal of medicinal chemistry. 53(15), 5759-69. [Abstract]
  • Bendova, P., Mackova, E., Haskova, P., Vavrova, A., Jirkovsky, E., Sterba, M., Popelova, O., Kalinowski, D., Kovarikova, P., Vavrova, K., Richardson, D., Simunek, T. (2010), Comparison of Clinically Used and Experimental Iron Chelators for Protection against Oxidative Stress-Induced Cellular Injury. Chemical research in toxicology. 23(6), 1105-14. [Abstract]
  • Richardson, D., Lane, D., Becker, E., Huang, M., Whitnall, M., Rahmanto, Y., Sheftel, A., Ponka, P. (2010), Mitochondrial iron trafficking and the integration of iron metabolism between the mitochondrion and cytosol. Proceedings of the National Academy of Sciences of the United States of America. 107(24), 10775-82. [Abstract]
  • Kovacevic, Z., Kalinowski, D., Lovejoy, D., Quach, P., Wong, J., Richardson, D. (2010), Iron Chelators: Development of Novel Compounds with High and Selective Anti-Tumour Activity. Current Drug Delivery. 7(3), 194-207. [Abstract]
  • Stariat, J., Kovaríková, P., Klimes, J., Kalinowski, D., Richardson, D. (2010), Development of an LC-MS/MS method for analysis of interconvertible Z/E isomers of the novel anticancer agent, Bp4eT. Analytical and Bioanalytical Chemistry. 397(1), 161-171. [Abstract]
  • Mrozek-Wilczkiewicz, A., Kalinowski, D., Musiol, R., Finster, J., Szurko, A., Serafin, K., Knas, M., Kamalapuram, S., Kovacevic, Z., Jampilek, J., Ratuszna, A., Rzeszowska-Wolny, J., Richardson, D., Polanski, J. (2010), Investigating the anti-proliferative activity of styrylazanaphthalenes and azanaphthalenediones. Bioorganic & medicinal chemistry. 18(7), 2664-2671. [Abstract]
  • Richardson, D., Huang, M., Whitnall, M., Becker, E., Ponka, P., Suryo Rahmanto, Y. (2010), The ins and outs of mitochondrial iron-loading: the metabolic defect in Friedreich's ataxia. Journal of molecular medicine (Berlin, Germany). 88(4), 323-9. [Abstract]
  • Lane, D., Richardson, D. (2010), Frataxin, a molecule of mystery: trading stability for function in its iron-binding site. Biochemical Journal. 426(2), e1-e3. [Abstract]
  • Saletta, F., Suryo Rahmanto, Y., Noulsri, E., Richardson, D. (2010), Iron Chelator-Mediated Alterations in Gene Expression: Identification of Novel Iron-Regulated Molecules that are Molecular Targets of HIF-1{alpha} and p53. Molecular pharmacology. 77(0), 443-58. [Abstract]
  • Liu, J., Obando, D., Schipanski, L., Groebler, L., Witting, P., Kalinowski, D., Richardson, D., Codd, R. (2010), Conjugates of Desferrioxamine B (DFOB) with Derivatives of Adamantane or with Orally Available Chelators as Potential Agents for Treating Iron Overload. Journal of medicinal chemistry. 53(3), 1370-82. [Abstract]
  • Singleton, W., McInnes, K., Cater, M., Winnall, W., McKirdy, R., Yu, Y., Taylor, P., Ke, B., Richardson, D., Mercer, J., La Fontaine, S. (2010), Role of Glutaredoxin1 and Glutathione in Regulating the Activity of the Copper-transporting P-type ATPases, ATP7A and ATP7B. Journal of Biological Chemistry. 285, 27111-27121. [Abstract]
  • Otevrel, J., Mandelova, Z., Pesko, M., Guo, J., Kralova, K., Sersen, F., Vejsova, M., Kalinowski, D., Kovacevic, Z., Coffey, A., Csollei, J., Richardson, D., Jampilek, J. (2010), Investigating the Spectrum of Biological Activity of Ring-Substituted Salicylanilides and Carbamoylphenylcarbamates. Molecules. 15(11), 8122-8142. [Abstract]
  • Kalinowski, D., Richardson, D. (2010), Cellular and Molecular Biology of Iron-Binding Proteins. In: Cellular and Molecular Biology of Metals. (pp.167-180).United States: Taylor and Francis.
  • Miao, Q., Xu, D., Wang, Z., Xu, L., Wang, T., Wu, Y., Lovejoy, D., Kalinowski, D., Richardson, D., Nie, G., Zhao, Y. (2010), Amphiphilic hyper-branched co-polymer nanoparticles for the controlled delivery of anti-tumor agents. Biomaterials. 31(28), 7364-7375. [Abstract]
  • Brychtova, K., Opatrilova, R., Raich, I., Kalinowski, D., Dvorakova, L., Placek, L., Csollei, J., Richardson, D., Jampilek, J. (2010), Investigating the activity of 2-substituted alkyl-6-(2,5-dioxopyrrolidin-1-yl)hexanoates as skin penetration enhancers. Bioorganic & Medicinal Chemistry. 18(24), 8556-8565. [Abstract]


  • Huang, M., Becker, E., Whitnall, M., Rahmanto, Y., Ponka, P., Richardson, D. (2009), Elucidation of the mechanism of mitochondrial iron loading in Friedreich's ataxia by analysis of a mouse mutant. Proceedings of the National Academy of Sciences of the United States of America. 106(38), 16381-16386. [Abstract]
  • Yu, Y., Kalinowski, D., Kovacevic, Z., Siafakas, A., Jansson, P., Stefani, C., Lovejoy, D., Sharpe, P., Bernhardt, P., Richardson, D. (2009), Thiosemicarbazones from the Old to New: Iron Chelators That Are More Than Just Ribonucleotide Reductase Inhibitors. Journal of medicinal chemistry. 52(17), 5271-94. [Abstract]
  • Kalinowski, D., Quach, P., Richardson, D. (2009), Thiosemicarbazones: the new wave in cancer treatment. Future Medicinal Chemistry. 1(6), 1143-1151. [Abstract]
  • Suryo, R., Richardson, D. (2009), Generation and characterization of transgenic mice hyper-expressing melanoma tumour antigen p97 (Melanotransferrin): No overt alteration in phenotype. Biochimica et biophysica acta. 1793(0), 1210-7. [Abstract]
  • Richardson, D., Kalinowski, D., Lau, S., Jansson, P., Lovejoy, D. (2009), Cancer cell iron metabolism and the development of potent iron chelators as anti-tumour agents. Biochimica et biophysica acta. 1790(0), 702-17. [Abstract]
  • Peslova, G., Petrak, J., Kuzelova, K., Hrdy, I., Halada, P., Kuchel, P., Soe-Lin, S., Ponka, P., Sutak, R., Becker, E., Huang, M., Suryo Rahmanto, Y., Richardson, D., Vyoral, D. (2009), Hepcidin, the hormone of iron metabolism, is bound specifically to {alpha}-2-macroglobulin in blood. Blood. 113(0), 6225-36. [Abstract]
  • Rosemary Siafakas, A., Richardson, D. (2009), Growth arrest and DNA damage-45 alpha (GADD45alpha). The international journal of biochemistry & cell biology. 41(0), 986-9. [Abstract]
  • Richardson, D., Kalinowski, D., Richardson, V., Sharpe, P., Lovejoy, D., Islam, M., Bernhardt, P. (2009), 2-Acetylpyridine Thiosemicarbazones are Potent Iron Chelators and Antiproliferative Agents: Redox Activity, Iron Complexation and Characterization of their Antitumor Activity. Journal of medicinal chemistry. 52(5), 1459-70. [Abstract]
  • Assinder, S., Dong, Q., Mangs, H., Richardson, D. (2009), Pharmacological Targeting of the Integrated AKT, PTEN and TGF-{beta} Pathways in Prostate Cancer. Molecular Pharmacology. 75(3), 429-436. [Abstract]
  • Bernhardt, P., Sharpe, P., Islam, M., Lovejoy, D., Kalinowski, D., Richardson, D. (2009), Iron Chelators of the Dipyridylketone Thiosemicarbazone Class: Precomplexation and Transmetalation Effects on Anticancer Activity. Journal of medicinal chemistry. 52(2), 407-15. [Abstract]
  • Assinder, S., Dong, Q., Kovacevic, Z., Richardson, D. (2009), The TGF-beta, PI3K/Akt and PTEN pathways: established and proposed biochemical integration in prostate cancer. Biochemical Journal. 417(2), 411-421. [Abstract]
  • Stariat, J., Kovaríková, P., Klimes, J., Lovejoy, D., Kalinowski, D., Richardson, D. (2009), HPLC methods for determination of two novel thiosemicarbazone anti-cancer drugs (N4mT and Dp44mT) in plasma and their application to in vitro plasma stability of these agents. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 877(3), 316-322. [Abstract]
  • Bohlken, A., Cheung, B., Bell, J., Koach, J., Smith, S., Sekyere, E., Thomas, W., Norris, M., Haber, M., Lovejoy, D., Richardson, D., Marshall, G. (2009), ATP7A is a novel target of retinoic acid receptor beta2 in neuroblastoma cells. British Journal of Cancer. 100(1), 96-105. [Abstract]
  • Mladĕnka, P., Kalinowski, D., Haskova, P., Bobrovová, Z., Hrdina, R., Simůnek, T., Nachtigal, P., Semecký, V., Vávrová, J., Holeckova, M., Palicka, V., Mazurová, Y., Jansson, P., Richardson, D. (2009), The novel iron chelator, 2-pyridylcarboxaldehyde 2-thiophenecarboxyl hydrazone, reduces catecholamine-mediated myocardial toxicity. Chemical research in toxicology. 22(1), 208-217. [Abstract]
  • Lovejoy, D., Yu, Y., Richardson, D. (2009), Chelators as Anti-Cancer Drugs. In: Encyclopedia of Cancer. (pp.0).Germany: Springer.
  • Sheftel, A., Richardson, D., Prchal, J., Ponka, P. (2009), Mitochondrial Iron Metabolism and Sideroblastic Anemia. Acta Haematologica. 122(2-3), 120-133. [Abstract]
  • Noulsri, E., Richardson, D., Lerdwana, S., Fucharoen, S., Yamagishi, T., Kalinowski, D., Pattanapanyasat, K. (2009), Antitumor activity and mechanism of action of the iron chelator, Dp44mT, against leukemic cells. American Journal of Hematology. 84(3), 170-176. [Abstract]