Professor David Gottlieb

Professor
Medicine, Westmead Clinical School
Westmead Millennium Institute for Medical Research

C24 - Westmead Hospital
The University of Sydney
NSW 2006 Australia

T: +61 2 9845 6033
F: +61 2 9687 2331
E:

Biographical details

David Gottlieb trained in internal medicine and hematology at Westmead Hospital in Sydney and the Royal Free Hospital in the UK. He is currently Professor of Haematology at the University of Sydney. He has been actively involved in clinical stem cell transplantation for over 25 years and is currently a senior physician on the Westmead Hospital Blood and Marrow Transplant Unit and the Medical Director of the Sydney Cellular Therapies Laboratory. His research interests are in the field of cell and gene therapy especially in the manipulation of the immune system post-transplant to reduce opportunistic infection and recurrence of malignant disease. He is currently directing a number of clinical studies of donor-derived and third party antigen specific T cells given to rapidly reconstitute immunity in the post-stem cell transplant setting.
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Current national competitive grants*

2013

Clinical implications of IL7R genotype: from disease risk to disease management
Stewart G, Booth D, Gottlieb D, McKay F, Vucic S, Rajasuriar R
NHMRC Project Grant ($682,326 over 3 years)

2012

Establishment of a bank of third party T cells to treat virus infections (that are resistant or unsuitable for other forms of antibiotic therapy) in immunocompromised and transplant patients across Australia
Gottlieb D
NHMRC Project Grants ($779,572 over 4 years)

Cell therapy for the prevention and treatment of invasive filamentous fungal infections in patients with haematological malignancies
Gottlieb D, Sorrell T
NHMRC Project Grants ($946,543 over 4 years)

* Grants administered through the University of Sydney

Keywords

Haematology; Immunology; cell and gene therapy; antigen specific T cells; Cell biology

Publications

2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008

2014

   
  • Bishop, D., Johnston, A., Kwan, J., Antonenas, V., Gottlieb, D. (2014), Haploidentical peripheral blood stem cell infusion in combination with chemotherapy for acute myeloid leukaemia in elderly patients. Internal Medicine Journal. 44(10), 1038-1040. [Abstract]
  • McSharry, B., Forbes, S., Cao, J., Avdic, S., Machala, E., Gottlieb, D., Abendroth, A., Slobedman, B. (2014), Human cytomegalovirus upregulates expression of the lectin, galectin-9, via induction of interferon-β. Journal of Virology. 88(18), 10990-10994. [Abstract]
  • Adam, R., Priglinger, M., Harrington, T., Gottlieb, D., Krause, M. (2014), An Unusual Cause of Cerebellar Hemorrhage in a Young Patient: Essential Thrombocythemia. Journal of Stroke and Cerebrovascular Diseases. 23(5), e373-374. [Abstract]
  • Mollee, P., Renaut, P., Gottlieb, D., Goodman, H. (2014), How to diagnose amyloidosis. Internal Medicine Journal. 44(1), 7-17. [Abstract]

2013

   
  • Avdic, S., Cao, J., McSharry, B., Clancy, L., Brown, R., Steain, M., Gottlieb, D., Abendroth, A., Slobedman, B. (2013), Human cytomegalovirus viral IL-10 polarizes monocytes towards a deactivated M2c phenotype to repress host immune responses. Journal of Virology. 87(18), 10273-10282. [Abstract]
  • Bilmon, I., Kwan, J., Gottlieb, D., Kerridge, I., McGurgan, M., Huang, G., George, B., Hertzberg, M., Bradstock, K. (2013), Haploidentical bone marrow transplants for hematological malignancies using non-myeloablative conditioning therapy and post-transplant immunosuppression with cyclophosphamide: results from a single Australian centre. Internal Medicine Journal. 43(2), 191-196. [Abstract]
  • Clancy, L., Blyth, E., Simms, R., Micklethwaite, K., Ma, C., Burgess, J., Antonenas, V., Shaw, P., Gottlieb, D. (2013), Cytomegalovirus-specific cytotoxic T lymphocytes can be efficiently expanded from granulocyte colony-stimulating factor-mobilized hemopoietic progenitor cell products ex vivo and safely transferred to stem cell transplantation recipients to facilitate immune reconstitution. Biology of Blood and Marrow Transplantation. 19(5), 725-734. [Abstract]
  • Garcia, M., Chapman, J., Shaw, P., Gottlieb, D., Ralph, A., Craig, J., Tong, A. (2013), The motivations, experiences, and perspectives of bone marrow and peripheral blood stem cell donors: thematic synthesis of qualitative studies. Biology of Blood and Marrow Transplantation. 19(7), 1046-1058. [Abstract]
  • Sartor, M., Gottlieb, D. (2013), A single tube 10-color flow cytometry assay optimizes detection of minimal residual disease in chronic lymphocytic leukemia. Cytometry. Part B, Clinical Cytometry. 84(2), 96-103. [Abstract]
  • Blyth, E., Clancy, L., Simms, R., Ma, C., Burgess, J., Deo, S., Byth, K., Dubosq, M., Shaw, P., Micklethwaite, K., Gottlieb, D. (2013), Donor-derived CMV specific T-cells reduce the requirement for CMV-directed pharmacotherapy after allogeneic stem cell transplantation. Blood. 121(18), 3745-3758. [Abstract]
  • Jones, K., Vari, F., Keane, C., Crooks, P., Nourse, J., Seymour, L., Gottlieb, D., Ritchie, D., Gill, D., Gandhi, M. (2013), Serum CD163 and TARC as disease response biomarkers in classical Hodgkin lymphoma. Clinical Cancer Research. 19(3), 731-742. [Abstract]

2012

   
  • Gaundar, S., Clancy, L., Blyth, E., Meyer, W., Gottlieb, D. (2012), Robust polyfunctional T-helper 1 responses to multiple fungal antigens from a cell population generated using an environmental strain of Aspergillus fumigatus. Cytotherapy. 14(9), 1119-1130. [Abstract]
  • Blyth, E., Gaundar, S., Clancy, L., Simms, R., Bilmon, I., Micklethwaite, K., Gottlieb, D. (2012), Clinical-grade varicella zoster virus-specific T cells produced for adoptive immunotherapy in hemopoietic stem cell transplant recipients. Cytotherapy. 14(6), 724-732. [Abstract]
  • George, L., George, B., Gottlieb, D., Hertzberg, M., Fernandez-Peñas, P. (2012), Lack of efficacy of rituximab in refractory sclerodermatous chronic GVHD. Bone Marrow Transplantation. 47(5), 737-738. [Abstract]
  • George, B., Kerridge, I., Gilroy, N., Huang, G., Hertzberg, M., Bradstock, K., Gottlieb, D. (2012), A risk score for early cytomegalovirus reactivation after allogeneic stem cell transplantation identifies low-, intermediate-, and high-risk groups: reactivation risk is increased by graft-versus-host disease only in the intermediate-risk group. Transplant Infectious Disease. 14(2), 141-148. [Abstract]
  • Jones, K., Nourse, J., Keane, C., Crooks, P., Gottlieb, D., Ritchie, D., Gill, D., Gandhi, M. (2012), Tumor-specific but not nonspecific cell-free circulating DNA can be used to monitor disease response in lymphoma. American Journal of Hematology. 87(3), 258-265. [Abstract]
  • Gaundar, S., Blyth, E., Clancy, L., Simms, R., Ma, C., Gottlieb, D. (2012), In vitro generation of influenza-specific polyfunctional CD4(+) T cells suitable for adoptive immunotherapy. Cytotherapy. 14(2), 182-193. [Abstract]
  • Suan, D., Booth, D., Kennedy, I., Downie, J., Earls, P., Gottlieb, D., Stewart, G., Lin, M. (2012), Vitreal deposits in Val71Ala transthyretin amyloidosis. Internal Medicine Journal. , 106-108. [Abstract]

2011

   
  • Blyth, E., Clancy, L., Simms, R., Gaundar, S., Oʼconnell, P., Micklethwaite, K., Gottlieb, D. (2011), BK Virus-Specific T Cells for Use in Cellular Therapy Show Specificity to Multiple Antigens and Polyfunctional Cytokine Responses. Transplantation. 92(10), 1077-84. [Abstract]
  • Fromm, P., Gottlieb, D., Bradstock, K., Hart, D. (2011), Cellular therapy to treat haematological and other malignancies: progress and pitfalls. Pathology. 43(6), 605-615. [Abstract]
  • To, L., Levesque, J., Herbert, K., Winkler, I., Bendall, L., Hiwase, D., Antonenas, V., Rice, A., Gottlieb, D., Mills, A., Rasko, J., Larsen, S., Beligaswatte, A., Nilsson, S., Cooney, J., Cambareri, A., Lewis, I. (2011), Mobilisation strategies for normal and malignant cells. Pathology. 43(6), 547-565. [Abstract]
  • Herbert, K., Levesque, J., Mills, A., Gottlieb, D., Cooney, J., Szer, J., Rasko, J., To, L. (2011), How we mobilize haemopoietic stem cells. Internal Medicine Journal. 41(8), 588-594. [Abstract]
  • George, B., Ferguson, P., Kerridge, I., Gilroy, N., Gottlieb, D., Hertzberg, M. (2011), The clinical impact of infection with Swine flu (H1N1 09) strain of influenza virus in hematopoietic stem cell transplant recipients. Biology of Blood and Marrow Transplantation. 17(1), 147-153. [Abstract]

2010

   
  • Gottlieb, D. (2010), T time for transplants. Blood. 116(22), 4391-4393. [Abstract]
  • Prabhu, S., Gottlieb, D., Varikatt, W., St Heaps, L., Diaz, S., Smith, A. (2010), Adult B-cell acute lymphoblastic leukemia with two unrelated abnormal cytogenetic clones. Cancer Genetics and Cytogenetics. 201(1), 24-27. [Abstract]
  • George, B., Pati, N., Gilroy, N., Ratnamohan, M., Huang, G., Kerridge, I., Hertzberg, M., Gottlieb, D., Bradstock, K. (2010), Pre-transplant cytomegalovirus (CMV) serostatus remains the most important determinant of CMV reactivation after allogeneic hematopoietic stem cell transplantation in the era of surveillance and preemptive therapy. Transplant infectious disease : an official journal of the Transplantation Society. 12(4), 322-9. [Abstract]
  • George, B., Kerridge, I., Gilroy, N., Huang, G., Hertzberg, M., Gottlieb, D., Bradstock, K. (2010), Fludarabine-based reduced intensity conditioning transplants have a higher incidence of cytomegalovirus reactivation compared with myeloablative transplants. Bone marrow transplantation. 45(5), 849-55. [Abstract]

2009

   
  • Kwan, V., Gottlieb, D. (2009), Endoscopic ultrasound-fine needle aspiration for the diagnosis of lymphoma: Are we there yet?. Journal of gastroenterology and hepatology. 24(12), 1808-1809. [Abstract]
  • Cheung, A., Gottlieb, D., Plachter, B., Pepperl-Klindworth, S., Avdic, S., Cunningham, A., Abendroth, A., Slobedman, B. (2009), The role of the human cytomegalovirus UL111A gene in down-regulating CD4+ T-cell recognition of latently infected cells: implications for virus elimination during latency. Blood. 114(19), 4128-4137. [Abstract]
  • Wallington-Beddoe, C., Gottlieb, D., Garvin, F., Antonenas, V., Sartor, M. (2009), Failure to achieve a threshold dose of CD34+CD110+ progenitor cells in the graft predicts delayed platelet engraftment after autologous stem cell transplantation for multiple myeloma. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 15(11), 1386-1393. [Abstract]
  • Bradstock, K., Hertzberg, M., Kerridge, I., Svennilson, J., George, B., McGurgan, M., Huang, G., Antonenas, V., Gottlieb, D. (2009), Single versus double unrelated umbilical cord blood units for allogeneic transplantation in adults with advanced hematological malignancies: a retrospective comparison of outcomes. Internal medicine journal. 39(11), 744-51. [Abstract]
  • Brooke, G., Rossetti, T., Pelekanos, R., Ilic, N., Murray, P., Hancock, S., Antonenas, V., Huang, G., Gottlieb, D., Bradstock, K., Atkinson, K. (2009), Manufacturing of human placenta-derived mesenchymal stem cells for clinical trials. British journal of haematology. 144(4), 571-9. [Abstract]
  • Micklethwaite, K., Garvin, F., Kariotis, M., Yee, L., Hansen, A., Antonenas, V., Sartor, M., Turtle, C., Gottlieb, D. (2009), Clinical-scale elutriation as a means of enriching antigen-presenting cells and manipulating alloreactivity. Cytotherapy. 11(2), 218-228. [Abstract]

2008

   
  • Micklethwaite, K., Clancy, L., Sandher, U., Hansen, A., Blyth, E., Antonenas, V., Sartor, M., Bradstock, K., Gottlieb, D. (2008), Prophylactic infusion of cytomegalovirus specific cytotoxic T-lymphocytes stimulated with Ad5f35pp65 gene modified dendritic cells following allogeneic haemopoietic stem cell transplantation. Blood. 112(10), 3974-81. [Abstract]
  • George, B., Kerridge, I., Gottlieb, D., Huang, G., Hertzberg, M., Svennilson, J., Bradstock, K. (2008), A reduced intensity conditioning protocol associated with excellent survival in patients with myelofibrosis. Bone marrow transplantation. 42(8), 567-8. [Abstract]