Professor David Handelsman

Professor
Medicine, Concord Clinical School
ANZAC Research Institute

C64 - ANZAC Research Institute
The University of Sydney
NSW 2006 Australia

T: +61 2 9767 9100
F: +61 2 9767 9101
E:
W: Related website

Research interests

Male Reproductive Health

Current national competitive grants*

2012

Role of androgens in polycystic ovary syndrome
Walters K, Handelsman D, Allan C
NHMRC Project Grants ($493,515 over 4 years)

* Grants administered through the University of Sydney

Publications

2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008

2014

   
  • Handelsman, D., Newman, J., Jimenez, M., McLachlan, R., Sartorius, G., Jones, G. (2014), Performance of Direct Estradiol Immunoassays with Human Male Serum Samples. Clinical Chemistry. 60(3), 510-517. [Abstract]
  • Le, T., Ashton, A., Mardini, M., Stanton, P., Funder, J., Handelsman, D., Mihailidou, A. (2014), ROLE OF ANDROGENS IN SEX DIFFERENCES IN CARDIAC DAMAGE DURING MYOCARDIAL INFARCTION. Endocrinology. 155(2), 568-575. [Abstract]
  • Yeap, B., Alfonso, H., Chubb, S., Handelsman, D., Hankey, G., Almeida, O., Golledge, J., Norman, P., Flicker, L. (2014), In Older Men an Optimal Plasma Testosterone Is Associated With Reduced All-Cause Mortality and Higher Dihydrotestosterone With Reduced Ischemic Heart Disease Mortality, While Estradiol Levels Do Not Predict Mortality. The Journal of Clinical Endocrinology and Metabolism. 99(1), E9-18. [Abstract]
  • Fairhall, N., Sherrington, C., Cameron, I., Blyth, F., Naganathan, V., Clemson, L., Le Couteur, D., Handelsman, D., Waite, L., Cumming, R. (2014), Predicting participation restriction in community-dwelling older men: the Concord Health and Ageing in Men Project. Age and Ageing. 43(1), 31-37. [Abstract]
  • Gnjidic, D., Le Couteur, D., Hilmer, S., Cumming, R., Blyth, F., Naganathan, V., Waite, L., Handelsman, D., Simon Bell, J. (2014), Sedative load and functional outcomes in community-dwelling older Australian men: the CHAMP study. Fundamental and Clinical Pharmacology. 28(1), 10-19. [Abstract]
  • Caldwell, A., Middleton, L., Jimenez, M., Desai, R., McMahon, A., Allan, C., Handelsman, D., Walters, K. (2014), Characterization of reproductive, metabolic and endocrine features of polycystic ovary syndrome in female hyperandrogenic mouse models. Endocrinology. 155(8), 3146-3159. [Abstract]
  • Zhao, B., Choi, J., Jaehne, M., Gao, Y., Desai, R., Tuckermann, J., Zhou, H., Handelsman, D., Simanainen, U. (2014), Glucocorticoid receptor in prostate epithelia is not required for corticosteroid-induced epithelial hyperproliferation in the mouse prostate. The Prostate. 74(10), 1068-1078. [Abstract]
  • Handelsman, D., Idan, A., Grainger, J., Goebel, C., Turner, L., Conway, A. (2014), Detection and effects on serum and urine steroid and LH of repeated GnRH analog (leuprolide) stimulation. Journal of Steroid Biochemistry and Molecular Biology. 141, 113-120. [Abstract]
  • Hsu, B., Cumming, R., Blyth, F., Naganathan, V., Le Couteur, D., Seibel, M., Waite, L., Handelsman, D. (2014), Longitudinal and cross-sectional relationships of circulating reproductive hormone levels to self-rated health and health-related quality of life in community-dwelling older men. Journal of Clinical Endocrinology and Metabolism. 99(5), 1638-1647. [Abstract]
  • Singh, G., Jimenez, M., Newman, R., Handelsman, D. (2014), Immunoreactive LH in long-term frozen human urine samples. Drug Testing and Analysis. 6(4), 336-341. [Abstract]
  • Singh, G., Turner, L., Desai, R., Jimenez, M., Handelsman, D. (2014), Pharmacokinetic-Pharmacodynamic Study of Subcutaneous Injection of Depot Nandrolone Decanoate Using Dried Blood Spots Sampling Coupled With Ultrapressure Liquid Chromatography, Tandem Mass Spectrometry (LC-MS) Assays. Journal of Clinical ndocrinology and Metabolism. 99(7), 2592¿2598. [Abstract]
  • Hazra, R., Upton, D., Jimenez, M., Desai, R., Handelsman, D., Allan, C. (2014), In vivo actions of the Sertoli cell glucocorticoid receptor. Endocrinology. 155(3), 1120-1130. [Abstract]
  • Hirani, V., Cumming, R., Naganathan, V., Blyth, F., Le Couteur, D., Handelsman, D., Waite, L., Seibel, M. (2014), Associations between serum 25-hydroxyvitamin D concentrations and multiple health conditions, physical performance measures, disability, and all-cause mortality: the Concord Health and Ageing in Men Project. Journal of the American Geriatrics Society. 62(3), 417-425. [Abstract]
  • Holden, C., Collins, V., Handelsman, D., Jolley, D., Pitts, M. (2014), Healthy aging in a cross-sectional study of Australian men: what has sex got to do with it?. The Aging Male. 17(1), 25-29. [Abstract]
  • Yeap, B., Knuiman, M., Divitini, M., Handelsman, D., Beilby, J., Beilin, J., McQuillan, B., Hung, J. (2014), Differential associations of testosterone, dihydrotestosterone and estradiol with physical, metabolic and health-related factors in community-dwelling men aged 17-97 years from the Busselton Health Survey. Clinical Endocrinology. 81(1), 100-108. [Abstract]
  • Purves-Tyson, T., Owens, S., Double, K., Desai, R., Handelsman, D., Weickert, C. (2014), Testosterone induces molecular changes in dopamine signaling pathway molecules in the adolescent male rat nigrostriatal pathway. PloS One. 9(3), e91151. [Abstract]
  • Kozan, P., Chalasani, S., Handelsman, D., Pike, A., Crawford, B. (2014), A Leydig cell tumor of the ovary resulting in extreme hyperandrogenism, erythrocytosis, and recurrent pulmonary embolism. Journal of Clinical Endocrinology and Metabolism. 99(1), 12-17. [Abstract]

2013

   
  • Bleicher, K., Cumming, R., Naganathan, V., Seibel, M., Blyth, F., Le Couteur, D., Handelsman, D., Creasey, H., Waite, L. (2013), Predictors of the rate of BMD loss in older men: findings from the CHAMP study. Osteoporosis International. 24(7), 1951-1963. [Abstract]
  • Hazra, R., Corcoran, L., Robson, M., McTavish, K., Upton, D., Handelsman, D., Allan, C. (2013), Temporal Role of Sertoli Cell Androgen Receptor Expression in Spermatogenic Development. Molecular Endocrinology. 27(1), 12-24. [Abstract]
  • Yeap, B., Alfonso, H., Chubb, S., Handelsman, D., Hankey, G., Golledge, J., Flicker, L., Norman, P. (2013), Lower plasma testosterone or dihydrotestosterone, but not estradiol, is associated with symptoms of intermittent claudication in older men. Clinical Endocrinology. 79(5), 725-732. [Abstract]
  • Handelsman, D. (2013), Global trends in testosterone prescribing, 2000-2011: expanding the spectrum of prescription drug misuse. The Medical Journal of Australia. 199(8), 548-551. [Abstract]
  • Handelsman, D., Wartofsky, L. (2013), Requirement for mass spectrometry sex steroid assays in the Journal of Clinical Endocrinology and Metabolism. The Journal of Clinical Endocrinology and Metabolism. 98, 3971-3973. [Abstract]
  • Handelsman, D., Sivananathan, T., Andres, L., Bathur, F., Jayadev, V., Conway, A. (2013), Randomised controlled trial of whether erotic material is required for semen collection: impact of informed consent on outcome. Andrology. 1, 943-947. [Abstract]
  • McNamara, K., Nakamura, Y., Sasano, H., Handelsman, D., Simanainen, U. (2013), Prostate epithelial AR inactivation leads to increased intraprostatic androgen synthesis. The Prostate. 73(3), 316-327. [Abstract]
  • Handelsman, D. (2013), Mechanisms of action of testosterone--unraveling a Gordian knot. New England Journal of Medicine. 369, 1058-1059. [Abstract]
  • Keski-Rahkonen, P., Huhtinen, K., Desai, R., Tim Harwood, D., Handelsman, D., Poutanen, M., Auriola, S. (2013), LC-MS analysis of estradiol in human serum and endometrial tissue: Comparison of electrospray ionization, atmospheric pressure chemical ionization and atmospheric pressure photoionization. Journal of Mass Spectrometry. 48(9), 1050-1058. [Abstract]
  • Handelsman, D. (2013), Mendelian randomization: loosening the Gordian knot of testosterone and male ageing. Asian Journal of Andrology. 15(5), 579-581. [Abstract]
  • Cheng, X., Jimenez, M., Desai, R., Middleton, L., Joseph, S., Ning, G., Allan, C., Smith, J., Handelsman, D., Walters, K. (2013), Characterizing the neuroendocrine and ovarian defects of androgen receptor-knockout female mice. American Journal of Physiology. Endocrinology and Metabolism. 305(6), E717-726. [Abstract]
  • Ilomaki, J., Gnjidic, D., Hilmer, S., Le Couteur, D., Naganathan, V., Cumming, R., Waite, L., Seibel, M., Blyth, F., Handelsman, D., Bell, J. (2013), Psychotropic drug use and alcohol drinking in community-dwelling older Australian men: the CHAMP study. Drug and Alcohol Review. 32(2), 218-222. [Abstract]
  • Birzniece, V., Umpleby, M., Poljak, A., Handelsman, D., Ho, K. (2013), Oral low-dose testosterone administration induces whole-body protein anabolism in postmenopausal women: a novel liver-targeted therapy. European Journal of Endocrinology. 169(3), 321-327. [Abstract]
  • Hazra, R., Jimenez, M., Desai, R., Handelsman, D., Allan, C. (2013), Sertoli cell androgen receptor expression regulates temporal fetal and adult Leydig cell differentiation, function and population size. Endocrinology. 154(9), 3410-3422. [Abstract]
  • Simanainen, U., Gao, Y., Desai, R., Jimenez, M., Spaliviero, J., Keast, J., Handelsman, D. (2013), Evidence for increased tissue androgen sensitivity in neurturin knockout mice. The Journal of Endocrinology. 218(2), 151-163. [Abstract]
  • Hirani, V., Naganathan, V., Cumming, R., Blyth, F., Le Couteur, D., Handelsman, D., Waite, L., Seibel, M. (2013), Associations Between Frailty and Serum 25-Hydroxyvitamin D and 1,25-Dihydroxyvitamin D Concentrations in Older Australian Men: The Concord Health and Ageing in Men Project. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. 68(9), 1112-1121. [Abstract]
  • Handelsman, D., Cooper, T. (2013), Falling sperm counts and global estrogenic pollution: what have we learned over 20 years?. Asian Journal of Andrology. 15, 159-161. [Abstract]
  • Cooper, T., Handelsman, D. (2013), Falling sperm counts and global oestrogenic pollution: postscript. Asian Journal of Andrology. 15, 208-211. [Abstract]
  • Handelsman, D. (2013), The Andrology of Adolescence. In: A Clinical Handbook in Adolescent Medicine. (pp.675-684).United States: World Scientific Publishing.
  • Hirani, V., Cumming, R., Blyth, F., Naganathan, V., Le Couteur, D., Handelsman, D., Waite, L., Seibel, M. (2013), Vitamin D Status among older community dwelling men living in a sunny country and associations with lifestyle factors: the Concord Health and Ageing in Men Project, Sydney, Australia. The Journal of Nutrition, Health and Aging. 17(7), 587-593. [Abstract]
  • Gnjidic, D., Le Couteur, D., Blyth, F., Travison, T., Rogers, K., Naganathan, V., Cumming, R., Waite, L., Seibel, M., Handelsman, D., McLachlan, A., Hilmer, S. (2013), Statin use and clinical outcomes in older men: a prospective population-based study. BMJ Open. 3(3), 1-10. [Abstract]

2012

   
  • Rodriguez, E., Weiss, D., Ferretti, M., Wang, H., Menshenia, J., Risbridger, G., Handelsman, D., Cunha, G., Baskin, L. (2012), Specific morphogenetic events in mouse external genitalia sex differentiation are responsive/dependent upon androgens and/or estrogens. Differentiation. 84(3), 269-279. [Abstract]
  • Yeap, B., Alfonso, H., Chubb, S., Handelsman, D., Hankey, G., Norman, P., Flicker, L. (2012), Reference Ranges and Determinants of Testosterone, Dihydrotestosterone, and Estradiol Levels Measured using Liquid Chromatography-Tandem Mass Spectrometry in a Population-Based Cohort of Older Men. Journal of Clinical Endocrinology and Metabolism. 97(11), 4030-4039. [Abstract]
  • Huhtinen, K., Desai, R., StÃ¥hle, M., Salminen, A., Handelsman, D., Perheentupa, A., Poutanen, M. (2012), Endometrial and Endometriotic Concentrations of Estrone and Estradiol Are Determined by Local Metabolism Rather than Circulating Levels. Journal of Clinical Endocrinology and Metabolism. 97(11), 4228-4235. [Abstract]
  • Conway, A., Hamblin, J., Handelsman, D. (2012), Hormone treatment of gender identity disorder in a cohort of children and adolescents. Medical Journal of Australia. 197(5), 273. [Abstract]
  • Gnjidic, D., Hilmer, S., Blyth, F., Naganathan, V., Waite, L., Seibel, M., McLachlan, A., Cumming, R., Handelsman, D., Le Couteur, D. (2012), Polypharmacy cutoff and outcomes: five or more medicines were used to identify community-dwelling older men at risk of different adverse outcomes. Journal of Clinical Epidemiology. 65(9), 989-995. [Abstract]
  • McNamara, K., Handelsman, D., Simanainen, U. (2012), The mouse as a model to investigate sex steroid metabolism in the normal and pathological prostate. Journal of Steroid Biochemistry and Molecular Biology. 131(3-5), 107-121. [Abstract]
  • Le Couteur, D., Handelsman, D. (2012), DNA damage, NF-κB and accelerated aging. Asian Journal of Andrology. 14(6), 811¿812. [Abstract]
  • Barroso, O., Handelsman, D., Strasburger, C., Thevis, M. (2012), Analytical challenges in the detection of peptide hormones for anti-doping purposes. Bioanalysis. 4(13), 1577-1590. [Abstract]
  • Handelsman, D. (2012), Pharmacoepidemiology of testosterone prescribing in Australia, 1992-2010. Medical Journal of Australia. 196(10), 642-645. [Abstract]
  • Drummond, E., Martins, R., Handelsman, D., Harvey, A. (2012), Altered expression of Alzheimer's disease-related proteins in male hypogonadal mice. Endocrinology. 153(6), 2789-2799. [Abstract]
  • Simanainen, U., Gao, Y., Walters, K., Watson, G., Desai, R., Jimenez, M., Handelsman, D. (2012), Androgen Resistance in Female Mice Increases Susceptibility to DMBA-Induced Mammary Tumors. Hormones & Cancer. 3(3), 113-124. [Abstract]
  • Sartorius, G., Spasevska, S., Idan, A., Turner, L., Forbes, E., Zamojska, A., Allan, C., Ly, L., Conway, A., McLachlan, R., Handelsman, D. (2012), Serum Testosterone, Dihydrotestosterone and Estradiol Concentrations in Older Men Self-Reporting Very Good Health:The Healthy Man Study. Clinical Endocrinology. 77(5), 755-763. [Abstract]
  • Sivananthan, T., Bathur, F., Jimenez, M., Conway, A., Idan, A., Handelsman, D. (2012), Objective non-intrusive markers of sperm production and sexual activity. Asian Journal of Andrology. 14(3), 476-480. [Abstract]
  • Litchfield, M., Cumming, R., Smith, D., Naganathan, V., Le Couteur, D., Waite, L., Blyth, F., Handelsman, D. (2012), Prostate-specific antigen levels in men aged 70 years and over: findings from the CHAMP study. Medical Journal of Australia. 196(6), 395-398. [Abstract]
  • Handelsman, D., Simanainen, U., Walters, K., Allan, C. (2012), Estradiol Immunoassays for Mice: Not Fit for Purpose. Endocrinology. , 1501.
  • Gnjidic, D., Hilmer, S., Blyth, F., Naganathan, V., Cumming, R., Handelsman, D., McLachlan, A., Abernethy, D., Banks, E., Le Couteur, D. (2012), High-risk prescribing and incidence of frailty among older community-dwelling men. Clinical pharmacology and therapeutics. 91(3), 521-528. [Abstract]
  • Gnjidic, D., Stanaway, F., Cumming, R., Waite, L., Blyth, F., Naganathan, V., Handelsman, D., Le Couteur, D. (2012), Mild Cognitive Impairment Predicts Institutionalization among Older Men: A Population-Based Cohort Study. PLoS One. 7(9), e46061. [Abstract]
  • Purves-Tyson, T., Handelsman, D., Double, K., Owens, S., Bustamante, S., Weickert, C. (2012), Testosterone regulation of sex steroid-related mRNAs and dopamine-related mRNAs in adolescent male rat substantia nigra. BMC Neuroscience. 13(1), 95. [Abstract]
  • Steinbeck, K., Hazell, P., Cumming, R., Skinner, S., Ivers, R., Booy, R., Fulcher, G., Handelsman, D., Martin, A., Morgan, G., Starling, J., Bauman, A., Rawsthorne, M., Bennett, D., Chow, C., Lam, M., Kelly, P., Brown, N., Paxton, K., Hawke, C. (2012), The study design and methodology for the ARCHER study - adolescent rural cohort study of hormones, health, education, environments and relationships. BMC Pediatrics. 12(1), 143. [Abstract]
  • Walters, K., Middleton, L., Joseph, S., Hazra, R., Jimenez, M., Simanainen, U., Allan, C., Handelsman, D. (2012), Targeted loss of androgen receptor signaling in murine granulosa cells of preantral and antral follicles causes female subfertility. Biology of Reproduction. 87(6), 151. [Abstract]
  • McGrath, K., Li, X., Gaus, K., Williams, P., Celermajer, D., Handelsman, D., Heather, A. (2012), Androgens Rapidly Activate Nuclear Factor-Kappa B via Intracellular Ca2 Signalling in Human Vascular Endothelial Cells. Journal of Steroids & Hormonal Science. S2, 005.
  • Walters, K., Allan, C., Handelsman, D. (2012), Rodent models for human polycystic ovary syndrome. Biology of Reproduction. 86(5), 149. [Abstract]

2011

   
  • Bleicher, K., Cumming, R., Naganathan, V., Travison, T., Sambrook, P., Blyth, F., Handelsman, D., Le Couteur, D., Waite, L., Creasey, H., Seibel, M. (2011), The role of fat and lean mass in bone loss in older men: Findings from the CHAMP study. Bone. 49(6), 1299-1305. [Abstract]
  • Simanainen, U., McNamara, K., Gao, Y., McPherson, S., Desai, R., Jimenez, M., Handelsman, D. (2011), Anterior prostate epithelial AR inactivation modifies estrogen receptor expression and increases estrogen sensitivity. American journal of physiology. Endocrinology and metabolism. 301(4), E727-35. [Abstract]
  • Allan, C., Handelsman, D. (2011), The skeleton gets a (reproductive) life. Asian Journal of Andrology. 13(5), 651-652. [Abstract]
  • Bleicher, K., Cumming, R., Naganathan, V., Seibel, M., Sambrook, P., Blyth, F., Le Couteur, D., Handelsman, D., Creasey, H., Waite, L. (2011), Lifestyle factors, medications, and disease influence bone mineral density in older men: findings from the CHAMP study. Osteoporosis International. 22(9), 2421-2437. [Abstract]
  • Stanaway, F., Cumming, R., Naganathan, V., Blyth, F., Handelsman, D., Le Couteur, D., Waite, L., Creasey, H., Seibel, M., Sambrook, P. (2011), Ethnicity and falls in older men: low rate of falls in Italian-born men in Australia. Age and Ageing. 40(5), 595-601. [Abstract]
  • Simanainen, U., Brogley, M., Gao, Y., Jimenez, M., Harwood, D., Handelsman, D., Robins, D. (2011), Length of the human androgen receptor glutamine tract determines androgen sensitivity in vivo. Molecular and cellular endocrinology. 342(1-2), 81-6. [Abstract]
  • Travison, T., Nguyen, A., Naganathan, V., Stanaway, F., Blyth, F., Cumming, R., Le Couteur, D., Sambrook, P., Handelsman, D. (2011), Changes in Reproductive Hormone Concentrations Predict the Prevalence and Progression of the Frailty Syndrome in Older Men: The Concord Health and Ageing in Men Project. Journal of Clinical Endocrinology and Metabolism. 96(8), 2464-2474. [Abstract]
  • Nabipour, I., Cumming, R., Handelsman, D., Litchfield, M., Naganathan, V., Waite, L., Creasey, H., Janu, M., Le Couteur, D., Sambrook, P., Seibel, M. (2011), Socioeconomic status and bone health in community-dwelling older men: the CHAMP Study. Osteoporosis International. 22(5), 1343-1353. [Abstract]
  • Handelsman, D. (2011), Commentary: androgens and "anabolic steroids": the one-headed janus. Endocrinology. 152(5), 1752-1754. [Abstract]
  • Handelsman, D., Turner, L., Conway, A. (2011), Doctors breaching patient privacy: Orwell redux. The Medical Journal of Australia. 194(8), 403-404. [Abstract]
  • Birzniece, V., Meinhardt, U., Umpleby, M., Handelsman, D., Ho, K. (2011), Interaction between Testosterone and Growth Hormone on Whole-Body Protein Anabolism Occurs in the Liver. The Journal of Clinical Endocrinology and Metabolism. 96(4), 1060-1067. [Abstract]
  • Handelsman, D. (2011), Androgen misuse and abuse. Best Practice & Research. Clinical Endocrinology & Metabolism. 25(2), 377-389. [Abstract]
  • Akram, O., Bursill, C., Desai, R., Heather, A., Kazlauskas, R., Handelsman, D., Lambert, G. (2011), Evaluation of androgenic activity of nutraceutical-derived steroids using mammalian and yeast in vitro androgen bioassays. Analytical Chemistry. 83(6), 2065-2074. [Abstract]
  • Simanainen, U., Lampinen, A., Henneicke, H., Brennan, T., Heinevetter, U., Harwood, D., McNamara, K., Herrmann, M., Seibel, M., Handelsman, D., Zhou, H. (2011), Long-Term corticosterone treatment induced lobe-specific pathology in mouse prostate. The Prostate. 71, 289-97. [Abstract]
  • Blyth, F., Cumming, R., Nicholas, M., Creasey, H., Handelsman, D., Le Couteur, D., Naganathan, V., Sambrook, P., Seibel, M., Waite, L. (2011), Intrusive pain and worry about health in older men: The CHAMP study. Pain. 152(2), 447-52. [Abstract]
  • Handelsman, D., Allan, C., Walters, K., Simanainen, U. (2011), Genetic models for hormonal regulation of reproduction. Australian Biochemist. 42(1), 4-7.
  • Stanaway, F., Blyth, F., Cumming, R., Naganathan, V., Handelsman, D., Waite, L., Sambrook, P., Creasey, H., Seibel, M., Le Couteur, D. (2011), Back pain in older male Italian-born immigrants in Australia: The importance of socioeconomic factors. European Journal of Pain. 15(1), 70-76. [Abstract]
  • Stanaway, F., Gnjidic, D., Blyth, F., Le Couteur, D., Naganathan, V., Waite, L., Seibel, M., Handelsman, D., Sambrook, P., Cumming, R. (2011), How fast does the Grim Reaper walk? Receiver operating characteristics curve analysis in healthy men aged 70 and over. BMJ. 343, d7679. [Abstract]
  • Le Couteur, D., Benson, V., McMahon, A., Blyth, F., Handelsman, D., Seibel, M., Kennerson, M., Naganathan, V., Cumming, R., de Cabo, R. (2011), Determinants of Serum-Induced SIRT1 Expression in Older Men: The CHAMP Study. Journals of Gerontology. Series A: Biological Sciences & Medical Sciences. 66(1), 3-8. [Abstract]
  • Handelsman, D. (2011), RFD Award Lecture 2010.Hormonal regulation of spermatogenesis: insights from constructing genetic models. Reproduction, fertility, and development. 23(4), 507-19. [Abstract]
  • Handelsman, D. (2011), An old emperor finds new clothing: rejuvenation in our time. Asian Journal of Andrology. 13(1), 125-129. [Abstract]

2010

   
  • Allan, C., Kalak, R., Dunstan, C., McTavish, K., Zhou, H., Handelsman, D., Seibel, M. (2010), Follicle-stimulating hormone increases bone mass in female mice. Proceedings of the National Academy of Sciences of the United States of America. 107(52), 22629-34. [Abstract]
  • Nabipour, I., Sambrook, P., Blyth, F., Janu, M., Waite, L., Naganathan, V., Handelsman, D., Le Couteur, D., Cumming, R., Seibel, M. (2010), Serum uric acid is associated with bone health in older men: A cross-sectional, population-based study. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. (5). [Abstract]
  • Idan, A., Griffiths, K., Harwood, D., Seibel, M., Turner, L., Conway, A., Handelsman, D. (2010), Long-Term Effects of Dihydrotestosterone Treatment on Prostate Growth in Healthy, Middle-Aged Men Without Prostate Disease: A Randomized, Placebo-Controlled Trial. Annals of Internal Medicine. 153(10), 621-632. [Abstract]
  • Hairi, N., Cumming, R., Naganathan, V., Handelsman, D., Le Couteur, D., Creasey, H., Waite, L., Seibel, M., Sambrook, P. (2010), Loss of Muscle Strength, Mass (Sarcopenia), and Quality (Specific Force) and Its Relationship with Functional Limitation and Physical Disability: The Concord Health and Ageing in Men Project. Journal of the American Geriatrics Society. 58(11), 2055-2062. [Abstract]
  • Bleicher, K., Naganathan, V., Cumming, R., Seibel, M., Sambrook, P., Blyth, F., Le Couteur, D., Handelsman, D., Waite, L., Creasey, H. (2010), Prevalence and treatment of osteoporosis in older Australian men: findings from the CHAMP study. The Medical Journal of Australia. 193(7), 387-391. [Abstract]
  • Handelsman, D. (2010), Testosterone and male ageing: spinning the wheels. The Medical Journal of Australia. 193(7), 379-380. [Abstract]
  • Ly, L., Sartorius, G., Hull, L., Leung, A., Swerdloff, R., Wang, C., Handelsman, D. (2010), Accuracy of Calculated Free Testosterone Formulae In Men. Clinical endocrinology. 73(3), 382-8. [Abstract]
  • McNamara, K., Harwood, D., Simanainen, U., Walters, K., Jimenez, M., Handelsman, D. (2010), Measurement of sex steroids in murine blood and reproductive tissues by liquid chromatography-tandem mass spectrometry. The Journal of steroid biochemistry and molecular biology. 121(3-5), 611-8. [Abstract]
  • Maclean, H., Moore, A., Sastra, S., Morris, H., Ghasem-Zadeh, A., Rana, K., Axell, A., Notini, A., Handelsman, D., Seeman, E., Zajac, J., Davey, R. (2010), DNA-binding-dependent androgen receptor signaling contributes to gender differences and has physiological actions in males and females. The Journal of Endocrinology. 206(1), 93-103. [Abstract]
  • Le Couteur, D., Blyth, F., Creasey, H., Handelsman, D., Naganathan, V., Sambrook, P., Seibel, M., Waite, L., Cumming, R. (2010), The Association of Alanine Transaminase With Aging, Frailty, and Mortality. The journals of gerontology. Series A, Biological sciences and medical sciences. 65(7), 712-7. [Abstract]
  • Fennell, C., Sartorius, G., Ly, L., Turner, L., Liu, P., Conway, A., Handelsman, D. (2010), Randomized cross-over clinical trial of injectable vs. implantable depot testosterone for maintenance of testosterone replacement therapy in androgen deficient men. Clinical endocrinology. 73(1), 102-9. [Abstract]
  • Chow, R., Handelsman, D., Ng, M. (2010), Minireview: Rapid Actions of Sex Steroids in the Endothelium. Endocrinology. 151(6), 2411-22. [Abstract]
  • Allan, C., Couse, J., Simanainen, U., Spaliviero, J., Jimenez, M., Rodriguez, K., Korach, K., Handelsman, D. (2010), Estradiol Induction of Spermatogenesis Is Mediated via an Estrogen Receptor-{alpha} Mechanism Involving Neuroendocrine Activation of Follicle-Stimulating Hormone Secretion. Endocrinology. 151(6), 2800-10. [Abstract]
  • Kwong, P., Cumming, R., Chan, L., Seibel, M., Naganathan, V., Creasey, H., Le Couteur, D., Waite, L., Sambrook, P., Handelsman, D. (2010), Urinary incontinence and quality of life among older community-dwelling Australian men: the CHAMP study. Age and Ageing. 39(3), 349-354. [Abstract]
  • Sartorius, G., Fennell, C., Spasevska, S., Turner, L., Conway, A., Handelsman, D. (2010), Factors influencing time course of pain after depot oil intramuscular injection of testosterone undecanoate. Asian Journal of Andrology. 12(2), 227-233. [Abstract]
  • Rochat, S., Cumming, R., Blyth, F., Creasey, H., Handelsman, D., Le Couteur, D., Naganathan, V., Sambrook, P., Seibel, M., Waite, L. (2010), Frailty and use of health and community services by community-dwelling older men: the Concord Health and Ageing in Men Project. Age and Ageing. 39(2), 228-233. [Abstract]
  • Sieveking, D., Lim, P., Chow, R., Dunn, L., Bao, S., McGrath, K., Heather, A., Handelsman, D., Celermajer, D., Ng, M. (2010), A sex-specific role for androgens in angiogenesis. The Journal of Experimental Medicine. 207(2), 345-352. [Abstract]
  • Ip, F., di Pierro, I., Brown, R., Cunningham, I., Handelsman, D., Liu, P. (2010), Trough serum testosterone predicts the development of polycythemia in hypogonadal men treated for up to 21 years with subcutaneous testosterone pellets. European journal of endocrinology / European Federation of Endocrine Societies. 162(2), 385-90. [Abstract]
  • Mitchell, S., Kirkpatrick, C., Le Couteur, D., Naganathan, V., Sambrook, P., Seibel, M., Blyth, F., Waite, L., Handelsman, D., Cumming, R., Hilmer, S. (2010), Estimation of lean body weight in older community-dwelling men. British Journal of Clinical Pharmacology. 69(2), 118-127. [Abstract]
  • Stanaway, F., Cumming, R., Naganathan, V., Blyth, F., Creasey, H., Waite, L., Handelsman, D., Seibel, M. (2010), Depressive symptoms in older male Italian immigrants in Australia: the Concord Health and Ageing in Men Project. The Medical Journal of Australia. 192(3), 158-162. [Abstract]
  • Meier, C., Seibel, M., Handelsman, D. (2010), Testicular dysfunction. In: Osteoporosis In Men: The Effects of Gender on Skeletal Health. (pp.423-434).United States: Elsevier Academic.
  • Brinkworth, M., Handelsman, D. (2010), Environmental influences on male reproductive health. In: Andrology - Male Reproductive Health and Dysfunction. (pp.365-390).Germany: Springer-Verlag.
  • Handelsman, D. (2010), Androgen Physiology, Pharmacology and Abuse. In: Endocrinology 6th Edition. (pp.2469-2498).United States: Elsevier Inc.
  • Handelsman, D. (2010), Male contraception. In: Endocrinology 6th Edition. (pp.2580-2591).United States: Elsevier Inc.
  • Sartorius, G., Handelsman, D. (2010), Testicular dysfunction in systemic disease. In: Andrology - Male Reproductive Health and Dysfunction. (pp.339-364).Germany: Springer-Verlag.
  • Holden, C., McLachlan, R., Pitts, M., Cumming, R., Wittert, G., Ehsani, J., de Kretser, D., Handelsman, D. (2010), Determinants of male reproductive health disorders: the Men in Australia Telephone Survey (MATeS). BMC Public Health. 10, 96. [Abstract]
  • Cawley, A., Collins, M., Kazlauskas, R., Handelsman, D., Heywood, R., Longworth, M., Arenas-Queralt, A. (2010), Stable isotope ratio profiling of testosterone preparations. Drug Testing and Analysis. 2(11-12), 557-567. [Abstract]
  • Handelsman, D., Cooper, T. (2010), Afterword to Semen Analysis in 21st Century Medicine special issue in Asian Journal of Andrology. Asian Journal of Andrology. 12(1), 118-123. [Abstract]
  • Handelsman, D., Cooper, T. (2010), Foreword to Semen Analysis in 21st Century Medicine special issue in Asian Journal of Andrology. Asian Journal of Andrology. 12, 7-10. [Abstract]
  • Donat, R., Lalaka, A., Lin, B., Mitterdorfer, A., Handelsman, D. (2010), How Useful Is Semen Cytology in the Non-Invasive Diagnosis of Prostate Cancer?. Current Urology. 4(3), 119-124.
  • Walters, K., Simanainen, U., Handelsman, D. (2010), Molecular insights into androgen actions in male and female reproductive function from androgen receptor knockout models. Human reproduction update. 16(5), 543-58. [Abstract]

2009

   
  • Harwood, D., Handelsman, D. (2009), Development and validation of a sensitive liquid chromatography-tandem mass spectrometry assay to simultaneously measure androgens and estrogens in serum without derivatization. Clinica Chimica Acta. 409(1-2), 78-84. [Abstract]
  • Birzniece, V., Meinhardt, U., Handelsman, D., Ho, K. (2009), Testosterone stimulates extra-hepatic but not hepatic fat oxidation (Fox): comparison of oral and transdermal testosterone administration in hypopituitary men. Clinical Endocrinology. 71(5), 715-721. [Abstract]
  • Lim, P., Robson, M., Spaliviero, J., McTavish, K., Jimenez, M., Zajac, J., Handelsman, D., Allan, C. (2009), Sertoli cell androgen receptor DNA binding domain is essential for the completion of spermatogenesis. Endocrinology. 150(10), 4755-65. [Abstract]
  • Handelsman, D., Goebel, C., Idan, A., Jimenez, M., Trout, G., Kazlauskas, R. (2009), Effects of recombinant human luteinizing hormone and human chorionic gonadotropin on serum and urine LH and androgens in men. Clinical endocrinology. 71(3), 417-28. [Abstract]
  • MacLean, H., Handelsman, D. (2009), Unraveling androgen action in muscle: genetic tools probing cellular mechanisms. Endocrinology. 150(8), 3437-3439. [Abstract]
  • Walters, K., McTavish, K., Seneviratne, M., Jimenez, M., McMahon, A., Allan, C., Salamonsen, L., Handelsman, D. (2009), Subfertile female androgen receptor knockout mice exhibit defects in neuroendocrine signaling, intraovarian function, and uterine development but not uterine function. Endocrinology. 150(7), 3274-3282. [Abstract]
  • Gnjidic, D., Cumming, R., Le Couteur, D., Handelsman, D., Naganathan, V., Abernethy, D., Hilmer, S. (2009), Drug Burden Index and physical function in older Australian men. British Journal of Clinical Pharmacology. 68(1), 97-105. [Abstract]
  • Simanainen, U., McNamara, K., Gao, Y., Handelsman, D. (2009), Androgen sensitivity of prostate epithelium is enhanced by postnatal androgen receptor inactivation. American Journal of Physiology: Endocrinology and Metabolism. 296(6), E1335-E1343. [Abstract]
  • Allan, C., Lim, P., Robson, M., Spaliviero, J., Handelsman, D. (2009), Transgenic mutant D567G but not wild-type human FSH receptor overexpression provides FSH-independent and promiscuous glycoprotein hormone Sertoli cell signaling. American Journal of Physiology: Endocrinology and Metabolism. 296(5), E1022-E1028. [Abstract]
  • Cumming, R., Handelsman, D., Seibel, M., Creasey, H., Sambrook, P., Waite, L., Naganathan, V., Couteur, D., Litchfield, M. (2009), Cohort profile: The Concord Health and Ageing in Men Project (CHAMP). International journal of epidemiology. 38(0), 374-8. [Abstract]
  • Sartorius, G., Ly, L., Sikaris, K., McLachlan, R., Handelsman, D. (2009), Predictive accuracy and sources of variability in calculated free testosterone estimates. Annals of Clinical Biochemistry. 46(Pt 2), 137-143. [Abstract]
  • Liu, P., Gordon Baker, H., Jayadev, V., Zacharin, M., Conway, A., Handelsman, D. (2009), Induction of spermatogenesis and fertility during gonadotropin treatment of gonadotropin deficient infertile men: predictors of fertility outcome. The Journal of clinical endocrinology and metabolism. 94(0), 801-8. [Abstract]
  • McRobb, L., Handelsman, D., Heather, A. (2009), Androgen-induced progression of arterial calcification in apolipoprotein E-null mice is uncoupled from plaque growth and lipid levels. Endocrinology. 150(2), 841-848. [Abstract]
  • Roa, J., Castellano, J., Navarro, V., Handelsman, D., Pinilla, L., Tena-Sempere, M. (2009), Kisspeptins and the control of gonadotropin secretion in male and female rodents. Peptides. 30(1), 57-66. [Abstract]

2008

   
  • Blyth, F., Rochat, S., Cumming, R., Creasey, H., Handelsman, D., Couteur, D., Naganathan, V., Sambrook, P., Seibel, M., Waite, L. (2008), Pain, frailty and comorbidity on older men: The CHAMP study. Pain. 140(0), 224-30. [Abstract]
  • Ho, L., Kench, J., Handelsman, D., Scheffer, G., Stricker, P., Grygiel, J., Sutherland, R., Henshall, S., Allen, J., Horvath, L. (2008), Androgen regulation of multidrug resistance-associated protein 4 (MRP4/ABCC4) in prostate cancer. The Prostate. 68(13), 1421-9. [Abstract]
  • Nguyen, T., Nelson, A., Howe, C., Seibel, M., Baxter, R., Handelsman, D., Kazlauskas, R., Ho, K. (2008), Within-Subject Variability and Analytic Imprecision of Insulin-Like Growth Factor Axis and Collagen Markers: Implications for Clinical Diagnosis and Doping Tests. Clinical chemistry. 54(8), 1268-76. [Abstract]
  • Simanainen, U., McNamara, K., Davey, R., Zajac, J., Handelsman, D. (2008), Severe subfertility in mice with AR inactivation in sex accessory organs, but not in testis. Endocrinology. 149(7), 3330-8. [Abstract]
  • Nelson, A., Meinhardt, U., Hansen, J., Walker, I., Stone, G., Howe, C., Leung, K., Seibel, M., Baxter, R., Handelsman, D., Kazlauskas, R., Ho, K. (2008), Pharmacodynamics of GH abuse biomarkers and the influence of gender and testosterone: a randomized double-blind placebo-controlled study in young recreational athletes. The Journal of clinical endocrinology and metabolism. 93(6), 2213-22. [Abstract]
  • Handelsman, D. (2008), Indirect androgen doping by oestrogen blockade in sports. British Journal of Pharmacology. 154(3), 598-605. [Abstract]
  • Handelsman, D., Heather, A. (2008), Androgen abuse in sports. Asian Journal of Andrology. 10(3), 403-415. [Abstract]
  • McRobb, L., Handelsman, D., Kazlauskas, R., Wilkinson, S., McLeod, M., Heather, A. (2008), Structure-activity relationships of synthetic progestins in a yeast-based in vitro androgen bioassay. The Journal of steroid biochemistry and molecular biology. 110, 39-47. [Abstract]
  • Handelsman, D., Gooren, L. (2008), Hormones and sport: physiology, pharmacology and forensic science. Asian Journal of Andrology. 10, 348-350. [Abstract]
  • Liu, P., Swerdloff, R., Anawalt, B., Anderson, R., Bremner, W., Elliesen, J., Gu, Y., Kersemaekers, W., McLachlan, R., Meriggiola, M., Nieschlag, E., Sitruk-Ware, R., Vogelsong, K., Wang, X., Wu, F., Zitzmann, M., Handelsman, D., Wang, C. (2008), Determinants of the Rate and Extent of Spermatogenic Suppression during Hormonal Male Contraception: An Integrated Analysis. The Journal of Clinical Endocrinology and Metabolism. 93(5), 1774-1783. [Abstract]
  • Walters, K., Allan, C., Handelsman, D. (2008), Androgen actions and the ovary. Biology of reproduction. 78(3), 380-389. [Abstract]
  • Meier, C., Nguyen, T., Handelsman, D., Schindler, C., Kushnir, M., Rockwood, A., Meikle, A., Center, J., Eisman, J., Seibel, M. (2008), Endogenous sex hormones and incident fracture risk in older men: the Dubbo Osteoporosis Epidemiology Study. Archives of internal medicine. 168(1), 47-54. [Abstract]
  • Lim, P., Allan, C., Notini, A., Axell, A., Spaliviero, J., Jimenez, M., Davey, R., McManus, J., Maclean, H., Zajac, J., Handelsman, D. (2008), Oestradiol-induced spermatogenesis requires a functional androgen receptor. Reproduction, fertility, and development. 20(8), 861-870. [Abstract]