Dr Daniel Speidel

Senior Lecturer
Medicine, Children's Medical Research Institute

T: +61 2 9687 2800
F: 96872120
E:

Biographical details

2004 PhD Biochemistry, University Hannover, Germany [More...]

Research interests

DNA damage responses, apoptosis, cell cycle regulation, p53

Current national competitive grants*

2012

DNA damage induced cell cycle alterations: how significant are they for tumour suppression and the response of different tissues to cytotoxic agents in vivo?
Speidel D
Cure Cancer Australia Foundation Research Support ($180,000 over 3 years)

* Grants administered through the University of Sydney

Keywords

Biochemistry; Cell biology; Biological sciences; Haematological malignancy

International links

United Kingdom. (University of Kent) Research collaboration on p53-activating drugs with Prof Martin Michaelis.

Publications

2014 | 2012 | 2011 | 2010 | 2008

2014

   
  • Cinatl, J., Speidel, D., Hardcastle, I., Michaelis, M. (2014), Resistance acquisition to MDM2 inhibitors. Biochemical Society Transactions. 42(4), 752-757. [Abstract]
  • Chircop, M., Speidel, D. (2014), Cellular stress responses in cancer and cancer therapy. Frontiers in Oncology. 4, 304. [Abstract]

2012

   
  • Michaelis, M., Rothweiler, F., Agha, B., Barth, S., Voges, Y., Löschmann, N., von Deimling, A., Breitling, R., Wilhelm Doerr, H., Rödel, F., Speidel, D., Cinatl, J. (2012), Human neuroblastoma cells with acquired resistance to the p53 activator RITA retain functional p53 and sensitivity to other p53 activating agents. Cell Death & Disease. 3, e294. [Abstract]

2011

   
  • Heinlein, C., Speidel, D. (2011), High-resolution cell cycle and DNA ploidy analysis in tissue samples. Current Protocols in Cytometry. Chapter 7, Unit7.39. [Abstract]
  • Speidel, D. (2011), The magic trick of hepatocytes: uncoupling genomic instability from cancer. Trends in molecular medicine. , 117-8. [Abstract]
  • Michaelis, M., Rothweiler, F., Barth, S., Cinatl, J., van Rikxoort, M., Löschmann, N., Voges, Y., Breitling, R., von Deimling, A., Rödel, F., Weber, K., Fehse, B., Mack, E., Stiewe, T., Doerr, H., Speidel, D., Cinatl, J. (2011), Adaptation of cancer cells from different entities to the MDM2 inhibitor nutlin-3 results in the emergence of p53-mutated multi-drug-resistant cancer cells. Cell Death & Disease. 2, e243. [Abstract]

2010

   
  • Speidel, D., Stocking, C. (2010), Caspase 3 activity in whole cell extracts of Ba/F3 cells is unrelated to apoptosis. Cell cycle (Georgetown, Tex.). , 3823-5. [Abstract]
  • Heinlein, C., Deppert, W., Braithwaite, A., Speidel, D. (2010), A rapid and optimization-free procedure allows the in vivo detection of subtle cell cycle and ploidy alterations in tissues by flow cytometry. Cell Cycle. 9(17), 3584-3590. [Abstract]
  • Kim, E., Wüstenberg, R., Rübsam, A., Schmitz-Salue, C., Warnecke, G., Bücker, E., Pettkus, N., Speidel, D., Rohde, V., Schulz-Schaeffer, W., Deppert, W., Giese, A. (2010), Chloroquine activates the p53 pathway and induces apoptosis in human glioma cells. Neuro-Oncology. 12(4), 389-400. [Abstract]
  • Speidel, D. (2010), Transcription-independent p53 apoptosis: an alternative route to death. Trends in Cell Biology. 20(1), 14-24. [Abstract]

2008

   
  • Heinlein, C., Krepulat, F., Löhler, J., Speidel, D., Deppert, W., Tolstonog, G. (2008), Mutant p53(R270H) gain of function phenotype in a mouse model for oncogene-induced mammary carcinogenesis. International journal of cancer. Journal international du cancer. 122(8), 1701-9. [Abstract]
  • Engelmann, A., Speidel, D., Bornkamm, G., Deppert, W., Stocking, C. (2008), Gadd45 beta is a pro-survival factor associated with stress-resistant tumors. Oncogene. 27(10), 1429-38. [Abstract]