Associate Professor Fazlul Huq

Associate Professor
Biomedical Sciences, School of Medical Sciences

C42 - Cumberland Campus
The University of Sydney
NSW 2006 Australia

T: +61 2 9351 9522
F: +61 2 9351 9520
E:

Research interests

Designing tumour active compounds with wider spectrum of activity and reduced side effects

Teaching areas

A/Prof Fazlul Huq teaching toxicology, biochemistry and biophysics to students in the Faculty of Health Sciences

PhD and Masters' project opportunities

Studies on tumour active compounds

Keywords

Bioinformatics; Biochemistry; Cell biology; Drug design; Cancer

Publications

2012 | 2011 | 2010 | 2009 | 2008 | 2007

2012

   
  • Deqnah, N., Yu, J., Beale, P., Huq, F. (2012), Studies on the Activity of Two Trans-Planaramine Platinum(II) Complexes Coded as DH4 and DH5 in Human Ovarian Tumour Models. Anticancer Research. 32(12), 5331-5336. [Abstract]
  • Mazumder, M., Beale, P., Chan, C., Yu, J., Huq, F. (2012), Epigallocatechin Gallate Acts Synergistically in Combination with Cisplatin and Designed trans-palladiums in Ovarian Cancer Cells. Anticancer Research. 32(11), 4851-4860. [Abstract]
  • Nessa, M., Beale, P., Chan, C., Yu, J., Huq, F. (2012), Studies on combination of platinum drugs Cisplatin and oxaliplatin with phytochemicals anethole and curcumin in ovarian tumour models. Anticancer Research. 32(11), 4843-4850. [Abstract]
  • Mazumder, M., Beale, P., Chan, C., Yu, J., Huq, F. (2012), Synthesis and Cytotoxicity of Three trans-Palladium Complexes Containing Planaramine Ligands in Human Ovarian Tumor Models. ChemMedChem. 7(10), 1840-1846. [Abstract]
  • Hamad, S., Beale, P., Yu, J., Fisher, K., Huq, F. (2012), Synthesis and Activity of [{Cis-PtCl(NH3)2}2µ{Trans-Pt(3-Hydroxypyridine)2(H2N(CH2)6NH2)2}]Cl4 in the Human Ovarian Tumour Models. Medicinal Chemistry. 8(3), 384-391. [Abstract]
  • Deqnah, N., Yu, J., Beale, P., Fisher, K., Huq, F. (2012), Synthesis of trans-bis-(2-hydroxypyridine)dichloroplatinum(II) and its activity in human ovarian tumour models. Anticancer Research. 32(1), 135-140. [Abstract]
  • Nessa, M., Beale, P., Chan, C., Yu, J., Huq, F. (2012), Combinations of resveratrol, cisplatin and oxaliplatin applied to human ovarian cancer cells. Anticancer Research. 32(1), 53-59. [Abstract]

2011

   
  • Yunos, N., Beale, P., Yu, J., Huq, F. (2011), Synergism from the combination of oxaliplatin with selected phytochemicals in human ovarian cancer cell lines. Anticancer Research. 31(12), 4283-4290. [Abstract]
  • Nessa, M., Beale, P., Chan, C., Yu, J., Huq, F. (2011), Synergism from combinations of Cisplatin and oxaliplatin with quercetin and thymoquinone in human ovarian tumour models. Anticancer Research. 31(11), 3789-3797. [Abstract]
  • Alshehri, A., Beale, P., Yu, J., Huq, F. (2011), Synergism from Combination of Cisplatin and Multicentred Platinums Coded as DH6Cl and TH1 in the Human Ovarian Tumour Models. Medicinal Chemistry. 7(6), 593-598. [Abstract]
  • Al-Eisawi, Z., Beale, P., Chan, C., Yu, J., Huq, F. (2011), Modulation of Cisplatin Cytotoxicity due to its Combination with Bortezomib and the Nature of its Administration. Anticancer Research. 31(9), 2757-2762. [Abstract]
  • Huq, F., Danish, M., Starosta, W., Leciejewicz, J. (2011), trans-Bis(3-hy-droxy-pyridine-?N)diiodidoplatinum(II) dimethyl sulfoxide disolvate. Acta Crystallographica. Section E: Structure Reports Online. 67(Pt 6), m721. [Abstract]
  • Yunos, N., Beale, P., Yu, J., Huq, F. (2011), Synergism from Sequenced Combinations of Curcumin and Epigallocatechin-3-gallate with Cisplatin in the Killing of Human Ovarian Cancer Cells. Anticancer Research. 31(4), 1131-1140. [Abstract]
  • Al-Shuneigat, J., Qing, Y., Beale, P., Fisher, K., Huq, F. (2011), Studies on synthesis, activity and binding with DNA of a new trinuclear platinum compound [{trans-PtCl(NH3)2}2{trans-Pt(thiazole)2}{H2N(CH2)(6NH2}2]Cl3(NO3). Medicinal Chemistry. 7(1), 1-8. [Abstract]
  • Al-Shuneigat, J., Mahgoub, S., Huq, F. (2011), Colorectal carcinoma: nucleosomes, carcinoembryonic antigen and ca 19-9 as apoptotic markers; a comparative study. Journal of Biomedical Science. 18(1), 50. [Abstract]

2010

   
  • Alshehri, A., Beale, P., Yu, J., Huq, F. (2010), Synergism from combination of Cisplatin and a trans-platinum compound in ovarian cancer cell lines. Anticancer Research. 30(11), 4547-4553. [Abstract]
  • Yunos, N., Beale, P., Yu, J., Strain, D., Huq, F. (2010), Studies on combinations of platinum with Paclitaxel and colchicine in ovarian cancer cell lines. Anticancer Research. 30(10), 4025-4037. [Abstract]
  • Al-Shuneigat, J., Yu, J., Beale, P., Fisher, K., Huq, F. (2010), Studies on two new mixed ligand platinum compounds with a trans-geometry. Med Chem. 6(5), 321-8. [Abstract]

2009

   
  • Farhad, M., Yu, J., Beale, P., Fisher, K., Huq, F. (2009), Studies on the synthesis and activity of three tripalladium complexes containing planaramine ligands. ChemMedChem. 4(11), 1841-1849. [Abstract]
  • Huq, F., Tayyem, H., Yu, J., Beale, P., Fisher, K. (2009), Synthesis, activity and binding with DNA of [{trans-PtCl(NH(3))(2)}(2)micro-{trans-Pd(4-hydroxypyridine) (2) (H(2)N(CH(2))(6)NH(2))(2)]Cl(4) (TH8). Medicinal Chemistry. 5(4), 372-381. [Abstract]
  • Huq, F., Yu, J., Beale, P. (2009), Studies on New Platinum Compounds. In: Platinum and Other Heavy Metal Compounds in Cancer Chemotherapy: Molecular Mechanisms and Clinical Applications. (pp.11-17).United States: Humana Press.

2008

   
  • Tayyem, H., Huq, F., Yu, J., Beale, P., Fisher, K. (2008), Synthesis and Activity of a Trinuclear Platinum Complex: [{trans-PtCl(NH(3))(2)}(2)mu-{trans-Pt(3-hydroxypyridine)(2)(H(2)N(CH(2))(6)NH(2))(2)}]Cl(4) in Ovarian Cancer Cell Lines. ChemMedChem. 3(1), 145-151. [Abstract]
  • Huq, F. (2008), Molecular Modelling Analysis of the Metabolism of Udenafil. Journal of Pharmacology and Toxicology. 3(2), 109-117.
  • Huq, F. (2008), Molecular Modelling Analysis of the Metabolism of Venlafaxine. Journal of Pharmacology and Toxicology. 3(1), 27-33.
  • Huq, F. (2008), Molecular Modelling Analysis of the Metabolism of Zolpidem. Journal of Pharmacology and Toxicology. 3(2), 93-101.
  • Huq, F. (2008), Molecular Modelling Analysis of the Metabolism of Ramelteon. Journal of Pharmacology and Toxicology. 3(2), 119-126.
  • Huq, F., Fasim, F. (2008), Molecular Modelling Analysis of The Metabolism of Strychnine. International Journal of Pure and Applied Chemistry. 3(4), 241-246.
  • Huq, F. (2008), Molecular Modelling Analysis of the Metabolism of Rasagiline. Journal of Pharmacology and Toxicology. 3(2), 168-172.
  • Huq, F. (2008), Molecular Modelling Analysis of the Metabolism of Methimazole. Journal of Pharmacology and Toxicology. 3(1), 11-19.
  • Huq, F. (2008), Molecular Modelling Analysis of the Metabolism of Entecavir. Journal of Pharmacology and Toxicology. 3(1), 41-46.
  • Huq, F. (2008), Molecular Modelling Analysis of the Metabolism of Terbinafine. Journal of Pharmacology and Toxicology. 3(2), 64-74.
  • Huq, F. (2008), Molecular Modelling Analysis of the Metabolism of Maraviroc. Journal of Pharmacology and Toxicology. 3(2), 79-89.
  • Huq, F. (2008), Molecular Modelling Analysis of the Metabolism of Ambroxol. Journal of Pharmacology and Toxicology. 3(2), 147-152.

2007

   
  • Huq, F., Tayyem, H., Beale, P., Yu, J. (2007), Studies on the activity of three palladium(II) compounds of the form: Trans-PdL(2)Cl(2) where L=2-hydroxypyridine, 3-hydroxypyridine, and 4-hydroxypyridine. Journal of inorganic biochemistry. 101, 30-5. [Abstract]
  • Huq, F. (2007), Metabolism of ketoprofen – a molecular modelling analysis. International Journal of Pure and Applied Chemistry. 2(2), 229-234.
  • Huq, F. (2007), Semi-empirical and DFT analyses of the metabolism of hydrazine. International Journal of Pure and Applied Chemistry. 1(4), 455-459.
  • Huq, F. (2007), Molecular modelling analysis of the metabolism of scopolamine. International Journal of Pure and Applied Chemistry. 2(3), 271-280.
  • Huq, F. (2007), A Molecular Modelling Analysis of the Metabolism of Mexiletine. Journal of Pharmacology and Toxicology. 2(7), 638-645.
  • Huq, F. (2007), Molecular Modelling Analysis of the Antioxidant Activity of Probucol. Asian Journal of Biochemistry. 2(5), 354-358.
  • Huq, F. (2007), Molecular Modelling Analysis of the Metabolism of Mefenamic Acid. Journal of Pharmacology and Toxicology. 2, 72-79.
  • Huq, F. (2007), Molecular Modelling Analysis of the Metabolism of Fentanyl. Journal of Pharmacology and Toxicology. 2(2), 176-182.
  • Huq, F. (2007), Molecular Modelling Analysis of the Metabolism of Anagrelide. International Journal of Cancer Research. 3(1), 33-38.
  • Huq, F. (2007), Structure of Hexakis(trimethylsilylmethyl)dimolybdenum: The First Compound Reported to have a Mo Mo Bond. Asian Journal of Chemistry. 19(1), 49-54.
  • Huq, F. (2007), Molecular modelling analyses of the relative stability of alkenes, arenes and their epoxides and diols. Asian Journal of Chemistry. 19(1), 39-48.
  • Huq, F. (2007), Molecular modelling analysis of the metabolism of aspirin. Asian Journal of Chemistry. 19(1), 102-108.
  • Huq, F. (2007), Modular modelling analysis of the o-, m- and p-directing influences of substituents in electrophilic attack on aromatic compounds. Asian Journal of Chemistry. 19(1), 55-66.
  • Huq, F. (2007), Molecular modelling analysis of the metabolism of zileuton. International Journal of Pure and Applied Chemistry. 2, 263-269.
  • Huq, F. (2007), Molecular modelling analysis of the metabolism of methamphetamine. International Journal of Pure and Applied Chemistry. 2(1), 27-35.
  • Huq, F. (2007), Metabolism of isoniazid – a molecular modelling analysis. International Journal of Pure and Applied Chemistry. 2(1), 1-9.
  • Huq, F. (2007), Metabolism of vinyl chloride – a molecular modelling analysis. International Journal of Pure and Applied Chemistry. 2, 11-18.
  • Huq, F. (2007), Metabolism of mefenamic acid – a molecular modelling analysis. International Journal of Pure and Applied Chemistry. 2(1), 121-126.
  • Huq, F. (2007), Molecular Modelling Analysis of the Metabolism of Irbesartan. Journal of Pharmacology and Toxicology. 2(3), 238-247.
  • Huq, F. (2007), Molecular Modelling Analysis of the Metabolism of Eszopiclone. Journal of Pharmacology and Toxicology. 2(8), 732-736.
  • Huq, F. (2007), Molecular Modelling Analysis of the Metabolism of Clotrimazole. Journal of Pharmacology and Toxicology. 2(8), 748-752.
  • Huq, F. (2007), Molecular Modelling Analyses of the Metabolism of Clofarabine. Journal of Pharmacology and Toxicology. 2(7), 599-609.
  • Huq, F. (2007), Molecular Modelling Analysis of the Metabolism of Thiabendazole. Journal of Pharmacology and Toxicology. 2(6), 524-532.
  • Huq, F. (2007), A Molecular Modelling Analysis of Luliconazole, Lanconazole and Bifonazole. Journal of Pharmacology and Toxicology. 2(6), 567-573.
  • Huq, F. (2007), Molecular Modelling Analysis of the Metabolism of Tegaserod. Journal of Pharmacology and Toxicology. 2(5), 447-455.
  • Huq, F. (2007), Molecular Modelling Analysis of the Metabolism of Toluene. Journal of Pharmacology and Toxicology. 2(1), 20-32.
  • Huq, F. (2007), Molecular Modelling Analysis of the Metabolism of Cocaine. Journal of Pharmacology and Toxicology. 2(2), 114-130.
  • Huq, F. (2007), Molecular Modelling Analysis of the Metabolism of Latanoprost. Journal of Pharmacology and Toxicology. 2(4), 359-365.
  • Huq, F. (2007), Molecular modelling analysis of the metabolism of Loxapine. International Journal of Pure and Applied Chemistry. 2(2), 183-189.
  • Huq, F. (2007), Molecular Modelling Analysis of the Metabolism of Phenytoin. Journal of Pharmacology and Toxicology. 2(1), 63-71.
  • Huq, F. (2007), Molecular Modelling Analysis of the Metabolism of Enoxacin. Journal of Pharmacology and Toxicology. 2(3), 284-289.
  • Huq, F. (2007), Molecular Modelling Analysis of the Metabolism of Paracetamol. Journal of Pharmacology and Toxicology. 2(2), 142-150.
  • Huq, F. (2007), Molecular Modelling Analysis of the Metabolism of Meropenem. Journal of Pharmacology and Toxicology. 2(3), 295-299.
  • Huq, F., Daghriri, H., Yu, J., Beale, P., Fisher, K. (2007), Syntheses and Characterisation of Four Trinuclear Complexes of The Form: [{Trans-Ptcl(NH3)2}2m-{Trans-Pd(NH3)2(H2N(CH2)Nnh2)2]Cl4 Where N = 4 to 7. International Journal of Pure and Applied Chemistry. 1(4), 493-507.
  • Huq, F. (2007), Molecular modeling analysis of the metabolism of tarceva. International Journal of Pure and Applied Chemistry. 2, 281-287.
  • Huq, F. (2007), Molecular modelling analysis of the metabolism of duloxetine. International Journal of Pure and Applied Chemistry. 2, 297-302.
  • Huq, F. (2007), Molecular modelling analysis of the metabolism of lumiracoxib. International Journal of Pure and Applied Chemistry. 2, 377-385.
  • Huq, F., Yunos, N. (2007), Molecular modelling analysis of the metabolism of andrographolide. International Journal of Pure and Applied Chemistry. 2, 359-369.
  • Huq, F. (2007), Metabolic activation of toluene – a molecular modelling analysis. International Journal of Pure and Applied Chemistry. 2(1), 105-120.
  • Huq, F. (2007), Metabolic activation of paracetamol – a molecular modelling analysis. International Journal of Pure and Applied Chemistry. 2(1), 43-49.
  • Huq, F. (2007), Metabolic activation of chloroform – a molecular modelling analysis. International Journal of Pure and Applied Chemistry. 2(1), 37-42.
  • Huq, F. (2007), Metabolism of niclosamide – a molecular modelling analysis. International Journal of Pure and Applied Chemistry. 2(1), 77-83.
  • Huq, F. (2007), Molecular modelling analyses of the dimerization of acetic acid in non-polar solvents. Asian Journal of Chemistry. 19(1), 27-33.
  • Huq, F. (2007), Molecular modelling analysis of the metabolism of mirtazapine. International Journal of Pure and Applied Chemistry. 2, 289-296.
  • Huq, F. (2007), Molecular Modelling Analysis of the Formation of HX.H2O Aggregates and (HX)n Oligomers where X = F, Cl, Br and I. International Journal of Pure and Applied Chemistry. 2, 19-25.
  • Huq, F. (2007), A Molecular Modelling Analysis of Toxicity of Fosamax and Risedronate. Journal of Pharmacology and Toxicology. 2(5), 489-495.
  • Huq, F., Al-Shuneigat, H. (2007), Molecular Modelling Analysis of the Metabolism of Methadone. Asian Journal of Biochemistry. 2(1), 19-30.
  • Huq, F. (2007), Molecular modelling analysis of the metabolism of carbon tetrachloride. International Journal of Pure and Applied Chemistry. 2(1), 85-91.
  • Huq, F., Yunos, N. (2007), A molecular modelling analysis of the toxicity of Aflatoxin B1 and its modulation by Chlorophyllin. International Journal of Pure and Applied Chemistry. 2, 371-376.
  • Huq, F. (2007), Molecular Modelling Analysis of the Metabolism of Tolterodine. Journal of Pharmacology and Toxicology. 2(4), 319-327.
  • Huq, F. (2007), Molecular modelling analysis of the metabolism of trilostane. International Journal of Pure and Applied Chemistry. 2, 353-358.
  • Huq, F., Ababneh, D. (2007), Molecular Modelling Analysis of the Metabolic Activation of Ethylene Glycol. Journal of Pharmacology and Toxicology. 2(1), 54-62.
  • Huq, F. (2007), Molecular Modelling Analysis of the Metabolism of Naphthalene. Journal of Pharmacology and Toxicology. 2, 33-43.
  • Huq, F., Al-qassab, S. (2007), Molecular modelling analysis of the metabolism of raloxifene. International Journal of Pure and Applied Chemistry. 2(2), 197-204.
  • Huq, F., Ababneh, D., Alshehri, A. (2007), Molecular modelling analysis of the metabolism of carbamazepine. International Journal of Pure and Applied Chemistry. 2(2), 235-243.
  • Huq, F. (2007), Molecular modelling analysis of the metabolism of diflunisal. International Journal of Pure and Applied Chemistry. 2(2), 191-196.
  • Huq, F. (2007), Molecular Modelling Analysis of the Metabolism of Fenbufen. Asian Journal of Biochemistry. 2(1), 50-57.
  • Huq, F. (2007), Molecular Modelling Analysis of the Metabolism of Aniracetam. Asian Journal of Biochemistry. 2(3), 164-171.
  • Huq, F. (2007), Molecular Modelling Analysis of the Metabolism of Troglitazone. Asian Journal of Biochemistry. 2(4), 256-262.
  • Huq, F. (2007), Molecular modelling analysis of the metabolism of Nefazodone. International Journal of Pure and Applied Chemistry. 2(2), 155-165.
  • Huq, F. (2007), Molecular modelling analysis of the metabolism of mifepristone. International Journal of Pure and Applied Chemistry. 2(2), 175-181.
  • Huq, F. (2007), Molecular Modelling Analysis of the Metabolism of Ceftiofur. Journal of Pharmacology and Toxicology. 2(4), 340-349.