Associate Professor Fazlul Huq

Associate Professor
Biomedical Sciences, School of Medical Sciences

C42 - Cumberland Campus
The University of Sydney
NSW 2006 Australia

T: +61 2 9351 9522
F: +61 2 9351 9520
E:

Research interests

Designing tumour active compounds with wider spectrum of activity and reduced side effects and use of combination between phytochemicals and targeted therapy to overcome drug resistance

Teaching areas

A/Prof Fazlul Huq teaching toxicology, biochemistry and biophysics to students in the Faculty of Health Sciences

PhD and Masters' project opportunities

Studies on tumour active compounds

Keywords

Bioinformatics; Biochemistry; Cell biology; Drug design; Cancer

Publications

2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008

2014

   
  • Hamad, S., Beale, P., Yu, J., Huq, F. (2014), Synthesis and antitumour activity of a new trinuclear platinum compound [{cis-PtCl(NH3)2μ {trans-Pt(3-hydroxypyridine)2H2N(CH2)5NH2)2}] Cl4 in human ovarian cancer cells. Anticancer Research. 34(4), 1923-1929. [Abstract]
  • Huq, F., Yu, J., Beale, P., Chan, C., Arzuman, L., Nessa, M., Mazumder, M. (2014), Combinations of platinums and selected phytochemicals as a means of overcoming resistance in ovarian cancer. Anticancer Research. 34(1), 541-545. [Abstract]
  • Hamad, S., Beale, P., Yu, J., Huq, F. (2014), Synthesis and activity of three new trinuclear platinums with cis-geometry for terminal metal centres. Journal of Biomedical Science. 21(1), 41. [Abstract]

2013

   
  • Deqnah, N., Yu, J., Beale, P., Fisher, K., Huq, F. (2013), Synthesis of Trans-(4-hydroxypyridine)(Ammine)Dichloroplatinum(II) and its Activity in the Human Ovarian Tumour Models. Medicinal Chemistry. 9(4), 539-544. [Abstract]
  • Yunos, N., Mutalip, S., Jauri, M., Yu, J., Huq, F. (2013), Anti-proliferative and Pro-apoptotic Effects from Sequenced Combinations of Andrographolide and Cisplatin on Ovarian Cancer Cell Lines. Anticancer Research. 33(10), 4365-4371. [Abstract]
  • Al-Eisawi, Z., Beale, P., Chan, C., Yu, J., Huq, F. (2013), Carboplatin and oxaliplatin in sequenced combination with bortezomib in ovarian tumour models. Journal of Ovarian Research. 6(1), 78. [Abstract]
  • Lal, B., Badshah, A., Altaf, A., Tahir, M., Ullah, S., Huq, F. (2013), Study of new ferrocene incorporated N,N'-disubstituted thioureas as potential antitumour agents. Australian Journal of Chemistry. 66, 1352-1160.

2012

   
  • Deqnah, N., Yu, J., Beale, P., Huq, F. (2012), Studies on the Activity of Two Trans-Planaramine Platinum(II) Complexes Coded as DH4 and DH5 in Human Ovarian Tumour Models. Anticancer Research. 32(12), 5331-5336. [Abstract]
  • Nessa, M., Beale, P., Chan, C., Yu, J., Huq, F. (2012), Studies on combination of platinum drugs Cisplatin and oxaliplatin with phytochemicals anethole and curcumin in ovarian tumour models. Anticancer Research. 32(11), 4843-4850. [Abstract]
  • Mazumder, M., Beale, P., Chan, C., Yu, J., Huq, F. (2012), Epigallocatechin Gallate Acts Synergistically in Combination with Cisplatin and Designed trans-palladiums in Ovarian Cancer Cells. Anticancer Research. 32(11), 4851-4860. [Abstract]
  • Mazumder, M., Beale, P., Chan, C., Yu, J., Huq, F. (2012), Synthesis and Cytotoxicity of Three trans-Palladium Complexes Containing Planaramine Ligands in Human Ovarian Tumor Models. ChemMedChem. 7(10), 1840-1846. [Abstract]
  • Hamad, S., Beale, P., Yu, J., Fisher, K., Huq, F. (2012), Synthesis and Activity of [{Cis-PtCl(NH3)2}2ยต{Trans-Pt(3-Hydroxypyridine)2(H2N(CH2)6NH2)2}]Cl4 in the Human Ovarian Tumour Models. Medicinal Chemistry. 8(3), 384-391. [Abstract]
  • Lal, B., Badshah, A., Altaf, A., Tahir, M., Ullah, S., Huq, F. (2012), Synthesis, characterization and antitumor activity of new ferrocene incorporated N,N'-disubstituted thioureas. Dalton Transactions. 41(48), 14643-14650.
  • Deqnah, N., Yu, J., Beale, P., Fisher, K., Huq, F. (2012), Synthesis of trans-bis-(2-hydroxypyridine)dichloroplatinum(II) and its activity in human ovarian tumour models. Anticancer Research. 32(1), 135-140. [Abstract]
  • Nessa, M., Beale, P., Chan, C., Yu, J., Huq, F. (2012), Combinations of resveratrol, cisplatin and oxaliplatin applied to human ovarian cancer cells. Anticancer Research. 32(1), 53-59. [Abstract]

2011

   
  • Yunos, N., Beale, P., Yu, J., Huq, F. (2011), Synergism from the combination of oxaliplatin with selected phytochemicals in human ovarian cancer cell lines. Anticancer Research. 31(12), 4283-4290. [Abstract]
  • Nessa, M., Beale, P., Chan, C., Yu, J., Huq, F. (2011), Synergism from combinations of Cisplatin and oxaliplatin with quercetin and thymoquinone in human ovarian tumour models. Anticancer Research. 31(11), 3789-3797. [Abstract]
  • Alshehri, A., Beale, P., Yu, J., Huq, F. (2011), Synergism from Combination of Cisplatin and Multicentred Platinums Coded as DH6Cl and TH1 in the Human Ovarian Tumour Models. Medicinal Chemistry. 7(6), 593-598. [Abstract]
  • Al-Eisawi, Z., Beale, P., Chan, C., Yu, J., Huq, F. (2011), Modulation of Cisplatin Cytotoxicity due to its Combination with Bortezomib and the Nature of its Administration. Anticancer Research. 31(9), 2757-2762. [Abstract]
  • Huq, F., Danish, M., Starosta, W., Leciejewicz, J. (2011), trans-Bis(3-hy-droxy-pyridine-?N)diiodidoplatinum(II) dimethyl sulfoxide disolvate. Acta Crystallographica. Section E: Structure Reports Online. 67(Pt 6), m721. [Abstract]
  • Yunos, N., Beale, P., Yu, J., Huq, F. (2011), Synergism from Sequenced Combinations of Curcumin and Epigallocatechin-3-gallate with Cisplatin in the Killing of Human Ovarian Cancer Cells. Anticancer Research. 31(4), 1131-1140. [Abstract]
  • Al-Shuneigat, J., Qing, Y., Beale, P., Fisher, K., Huq, F. (2011), Studies on synthesis, activity and binding with DNA of a new trinuclear platinum compound [{trans-PtCl(NH3)2}2{trans-Pt(thiazole)2}{H2N(CH2)(6NH2}2]Cl3(NO3). Medicinal Chemistry. 7(1), 1-8. [Abstract]
  • Al-Shuneigat, J., Mahgoub, S., Huq, F. (2011), Colorectal carcinoma: nucleosomes, carcinoembryonic antigen and ca 19-9 as apoptotic markers; a comparative study. Journal of Biomedical Science. 18(1), 50. [Abstract]

2010

   
  • Alshehri, A., Beale, P., Yu, J., Huq, F. (2010), Synergism from combination of Cisplatin and a trans-platinum compound in ovarian cancer cell lines. Anticancer Research. 30(11), 4547-4553. [Abstract]
  • Yunos, N., Beale, P., Yu, J., Strain, D., Huq, F. (2010), Studies on combinations of platinum with Paclitaxel and colchicine in ovarian cancer cell lines. Anticancer Research. 30(10), 4025-4037. [Abstract]
  • Al-Shuneigat, J., Yu, J., Beale, P., Fisher, K., Huq, F. (2010), Studies on two new mixed ligand platinum compounds with a trans-geometry. Med Chem. 6(5), 321-8. [Abstract]

2009

   
  • Farhad, M., Yu, J., Beale, P., Fisher, K., Huq, F. (2009), Studies on the synthesis and activity of three tripalladium complexes containing planaramine ligands. ChemMedChem. 4(11), 1841-1849. [Abstract]
  • Huq, F., Tayyem, H., Yu, J., Beale, P., Fisher, K. (2009), Synthesis, activity and binding with DNA of [{trans-PtCl(NH(3))(2)}(2)micro-{trans-Pd(4-hydroxypyridine) (2) (H(2)N(CH(2))(6)NH(2))(2)]Cl(4) (TH8). Medicinal Chemistry. 5(4), 372-381. [Abstract]
  • Huq, F., Yu, J., Beale, P. (2009), Studies on New Platinum Compounds. In: Platinum and Other Heavy Metal Compounds in Cancer Chemotherapy: Molecular Mechanisms and Clinical Applications. (pp.11-17).United States: Humana Press.

2008

   
  • Tayyem, H., Huq, F., Yu, J., Beale, P., Fisher, K. (2008), Synthesis and Activity of a Trinuclear Platinum Complex: [{trans-PtCl(NH(3))(2)}(2)mu-{trans-Pt(3-hydroxypyridine)(2)(H(2)N(CH(2))(6)NH(2))(2)}]Cl(4) in Ovarian Cancer Cell Lines. ChemMedChem. 3(1), 145-151. [Abstract]
  • Huq, F. (2008), Molecular Modelling Analysis of the Metabolism of Udenafil. Journal of Pharmacology and Toxicology. 3(2), 109-117.
  • Huq, F. (2008), Molecular Modelling Analysis of the Metabolism of Venlafaxine. Journal of Pharmacology and Toxicology. 3(1), 27-33.
  • Huq, F. (2008), Molecular Modelling Analysis of the Metabolism of Zolpidem. Journal of Pharmacology and Toxicology. 3(2), 93-101.
  • Huq, F. (2008), Molecular Modelling Analysis of the Metabolism of Ramelteon. Journal of Pharmacology and Toxicology. 3(2), 119-126.
  • Huq, F., Fasim, F. (2008), Molecular Modelling Analysis of The Metabolism of Strychnine. International Journal of Pure and Applied Chemistry. 3(4), 241-246.
  • Huq, F. (2008), Molecular Modelling Analysis of the Metabolism of Rasagiline. Journal of Pharmacology and Toxicology. 3(2), 168-172.
  • Huq, F. (2008), Molecular Modelling Analysis of the Metabolism of Methimazole. Journal of Pharmacology and Toxicology. 3(1), 11-19.
  • Huq, F. (2008), Molecular Modelling Analysis of the Metabolism of Entecavir. Journal of Pharmacology and Toxicology. 3(1), 41-46.
  • Huq, F. (2008), Molecular Modelling Analysis of the Metabolism of Terbinafine. Journal of Pharmacology and Toxicology. 3(2), 64-74.
  • Huq, F. (2008), Molecular Modelling Analysis of the Metabolism of Maraviroc. Journal of Pharmacology and Toxicology. 3(2), 79-89.
  • Huq, F. (2008), Molecular Modelling Analysis of the Metabolism of Ambroxol. Journal of Pharmacology and Toxicology. 3(2), 147-152.