Associate Professor Helen Rizos

Honorary Principal Research Fellow & Associate Professor
Medicine, Westmead Clinical School
Westmead Millennium Institute for Medical Research

T: +61 2 9850 2762
F: +61 2 9850 2701
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Grants | Publications

 

Current national competitive grants*

2011

Senior Research Fellowship A
Rizos H
NHMRC Career Award: Research Fellowship ($570,640 over 5 years)

* Grants administered through the University of Sydney

Publications

2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008

2014

   
  • Todd, J., Scurr, L., Becker, T., Kefford, R., Rizos, H. (2014), The MAPK pathway functions as a redundant survival signal that reinforces the PI3K cascade in c-Kit mutant melanoma. Oncogene. 33(2), 236-245. [Abstract]
  • Croft, A., Tay, K., Boyd, S., Guo, S., Jiang, C., Lai, F., Tseng, H., Jin, L., Rizos, H., Hersey, P., Zhang, X. (2014), Oncogenic Activation of MEK/ERK Primes Melanoma Cells for Adaptation to Endoplasmic Reticulum Stress. The Journal of Investigative Dermatology. 134(2), 488-497. [Abstract]
  • Carlino, M., Todd, J., Gowrishankar, K., Mijatov, B., Pupo, G., Fung, C., Snoyman, S., Hersey, P., Long, G., Kefford, R., Rizos, H. (2014), Differential activity of MEK and ERK inhibitors in BRAF inhibitor resistant melanoma. Molecular Oncology. 8(3), 544-554. [Abstract]
  • Parmenter, T., Kleinschmidt, M., Kinross, K., Bond, S., Li, J., Kaadige, M., Rao, A., Sheppard, K., Hugo, W., Pupo, G., Pearson, R., McGee, S., Long, G., Scolyer, R., Rizos, H., Lo, R., Cullinane, C., Ayer, D., Ribas, A., Johnstone, R., Hicks, R., McArthur, G. (2014), Response of BRAF-mutant melanoma to BRAF inhibition is mediated by a network of transcriptional regulators of glycolysis. Cancer Discovery. 4(4), 423-433. [Abstract]
  • Rizos, H., Menzies, A., Pupo, G., Carlino, M., Fung, C., Hyman, J., Haydu, L., Mijatov, B., Becker, T., Boyd, S., Howle, J., Saw, R., Thompson, J., Kefford, R., Scolyer, R., Long, G. (2014), BRAF inhibitor resistance mechanisms in metastatic melanoma: spectrum and clinical impact. Clinical Cancer Research. 20(7), 1965-1977. [Abstract]
  • Becker, T., Boyd, S., Mijatov, B., Gowrishankar, K., Snoyman, S., Pupo, G., Scolyer, R., Mann, G., Kefford, R., Zhang, X., Rizos, H. (2014), Mutant B-RAF-Mcl-1 survival signaling depends on the STAT3 transcription factor. Oncogene. 33, 1158¿1166. [Abstract]
  • Chien, A., Haydu, L., Biechele, T., Kulikauskas, R., Rizos, H., Kefford, R., Scolyer, R., Moon, R., Long, G. (2014), Targeted BRAF Inhibition Impacts Survival in Melanoma Patients with High Levels of Wnt/β-Catenin Signaling. PloS One. 9(4), e94748. [Abstract]

2013

   
  • Fung, C., Pupo, G., Scolyer, R., Kefford, R., Rizos, H. (2013), p16(INK) (4a) deficiency promotes DNA hyper-replication and genetic instability in melanocytes. Pigment Cell & Melanoma Research. 26(2), 236-246. [Abstract]
  • Boyd, S., Mijatov, B., Pupo, G., Tran, S., Gowrishankar, K., Shaw, H., Goding, C., Scolyer, R., Mann, G., Kefford, R., Rizos, H., Becker, T. (2013), Oncogenic B-RAF(V600E) Signaling Induces the T-Box3 Transcriptional Repressor to Repress E-Cadherin and Enhance Melanoma Cell Invasion. The Journal of Investigative Dermatology. 133(5), 1269-1277. [Abstract]
  • Carlino, M., Gowrishankar, K., Saunders, C., Pupo, G., Snoyman, S., Zhang, X., Saw, R., Becker, T., Kefford, R., Long, G., Rizos, H. (2013), Anti-proliferative effects of continued mitogen activated protein kinase pathway inhibition following acquired resistance to BRAF and/or MEK inhibition in melanoma. Molecular Cancer Therapeutics. 12(7), 1332-1342. [Abstract]
  • Todd, J., Becker, T., Kefford, R., Rizos, H. (2013), Secondary c-Kit mutations confer acquired resistance to rtk inhibitors in c-Kit mutant melanoma cells. Pigment Cell and Melanoma Research. 26(4), 518-526. [Abstract]
  • Long, G., Wilmott, J., Haydu, L., Tembe, V., Sharma, R., Rizos, H., Thompson, J., Howle, J., Scolyer, R., Kefford, R. (2013), Effects of BRAF inhibitors on human melanoma tissue before treatment, early during treatment and on progression. Pigment Cell and Melanoma Research. 26(4), 499-508. [Abstract]
  • Tran, S., Rizos, H. (2013), Human nevi lack distinguishing senescence traits. Aging. 5, 98-99. [Abstract]
  • Ye, Y., Jin, L., Wilmott, J., Hu, W., Yosufi, B., Thorne, R., Liu, T., Rizos, H., Yan, X., Dong, L., Tay, K., Tseng, H., Guo, S., de Bock, C., Jiang, C., Wang, C., Wu, M., Zhang, L., Hersey, P., Scolyer, R., Zhang, X. (2013), PI(4,5)P2 5-phosphatase A regulates PI3K/Akt signalling and has a tumour suppressive role in human melanoma. Nature Communications. 4, 1508. [Abstract]
  • Tran, S., Rizos, H. (2013), Monitoring Oncogenic B-RAF-Induced Senescence in Melanocytes. In: Methods in Molecular Biology: Cell Senescence. (pp.313-326).United States: Springer Science +Business Media.

2012

   
  • Wilmott, J., Tembe, V., Howle, J., Sharma, R., Thompson, J., Rizos, H., Lo, R., Kefford, R., Scolyer, R., Long, G. (2012), Intratumoral molecular heterogeneity in a BRAF-mutant, BRAF inhibitor-resistant melanoma: a case illustrating the challenges for personalized medicine. Molecular Cancer Therapeutics. 11(12), 2704-2708. [Abstract]
  • Gowrishankar, K., Snoyman, S., Pupo, G., Becker, T., Kefford, R., Rizos, H. (2012), Acquired Resistance to BRAF Inhibition Can Confer Cross-Resistance to Combined BRAF/MEK Inhibition. The Journal of Investigative Dermatology. 132(7), 1850-1859. [Abstract]
  • David, M., Huynh, M., Kelly, E., Rizos, H., Coleman, H., Rogers, G., Zoellner, H. (2012), Membrane and Cytoplasmic Marker Exchange Between Malignant Neoplastic Cells and Fibroblasts Via Intermittent Contact: Increased Tumour Cell Diversity Independent of Genetic Change. Journal of Pathology. 228(4), 495-505. [Abstract]
  • Tran, S., Haferkamp, S., Scurr, L., Gowrishankar, K., Becker, T., Desilva, C., Thompson, J., Scolyer, R., Kefford, R., Rizos, H. (2012), Absence of Distinguishing Senescence Traits in Human Melanocytic Nevi. Journal of Investigative Dermatology. 132(9), 2226-2234. [Abstract]
  • Zhou, L., Pupo, G., Gupta, P., Liu, B., Tran, S., Rahme, R., Wang, B., Rua, R., Rizos, H., Carroll, A., Cairns, M., Saksena, N. (2012), A parallel genome-wide mRNA and microRNA profiling of the frontal cortex of HIV patients with and without HIV-associated dementia shows the role of axon guidance and downstream pathways in HIV-mediated neurodegeneration. BMC Genomics. 13, 677. [Abstract]

2011

   
  • Scurr, L., McKenzie, H., Becker, T., Irvine, M., Lai, K., Mann, G., Scolyer, R., Kefford, R., Rizos, H. (2011), Selective Loss of Wild-Type p16(INK4a) Expression in Human Nevi. The Journal of Investigative Dermatology. 131(11), 2329-2332. [Abstract]
  • Medic, S., Rizos, H., Ziman, M. (2011), Differential PAX3 functions in normal skin melanocytes and melanoma cells. Biochemical and Biophysical Research Communications. 411(4), 832-837. [Abstract]
  • Avery-Kiejda, K., Bowden, N., Croft, A., Scurr, L., Kairupan, C., Ashton, K., Talseth-Palmer, B., Rizos, H., Zhang, X., Scott, R., Hersey, P. (2011), P53 in human melanoma fails to regulate target genes associated with apoptosis and the cell cycle and may contribute to proliferation. BMC Cancer. 11, 203. [Abstract]
  • Rizos, H., Scurr, L. (2011), Senescence. In: Melanoma Development:Molecular Biology, Genetics and Clinical Application. (pp.235-254).United States: Springer Science+Business Media.

2010

   
  • Becker, T., Philipsz, S., Scurr, L., Fung, C., Haferkamp, S., Kefford, R., Rizos, H. (2010), Oncogenic B-RAF(V600E) Promotes Anchorage-Independent Survival of Human Melanocytes. The Journal of investigative dermatology. 130(8), 2144-7. [Abstract]
  • McKenzie, H., Fung, C., Becker, T., Irvine, M., Mann, G., Kefford, R., Rizos, H. (2010), Predicting functional significance of cancer-associated p16(INK4a) mutations in CDKN2A. Human mutation. 31(6), 692-701. [Abstract]
  • Scurr, L., Pupo, G., Becker, T., Lai, K., Schrama, D., Haferkamp, S., Irvine, M., Scolyer, R., Mann, G., Becker, J., Kefford, R., Rizos, H. (2010), IGFBP7 is not required for B-RAF-induced melanocyte senescence. Cell. 141(4), 717-727. [Abstract]
  • Irvine, M., Philipsz, S., Frausto, M., Mijatov, B., Gallagher, S., Fung, C., Becker, T., Kefford, R., Rizos, H. (2010), Amino terminal hydrophobic import signals target the p14(ARF) tumor suppressor to the mitochondria. Cell cycle (Georgetown, Tex.). 9(4), 829-39. [Abstract]
  • Zhou, L., Diefenbach, E., Crossett, B., Tran, S., Ng, T., Rizos, H., Rua, R., Wang, B., Kapur, A., Gandhi, K., Brew, B., Saksena, N. (2010), First evidence of overlaps between HIV-Associated Dementia (HAD) and non-viral neurodegenerative diseases: proteomic analysis of the frontal cortex from HIV+ patients with and without dementia. Molecular Neurodegeneration. 5, 27. [Abstract]
  • Jiang, C., Lai, F., Tay, K., Croft, A., Rizos, H., Becker, T., Yang, F., Liu, H., Thorne, R., Hersey, P., Zhang, X. (2010), Apoptosis of human melanoma cells induced by inhibition of B-RAF(V600E) involves preferential splicing of bim(S). Cell death & disease. 1(9), e69. [Abstract]

2009

   
  • Haferkamp, S., Scurr, L., Becker, T., Frausto, M., Kefford, R., Rizos, H. (2009), Oncogene-Induced Senescence Does Not Require the p16(INK4a) or p14ARF Melanoma Tumor Suppressors. The Journal of investigative dermatology. 129(6), 1983-91. [Abstract]
  • Haferkamp, S., Tran, S., Becker, T., Scurr, L., Kefford, R., Rizos, H. (2009), The relative contributions of the p53 and pRb pathways in oncogene-induced melanocyte senescence. Aging. 1(6), 542-56. [Abstract]
  • McKenzie, H., Becker, T., Scurr, L., Kefford, R., Rizos, H. (2009), Wild type and melanoma-associated mutant p16(IN4a) proteins do not oligomerize in vivo. Pigment Cell & Melanoma Research. , 131-133. [Abstract]
  • Becker, T., Haferkamp, S., Dijkstra, M., Scurr, L., Frausto, M., Diefenbach, E., Scolyer, R., Reisman, D., Mann, G., Kefford, R., Rizos, H. (2009), The chromatin remodelling factor BRG1 is a novel binding partner of the tumor suppressor p16INK4a. Molecular Cancer. 8, 4. [Abstract]

2008

   
  • Gallagher, S., Thompson, J., Indsto, J., Scurr, L., Lett, M., Gao, B., Dunleavey, R., Mann, G., Kefford, R., Rizos, H. (2008), p16INK4a expression and absence of activated B-RAF are independent predictors of chemosensitivity in melanoma tumors. Neoplasia. 10(11), 1231-1239. [Abstract]
  • Scurr, L., Guminski, A., Chiew, Y., Balleine, R., Sharma, R., Lei, Y., Pryor, K., Wain, G., Brand, A., Byth, K., Kennedy, C., Rizos, H., Harnett, P., Defazio, A. (2008), Ankyrin Repeat Domain 1, ANKRD1, a Novel Determinant of Cisplatin Sensitivity Expressed in Ovarian Cancer. Clinical Cancer Research. 14(21), 6924-6932. [Abstract]
  • Haferkamp, S., Becker, T., Scurr, L., Kefford, R., Rizos, H. (2008), p16(INK4a)-induced senescence is disabled by melanoma-associated mutations. Aging cell. 7(5), 733-745. [Abstract]