Dr Helen Rizos

NHMRC Principal Research Fellow
Medicine, Westmead Clinical School
Westmead Millennium Institute for Medical Research

C24 - Westmead Hospital
The University of Sydney
NSW 2006 Australia

T:	+61 2 9845 9059
F:	+61 2 9845 9102
E:

Current national competitive grants*

2011

Senior Research Fellowship A
Rizos H
NHMRC Career Award: Research Fellowship ($570,640 over 5 years)

Manipulating the B-RAF/MEK pathway in the genesis and treatment of melanoma
Rizos H, Kefford R, Long G, Zhang X
National Health and Medical Research Council Project Grant ($543,390 over 3 years)

Dissecting PTEN-regulated pathways in the genesis of melanoma
Rizos H
National Health and Medical Research Council Project Grant ($292,524 over 3 years)

Characterisation of p14ARF intracellular trafficking pathways
Rizos H
Australian Research Council Discovery Project ($300,000 over 3 years)

* Grants administered through the University of Sydney

Keywords

Molecular biology; Melanoma and skin cancer; Cell biology

Publications

2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007

2013

Fung, C., Pupo, G., Scolyer, R., Kefford, R., Rizos, H. (2013), p16(INK) (4a) deficiency promotes DNA hyper-replication and genetic instability in melanocytes. Pigment Cell & Melanoma Research. 26(2), 236-246. [Abstract]
Boyd, S., Mijatov, B., Pupo, G., Tran, S., Gowrishankar, K., Shaw, H., Goding, C., Scolyer, R., Mann, G., Kefford, R., Rizos, H., Becker, T. (2013), Oncogenic B-RAF(V600E) Signaling Induces the T-Box3 Transcriptional Repressor to Repress E-Cadherin and Enhance Melanoma Cell Invasion. The Journal of Investigative Dermatology. 133(5), 1269-1277. [Abstract]

2012

Wilmott, J., Tembe, V., Howle, J., Sharma, R., Thompson, J., Rizos, H., Lo, R., Kefford, R., Scolyer, R., Long, G. (2012), Intratumoral molecular heterogeneity in a BRAF-mutant, BRAF inhibitor-resistant melanoma: a case illustrating the challenges for personalized medicine. Molecular Cancer Therapeutics. 11(12), 2704-2708. [Abstract]
Gowrishankar, K., Snoyman, S., Pupo, G., Becker, T., Kefford, R., Rizos, H. (2012), Acquired Resistance to BRAF Inhibition Can Confer Cross-Resistance to Combined BRAF/MEK Inhibition. The Journal of Investigative Dermatology. 132(7), 1850-1859. [Abstract]
David, M., Huynh, M., Kelly, E., Rizos, H., Coleman, H., Rogers, G., Zoellner, H. (2012), Membrane and Cytoplasmic Marker Exchange Between Malignant Neoplastic Cells and Fibroblasts Via Intermittent Contact: Increased Tumour Cell Diversity Independent of Genetic Change. Journal of Pathology. 228(4), 495-505. [Abstract]
Tran, S., Haferkamp, S., Scurr, L., Gowrishankar, K., Becker, T., Desilva, C., Thompson, J., Scolyer, R., Kefford, R., Rizos, H. (2012), Absence of Distinguishing Senescence Traits in Human Melanocytic Nevi. Journal of Investigative Dermatology. 132(9), 2226-2234. [Abstract]
Zhou, L., Pupo, G., Gupta, P., Liu, B., Tran, S., Rahme, R., Wang, B., Rua, R., Rizos, H., Carroll, A., Cairns, M., Saksena, N. (2012), A parallel genome-wide mRNA and microRNA profiling of the frontal cortex of HIV patients with and without HIV-associated dementia shows the role of axon guidance and downstream pathways in HIV-mediated neurodegeneration. BMC Genomics. 13, 677. [Abstract]

2011

Scurr, L., McKenzie, H., Becker, T., Irvine, M., Lai, K., Mann, G., Scolyer, R., Kefford, R., Rizos, H. (2011), Selective Loss of Wild-Type p16(INK4a) Expression in Human Nevi. The Journal of Investigative Dermatology. 131(11), 2329-2332. [Abstract]
Medic, S., Rizos, H., Ziman, M. (2011), Differential PAX3 functions in normal skin melanocytes and melanoma cells. Biochemical and Biophysical Research Communications. 411(4), 832-837. [Abstract]
Avery-Kiejda, K., Bowden, N., Croft, A., Scurr, L., Kairupan, C., Ashton, K., Talseth-Palmer, B., Rizos, H., Zhang, X., Scott, R., Hersey, P. (2011), P53 in human melanoma fails to regulate target genes associated with apoptosis and the cell cycle and may contribute to proliferation. BMC Cancer. 11, 203. [Abstract]
Rizos, H., Scurr, L. (2011), Senescence. In: Melanoma Development:Molecular Biology, Genetics and Clinical Application. (pp.235-254).United States: Springer Science+Business Media.

2010

Becker, T., Philipsz, S., Scurr, L., Fung, C., Haferkamp, S., Kefford, R., Rizos, H. (2010), Oncogenic B-RAF(V600E) Promotes Anchorage-Independent Survival of Human Melanocytes. The Journal of investigative dermatology. 130(8), 2144-7. [Abstract]
McKenzie, H., Fung, C., Becker, T., Irvine, M., Mann, G., Kefford, R., Rizos, H. (2010), Predicting functional significance of cancer-associated p16(INK4a) mutations in CDKN2A. Human mutation. 31(6), 692-701. [Abstract]
Scurr, L., Pupo, G., Becker, T., Lai, K., Schrama, D., Haferkamp, S., Irvine, M., Scolyer, R., Mann, G., Becker, J., Kefford, R., Rizos, H. (2010), IGFBP7 is not required for B-RAF-induced melanocyte senescence. Cell. 141(4), 717-727. [Abstract]
Irvine, M., Philipsz, S., Frausto, M., Mijatov, B., Gallagher, S., Fung, C., Becker, T., Kefford, R., Rizos, H. (2010), Amino terminal hydrophobic import signals target the p14(ARF) tumor suppressor to the mitochondria. Cell cycle (Georgetown, Tex.). 9(4), 829-39. [Abstract]
Jiang, C., Lai, F., Tay, K., Croft, A., Rizos, H., Becker, T., Yang, F., Liu, H., Thorne, R., Hersey, P., Zhang, X. (2010), Apoptosis of human melanoma cells induced by inhibition of B-RAF(V600E) involves preferential splicing of bim(S). Cell death & disease. 1(9), e69. [Abstract]
Zhou, L., Diefenbach, E., Crossett, B., Tran, S., Ng, T., Rizos, H., Rua, R., Wang, B., Kapur, A., Gandhi, K., Brew, B., Saksena, N. (2010), First evidence of overlaps between HIV-Associated Dementia (HAD) and non-viral neurodegenerative diseases: proteomic analysis of the frontal cortex from HIV+ patients with and without dementia. Molecular Neurodegeneration. 5, 27. [Abstract]

2009

Haferkamp, S., Scurr, L., Becker, T., Frausto, M., Kefford, R., Rizos, H. (2009), Oncogene-Induced Senescence Does Not Require the p16(INK4a) or p14ARF Melanoma Tumor Suppressors. The Journal of investigative dermatology. 129(6), 1983-91. [Abstract]
Haferkamp, S., Tran, S., Becker, T., Scurr, L., Kefford, R., Rizos, H. (2009), The relative contributions of the p53 and pRb pathways in oncogene-induced melanocyte senescence. Aging. 1(6), 542-56. [Abstract]
McKenzie, H., Becker, T., Scurr, L., Kefford, R., Rizos, H. (2009), Wild type and melanoma-associated mutant p16(IN4a) proteins do not oligomerize in vivo. Pigment Cell & Melanoma Research. , 131-133. [Abstract]
Becker, T., Haferkamp, S., Dijkstra, M., Scurr, L., Frausto, M., Diefenbach, E., Scolyer, R., Reisman, D., Mann, G., Kefford, R., Rizos, H. (2009), The chromatin remodelling factor BRG1 is a novel binding partner of the tumor suppressor p16INK4a. Molecular Cancer. 8, 4. [Abstract]

2008

Gallagher, S., Thompson, J., Indsto, J., Scurr, L., Lett, M., Gao, B., Dunleavey, R., Mann, G., Kefford, R., Rizos, H. (2008), p16INK4a expression and absence of activated B-RAF are independent predictors of chemosensitivity in melanoma tumors. Neoplasia. 10(11), 1231-1239. [Abstract]
Scurr, L., Guminski, A., Chiew, Y., Balleine, R., Sharma, R., Lei, Y., Pryor, K., Wain, G., Brand, A., Byth, K., Kennedy, C., Rizos, H., Harnett, P., Defazio, A. (2008), Ankyrin Repeat Domain 1, ANKRD1, a Novel Determinant of Cisplatin Sensitivity Expressed in Ovarian Cancer. Clinical Cancer Research. 14(21), 6924-6932. [Abstract]
Haferkamp, S., Becker, T., Scurr, L., Kefford, R., Rizos, H. (2008), p16(INK4a)-induced senescence is disabled by melanoma-associated mutations. Aging cell. 7(5), 733-745. [Abstract]

2007

Packer, L., Pavey, S., Boyle, G., Stark, M., Ayub, A., Rizos, H., Hayward, N. (2007), Gene expression profiling in melanoma identifies novel downstream effectors of p14ARF. International journal of cancer. Journal international du cancer. 121(4), 784-790. [Abstract]
Rizos, H., Scurr, L., Irvine, M., Alling, N., Kefford, R. (2007), p14ARF Regulates E2F-1 Ubiquitination and Degradation via a p53-Dependent Mechanism. Cell cycle (Georgetown, Tex.). 6(14), 1741-7. [Abstract]

The University of Sydney - Cancer Research Network