You are here: Home / Cancer Research Network / Professor Juergen Reichardt / Professor Juergen Reichardt 

Professor Juergen Reichardt

Plunkett Chair of Molecular Biology (Medicine)
Medicine, School of Medical Sciences
Bosch Institute

K25 - Medical Foundation Building
The University of Sydney
NSW 2006 Australia

T: +61 2 9036 3354
F: +61 2 9036 3357
E:

W: Related website
Related website

Research interests

As human geneticists and biochemists we wish to understand how the human genome in conjunction with the environment produces the multitude of human phenotypes. We are particularly interested in the contribution of human genetic variation to common, complex significant public health problems. We also have an interest in understanding the genetics of human metabolism and genetic variation thereof.

This laboratory has a longstanding tradition of characterizing human galactose-metabolic enzymes and associated diseases. We are currently also investigating two complex disease phenotypes with significant public health impact: various cancers and heart disease. Our strategy is to dissect these diseases through a step-wise, candidate gene approach. Our systematic choice of candidate genes for these diseases was dictated by the hypothesized involvement of particular metabolic pathways in pathogenesis. In prostate cancer we are currently investigating three androgen metabolic genes since androgens have been reported to regulate cell division in the prostate. We have focused on the steroid 5α-reductase type II (SRD5A2) locus and are currently exploring also the HSD3B2 and HSD17B3 genes. Investigations into colon cancer and atherosclerosis are also under way.

Back to Top

International links

Italy. (Tor Vergata University, Rome) 1990-present.
Australia. (Hanson Institute, Adelaide) 2006-present.
United States. (MD Anderson Cancer Center, Houston) 2000-present.

Back to Top

Publications

2010 | 2009 | 2008 | 2007 | 2006

2010

   
  • Price, D., Chau, C., Till, C., Goodman, P., Baum, C., Ockers, S., English, B., Minasian, L., Parnes, H., Hsing, A., Reichardt, J., Hoque, A., Tangen, C., Kristal, A., Thompson, I., Figg, W. (2010), Androgen Receptor CAG Repeat Length and Association With Prostate Cancer Risk: Results From the Prostate Cancer Prevention Trial. The Journal of urology. 184(6), 2297-302. [Abstract]
  • Goodman, P., Tangen, C., Kristal, A., Thompson, I., Lucia, M., Platz, E., Figg, W., Hoque, A., Hsing, A., Neuhouser, M., Parnes, H., Reichardt, J., Santella, R., Till, C., Lippman, S. (2010), Transition of a clinical trial into translational research: the prostate cancer prevention trial experience. Cancer Prevention Research. 3(12), 1523-1533. [Abstract]
  • Hulin-Curtis, S., Petit, D., Figg, W., Hsing, A., Reichardt, J. (2010), Finasteride metabolism and pharmacogenetics: new approaches to personalized prevention of prostate cancer. Future Oncology. 6(12), 1897-1913. [Abstract]
  • Das, K., Lorena, P., Ng, L., Lim, D., Shen, L., Siow, W., Teh, M., Reichardt, J., Salto-Tellez, M. (2010), Differential expression of steroid 5{alpha}-reductase isozymes and association with disease severity and angiogenic genes predict their biological role in prostate cancer. Endocrine-Related Cancer. 17(3), 757-770. [Abstract]
  • Flanagan, J., McMahon, G., Brendan Chia, S., Fitzpatrick, P., Tighe, O., O'Neill, C., Briones, P., Gort, L., Kozak, L., Magee, A., Naughten, E., Radomyska, B., Schwartz, M., Shin, J., Strobl, W., Tyfield, L., Waterham, H., Russell, H., Bertorelle, G., Reichardt, J., Mayne, P., Croke, D. (2010), The role of human demographic history in determining the distribution and frequency of transferase-deficient galactosaemia mutations. Heredity. 104(2), 148-54. [Abstract]
  • Musumeci, L., Arthur, J., Cheung, F., Hoque, A., Lippman, S., Reichardt, J. (2010), Single Nucleotide Differences (SNDs) in the dbSNP Database May Lead to Errors in Genotyping and Haplotyping Studies. Human Mutation. 31(1), 67-73. [Abstract]
  • Arthur, J., Reichardt, J. (2010), Modeling Single Nucleotide Polymorphisms in the Human AKR1C1 and AKR1C2 Genes: Implications for Functional and Genotyping Analyses. PloS one. 5(12), e15604. [Abstract]

2009

   
Back to Top
  • Makridakis, N., Phipps, T., Srivastav, S., Reichardt, J. (2009), PCR-free method detects high frequency of genomic instability in prostate cancer. Nucleic acids research. 37(22), 7441-6. [Abstract]
  • Reichardt, J., Hsing, A. (2009), Androgen metabolic genes in prostate cancer predisposition and progression. In: Androgen Action in Prostate Cancer. (pp.141-154).United States: Springer.
  • Makridakis, N., Caldas Ferraz, L., Reichardt, J. (2009), Genomic analysis of cancer tissue reveals that somatic mutations commonly occur in a specific motif. Human mutation. 30(1), 39-48. [Abstract]

2008

   
Back to Top
  • Pearce, C., Van Den Berg, D., Makridakis, N., Reichardt, J., Ross, R., Pike, M., Kolonel, L., Henderson, B. (2008), No association between the SRD5A2 gene A49T missense variant and prostate cancer risk: lessons learned. Human molecular genetics. 17(16), 2456-2461. [Abstract]
  • Shai, R., Reichardt, J., Chen, T. (2008), Pharmacogenomics of brain cancer and personalized medicine in malignant gliomas. Future oncology. 4(4), 525-534. [Abstract]
  • Chu, L., Reichardt, J., Hsing, A. (2008), Androgens and the molecular epidemiology of prostate cancer. Current opinion in endocrinology, diabetes, and obesity. 15(3), 261-270. [Abstract]
  • Reichardt, J. (2008), Realizing the full potential of the sequenced human genome. Trends in Genetics. , 219-220. [Abstract]

2007

   
Back to Top
  • Reichardt, J. (2007), Quo vadis, genoma? A call to pipettes for biochemists. Trends in biochemical sciences. , 529-30. [Abstract]
  • D'Amico, F., Biancolella, M., Margiotti, K., Reichardt, J., Novelli, G. (2007), Genomic biomarkers, androgen pathway and prostate cancer. Pharmacogenomics. 8(6), 645-661. [Abstract]
  • Reichardt, J., Tilley, W. (2007), The 3rd Pacific Rim meeting on breast and prostate cancer: progress in hormonal carcinogenesis and the enduring influence of Ron Ross. Cancer research. 67(10), 4550-4552. [Abstract]
  • Mehrian-Shai, R., Chen, C., Shi, T., Horvath, S., Nelson, S., Reichardt, J., Sawyers, C. (2007), Insulin growth factor-binding protein 2 is a candidate biomarker for PTEN status and PI3K/Akt pathway activation in glioblastoma and prostate cancer. Proceedings of the National Academy of Sciences of the United States of America. 104(13), 5563-5568. [Abstract]
  • Chokkalingam, A., Stanczyk, F., Reichardt, J., Hsing, A. (2007), Molecular epidemiology of prostate cancer: hormone-related genetic loci. Frontiers in bioscience : a journal and virtual library. 12, 3436-3460. [Abstract]

2006

   
Back to Top
  • Reichardt, J. (2006), Unexpected biochemical and pharmacogenetic consequences of SNPs and haplotypes: a cautionary tale for human molecular genetics and epidemiology. Genomics. , 673-4. [Abstract]
  • Mehrian-Shai, R., Reichardt, J. (2006), Genomics in breast and prostate cancer: assessment of the current state and future perspectives. Future oncology (London, England). 2(3), 357-62. [Abstract]