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Dr Liza Cubeddu

National Breast Cancer Foundation Fellow
School of Molecular Bioscience

G08 - Biochemistry Building
The University of Sydney
NSW 2006 Australia

T: +61 2 9351 2475
F: +61 2 9351 4726
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Biographical details

2002 PhD in Biological Chemistry - Macquarie University, Sydney, Australia [More...]

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Research interests

Liza Cubeddu's research interests lie in understanding the biological and structural basis of the interaction between proteins and DNA in gene regulation and in the DNA repair framework. To do this, she uses a combination of protein chemistry, biophysics, molecular biology and cell biology. Liza is particularly interested in how deficiencies in these cellular processes lead to diseases, such as cancer, and how gene regulation and DNA repair are linked in oncogenesis.

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Current national competitive grants*

2011

Inhibiting protein-protein interactions involved in neural development and disease
Matthews J, Cubeddu L
ARC Discovery Project ($420,000 over 3 years)

* Grants administered through the University of Sydney

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Keywords

Genetic diseases; Cell biology; Biochemistry; Breast cancer

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Publications

2012 | 2011 | 2010 | 2009 | 2008 | 2007

2012

   
  • Cubeddu, L., Joseph, S., Richard, D., Matthews, J. (2012), Contribution of DEAF1 Structural Domains to the Interaction with the Breast Cancer Oncogene LMO4. PLoS One. 7(6), e39218. [Abstract]

2011

   
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  • Richard, D., Cubeddu, L., Urquhart, A., Bain, A., Bolderson, E., Menon, D., White, M., Khanna, K. (2011), hSSB1 interacts directly with the MRN complex stimulating its recruitment to DNA double-strand breaks and its endo-nuclease activity. Nucleic acids research. 39(9), 3643-51. [Abstract]
  • Richard, D., Savage, K., Bolderson, E., Cubeddu, L., So, S., Ghita, M., Chen, D., White, M., Richard, K., Prise, K., Schettino, G., Khanna, K. (2011), hSSB1 rapidly binds at the sites of DNA double-strand breaks and is required for the efficient recruitment of the MRN complex. Nucleic acids research. 39, 1692-702. [Abstract]

2010

   
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  • Sobti, M., Cubeddu, L., Haynes, P., Mabbutt, B. (2010), Engineered rings of mixed yeast Lsm proteins show differential interactions with translation factors and U-rich RNA. Biochemistry. 49(11), 2335-2345. [Abstract]

2009

   
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  • Swarbrick, J., Cubeddu, L., Ball, G., Curmi, P., Gooley, A., Williams, K., Mabbutt, B. (2009), NMR assignment of prespore specific antigen--a cell surface adhesion glycoprotein from Dictyostelium discoideum. Biomolecular NMR assignments. 3(1), 1-3. [Abstract]
  • Matthews, J., Bhati, M., Lehtomaki, E., Mansfield, R., Cubeddu, L., Mackay, J. (2009), It Takes Two to Tango: The Structure and Function of LIM, RING, PHD and MYND Domains. Current pharmaceutical design. 15(31), 3681-3696. [Abstract]

2008

   
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  • Richard, D., Bolderson, E., Cubeddu, L., Wadsworth, R., Savage, K., Sharma, G., Nicolette, M., Tsvetanov, S., McIlwraith, M., Pandita, R., Takeda, S., Hay, R., Gautier, J., West, S., Paull, T., Pandita, T., White, M., Khanna, K. (2008), Single-stranded DNA-binding protein hSSB1 is critical for genomic stability. Nature. 453(7195), 677-681. [Abstract]
  • Richards, J., Cubeddu, L., Roberts, J., Liu, H., White, M. (2008), The archaeal XPB protein is a ssDNA-dependent ATPase with a novel partner. Journal of molecular biology. 376(3), 634-644. [Abstract]

2007

   
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  • Cubeddu, L., Walkinshaw, M., Gallagher, M., Heinemann, U., Max, K., Wear, M., Estibeiro, P., Morgan, H., Sadler, P. (2007), Sequence specificity of single-stranded DNA-binding proteins: a novel DNA microarray approach. NUCLEIC ACIDS RESEARCH. 35(10), E75 1-9. [Abstract]