Dr Liza Cubeddu

National Breast Cancer Foundation Fellow
School of Molecular Bioscience

G08 - Biochemistry Building
The University of Sydney
NSW 2006 Australia

T: +61 2 9351 2475
F: +61 2 9351 4726

Biographical details

2002 PhD in Biological Chemistry - Macquarie University, Sydney, Australia [More...]

Research interests

Liza Cubeddu's research interests lie in understanding the biological and structural basis of the interaction between proteins and DNA in gene regulation and in the DNA repair framework. To do this, she uses a combination of protein chemistry, biophysics, molecular biology and cell biology. Liza is particularly interested in how deficiencies in these cellular processes lead to diseases, such as cancer, and how gene regulation and DNA repair are linked in oncogenesis.


2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008


  • Gamsjaeger, R., Kariawasam, R., Touma, C., Kwan, A., White, M., Cubeddu, L. (2014), Backbone and side-chain (1)H, (13)C and (15)N resonance assignments of the OB domain of the single stranded DNA binding protein from Sulfolobus solfataricus and chemical shift mapping of the DNA-binding interface. Biomolecular NMR Assignments. 8(2), 243-246. [Abstract]
  • Joseph, S., Kwan, A., Mackay, J., Cubeddu, L., Matthews, J. (2014), Backbone and side-chain assignments of a tethered complex between lmo4 and deaf-1. Biomolecular NMR Assignments. 8(1), 141-144. [Abstract]
  • Joseph, S., Kwan, A., Stokes, P., Mackay, J., Cubeddu, L., Matthews, J. (2014), The Structure of an LIM-Only Protein 4 (LMO4) and Deformed Epidermal Autoregulatory Factor-1 (DEAF1) Complex Reveals a Common Mode of Binding to LMO4. PloS One. 9(10), e109108. [Abstract]


  • Gamsjaeger, R., O'Connell, M., Cubeddu, L., Shepherd, N., Lowry, J., Kwan, A., Vandevenne, M., Swanton, M., Matthews, J., Mackay, J. (2013), A structural analysis of DNA binding by myelin transcription factor 1 double zinc fingers. The Journal of Biological Chemistry. 288(49), 35180-35191. [Abstract]
  • Gamsjaeger, R., Kariawasam, R., Bang, L., Touma, C., Nguyen, C., Matthews, J., Cubeddu, L., Mackay, J. (2013), Semi-quantitative and quantitative analysis of protein-DNA interactions using steady-state measurements in Surface-Plasmon-Resonance competition experiments. Analytical Biochemistry. 440(2), 178-185. [Abstract]


  • Cubeddu, L., Joseph, S., Richard, D., Matthews, J. (2012), Contribution of DEAF1 Structural Domains to the Interaction with the Breast Cancer Oncogene LMO4. PLoS One. 7(6), e39218. [Abstract]


  • Richard, D., Cubeddu, L., Urquhart, A., Bain, A., Bolderson, E., Menon, D., White, M., Khanna, K. (2011), hSSB1 interacts directly with the MRN complex stimulating its recruitment to DNA double-strand breaks and its endo-nuclease activity. Nucleic acids research. 39(9), 3643-51. [Abstract]
  • Richard, D., Savage, K., Bolderson, E., Cubeddu, L., So, S., Ghita, M., Chen, D., White, M., Richard, K., Prise, K., Schettino, G., Khanna, K. (2011), hSSB1 rapidly binds at the sites of DNA double-strand breaks and is required for the efficient recruitment of the MRN complex. Nucleic acids research. 39, 1692-702. [Abstract]


  • Sobti, M., Cubeddu, L., Haynes, P., Mabbutt, B. (2010), Engineered rings of mixed yeast Lsm proteins show differential interactions with translation factors and U-rich RNA. Biochemistry. 49(11), 2335-2345. [Abstract]


  • Swarbrick, J., Cubeddu, L., Ball, G., Curmi, P., Gooley, A., Williams, K., Mabbutt, B. (2009), NMR assignment of prespore specific antigen--a cell surface adhesion glycoprotein from Dictyostelium discoideum. Biomolecular NMR assignments. 3(1), 1-3. [Abstract]
  • Matthews, J., Bhati, M., Lehtomaki, E., Mansfield, R., Cubeddu, L., Mackay, J. (2009), It Takes Two to Tango: The Structure and Function of LIM, RING, PHD and MYND Domains. Current pharmaceutical design. 15(31), 3681-3696. [Abstract]


  • Richard, D., Bolderson, E., Cubeddu, L., Wadsworth, R., Savage, K., Sharma, G., Nicolette, M., Tsvetanov, S., McIlwraith, M., Pandita, R., Takeda, S., Hay, R., Gautier, J., West, S., Paull, T., Pandita, T., White, M., Khanna, K. (2008), Single-stranded DNA-binding protein hSSB1 is critical for genomic stability. Nature. 453(7195), 677-681. [Abstract]
  • Richards, J., Cubeddu, L., Roberts, J., Liu, H., White, M. (2008), The archaeal XPB protein is a ssDNA-dependent ATPase with a novel partner. Journal of molecular biology. 376(3), 634-644. [Abstract]