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Professor Jacqueline Matthews

Professor of Protein Chemistry and NHMRC Senior Research Fellow
School of Molecular Bioscience

G08 - Biochemistry Building
The University of Sydney
NSW 2006 Australia

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F: x14726
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Research interests

The 30,000 or so genes in your genome encode proteins that work together in a coordinated fashion to regulate every biological process in the body. Jacqui Matthews' team is interested in finding out not just how proteins achieve these important biological processes, but also whether artificial regulation of these activities through the design of specific protein inhibitors is possible. In particular, they are investigating the protein-protein and protein-DNA interactions that occur during normal cellular development and comparing them with interactions that cause diseases states such as T-cell leukemia, beta-thalassaemia and breast cancer. To do this, they are using a range of techniques including:

* molecular biology

* biophysical methods

* structural methods

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PhD and Masters' project opportunities

Regulatory Proteins in Development and Disease

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Current national competitive grants*

2011

LMO2-containing complexes in leukemia and blood cell development
Matthews J, Mackay J, Guss J
NHMRC Project Grant ($1,084,552 over 3 years)

Inhibiting protein-protein interactions involved in neural development and disease
Matthews J, Cubeddu L
ARC Discovery Project ($420,000 over 3 years)

2009

NHMRC Senior Research Fellowship B
Matthews J
NHMRC Research Fellowship ($587,812 over 5 years)

* Grants administered through the University of Sydney

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Keywords

Structural Biology; Molecular biology; Biochemistry; Breast cancer

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Publications

2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007

2013

   
  • Matthews, J., Lester, K., Joseph, S., Curtis, D. (2013), LIM-domain-only proteins in cancer. Nature Reviews. Cancer. 13(2), 111-122. [Abstract]

2012

   
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  • Gadd, M., Jacques, D., Guss, J., Matthews, J. (2012), Crystallization and diffraction of an Isl1-Ldb1 complex. Acta Crystallographica. Section F: Structural Biology and Crystallization Communications. 68(Pt 11), 1398-1401. [Abstract]
  • Dastmalchi, S., Wilkinson-White, L., Kwan, A., Gamsjaeger, R., Mackay, J., Matthews, J. (2012), Solution structure of a tethered Lmo2(LIM2) /Ldb1(LID) complex. Protein Science. 21(11), 1768-1774. [Abstract]
  • O'Connell, M., Vandevenne, M., Nguyen, C., Matthews, J., Gamsjaeger, R., Segal, D., Mackay, J. (2012), Modular Assembly of RanBP2-Type Zinc Finger Domains to Target Single-Stranded RNA. Angewandte Chemie (International Edition). 51(22), 5371-5375. [Abstract]
  • Wilkinson, B., Stone, R., Capicciotti, C., Thaysen-Andersen, M., Matthews, J., Packer, N., Ben, R., Payne, R. (2012), Total synthesis of homogeneous antifreeze glycopeptides and glycoproteins. Angewandte Chemie (International Edition). 51(15), 3606-3610. [Abstract]
  • Hsieh, Y., Wilkinson, B., O'Connell, M., Mackay, J., Matthews, J., Payne, R. (2012), Synthesis of the bacteriocin glycopeptide sublancin 168 and S-glycosylated variants. Organic Letters. 14(7), 1910-1913. [Abstract]
  • Liew, C., Kwan, A., Stokes, P., Mackay, J., Matthews, J. (2012), ¹H, ¹⁵N and ¹³C assignments of an intramolecular LMO4-LIM1/CtIP complex. Biomolecular NMR Assignments. 6(1), 31-34. [Abstract]
  • Hauswirth, R., Haase, B., Blatter, M., Brooks, S., Burger, D., Drögemüller, C., Gerber, V., Henke, D., Janda, J., Jude, R., Magdesian, K., Matthews, J., Poncet, P., Svansson, V., Tozaki, T., Wilkinson-White, L., Penedo, M., Rieder, S., Leeb, T. (2012), Mutations in MITF and PAX3 cause "splashed white" and other white spotting phenotypes in horses. PLoS Genetics. 8(4), e1002653. [Abstract]
  • Yeo, G., Baldock, C., Tuukkanen, A., Roessle, M., Dyksterhuis, L., Wise, S., Matthews, J., Mithieux, S., Weiss, A. (2012), Tropoelastin bridge region positions the cell-interactive C terminus and contributes to elastic fiber assembly. Proceedings of the National Academy of Sciences of the United States of America. 109(8), 2878-2883. [Abstract]
  • Matthews, J., Sunde, M. (2012), Dimers, oligomers, everywhere. In: Advances in Experimental Medicine and Biology: Protein Dimerization and Oligomerization in Biology. (pp.1-18).United States: Springer Science+Business Media, LLC.
  • Bhati, M., Lee, C., Gadd, M., Jeffries, C., Kwan, A., Whitten, A., Trewhella, J., Mackay, J., Matthews, J. (2012), Solution Structure of the LIM-Homeodomain Transcription Factor Complex Lhx3/Ldb1 and the Effects of a Pituitary Mutation on Key Lhx3 Interactions. PLoS One. 7(7), e40719. [Abstract]
  • Cubeddu, L., Joseph, S., Richard, D., Matthews, J. (2012), Contribution of DEAF1 Structural Domains to the Interaction with the Breast Cancer Oncogene LMO4. PLoS One. 7(6), e39218. [Abstract]

2011

   
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  • Gadd, M., Bhati, M., Jeffries, C., Langley, D., Trewhella, J., Guss, J., Matthews, J. (2011), The structural basis for partial redundancy in a class of transcription factors, the lim-homeodomain proteins, in neural cell type specification. The Journal of biological chemistry. 286(50), 42971-80. [Abstract]
  • Wilkinson-White, L., Gamsjaeger, R., Dastmalchi, S., Wienert, B., Stokes, P., Crossley, M., Mackay, J., Matthews, J. (2011), Structural basis of simultaneous recruitment of the transcriptional regulators LMO2 and FOG1/ZFPM1 by the transcription factor GATA1. Proceedings of the National Academy of Sciences of the United States of America. 108(35), 14443-14448. [Abstract]
  • Wissmueller, S., Font, J., Liew, C., Cram, E., Schroeder, T., Turner, J., Crossley, M., Mackay, J., Matthews, J. (2011), Protein-protein interactions: Analysis of a false positive GST pulldown result. Proteins. 79(8), 2365-71. [Abstract]

2010

   
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  • Wilkinson-White, L., Dastmalchi, S., Kwan, A., Ryan, D., Mackay, J., Matthews, J. (2010), (1)H, (15)N and (13)C assignments of an intramolecular Lmo2-LIM2/Ldb1-LID complex. Biomolecular NMR assignments. 4(2), 203-6. [Abstract]
  • Cross, A., Jeffries, C., Trewhella, J., Matthews, J. (2010), LIM domain binding proteins one and two have different oligomeric states. Journal of molecular biology. 399(1), 133-44. [Abstract]

2009

   
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  • Lowry, J., Gamsjaeger, R., Thong, S., Hung, W., Kwan, A., Broitman-Maduro, G., Matthews, J., Maduro, M., Mackay, J. (2009), Structural analysis of med-1 reveals unexpected diversity in the mechanism of DNA recognition by gata-type zinc finger domains. The Journal of biological chemistry. 284(0), 5827-35. [Abstract]
  • Gadd, M., Langley, D., Guss, J., Matthews, J. (2009), Crystallization and diffraction of an Lhx4-Isl2 complex. Acta crystallographica. Section F, Structural biology and crystallization communications. 65(Pt 2), 151-153. [Abstract]
  • Lowther, J., Robinson, M., Donnelly, S., Xu, W., Stack, C., Matthews, J., Dalton, J. (2009), The Importance of pH in Regulating the Function of the Fasciola hepatica Cathepsin L1 Cysteine Protease. PLoS neglected tropical diseases. 3(1), e369. [Abstract]
  • Matthews, J., Bhati, M., Lehtomaki, E., Mansfield, R., Cubeddu, L., Mackay, J. (2009), It Takes Two to Tango: The Structure and Function of LIM, RING, PHD and MYND Domains. Current pharmaceutical design. 15(31), 3681-3696. [Abstract]

2008

   
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  • Pilotelle-Bunner, A., Matthews, J., Cornelius, F., Apell, H., Sebban, P., Clarke, R. (2008), ATP Binding Equilibria of the Na(+),K(+)-ATPase (dagger). Biochemistry. 47(49), 13103-13114. [Abstract]
  • Matthews, J., Bhati, M., Craig, V., Deane, J., Jeffries, C., Lee, C., Nancarrow, A., Ryan, D., Sunde, M. (2008), Competition between LIM-binding domains. Biochemical Society Transactions. 36(6), 1393-1397. [Abstract]
  • Matthews, J., Loughlin, F., Mackay, J. (2008), Designed metal-binding sites in biomolecular and bioinorganic interactions. Current opinion in structural biology. 18, 484-90. [Abstract]
  • Bhati, M., Lee, C., Nancarrow, A., Lee, M., Craig, V., Bach, I., Guss, J., Mackay, J., Matthews, J. (2008), Implementing the LIM code: the structural basis for cell type-specific assembly of LIM-homeodomain complexes. The EMBO journal. 27, 2018-29. [Abstract]
  • Bhati, M., Lee, M., Nancarrow, A., Bach, I., Guss, J., Matthews, J. (2008), Crystallization of an Lhx3-Isl1 complex. Acta crystallographica. Section F, Structural biology and crystallization communications. 64(Pt 4), 297-299. [Abstract]

2007

   
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  • Chong, S., Vickaryous, N., Ashe, A., Zamudio, N., Youngson, N., Hemley, S., Stopka, T., Skoultchi, A., Matthews, J., Scott, H., de Kretser, D., O'Bryan, M., Blewitt, M., Whitelaw, E. (2007), Modifiers of epigenetic reprogramming show paternal effects in the mouse. Nature genetics. 39(5), 614-622. [Abstract]
  • Stokes, P., Thompson, L., Marianayagam, N., Matthews, J. (2007), Dimerization of CtIP may stabilize in vivo interactions with the Retinoblastoma-pocket domain. Biochemical and biophysical research communications. 354(1), 197-202. [Abstract]