Dr Michaela Kirschner

Postdoctoral Research Fellow
Medicine, Concord Clinical School
Asbestos Diseases Research Institute

Asbestos Diseases Research Institute
The University of Sydney
NSW 2006 Australia

T: +61 2 9767 9800
F: +61 2 9767 9860
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Curriculum vitae

Research interests

I work as a postdoctoral research fellow at the Asbestos Diseases Research Institute, where we undertake translational research with the aim to improve diagnosis and treatment of malignant pleural mesothelioma.

The main focus of my work is on the identification of novel diagnostic and/or prognostic biomarkers for malignant pleural mesothelioma, and I am mainly working on two microRNA-based projects:

1) Cell-free microRNAs in the circulation as (early) diagnostic markers for malignant pleural mesothelioma

2) Tumour microRNAs as markers predicting patients benefiting from radical surgery.

In addition I am also involved in projects investigating the functional role both microRNAs and long non-coding RNAs play in the development/progression of malignant pleural mesothelioma.

Keywords

Biological markers; Molecular biology; microRNA; Cancer; Malignant mesothelioma

Publications

2014 | 2013 | 2012 | 2011

2014

   
  • Linton, A., Cheng, Y., Griggs, K., Kirschner, M., Gattani, S., Srikaran, S., Chuan-Hao Kao, S., McCaughan, B., Klebe, S., van Zandwijk, N., Reid, G. (2014), An RNAi-based screen reveals PLK1, CDK1 and NDC80 as potential therapeutic targets in malignant pleural mesothelioma. British Journal of Cancer. 110(2), 510-519. [Abstract]

2013

   
  • Wright, C., Kirschner, M., van Zandwijk, N., Reid, G. (2013), Does miR-1 play a role in malignant pleural mesothelioma development and progression?. Chest. , 1971. [Abstract]
  • Reid, G., Pel, M., Kirschner, M., Cheng, Y., Mugridge, N., Weiss, J., Williams, M., Wright, C., Edelman, J., Vallely, M., McCaughan, B., Klebe, S., Brahmbhatt, H., Macdiarmid, J., van Zandwijk, N. (2013), Restoring expression of miR-16: a novel approach to therapy for malignant pleural mesothelioma. Annals of Oncology. 24(12), 3128-3135. [Abstract]
  • Cheng, Y., Kirschner, M., Cheng, N., Gattani, S., Klebe, S., Edelman, J., Vallely, M., McCaughan, B., Jin, H., van Zandwijk, N., Reid, G. (2013), ZIC1 Is Silenced and Has Tumor Suppressor Function in Malignant Pleural Mesothelioma. Journal of Thoracic Oncology. 8(10), 1317-1328. [Abstract]
  • Kirschner, M., van Zandwijk, N., Reid, G. (2013), Cell-free microRNAs: potential biomarkers in need of standardized reporting. Frontiers in Genetics. 4, 56. [Abstract]
  • Kirschner, M., Edelman, J., Kao, S., Vallely, M., van Zandwijk, N., Reid, G. (2013), The Impact of Hemolysis on Cell-Free microRNA Biomarkers. Frontiers in Genetics. 4, 94. [Abstract]
  • Wright, C., Kirschner, M., Cheng, Y., O'Byrne, K., Gray, S., Schelch, K., Hoda, M., Klebe, S., McCaughan, B., van Zandwijk, N., Reid, G. (2013), Long Non Coding RNAs (lncRNAs) Are Dysregulated in Malignant Pleural Mesothelioma (MPM). PloS One. 8(8), e70940. [Abstract]

2012

   
  • Kirschner, M., Cheng, Y., Badrian, B., Kao, S., Creaney, J., Edelman, J., Armstrong, N., Vallely, M., Musk, A., Robinson, B., McCaughan, B., Klebe, S., Mutsaers, S., van Zandwijk, N., Reid, G. (2012), Increased Circulating miR-625-3p: A Potential Biomarker for Patients With Malignant Pleural Mesothelioma. Journal of Thoracic Oncology. 7(7), 1184-1191. [Abstract]

2011

   
  • Reid, G., Kirschner, M., van Zandwijk, N. (2011), Circulating microRNAs: Association with disease and potential use as biomarkers. Critical reviews in oncology/hematology. 80(2), 193-208. [Abstract]
  • Kirschner, M., Kao, S., Edelman, J., Armstrong, N., Vallely, M., van Zandwijk, N., Reid, G. (2011), Haemolysis during Sample Preparation Alters microRNA Content of Plasma. PloS One. 6(9), e24145. [Abstract]