Professor Nicholas Manolios

Medicine, Westmead Clinical School

C24 - Westmead Hospital
The University of Sydney
NSW 2006 Australia

T: +61 2 9845 6305
F: +61 2 98458317
W: Related website

Biographical details

Research interests

Professor Nicholas Manolios research interests are: (i) Structure and assembly of the T-cell antigen receptor, in particular, its role in the predisposition and causation of auto-immune and inflammatory rheumatic disorders, and (ii) Structure-function relationships of T cell assembly and T-cell activation, and how synthetic peptides may be used as therapeutic agents to suppress inflammation. Recent research hs focussed on drug delivery.

PhD and Masters' project opportunities

Phosphoproteomics in early T-cell signalling   +
Gene therapy for arthritis   +
Towards a cure for Type I diabetes mellitus   +

+ indicates the opportunity is full and unavailable.


Musculoskeletal diseases; Immunology; Drug design; Arthritis; Autoimmunity


2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009


  • Chan, M., Kefford, R., Carlino, M., Clements, A., Manolios, N. (2015), Arthritis and Tenosynovitis Associated With the Anti-PD1 Antibody Pembrolizumab in Metastatic Melanoma. Journal of Immunotherapy. 38(1), 37-39. [Abstract]


  • Ali, M., Amon, M., Bender, V., Bolte, A., Separovic, F., Benson, H., Manolios, N. (2014), Cyclization enhances function of linear anti-arthritic peptides. Clinical Immunology. 150(1), 121-133. [Abstract]
  • Angelides, S., El-Mashaleh, M., Anagnostou, M., Howe, G., Spencer, D., Kumar, V., Manolios, N. (2014), The role of 99mTc-labelled glucosamine (99mTc-ECDG) in the evaluation of rheumatic joint disease: a screening experience. Nuclear Medicine Communications. 35(6), 655-665. [Abstract]
  • Wong, M., Tso, A., Ali, M., Hawthorne, W., Manolios, N. (2014), Novel T-cell inhibiting peptides delay the onset of Type 1 diabetes in non-obese diabetic mice. Diabetes & Metabolism. 40, 229-234. [Abstract]
  • Vanniasinghe, A., Manolios, N., Schibeci, S., Lakhiani, C., Kamali-Sarvestani, E., Sharma, R., Kumar, V., Moghaddam, M., Ali, M., Bender, V. (2014), Targeting fibroblast-like synovial cells at sites of inflammation with peptide targeted liposomes results in inhibition of experimental arthritis. Clinical Immunology. 151(1), 43-54. [Abstract]
  • Erfani, T., Manolios, N., Howe, G., Spencer, D. (2014), Acute gross painless transudative ascites in a patient with lupus. BMJ Case Reports. 2014, 201503. [Abstract]


  • Meade, T., Cumming, S., Hallab, L., Spencer, D., Howe, G., Manolios, N. (2013), A preliminary investigation of cognitive function in rheumatoid arthritis patients on long term methotrexate treatment. Journal of Health Psychology. 18(10), 1353-1359. [Abstract]
  • Raguine, L., Ali, M., Bender, V., Diefenbach, E., Doddareddy, M., Hibbs, D., Manolios, N. (2013), Alanine scan of an immunosuppressive peptide (CP): Analysis of structure - function relationships. Chemical Biology & Drug Design. 81(2), 167-174. [Abstract]
  • Meade, T., Sharpe, L., Hallab, L., Aspanell, D., Manolios, N. (2013), Navigating Motherhood Choices in the context of Rheumatoid Arthritis: Women's Stories. Musculoskeletal Care. 11(2), 73-82. [Abstract]
  • Jordan, A., Spencer, D., Howe, G., Manolios, N. (2013), Cauda equina syndrome in ankylosing spondylitis. Journal of Clinical Rheumatology. 19(3), 163. [Abstract]
  • Meade, T., Manolios, N. (2013), Cognitive function in rheumatoid arthritis. Arthritis Care & Research. , 1390. [Abstract]
  • Williams, A., Bloomfield, L., Milthorpe, E., Aspinall, D., Filocamo, K., Wellsmore, T., Manolios, N., Jayasinghe, U., Harris, M. (2013), Effectiveness of moving on: an Australian designed generic self-management program for people with a chronic illness. BMC Health Services Research. 13, 90. [Abstract]
  • Manolios, N., Burneikis, A., Spencer, D., Howe, G. (2013), Failure of anti-TNF therapy to reactivate previously septic prosthetic joints. BMJ Case Reports. 2013, bcr2013009827. [Abstract]


  • Tong, D., Manolios, N., Howe, G., Spencer, D. (2012), New onset sarcoid-like granulomatosis developing during Anti-TNF therapy: an under-recognised complication. Internal Medicine Journal. 42(1), 89-94. [Abstract]
  • Spencer, D., Howe, G., Manolios, N. (2012), No more excuses: fracture liaison services work and are cost-effective. Medical Journal of Australia. 196(6), 384. [Abstract]
  • Covic, T., Cumming, S., Pallant, J., Manolios, N., Emery, P., Conaghan, P., Tennant, A. (2012), Depression and anxiety in patients with rheumatoid arthritis: prevalence rates based on a comparison of the Depression, Anxiety and Stress Scale (DASS) and the hospital, Anxiety and Depression Scale (HADS). BMC Psychiatry. 12, 6. [Abstract]


  • Lu, Y., Sharma, R., Ali, M., Byth, K., Manolios, N. (2011), Anti-Arthritic Effects of Immunomodulatory Peptide Injected in Joints. Current Drug Delivery. 8(6), 600-606. [Abstract]
  • Otvos, L., Shao, W., Vanniasinghe, A., Amon, M., Holub, M., Kovalszky, I., Wade, J., Doll, M., Cohen, P., Manolios, N., Surmacz, E. (2011), Toward understanding the role of leptin and leptin receptor antagonism in preclinical models of rheumatoid arthritis. Peptides. 32(8), 1567-1574. [Abstract]
  • Ali, M., Vanniasinghe, A., Kumar, V., Barnett, R., Alberto, R., Manolios, N. (2011), (99m)Tc-technetium labeling of antiarthritic peptides to evaluate homing and biodistribution at inflamed joints. Nuclear Medicine and Biology. 38(5), 751-756. [Abstract]
  • Zheng, G., Torres, A., Ali, M., Manolios, N., Price, W. (2011), NMR Study of the structure and self-association of core peptide in aqueous solution and DPC micelles. Biopolymers. 96(2), 177-80. [Abstract]


  • Russo, R., Hughes, M., Manolios, N. (2010), Biopsy Diagnosis of Early Myositis Ossificans Without Radiologic Evidence of Calcification: Success of Early Surgical Resection. Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases. 16(8), 385-7. [Abstract]
  • Wong, M., Hawthorne, W., Manolios, N. (2010), Gene therapy in diabetes. Self Nonself. 1(3), 165-175. [Abstract]
  • Tong, D., Murad, A., Manolios, N., Howe, G., Spencer, D. (2010), Pseudohypercalcaemia in mixed cryoglobulinaemia (IgMkappa/polyclonal IgG): a rare complication of Sj??gren's syndrome. Clinical Rheumatology. 29(4), 439-441. [Abstract]
  • Tong, D., Karunaratne, N., Howe, G., Spencer, D., Manolios, N. (2010), Clinical images: Calcifying pseudoneoplasm of the neuraxis. Arthritis and Rheumatism. 62(3), 704. [Abstract]
  • Manolios, N., Ali, M., Bender, V. (2010), T-cell antigen receptor (TCR) transmembrane peptides: A new paradigm for the treatment of autoimmune diseases. Cell adhesion & migration. 4(2), 273-83. [Abstract]


  • Vanniasinghe, A., Bender, V., Manolios, N. (2009), The Potential of Liposomal Drug Delivery for the Treatment of Inflammatory Arthritis. Seminars in arthritis and rheumatism. 39(0), 182-96. [Abstract]
  • Tong, D., Eather, S., Manolios, N. (2009), Psoriatic arthritis and chronic lymphoedema: treatment efficacy by adalimumab. Clinical Rheumatology. 28(11), 1349-1350. [Abstract]
  • Varatharajan, N., Lim, I., Anandacoomarasamy, A., Russo, R., Byth, K., Spencer, D., Manolios, N., Howe, G. (2009), Methotrexate: long-term safety and efficacy in an Australian consultant rheumatology practice. Internal Medicine Journal. 39(4), 228-236. [Abstract]