Honorary Associate Professor Qihan Dong

Honorary Associate Professor
Medicine, Central Clinical School
Bosch Institute

D06 - Blackburn Building
The University of Sydney
NSW 2006 Australia

T: +61 2 9515 5186
F: +61 2 9516 1273
E:

Biographical details

Research interests

Dong's team is investigating the mechanism of, and the way to prevent, cancer recurrence. Cancers are made up of both actively dividing and "resting" cancer cells. These “resting” (quiescent) cancer cells are thought to be central to recurrence, after actively dividing cancer cells are eliminated by chemo- or radio-therapy. Based on statistic in the United States in 2011, there are 12 million people living with cancer and hence how to prevent cancer recurrence is of critical importance. Dong’s team using Gene Chip technology has identified a list of genes that are aberrantly increased in their product levels in advanced form of prostate cancer compared with organ-confined prostate cancer. This is important as the regulatory signals required for quiescent cancer cells to re-enter the cell cycle have not been fully elucidated. Identification of these signals will provide needed molecular targets for preventing cancer recurrence. In addition, the team has made progress in designing prevention strategies with the ultimate goal of providing cancer survivors with these interventions when the disease is in remission. Based on the principal of efficacy and no toxicity, the team has examined the potential of compounds isolated from edible plant, citrus peel extract, and traditional Chinese medicine in blocking the transition from the “resting” to actively dividing cancer cells.

Publications

2014 | 2013 | 2012 | 2010 | 2009 | 2008

2014

   
  • Xie, C., Yao, M., Dong, Q. (2014), Proliferating cell unclear antigen-associated factor (PAF15): a novel oncogene. International Journal of Biochemistry & Cell Biology. 50, 127-131. [Abstract]

2013

   
  • Xie, C., Powell, C., Yao, M., Wu, J., Dong, Q. (2013), Ubiquitin-conjugating enzyme E2C: A potential cancer biomarker. The International Journal of Biochemistry & Cell Biology. 47C, 113-117. [Abstract]
  • Garbutcheon-Singh, K., Myers, S., Harper, B., Ng, N., Dong, Q., Xie, C., Aldrich-Wright, J. (2013), The effects of 56MESS on mitochondrial and cytoskeletal proteins and the cell cycle in MDCK cells. Metallomics. 5(8), 1061-1067. [Abstract]
  • Ghalayini, M., Dong, Q., Richardson, D., Assinder, S. (2013), Proteolytic cleavage and truncation of NDRG1 in human prostate cancer cells, but not normal prostate epithelial cells. Bioscience Reports. 33(3), e00042. [Abstract]
  • Hua, S., Yao, M., Vignarajan, S., Witting, P., Hejazi, L., Gong, Z., Teng, Y., Niknami, M., Assinder, S., Richardson, D., Dong, Q. (2013), Cytosolic phospholipase A2alpha sustains pAKT, pERK and AR levels in PTEN-null/mutated prostate cancer cells. Biochimica et Biophysica Acta. 1831(6), 1146-1157. [Abstract]
  • Dixon, K., Lui, G., Kovacevic, Z., Zhang, D., Yao, M., Chen, Z., Dong, Q., Assinder, S., Richardson, D. (2013), Dp44mT targets the AKT, TGF-β and ERK pathways via the metastasis suppressor NDRG1 in normal prostate epithelial cells and prostate cancer cells. British Journal of Cancer. 108(2), 409-419. [Abstract]
  • Xiao, W., Graham, P., Hao, J., Chang, L., Ni, J., Power, C., Dong, Q., Kearsley, J., Li, Y. (2013), Combination Therapy with the Histone Deacetylase Inhibitor LBH589 and Radiation Is an Effective Regimen for Prostate Cancer Cells. PloS One. 8(8), e74253. [Abstract]

2012

   
  • Yao, M., Xie, C., Constantine, M., Hua, S., Hambly, B., Jardine, G., Sved, P., Dong, Q. (2012), How can food extracts consumed in the Mediterranean and East Asia suppress prostate cancer proliferation?. British Journal of Nutrition. 108(3), 424-430. [Abstract]

2010

   
  • Niknami, M., Vignarajan, S., Yao, M., Hua, S., Witting, P., Kita, Y., Shimizu, T., Sved, P., Patel, M., Dong, Q. (2010), Decrease in expression or activity of cytosolic phospholipase A(2)alpha increases cyclooxygenase-1 action: A cross-talk between key enzymes in arachidonic acid pathway in prostate cancer cells. Biochimica et Biophysica Acta. 1801(7), 731-737. [Abstract]
  • Assinder, S., Au, E., Dong, Q., Winnick, C. (2010), A novel splice variant of the beta-tropomyosin (TPM2) gene in prostate cancer. Molecular Carcinogenesis. 49(6), 525-531. [Abstract]
  • Scott, K., Sajinovic, M., Hein, J., Nixdorf, S., Galettis, P., Liauw, W., de Souza, P., Dong, Q., Graham, G., Russell, P. (2010), Emerging roles for phospholipase A(2) enzymes in cancer. Biochimie. 92(6), 601-10. [Abstract]
  • Singh, J., Xie, C., Yao, M., Hua, S., Vignarajan, S., Jardine, G., Hambly, B., Sved, P., Dong, Q. (2010), Food extracts consumed in Mediterranean countries and East Asia reduce protein concentrations of androgen receptor, phospho-protein kinase B, and phospho-cytosolic phospholipase A(2)alpha in human prostate cancer cells. Journal of Nutrition. 140(4), 786-791. [Abstract]
  • Young, L., Dong, Q. (2010), Targeted Amplification of Mutant Strands for Efficient Site-Directed Mutagenesis and Mutant Screening. In: Methods in Molecular Biology: In Vitro Mutagenesis Protocols. (pp.147-155).United States: Humana Press.
  • Yao, M., Taylor, R., Richards, M., Sved, P., Wong, J., Eisinger, D., Xie, C., Salomon, R., Risbridger, G., Dong, Q. (2010), Prostate-Regenerating Capacity of Cultured Human Adult Prostate Epithelial Cells. Cells, Tissues, Organs. 191(3), 203-212. [Abstract]

2009

   
  • Niknami, M., Dong, Q., Witting, P. (2009), Pitfalls in the use of arachidonic acid oxidation products to assign lipoxygenase activity in cancer cells. Free Radical Research. 43(10), 951-956. [Abstract]
  • Richards, A., McGeechan, K., Niknam, M., Salomon, R., Kurek, C., Dong, Q., Patel, M. (2009), Prolonging androgen sensitivity in prostate cancer - a role for COX inhibitors?. ANZ Journal of Surgery. 79(9), 641-647. [Abstract]
  • Salomon, R., Young, L., Macleod, D., Yu, X., Dong, Q. (2009), Probasin promoter-driven expression of ID1 is not sufficient for carcinogenesis in rodent prostate. Journal of Histochemistry and Cytochemistry. 57(6), 599-604. [Abstract]
  • Niknami, M., Patel, M., Witting, P., Dong, Q. (2009), Molecules in focus: Cytosolic phospholipase A(2)-alpha. The International Journal of Biochemistry & Cell Biology. 41(5), 994-997. [Abstract]
  • Assinder, S., Dong, Q., Mangs, H., Richardson, D. (2009), Pharmacological Targeting of the Integrated AKT, PTEN and TGF-{beta} Pathways in Prostate Cancer. Molecular Pharmacology. 75(3), 429-436. [Abstract]
  • Assinder, S., Dong, Q., Kovacevic, Z., Richardson, D. (2009), The TGF-beta, PI3K/Akt and PTEN pathways: established and proposed biochemical integration in prostate cancer. Biochemical Journal. 417(2), 411-421. [Abstract]

2008

   
  • Patel, M., Singh, J., Niknami, M., Kurek, C., Yao, M., Lu, S., Maclean, F., King, N., Gelb, M., Scott, K., Russell, P., Boulas, J., Dong, Q. (2008), Cytosolic Phospholipase A2-{alpha}: A Potential Therapeutic Target for Prostate Cancer. Clinical Cancer Research. 14(24), 8070-8079. [Abstract]
  • Patel, M., Kurek, C., Dong, Q. (2008), The arachidonic acid pathway and its role in prostate cancer development and progression. The Journal of Urology. 179(5), 1668-1675. [Abstract]
  • Nikinami, M., Patel, M., Witting, P., Dong, Q. (2008), Aberrant activation of arachidonic acid and eicosanoid pathways-targets for treating prostate cancer. Recent Patents on Endocrine, Metabolic & Immune Drug Discovery. 2, 9-15.