Associate Professor Rachel Codd

Associate Professor
Pharmacology, School of Medical Sciences
Bosch Institute

D06 - Blackburn Building
The University of Sydney
NSW 2006 Australia

T: +61 2 9351 6738
F: +61 2 9351 3868
E:

Research interests

A chemical biology approach to drug design and development; chemical proteomics of bacterial iron uptake; EPR spectroscopy.

PhD and Masters' project opportunities

Chemical Biology of Siderophores

Keywords

Cancer; Microbiology; Bioinformatics; Drug design; Biochemistry

Publications

2013 | 2012 | 2011 | 2010 | 2009 | 2008

2013

   
  • Ejje, N., Soe, C., Gu, J., Codd, R. (2013), The variable hydroxamic acid siderophore metabolome of the marine actinomycete Salinispora tropica CNB-440. Metallomics. 5(11), 1519-1528. [Abstract]
  • Liddell, J., Obando, D., Liu, J., Ganio, G., Volitakis, I., Mok, S., Crouch, P., White, A., Codd, R. (2013), Lipophilic adamantyl- or deferasirox-based conjugates of desferrioxamine B have enhanced neuroprotective capacity: implications for Parkinson disease. Free Radical Biology & Medicine. 60, 147-156. [Abstract]
  • Pakchung, A., Lifa, T., Codd, R. (2013), Solution species of Fe(III), Ga(III), In(III) or Ln(III) and suberodihydroxamic acid from electrospray ionization mass spectrometry. RSC Advances. 3, 16051-16059.

2012

   
  • Gu, J., Codd, R. (2012), Copper(II)-based metal affinity chromatography for the isolation of the anticancer agent bleomycin from Streptomyces verticillus culture. Journal of Inorganic Biochemistry. 115, 198-203. [Abstract]
  • Soe, C., Pakchung, A., Codd, R. (2012), Directing the Biosynthesis of Putrebactin or Desferrioxamine B in Shewanella putrefaciens through the Upstream Inhibition of Ornithine Decarboxylase. Chemistry & Biodiversity. 9(9), 1880-1890. [Abstract]
  • Liao, V., Liu, T., Codd, R. (2012), Amide-based derivatives of β-alanine hydroxamic acid as histone deacetylase inhibitors: Attenuation of potency through resonance effects. Bioorganic & Medicinal Chemistry Letters. 22(19), 6200-6204. [Abstract]
  • Lifa, T., Ejje, N., Codd, R. (2012), Coordinate-bond-dependent solid-phase organic synthesis of biotinylated desferrioxamine B: a new route for metal-specific probes. Chemical Communications. 48(14), 2003-2005. [Abstract]
  • Hare, N., Soe, C., Rose, B., Harbour, C., Codd, R., Manos, J., Cordwell, S. (2012), Proteomics of Pseudomonas aeruginosa Australian epidemic strain 1 (AES-1) cultured under conditions mimicking the cystic fibrosis lung reveals increased iron acquisition via the siderophore pyochelin. Journal of proteome research. 11(2), 776-95. [Abstract]
  • Ejje, N., Lacey, E., Codd, R. (2012), Analytical-scale purification of trichostatin A from bacterial culture in a single step and with high selectivity using immobilised metal affinity chromatography. RSC Advances. 2(1), 333-337.

2011

   
  • Simpson, P., Codd, R. (2011), Cold adaptation of the mononuclear molybdoenzyme periplasmic nitrate reductase from the Antarctic bacterium Shewanella gelidimarina. Biochemical and biophysical research communications. 414(4), 783-8. [Abstract]
  • Pakchung, A., Soe, C., Lifa, T., Codd, R. (2011), Complexes Formed in Solution Between Vanadium(IV)/(V) and the Cyclic Dihydroxamic Acid Putrebactin or Linear Suberodihydroxamic Acid. Inorganic chemistry. 50(13), 5978-89. [Abstract]
  • Liu, J., Obando, D., Liao, V., Lifa, T., Codd, R. (2011), The many faces of the adamantyl group in drug design. European journal of medicinal chemistry. 46(6), 1949-63. [Abstract]
  • Groebler, L., Liu, J., Shanu, A., Codd, R., Witting, P. (2011), Comparing the potential renal protective activity of desferrioxamine B and the novel chelator desferrioxamine B-N-(3-hydroxyadamant-1-yl)carboxamide in a cell model of myoglobinuria. The Biochemical Journal. 435(3), 669-677. [Abstract]

2010

   
  • Wubben, J., Dogovski, C., Dobson, R., Codd, R., Gerrard, J., Parker, M., Perugini, M. (2010), Cloning, expression, purification and crystallization of dihydrodipicolinate synthase from the psychrophile Shewanella benthica. Acta Crystallographica. Section F: Structural Biology and Crystallization Communications. 66(Pt 11), 1511-1516. [Abstract]
  • Simpson, P., McKinzie, A., Codd, R. (2010), Resolution of two native monomeric 90 kDa nitrate reductase active proteins from Shewanella gelidimarina and the sequence of two napA genes. Biochemical and biophysical research communications. 398(1), 13-8. [Abstract]
  • Liu, J., Obando, D., Schipanski, L., Groebler, L., Witting, P., Kalinowski, D., Richardson, D., Codd, R. (2010), Conjugates of Desferrioxamine B (DFOB) with Derivatives of Adamantane or with Orally Available Chelators as Potential Agents for Treating Iron Overload. Journal of medicinal chemistry. 53(3), 1370-82. [Abstract]
  • Simpson, P., Richardson, D., Codd, R. (2010), The periplasmic nitrate reductase in Shewanella: the resolution, distribution and functional implications of two NAP isoforms, NapEDABC and NapDAGHB. Microbiology (Reading, England). 156(2), 302-12. [Abstract]
  • Fainerman-Melnikova, M., Clegg, J., Pakchung, A., Jensen, P., Codd, R. (2010), Structural diversity of complexes between Cu(II) or Ni(II) and endocyclic oxygen- or nitrogen-containing ligands: synthesis, X-ray structure determinations and circular dichroism spectra. CrystEngComm. 12, 4217-4225.

2009

   
  • Codd, R., Braich, N., Liu, J., Soe, C., Pakchung, A. (2009), Zn(II)-dependent histone deacetylase inhibitors: Suberoylanilide hydroxamic acid and trichostatin A. The international journal of biochemistry & cell biology. 41(4), 736-9. [Abstract]
  • Liu, J., Clegg, J., Codd, R. (2009), Methyl 3-[(1-adamantylcarbonyloxy)aminocarbonyl]propanoate. Acta Crystallographica. Section E: Structure Reports Online. E65(8), o1742-o1743.
  • Liu, J., Clegg, J., Codd, R. (2009), 2,5-Dioxopyrrolidin-1-yl adamantane-1-carboxylate. Acta Crystallographica. Section E: Structure Reports Online. E65(8), o1740-o1741.
  • Levina, A., Codd, R., Lay, P. (2009), Chromium in Cancer and Dietary Supplements. In: High Resolution EPR: Applications to Metalloenzymes and Metals in Medicine. (pp.551-579).United States: Springer.

2008

   
  • Pakchung, A., Soe, C., Codd, R. (2008), Studies of Iron-Uptake Mechanisms in Two Bacterial Species of the Shewanella Genus Adapted to Middle-Range (Shewanella putrefaciens) or Antarctic (Shewanella gelidimarina) Temperatures. Chemistry & biodiversity. 5(10), 2113-23. [Abstract]
  • Braich, N., Codd, R. (2008), Immobilised metal affinity chromatography for the capture of hydroxamate-containing siderophores and other Fe(iii)-binding metabolites directly from bacterial culture supernatants. The Analyst. 133(7), 877-880. [Abstract]
  • Codd, R. (2008), Traversing the coordination chemistry and chemical biology of hydroxamic acids. Coordination Chemistry Reviews. 252, 1387-1408.