Professor Robert Baxter

Medicine, Northern Clinical School
Kolling Institute of Medical Research

E25 - Royal North Shore Hospital
The University of Sydney
NSW 2006 Australia

T: +61 2 9926 4730
F: +61 2 9926 8484
W: Related website
Related website


Biochemistry; Cell biology; Proteomics; Cancer; Endocrinology


2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009


  • Pon, C., Firth, S., Baxter, R. (2015), Involvement of insulin-like growth factor binding protein-3 in peroxisome proliferator-activated receptor gamma-mediated inhibition of breast cancer cell growth. Molecular and Cellular Endocrinology. 399C, 354-361. [Abstract]


  • Martin, J., de Silva, H., Lin, M., Scott, C., Baxter, R. (2014), Inhibition of insulin-like growth factor binding protein-3 signaling through sphingosine kinase 1 sensitizes triple-negative breast cancer cells to EGF receptor blockade. Molecular Cancer Therapeutics. 13(2), 316-328. [Abstract]
  • Pillai, U., Phillips, K., Wilkins, G., Baxter, R., Benn, D., Parker, N., Smith, R., Marsh, D. (2014), Factors that May Influence the Willingness of Cancer Patients to Consent for Biobanking. Biopreservation and Biobanking. 12(6), 409-414. [Abstract]
  • Lin, M., Marzec, K., Martin, J., Baxter, R. (2014), The role of insulin-like growth factor binding protein-3 in the breast cancer cell response to DNA-damaging agents. Oncogene. 33(1), 85-96. [Abstract]
  • Wong, M., Xue, A., Julovi, S., Pavlakis, N., Samra, J., Hugh, T., Gill, A., Peters, L., Baxter, R., Smith, R. (2014), Co-targeting of epidermal growth factor receptor (EGFR) and PI3K overcomes PI3K/Akt oncogenic dependence in pancreatic ductal adenocarcinoma. Clinical Cancer Research. 20(15), 4047-4058. [Abstract]
  • Baxter, R. (2014), IGF binding proteins in cancer: mechanistic and clinical insights. Nature Reviews. Cancer. 14(5), 329-341. [Abstract]
  • Hoyos, C., Killick, R., Keenan, D., Baxter, R., Veldhuis, J., Liu, P. (2014), Continuous Positive Airway Pressure Increases Pulsatile Growth Hormone Secretion and Circulating Insulin-like Growth Factor-1 in a Time-Dependent Manner in Men With Obstructive Sleep Apnea: A Randomized Sham-Controlled Study. Sleep. 37(4), 733-741. [Abstract]


  • Soon, P., Kim, E., Pon, C., Gill, A., Moore, K., Spillane, A., Benn, D., Baaxter, R. (2013), Breast cancer-associated fibroblasts induce epithelial-to-mesenchymal transition in breast cancer cells. Endocrine-Related Cancer. 20(1), 1-12. [Abstract]
  • Grkovic, S., O'Reilly, V., Han, S., Hong, M., Baxter, R., Firth, S. (2013), IGFBP-3 binds GRP78, stimulates autophagy and promotes the survival of breast cancer cells exposed to adverse microenvironments. Oncogene. 32(19), 2412-2420. [Abstract]
  • Schedlich, L., Yenson, V., Baxter, R. (2013), TGF-beta-induced expression of IGFBP-3 regulates IGF1R signaling in human osteosarcoma cells. Molecular and Cellular Endocrinology. 377(1-2), 56-64. [Abstract]
  • Baxter, R. (2013), Insulin-like growth factor binding protein-3 (IGFBP-3): novel ligands mediate unexpected functions. Journal of Cell Communication and Signaling. 7(3), 179-189. [Abstract]
  • Chung, L., Shibli, S., Moore, K., Elder, E., Boyle, F., Marsh, D., Baxter, R. (2013), Tissue biomarkers of breast cancer and their association with conventional pathologic features. British Journal of Cancer. 108(2), 351-360. [Abstract]
  • Greenall, S., Bentley, J., Pearce, L., Scoble, J., Sparrow, L., Bartone, N., Xiao, X., Baxter, R., Cosgrove, L., Adams, T. (2013), Biochemical Characterization of Individual Human Glycosylated pro-Insulin-like Growth Factor (IGF)-II and big-IGF-II Isoforms Associated with Cancer. The Journal of Biological Chemistry. 288(1), 59-68. [Abstract]


  • Chung, L., Baxter, R. (2012), Breast cancer biomarkers: proteomic discovery and translation to clinically relevant assays. Expert Review of Proteomics. 9(6), 599-614. [Abstract]
  • Mertens-Walker, I., Baxter, R., Marsh, D. (2012), Gonadotropin signalling in epithelial ovarian cancer. Cancer Letters. 324(2), 152-159. [Abstract]
  • Xue, A., Chang, J., Chung, L., Samra, J., Hugh, T., Gill, A., Butturini, G., Baxter, R., Smith, R. (2012), Serum apolipoprotein C-II is prognostic for survival after pancreatic resection for adenocarcinoma. British Journal of Cancer. 107(11), 1883-1891. [Abstract]
  • de Silva, H., Firth, S., Twigg, S., Baxter, R. (2012), Interaction Between IGF Binding Protein-3 and TGF?? in the Regulation of Adipocyte Differentiation. Endocrinology. 153(10), 4799-4807. [Abstract]
  • Leong, S., Nunez, A., Lin, M., Crossett, B., Christopherson, R., Baxter, R. (2012), iTRAQ-Based Proteomic Profiling of Breast Cancer Cell Response to Doxorubicin and TRAIL. Journal of Proteome Research. 11(7), 3561-3572. [Abstract]
  • Gribben, L., Baxter, R., Marsh, D. (2012), Insulin-like growth factor binding protein-3 inhibits migration of endometrial cancer cells. Cancer letters. 317(1), 41-8. [Abstract]
  • Birzniece, V., Meinhardt, U., Gibney, J., Johannsson, G., Armstrong, N., Baxter, R., Ho, K. (2012), Differential Effects of Raloxifene and Estrogen on Body Composition in Growth Hormone-Replaced Hypopituitary Women. Journal of Clinical Endocrinology and Metabolism. 97(3), 1005-1012. [Abstract]
  • Leong, S., McKay, M., Christopherson, R., Baxter, R. (2012), Biomarkers of breast cancer apoptosis induced by chemotherapy and TRAIL. Journal of proteome research. 11(2), 1240-50. [Abstract]
  • Xue, A., Gandy, R., Chung, L., Baxter, R., Smith, R. (2012), Discovery of diagnostic biomarkers for pancreatic cancer in immunodepleted serum by SELDI-TOF MS. Pancreatology. 12(2), 124-129. [Abstract]
  • Jarajapu, Y., Cai, J., Yan, Y., Li Calzi, S., Kielczewski, J., Hu, P., Shaw, L., Firth, S., Chan-Ling, T., Boulton, M., Baxter, R., Grant, M. (2012), Protection of blood retinal barrier and systemic vasculature by insulin-like growth factor binding protein-3. PLoS One. 7(7), e39398. [Abstract]


  • Martin, J., Baxter, R. (2011), Signalling pathways of insulin-like growth factors (IGFs) and IGF binding protein-3. Growth factors (Chur, Switzerland). 29(6), 235-44. [Abstract]
  • Lin, W., Martin, J., Marsh, D., Jack, M., Baxter, R. (2011), Involvement of insulin-like growth factor binding protein-3 in the effects of the histone deacetylase inhibitor MS-275 in hepatoma cells. The Journal of biological chemistry. 286(34), 29540-7. [Abstract]
  • Gielen, M., Mesotten, D., Brugts, M., Coopmans, W., Van Herck, E., Vanhorebeek, I., Baxter, R., Lamberts, S., Janssen, J., Van den Berghe, G. (2011), Effect of Intensive Insulin Therapy on the Somatotropic Axis of Critically Ill Children. The Journal of clinical endocrinology and metabolism. 96(8), 2558-66. [Abstract]
  • Firth, S., Yan, X., Baxter, R. (2011), D440N Mutation in the Acid-Labile Subunit of Insulin-Like Growth Factor Complexes Inhibits Secretion and Complex Formation. Molecular endocrinology (Baltimore, Md.). 25(2), 307-14. [Abstract]
  • Kielczewski, J., Li Calzi, S., Shaw, L., Cai, J., Qi, X., Ruan, Q., Wu, L., Liu, L., Hu, P., Chan-Ling, T., Mames, R., Firth, S., Baxter, R., Turowski, P., Busik, J., Boulton, M., Grant, M. (2011), Free insulin-like growth factor binding protein-3 (IGFBP-3) reduces retinal vascular permeability in association with a reduction of acid sphingomyelinase (ASMase). Investigative Ophthalmology & Visual Science. 52(11), 8278-8286. [Abstract]


  • Bolitho, C., Hahn, M., Baxter, R., Marsh, D. (2010), The chemokine CXCL1 induces proliferation in epithelial ovarian cancer cells by transactivation of the epidermal growth factor receptor. Endocrine-related cancer. 17(4), 929-40. [Abstract]
  • Xue, A., Scarlett, C., Chung, L., Butturini, G., Scarpa, A., Gandy, R., Wilson, S., Baxter, R., Smith, R. (2010), Discovery of serum biomarkers for pancreatic adenocarcinoma using proteomic analysis. British journal of cancer. 103(3), 391-400. [Abstract]
  • Mertens-Walker, I., Bolitho, C., Baxter, R., Marsh, D. (2010), Gonadotropin-induced ovarian cancer cell migration and proliferation require extracellular signal-regulated kinase 1/2 activation regulated by calcium and protein kinase C{delta}. Endocrine-related cancer. 17(2), 335-49. [Abstract]
  • Birzniece, V., Meinhardt, U., Gibney, J., Johannsson, G., Baxter, R., Seibel, M., Ho, K. (2010), Modulatory Effect of Raloxifene and Estrogen on the Metabolic Action of Growth Hormone in Hypopituitary Women. The Journal of clinical endocrinology and metabolism. 95(5), 2099-106. [Abstract]
  • Westwood, M., Maqsood, A., Solomon, M., Whatmore, A., Davis, J., Baxter, R., Gevers, E., Robinson, I., Clayton, P. (2010), The effect of different patterns of growth hormone administration on the IGF axis, somatic and skeletal growth of the dwarf rat. American journal of physiology. Endocrinology and metabolism. 298(0), E467-76. [Abstract]
  • Yan, X., Baxter, R., Firth, S. (2010), Involvement of pregnancy-associated plasma protein-A2 in insulin-like growth factor (IGF) binding protein-5 proteolysis during pregnancy: a potential mechanism for increasing IGF bioavailability. Journal of Clinical Endocrinology and Metabolism. 95(3), 1412-1420. [Abstract]
  • Clifton, V., Hodyl, N., Murphy, V., Giles, W., Baxter, R., Smith, R. (2010), Effect of maternal asthma, inhaled glucocorticoids and cigarette use during pregnancy on the newborn insulin-like growth factor axis. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. 20(1), 39-48. [Abstract]


  • O'Han, M., Baxter, R., Schedlich, L. (2009), Effects of endogenous insulin-like growth factor binding protein-3 on cell cycle regulation in breast cancer cells. Growth Factors. 27(6), 394-408. [Abstract]
  • Baxter, R., Twigg, S. (2009), Actions of IGF binding proteins and related proteins in adipose tissue. Trends in endocrinology and metabolism: TEM. 20(10), 499-505. [Abstract]
  • Yan, X., Payet, L., Baxter, R., Firth, S. (2009), Activity of human pregnancy insulin-like growth factor binding protein-3: determination by reconstituting recombinant complexes. Endocrinology. 150(11), 4968-4976. [Abstract]
  • Martin, J., Lin, M., McGowan, E., Baxter, R. (2009), Potentiation of growth factor signaling by insulin-like growth factor binding protein-3 in breast epithelial cells requires sphingosine kinase activity. The Journal of biological chemistry. 284(38), 25542-52. [Abstract]
  • Chung, L., Baxter, R. (2009), Detection of growth hormone responsive proteins using SELDI-TOF mass spectrometry. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. 19(4), 383-7. [Abstract]
  • Chung, L., Nelson, A., Ho, K., Baxter, R. (2009), Proteomic profiling of growth hormone responsive proteins in human peripheral blood leukocytes. The Journal of clinical endocrinology and metabolism. 94(8), 3038-43. [Abstract]
  • Gosby, A., Stanton, L., Maloney, C., Thompson, M., Briody, J., Baxter, R., Bryson, J., Denyer, G., Caterson, I. (2009), Postnatal nutrition alters body composition in adult offspring exposed to maternal protein restriction. The British journal of nutrition. 101(0), 1878-84. [Abstract]
  • Chan, S., Schedlich, L., Twigg, S., Baxter, R. (2009), Inhibition of adipocyte differentiation by insulin-like growth factor-binding protein-3. American Journal of Physiology: Endocrinology and Metabolism. 296(4), E654-E663. [Abstract]