Professor Roger R Reddel

Sir Lorimer Dods Professor
Medicine, Children's Medical Research Institute

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Biographical details

Roger Reddel is the Lorimer Dods Professor and Director of Children's Medical Research Institute (CMRI). He also heads CMRI's Cancer Research Unit. He obtained a medical degree from the University of Sydney, trained in medical oncology at the Royal Prince Alfred Hospital, and is a Fellow of the Royal Australasian College of Physicians. Roger completed a PhD in cancer cell biology at the Ludwig Institute for Cancer Research in the University of Sydney's Department of Cancer Medicine, and received an NHMRC CJ Martin Fellowship and a Fulbright Fellowship to undertake postdoctoral research at the National Cancer Institute, Bethesda, Maryland, USA. He returned to Sydney to establish a laboratory at CMRI, attracted by the Institute's culture of fostering high quality basic research, and with the support of Cancer Council NSW's Bicentennial Fellowship. He has continued to receive major support from the Cancer Council, including being awarded the Carcinogenesis Fellowship for ten years, and Program Grants for ten years. [More...]

Research interests

cellular immortalisation, telomere biology, telomerase, alternative lengthening of telomeres

Current national competitive grants*

2012

Interaction of TRF2 with DNA repair proteins in Alternative Lengthening of Telomeres
Reddel R
NHMRC Project Grants ($287,175 over 3 years)

* Grants administered through the University of Sydney

Keywords

Cellular immortalisation; Brain tumours; Cellular senescence; tumour suppressor genes; Telomeres

Publications

2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008

2014

   
  • Lee, M., Hills, M., Conomos, D., Stutz, M., Dagg, R., Lau, L., Reddel, R., Pickett, H. (2014), Telomere extension by telomerase and ALT generates variant repeats by mechanistically distinct processes. Nucleic Acids Research. 42(3), 1733-1746. [Abstract]
  • Conomos, D., Reddel, R., Pickett, H. (2014), NuRD-ZNF827 recruitment to telomeres creates a molecular scaffold for homologous recombination. Nature Structural & Molecular Biology. 21(9), 760-770. [Abstract]
  • Gupta, R., Dong, Y., Solomon, P., Wettersten, H., Cheng, C., Min, J., Henson, J., Dogra, S., Hwang, S., Hammock, B., Zhu, L., Reddel, R., Saltzman, W., Weiss, R., Chang, S., Green, M., Wajapeyee, N. (2014), Synergistic tumor suppression by combined inhibition of telomerase and CDKN1A. Proceedings of the National Academy of Sciences of the United States of America. 111(30), E3062-3071. [Abstract]
  • Singh, R., Kalra, R., Hasan, K., Kaul, Z., Cheung, C., Huschtscha, L., Reddel, R., Kaul, S., Wadhwa, R. (2014), Molecular characterization of collaborator of ARF (CARF) as a DNA damage response and cell cycle checkpoint regulatory protein. Experimental Cell Research. 322(2), 324-334. [Abstract]

2013

   
  • Lau, L., Dagg, R., Henson, J., Au, A., Royds, J., Reddel, R. (2013), Detection of alternative lengthening of telomeres by telomere quantitative PCR. Nucleic Acids Research. 41(2), e34. [Abstract]
  • Pena, C., Cespedes, M., Lindh, M., Kiflemariam, S., Mezheyeuski, A., Edqvist, P., Hagglof, C., Birgisson, H., Bojmar, L., Jirstrom, K., Sandstrom, P., Olsson, E., Veerla, S., Gallardo, A., Sjoblom, T., Chang, A., Reddel, R., Mangues, R., Augsten, M., Ostman, A. (2013), STC1 expression by cancer-associated fibroblasts drives metastasis of colorectal cancer. Cancer Research. 73(4), 1287-1297. [Abstract]
  • Durukan Tolvanen, A., Westberg, J., Serlachius, M., Chang, A., Reddel, R., Andersson, L., Tatlisumak, T. (2013), Stanniocalcin 1 is important for poststroke functionality, but dispensable for ischemic tolerance. Neuroscience. 229, 49-54. [Abstract]
  • Conomos, D., Pickett, H., Reddel, R. (2013), Alternative lengthening of telomeres: remodeling the telomere architecture. Frontiers in Oncology. 3, 27. [Abstract]
  • Neumann, A., Watson, C., Noble, J., Pickett, H., Tam, P., Reddel, R. (2013), Alternative lengthening of telomeres in normal mammalian somatic cells. Genes and Development. 27(1), 18-23. [Abstract]

2012

   
  • Conomos, D., Stutz, M., Hills, M., Neumann, A., Bryan, T., Reddel, R., Pickett, H. (2012), Variant repeats are interspersed throughout the telomeres and recruit nuclear receptors in ALT cells. The Journal of Cell Biology. 199(6), 893-906. [Abstract]
  • Huschtscha, L., Napier, C., Noble, J., Bower, K., Au, A., Campbell, H., Braithwaite, A., Reddel, R. (2012), Enhanced isolation of fibroblasts from human skin explants. BioTechniques. 53(4), 239-244. [Abstract]
  • Lovejoy, C., Li, W., Reisenweber, S., Thongthip, S., Bruno, J., de Lange, T., De, S., Petrini, J., Sung, P., Jasin, M., Rosenbluh, J., Zwang, Y., Weir, B., Hatton, C., Ivanova, E., Macconaill, L., Hanna, M., Hahn, W., Lue, N., Reddel, R., Jiao, Y., Kinzler, K., Vogelstein, B., Papadopoulos, N., Meeker, A. (2012), Loss of ATRX, Genome Instability, and an Altered DNA Damage Response Are Hallmarks of the Alternative Lengthening of Telomeres Pathway. PLoS Genetics. 8(7), e1002772. [Abstract]
  • Shay, J., Reddel, R., Wright, W. (2012), Cancer. Cancer and telomeres--an ALTernative to telomerase. Science. 336(6087), 1388-1390. [Abstract]
  • Pickett, H., Reddel, R. (2012), The role of telomere trimming in normal telomere length dynamics. Cell Cycle. 11(7), 1309-1315. [Abstract]
  • Bower, K., Napier, C., Cole, S., Dagg, R., Lau, L., Duncan, E., Moy, E., Reddel, R. (2012), Loss of Wild-Type ATRX Expression in Somatic Cell Hybrids Segregates with Activation of Alternative Lengthening of Telomeres. PloS One. 7(11), e50062. [Abstract]
  • Bender, H., Murchison, E., Pickett, H., Deakin, J., Strong, M., Conlan, C., McMillan, D., Neumann, A., Greider, C., Hannon, G., Reddel, R., Graves, J. (2012), Extreme telomere length dimorphism in the Tasmanian devil and related marsupials suggests parental control of telomere length. PLoS One. 7(9), e46195. [Abstract]
  • Kaul, Z., Cesare, A., Huschtscha, L., Neumann, A., Reddel, R. (2012), Five dysfunctional telomeres predict onset of senescence in human cells. EMBO reports. 13(1), 52-9. [Abstract]

2011

   
  • Pickett, H., Henson, J., Au, A., Neumann, A., Reddel, R. (2011), Normal mammalian cells negatively regulate telomere length by telomere trimming. Human Molecular Genetics. 20(23), 4684-4692. [Abstract]
  • Yoon, A., Gao, R., Kaul, Z., Choi, I., Ryu, J., Noble, J., Kato, Y., Saito, S., Hirano, T., Ishii, T., Reddel, R., Yun, C., Kaul, S., Wadhwa, R. (2011), MicroRNA-296 is enriched in cancer cells and downregulates p21WAF1 mRNA expression via interaction with its 3' untranslated region. Nucleic acids research. 39(18), 8078-91. [Abstract]
  • Au, A., Hackl, T., Yeager, T., Cohen, S., Pass, H., Harris, C., Reddel, R. (2011), Telomerase activity in pleural malignant mesotheliomas. Lung cancer (Amsterdam, Netherlands). 73(3), 283-8. [Abstract]
  • Beesley, J., Pickett, H., Johnatty, S., Dunning, A., Chen, X., Li, J., Michailidou, K., Lu, Y., Rider, D., Palmieri, R., Stutz, M., Lambrechts, D., Despierre, E., Lambrechts, S., Vergote, I., Chang-Claude, J., Nickels, S., Vrieling, A., Flesch-Janys, D., Wang-Gohrke, S., Eilber, U., Bogdanova, N., Antonenkova, N., Runnebaum, I., Dörk, T., Goodman, M., Lurie, G., Wilkens, L., Matsuno, R., Kiemeney, L., Aben, K., Marees, T., Massuger, L., Fridley, B., Vierkant, R., Bandera, E., Olson, S., Orlow, I., Rodriguez-Rodriguez, L., Cook, L., Le, N., Brooks-Wilson, A., Kelemen, L., Campbell, I., Gayther, S., Ramus, S., Gentry-Maharaj, A., Menon, U., Ahmed, S., Baynes, C., Pharoah, P., Muir, K., Lophatananon, A., Chaiwerawattana, A., Wiangnon, S., Macgregor, S., Easton, D., Reddel, R., Goode, E., Chenevix-Trench, G. (2011), Functional polymorphisms in the TERT promoter are associated with risk of serous epithelial ovarian and breast cancers. PLoS One. 6(9), e24987. [Abstract]
  • Jiang, W., Nguyen, A., Cao, Y., Chang, A., Reddel, R. (2011), HP1-mediated formation of alternative lengthening of telomeres-associated PML bodies requires HIRA but not ASF1a. PloS one. 6(2), e17036. [Abstract]

2010

   
  • Henson, J., Reddel, R. (2010), Assaying and investigating Alternative Lengthening of Telomeres activity in human cells and cancers. FEBS letters. 584(17), 3800-11. [Abstract]
  • McDonald, K., McDonnell, J., Muntoni, A., Henson, J., Hegi, M., von Deimling, A., Wheeler, H., Cook, R., Biggs, M., Little, N., Robinson, B., Reddel, R., Royds, J. (2010), Presence of Alternative Lengthening of Telomeres Mechanism in Patients With Glioblastoma Identifies a Less Aggressive Tumor Type With Longer Survival. Journal of neuropathology and experimental neurology. 69(7), 729-36. [Abstract]
  • Capes-Davis, A., Theodosopoulos, G., Atkin, I., Drexler, H., Kohara, A., Macleod, R., Masters, J., Nakamura, Y., Reid, Y., Reddel, R., Freshney, R. (2010), Check your cultures! A list of cross-contaminated or misidentified cell lines. International journal of cancer. Journal international du cancer. 127(1), 1-8. [Abstract]
  • Cesare, A., Reddel, R. (2010), Alternative lengthening of telomeres: models, mechanisms and implications. Nature reviews. Genetics. 11(5), 319-30. [Abstract]
  • Reddel, R. (2010), Senescence: an antiviral defense that is tumor suppressive?. Carcinogenesis. 31(1), 19-26. [Abstract]

2009

   
  • Cesare, A., Kaul, Z., Cohen, S., Napier, C., Pickett, H., Neumann, A., Reddel, R. (2009), Spontaneous occurrence of telomeric DNA damage response in the absence of chromosome fusions. Nature structural & molecular biology. 16(12), 1244-51. [Abstract]
  • Henson, J., Cao, Y., Huschtscha, L., Chang, A., Au, A., Pickett, H., Reddel, R. (2009), DNA C-circles are specific and quantifiable markers of alternative-lengthening-of-telomeres activity. Nature biotechnology. 27(12), 1181-5. [Abstract]
  • Hinshelwood, R., Melki, J., Huschtscha, L., Paul, C., Song, J., Stirzaker, C., Reddel, R., Clark, S. (2009), Aberrant de novo methylation of the p16INK4A CpG island is initiated post gene silencing in association with chromatin remodelling and mimics nucleosome positioning. Human Molecular Genetics. 18(16), 3098-3109. [Abstract]
  • Huschtscha, L., Moore, J., Noble, J., Campbell, H., Royds, J., Braithwaite, A., Reddel, R. (2009), Normal human mammary epithelial cells proliferate rapidly in the presence of elevated levels of the tumor suppressors p53 and p21WAF1/CIP1. Journal of Cell Science. 122(Pt 16), 2989-2995. [Abstract]
  • Yuan, J., Yang, B., Zhong, Z., Shats, I., Milyavsky, M., Rotter, V., Lock, R., Reddel, R., Mackenzie, K. (2009), Upregulation of survivin during immortalization of nontransformed human fibroblasts transduced with telomerase reverse transcriptase. Oncogene. 28(29), 2678-89. [Abstract]
  • Graham, J., Mote, P., Salagame, U., van Dijk, J., Balleine, R., Huschtscha, L., Reddel, R., Clarke, C. (2009), DNA replication licensing and progenitor numbers are increased by progesterone in normal human breast. Endocrinology. 150(7), 3318-3326. [Abstract]
  • Jiang, W., Zhong, Z., Nguyen, A., Henson, J., Toouli, C., Braithwaite, A., Reddel, R. (2009), Induction of alternative lengthening of telomeres-associated PML bodies by p53/p21 requires HP1 proteins. The Journal of Cell Biology. 185(5), 797-810. [Abstract]
  • Nguyen, A., Chang, A., Reddel, R. (2009), Stanniocalcin-1 acts in a negative feedback loop in the prosurvival ERK1/2 signaling pathway during oxidative stress. Oncogene. 28(18), 1982-1992. [Abstract]
  • Pickett, H., Cesare, A., Johnston, R., Neumann, A., Reddel, R. (2009), Control of telomere length by a trimming mechanism that involves generation of t-circles. The EMBO journal. 28(7), 799-809. [Abstract]
  • Muntoni, A., Neumann, A., Hills, M., Reddel, R. (2009), Telomere elongation involves intra-molecular DNA replication in cells utilizing Alternative Lengthening of Telomeres. Human molecular genetics. 18(0), 1017-27. [Abstract]
  • Ng, L., Cropley, J., Pickett, H., Reddel, R., Suter, C. (2009), Telomerase activity is associated with an increase in DNA methylation at the proximal subtelomere and a reduction in telomeric transcription. Nucleic Acids Research. 37(4), 1152-1159. [Abstract]
  • Jiang, W., Henson, J., Neuman, A., Reddel, R. (2009), Protocol III: Detection of alternative lengthening of telomeres. In: Telomeres and Telomerase in Cancer. (pp.351-364).United States: Humana Press.
  • Reddel, R. (2009), Senescence and immortalization. In: Encyclopedia of Cancer. (pp.2697-2699).Germany: Springer.
  • Pickett, H., Reddel, R. (2009), Alternative lengthening of telomeres in human cells. In: Telomeres and Telomerase in Cancer. (pp.127-148).United States: Humana Press.

2008

   
  • Chen, Y., Campbell, H., Wiles, A., Eccles, M., Reddel, R., Braithwaite, A., Royds, J. (2008), PAX8 regulates telomerase reverse transcriptase and telomerase RNA component in glioma. Cancer Research. 68(14), 5724-5732. [Abstract]
  • Villa, R., Daidone, M., Motta, R., Venturini, L., De Marco, C., Vannelli, A., Kusamura, S., Baratti, D., Deraco, M., Costa, A., Reddel, R., Zaffaroni, N. (2008), Multiple mechanisms of telomere maintenance exist and differentially affect clinical outcome in diffuse malignant peritoneal mesothelioma. Clinical cancer research : an official journal of the American Association for Cancer Research. 14(13), 4134-4140. [Abstract]
  • Cao, Y., Bryan, T., Reddel, R. (2008), Increased copy number of the TERT and TERC telomerase subunit genes in cancer cells. Cancer Science. 99(6), 1092-1099. [Abstract]
  • Chang, A., Hook, J., Lemckert, F., McDonald, M., Nguyen, M., Hardeman, E., Little, D., Gunning, P., Reddel, R. (2008), The murine stanniocalcin 2 gene is a negative regulator of postnatal growth. Endocrinology. 149(5), 2403-2410. [Abstract]
  • Cao, Y., Huschtscha, L., Nouwens, A., Pickett, H., Neumann, A., Chang, A., Toouli, C., Bryan, T., Reddel, R. (2008), Amplification of telomerase reverse transcriptase gene in human mammary epithelial cells with limiting telomerase RNA expression levels. Cancer research. 68(9), 3115-3123. [Abstract]
  • Cohen, S., Reddel, R. (2008), A sensitive direct human telomerase activity assay. Nature Methods. 5(4), 355-360. [Abstract]
  • Cesare, A., Reddel, R. (2008), Alternative Lengthening of Telomeres in Mammalian Cells. In: Origin and Evolution of Telomeres. (pp.45-57).United States: Landes Bioscience.
  • Cesare, A., Reddel, R. (2008), Telomere uncapping and alternative lengthening of telomeres. Mechanisms of ageing and development. 129(0), 99-108. [Abstract]