Dr Scott Byrne

Cancer Institute NSW Senior Research Fellow and Senior Lecturer in Immunology
Medicine, Central Clinical School

D06 - Blackburn Building
The University of Sydney
NSW 2006 Australia

T: +61 2 9351 7308
F: +61 2 9036 5130

W: Related website

Research interests

My laboratory is interested in the cellular mechanisms underlying sunlight-induced immune suppression and tolerance. Specifically, we are exploring how ultraviolet radiation from the sun causes skin cancer by activating regulatory cells and suppressing the anti-tumour immune response. The cell to cell interaction and migration of mast cell and B lymphocytes are what we are currently focused on. Current and future research endeavours include investigating the role of regulatory cells and mast cells in autoimmune diseases such as multiple sclerosis, as well as dermatology related disorders such as polymorphic light eruption (PLE).

Teaching areas



Cancer; Immunology; Immune tolerance; Autoimmunity; Multiple sclerosis

International links

Austria. (University of Graz) Prof Peter Wolf.


2014 | 2013 | 2012 | 2011 | 2010 | 2009


  • Sarchio, S., Scolyer, R., Beaugie, C., McDonald, D., Marsh-Wakefield, F., Halliday, G., Byrne, S. (2014), Pharmacologically Antagonizing the CXCR4-CXCL12 Chemokine Pathway with AMD3100 Inhibits Sunlight-Induced Skin Cancer. The Journal of Investigative Dermatology. 134(4), 1091-1100. [Abstract]
  • Halliday, G., Byrne, S. (2014), An Unexpected Role: UVA-Induced Release of Nitric Oxide from Skin May Have Unexpected Health Benefits. Journal of Investigative Dermatology. 134(7), 1791-1794. [Abstract]
  • Gruber-Wackernagel, A., Byrne, S., Wolf, P. (2014), Polymorphous Light Eruption: Clinic Aspects and Pathogenesis. Dermatologic Clinics. 32(3), 315-334. [Abstract]
  • Byrne, S. (2014), How much sunlight is enough?. Photochemical & Photobiological Sciences. 13, 840. [Abstract]
  • Wolf, P., Gruber-Wackernagel, A., Bambach, I., Schmidbauer, U., Mayer, G., Absenger, M., Frohlich, E., Byrne, S. (2014), Photohardening of polymorphic light eruption patients decreases baseline epidermal Langerhans cell density while increasing mast cell numbers in the papillary dermis. Experimental dermatology. 23, 424-448. [Abstract]
  • Kaufman, K., Mactier, S., Armstrong, N., Mallawaaratchy, D., Byrne, S., Haydu, L., Jakrot, V., Thompson, J., Mann, G., Scolyer, R., Christopherson, R. (2014), Surface antigen profiles of leukocytes and melanoma cells in lymph node metastases are associated with survival in AJCC stage III melanoma patients. Clinical & Experimental Metastasis. 31, 407-421. [Abstract]
  • Byrne, S., Sarchio, S. (2014), AMD3100 protects from UV-induced skin cancer. Oncoimmunology. 3(1), e27562. [Abstract]


  • Wolf, P., Gruber-Wackernagel, A., Rinner, B., Griesbacher, A., Eberhard, K., Groselj-Strele, A., Mayer, G., Stauber, R., Byrne, S. (2013), Phototherapeutic hardening modulates systemic cytokine levels in patients with polymorphic light eruption. Photochemical & Photobiological Sciences. 12(1), 166-173. [Abstract]
  • Leighton, S., Kok, L., Halliday, G., Byrne, S. (2013), Inhibition of UV-induced uric acid production using Allopurinol prevents suppression of the contact hypersensitivity response. Experimental Dermatology. 22(3), 189-194. [Abstract]


  • Gruber-Wackernagel, A., Obermayer-Pietsch, B., Byrne, S., Wolf, P. (2012), Patients with polymorphic light eruption have decreased serum levels of 25-hydroxyvitamin-D(3) that increase upon 311 nm UVB photohardening. Photochemical & Photobiological Sciences. 11(12), 1831-1836. [Abstract]
  • Halliday, G., Damian, D., Rana, S., Byrne, S. (2012), The suppressive effects of ultraviolet radiation on immunity in the skin and internal organs: Implications for autoimmunity. Journal of Dermatological Science. 66(3), 176-182. [Abstract]
  • Sarchio, S., Kok, L., O'Sullivan, C., Halliday, G., Byrne, S. (2012), Dermal mast cells affect the development of sunlight-induced skin tumours. Experimental Dermatology. 21(4), 241-248. [Abstract]
  • Ullrich, S., Byrne, S. (2012), The immunologic revolution: photoimmunology. The Journal of Investigative Dermatology. 132(3 Pt 2), 896-905. [Abstract]


  • Halliday, G., Byrne, S., Damian, D. (2011), Ultraviolet a radiation: its role in immunosuppression and carcinogenesis. Seminars in Cutaneous Medicine and Surgery. 30(4), 214-221. [Abstract]
  • Byrne, S., Beaugie, C., O'Sullivan, C., Leighton, S., Halliday, G. (2011), The Immune-Modulating Cytokine and Endogenous Alarmin Interleukin-33 Is Upregulated in Skin Exposed to Inflammatory UVB Radiation. The American Journal of Pathology. 179(1), 211-222. [Abstract]
  • Gruber-Wackernagel, A., Bambach, I., Legat, F., Hofer, A., Byrne, S., Quehenberger, F., Wolf, P. (2011), Randomized double-blinded placebo-controlled intra-individual trial on 1,25-(OH)2 vitamin D3 analogue in polymorphic light eruption. The British journal of dermatology. 165(1), 152-63. [Abstract]
  • Gruber-Wackernagel, A., Heinemann, A., Konya, V., Byrne, S., Singh, T., Hofer, A., Legat, F., Wolf, P. (2011), Photohardening restores the impaired neutrophil responsiveness to chemoattractants leukotriene B4 and formyl-methionyl-leucyl-phenylalanin in patients with polymorphic light eruption. Experimental dermatology. 20(6), 473-6. [Abstract]


  • Tran, J., Pupovac, A., Taylor, R., Wiley, J., Byrne, S., Sluyter, R. (2010), Murine epidermal Langerhans cells and keratinocytes express functional P2X receptors. Experimental dermatology. 19(8), e151-7. [Abstract]


  • Stapelberg, M., Williams, R., Byrne, S., Halliday, G. (2009), The Alternative Complement Pathway Seems to be a UVA Sensor that Leads to Systemic Immunosuppression. The Journal of investigative dermatology. 129(11), 2694-701. [Abstract]
  • Wolf, P., Byrne, S., Gruber-Wackernagel, A. (2009), New insights into the mechanisms of polymorphic light eruption: resistance to ultraviolet radiation-induced immune suppression as an aetiological factor. Experimental dermatology. 18(4), 350- 356. [Abstract]
  • Byrne, S., Halliday, G. (2009), Sunlight induced immunosuppression: a role for inflammatory mediators in the induction of suppressor cells. In: Immunosuppression: New Research. (pp.185-207).United States: Nova Science.
  • Gruber-Wackernagel, A., Byrne, S., Wolf, P. (2009), Pathogenic mechanisms of polymorphic light eruption. Frontiers in Bioscience (Elite Edition). E1(0), 341-354. [Abstract]