Dr Stuart Fraser

Senior Lecturer
Physiology, School of Medical Sciences

K25 - Medical Foundation Building
The University of Sydney
NSW 2006 Australia

T: +61 2 9036 3313
F: +61 2 9036 3316
E:

Biographical details

Research interests

Our main interests focus upon the mechanisms controlling the formation of the blood, or hematopoietic lineages, in the embryo and how these processes can go awry in the adult.

PhD and Masters' project opportunities

Regulation of Hematopoietic Stem Cell Production in the Embryo and Adult   +
Red blood cell enucleation   +

+ indicates the opportunity is full and unavailable.

International links

Japan. (Kyushu University) Collaboration with Dr. Daisuke Sugiyama.

Publications

2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008

2014

   
  • Acosta, J., Goldsbury, C., Winnick, C., Badrock, A., Fraser, S., Laird, A., Hall, T., Don, E., Fifita, J., Blair, I., Nicholson, G., Cole, N. (2014), Mutant Human FUS Is Ubiquitously Mislocalized and Generates Persistent Stress Granules in Primary Cultured Transgenic Zebrafish Cells. PloS One. 9(6), e90572. [Abstract]
  • Zhang, H., Nieves, J., Fraser, S., Isern, J., Douvaras, P., Papatsenko, D., D'Souza, S., Lemischka, I., Dyer, M., Baron, M. (2014), Expression of podocalyxin separates the hematopoietic and vascular potentials of mouse embryonic stem cell-derived mesoderm. Stem Cells. 32(1), 191-203. [Abstract]

2013

   
  • Antas, V., Al-Drees, M., Prudence, A., Sugiyama, D., Fraser, S. (2013), Hemogenic Endothelium: A Vessel For Blood Production. The International Journal of Biochemistry & Cell Biology. 45(3), 692¿695. [Abstract]
  • Guiu, J., Shimizu, R., D'Altri, T., Fraser, S., Hatakeyama, J., Bresnick, E., Kageyama, R., Dzierzak, E., Yamamoto, M., Espinosa, L., Bigas, A. (2013), Hes repressors are essential regulators of hematopoietic stem cell development downstream of Notch signaling. The Journal of Experimental Medicine. 210(1), 71-84. [Abstract]
  • Vacaru, A., Isern, J., Fraser, S., Baron, M. (2013), Analysis of primitive erythroid cell proliferation and enucleation using a cyan fluorescent reporter in transgenic mice. Genesis. 51(11), 751-762. [Abstract]
  • Funnell, A., Mak, K., Twine, N., Pelka, G., Norton, L., Radziewic, T., Power, M., Wilkins, M., Bell-Anderson, K., Fraser, S., Perkins, A., Tam, P., Pearson, R., Crossley, M. (2013), Generation of mice deficient in both KLF3/BKLF and KLF8 reveals a genetic interaction and a role for these factors in embryonic globin gene silencing. Molecular and Cellular Biology. 33(15), 2976-2987. [Abstract]
  • Wee, N., Weinstein, D., Fraser, S., Assinder, S. (2013), The mammalian copper transporters CTR1 and CTR2 and their roles in development and disease. International Journal of Biochemistry & Cell Biology. 45(5), 960-963. [Abstract]
  • Fraser, S. (2013), The Modern Primitives: Applying New Technological Approaches to Explore the Biology of the Earliest Red Blood Cells. ISRN Hematology. 2013, 568928. [Abstract]
  • Sánchez-Pérez, A., Brown, G., Malik, R., Assinder, S., Cantlon, K., Gotsis, C., Dunbar, S., Fraser, S. (2013), Rapid detection of haemotropic mycoplasma infection of feline erythrocytes using a novel flow cytometric approach. Parasites & Vectors. 6, 158. [Abstract]

2012

   
  • Funnell, A., Norton, L., Mak, K., Burdach, J., Artuz, C., Twine, N., Wilkins, M., Power, C., Hung, T., Perdomo, J., Koh, P., Bell-Anderson, K., Orkin, S., Fraser, S., Perkins, A., Pearson, R., Crossley, M. (2012), The CACCC-binding protein KLF3/BKLF represses a subset of KLF1/EKLF target genes and is required for proper erythroid maturation in vivo. Molecular and Cellular Biology. 32(16), 3281-3292. [Abstract]
  • Baron, M., Isern, J., Fraser, S. (2012), The embryonic origins of erythropoiesis in mammals. Blood. 119(21), 4828-4837. [Abstract]
  • Mizuochi, C., Fraser, S., Biasch, K., Horio, Y., Kikushige, Y., Tani, K., Akashi, K., Tavian, M., Sugiyama, D. (2012), Intra-Aortic Clusters Undergo Endothelial to Hematopoietic Phenotypic Transition during Early Embryogenesis. PLoS One. 7(4), e35763. [Abstract]

2011

   
  • Isern, J., He, Z., Fraser, S., Nowotschin, S., Ferrer-Vaquer, A., Moore, R., Hadjantonakis, A., Schulz, V., Tuck, D., Gallagher, P., Baron, M. (2011), Single lineage transcriptome analysis reveals key regulatory pathways in primitive erythroid progenitors in the mouse embryo. Blood. 117(18), 4924-34. [Abstract]
  • Fraser, S., Midwinter, R., Berger, B., Stocker, R. (2011), Heme Oxygenase-1: A Critical Link between Iron Metabolism, Erythropoiesis, and Development. Advances in Hematology. 2011, 473709. [Abstract]
  • Sugiyama, D., Inoue-Yokoo, T., Fraser, S., Kulkeaw, K., Mizuochi, C., Horio, Y. (2011), Embryonic regulation of the mouse hematopoietic niche. The Scientific World Journal. 11, 1770-1780. [Abstract]

2010

   
  • Isern, J., Fraser, S., He, Z., Zhang, H., Baron, M. (2010), Dose-dependent regulation of primitive erythroid maturation and identity by the transcription factor Eklf. Blood. 116(19), 3972-80. [Abstract]
  • Isern, J., Fraser, S., He, Z., Baron, M. (2010), Developmental niches for embryonic erythroid cells. Blood cells, molecules & diseases. 44(4), 207-8. [Abstract]
  • Fraser, S., Isern, J., Baron, M. (2010), Use of transgenic fluorescent reporter mouse lines to monitor hematopoietic and erythroid development during embryogenesis. Methods in Enzymology. 476, 403-427. [Abstract]

2009

   
  • Zhang, H., Fraser, S., Papazoglu, C., Hoatlin, M., Baron, M. (2009), Transcriptional activation by the Mixl1 homeodomain protein in differentiating mouse embryonic stem cells. Stem Cells. 27(12), 2884-2895. [Abstract]
  • Fraser, S., Baron, M. (2009), Embryonic fates for extraembryonic lineages: New perspectives. Journal of Cellular Biochemistry. 107(4), 586-591. [Abstract]

2008

   
  • Isern, J., Fraser, S., He, Z., Baron, M. (2008), The fetal liver is a niche for maturation of primitive erythroid cells. Proceedings of the National Academy of Sciences of the United States of America. 105(18), 6662-6667. [Abstract]