Clinical Associate Professor Sandra O'Toole

Clinical Associate Professor
Medicine, Central Clinical School

C39 - Royal Prince Alfred Hospital
The University of Sydney
NSW 2006 Australia

T: 95157182
F: 951558405
E:

Research interests

My research interest focus on markers of breast cancer recurrence or progression in human tissues. I also have an interest in developmental pathways as potential novel therapeutic targets in breast cancer.

Keywords

Breast cancer

Publications

2013 | 2012 | 2011 | 2010 | 2009 | 2007

2013

   
  • Klein, O., Clements, A., Menzies, A., O'Toole, S., Kefford, R., Long, G. (2013), BRAF inhibitor activity in V600R metastatic melanoma. European Journal of Cancer. 49(5), 1073-1079. [Abstract]

2012

   
  • Coates, A., Millar, E., O'Toole, S., Molloy, T., Viale, G., Goldhirsch, A., Regan, M., Gelber, R., Sun, Z., Castiglione-Gertsch, M., Gusterson, B., Musgrove, E., Sutherland, R. (2012), Prognostic interaction between expression of p53 and estrogen receptor in patients with node-negative breast cancer: results from IBCSG Trials VIII and IX. Breast Cancer Research. 14(6), R143. [Abstract]

2011

   
  • Roberts, C., Millar, E., O'Toole, S., McNeil, C., Lehrbach, G., Pinese, M., Tobelmann, P., McCloy, R., Musgrove, E., Sutherland, R., Butt, A. (2011), Identification of PUMA as an estrogen target gene that mediates the apoptotic response to tamoxifen in human breast cancer cells and predicts patient outcome and tamoxifen responsiveness in breast cancer. Oncogene. 30(28), 3186-97. [Abstract]
  • Millar, E., Graham, P., McNeil, C., Browne, L., O'Toole, S., Boulghourjian, A., Kearsley, J., Papadatos, G., Delaney, G., Fox, C., Nasser, E., Capp, A., Sutherland, R. (2011), Prediction of outcome of early ER+ breast cancer is improved using a biomarker panel, which includes Ki-67 and p53. British journal of cancer. 105(2), 272-80. [Abstract]
  • O'Toole, S., Machalek, D., Shearer, R., Millar, E., Nair, R., Schofield, P., McLeod, D., Cooper, C., McNeil, C., McFarland, A., Nguyen, A., Ormandy, C., Qiu, M., Rabinovich, B., Martelotto, L., Vu, D., Hannigan, G., Musgrove, E., Christ, D., Sutherland, R., Watkins, D., Swarbrick, A. (2011), Hedgehog Overexpression Is Associated with Stromal Interactions and Predicts for Poor Outcome in Breast Cancer. Cancer Research. 71(11), 4002-4014. [Abstract]
  • O'Toole, S., Selinger, C., Millar, E., Lum, T., Beith, J. (2011), Molecular assays in breast cancer pathology. Pathology. 43(2), 116-127. [Abstract]
  • Cooper, W., O'toole, S., Boyer, M., Horvath, L., Mahar, A. (2011), What's new in non-small cell lung cancer for pathologists: the importance of accurate subtyping, EGFR mutations and ALK rearrangements. Pathology. 43(2), 103-115. [Abstract]
  • Chan, P., Möller, A., Liu, M., Sceneay, J., Wong, C., Waddell, N., Huang, K., Dobrovic, A., Millar, E., O'Toole, S., McNeil, C., Sutherland, R., Bowtell, D., Fox, S. (2011), The expression of the ubiquitin ligase SIAH2 (seven in absentia homolog 2) is mediated through gene copy number in breast cancer and is associated with a basal-like phenotype and p53 expression. Breast Cancer Research. 13(1), R19. [Abstract]
  • Colvin, E., Susanto, J., Kench, J., Ong, V., Mawson, A., Pinese, M., Chang, D., Rooman, I., O'Toole, S., Segara, D., Musgrove, E., Sutherland, R., Apte, M., Scarlett, C., Biankin, A. (2011), Retinoid signaling in pancreatic cancer, injury and regeneration. PloS One. 6(12), e29075. [Abstract]
  • Xu, H., Yan, M., Patra, J., Natrajan, R., Yan, Y., Swagemakers, S., Tomaszewski, J., Verschoor, S., Millar, E., van der Spek, P., Reis-Filho, J., Ramsay, R., O'Toole, S., McNeil, C., Sutherland, R., McKay, M., Fox, S. (2011), Enhanced RAD21 cohesin expression confers poor prognosis and resistance to chemotherapy in high grade luminal, basal and HER2 breast cancers. Breast cancer research : BCR. 13(1), R9. [Abstract]

2010

   
  • Hochgräfe, F., Zhang, L., O'Toole, S., Browne, B., Pinese, M., Porta Cubas, A., Lehrbach, G., Croucher, D., Rickwood, D., Boulghourjian, A., Shearer, R., Nair, R., Swarbrick, A., Faratian, D., Mullen, P., Harrison, D., Biankin, A., Sutherland, R., Raftery, M., Daly, R. (2010), Tyrosine Phosphorylation Profiling Reveals the Signaling Network Characteristics of Basal Breast Cancer Cells. Cancer research. 70(22), 9391-401. [Abstract]
  • Fleuren, E., O'Toole, S., Millar, E., McNeil, C., Lopez-Knowles, E., Boulghourjian, A., Croucher, D., Schramek, D., Brummer, T., Penninger, J., Sutherland, R., Daly, R. (2010), Overexpression of the oncogenic signal transducer Gab2 occurs early in breast cancer development. International journal of cancer. Journal international du cancer. 127(6), 1486-92. [Abstract]
  • Murphy, N., Biankin, A., Millar, E., McNeil, C., O'Toole, S., Segara, D., Crea, P., Olayioye, M., Lee, C., Fox, S., Morey, A., Christie, M., Musgrove, E., Daly, R., Lindeman, G., Henshall, S., Visvader, J., Sutherland, R. (2010), Loss of STARD10 expression identifies a group of poor prognosis breast cancers independent of HER2/Neu and triple negative status. International journal of cancer. Journal international du cancer. 126(6), 1445-53. [Abstract]
  • Palmer, C., Corpuz, T., Guirguis, M., O'Toole, S., Yan, K., Bu, Y., Jorgenson, J., Talbot, M., Lloyd, A., Zekry, A. (2010), The effect of obesity on intrahepatic cytokine and chemokine expression in chronic hepatitis C infection. Gut. 59(0), 397-404. [Abstract]
  • López-Knowles, E., O'Toole, S., McNeil, C., Millar, E., Qiu, M., Crea, P., Daly, R., Musgrove, E., Sutherland, R. (2010), PI3K pathway activation in breast cancer is associated with the basal-like phenotype and cancer-specific mortality. International journal of cancer. Journal international du cancer. 126(5), 1121-31. [Abstract]
  • Zardawi, S., Zardawi, I., McNeil, C., Millar, E., McLeod, D., Morey, A., Crea, P., Murphy, N., Pinese, M., Lopez-Knowles, E., Oakes, S., Ormandy, C., Qiu, M., Hamilton, A., Spillane, A., Soon Lee, C., Sutherland, R., Musgrove, E., O'Toole, S. (2010), High Notch1 protein expression is an early event in breast cancer development and is associated with the HER-2 molecular subtype. Histopathology. 56(3), 286-296. [Abstract]
  • Nair, R., Junankar, S., O'Toole, S., Shah, J., Borowsky, A., Bishop, J., Swarbrick, A. (2010), Redefining the expression and function of the inhibitor of differentiation 1 in mammary gland development. PLoS One. 5(8), e11947. [Abstract]
  • López-Knowles, E., Zardawi, S., McNeil, C., Millar, E., Crea, P., Musgrove, E., Sutherland, R., O'Toole, S. (2010), Cytoplasmic localization of beta-catenin is a marker of poor outcome in breast cancer patients. Cancer Epidemiology, Biomarkers & Prevention. 19(1), 301-309. [Abstract]

2009

   
  • Millar, E., Graham, P., O'Toole, S., McNeil, C., Browne, L., Morey, A., Eggleton, S., Beretov, J., Theocharous, C., Capp, A., Nasser, E., Kearsley, J., Delaney, G., Papadatos, G., Fox, C., Sutherland, R. (2009), Prediction of local recurrence, distant metastases, and death after breast-conserving therapy in early-stage invasive breast cancer using a five-biomarker panel. Journal of Clinical Oncology. 27(28), 4701-4708. [Abstract]
  • O'Toole, S., Swarbrick, A., Sutherland, R. (2009), The Hedgehog signalling pathway as a therapeutic target in early breast cancer development. Expert Opinion On Therapeutic Targets. 13(9), 1095-1103. [Abstract]
  • Millar, E., Dean, J., McNeil, C., O'Toole, S., Henshall, S., Tran, T., Lin, J., Quong, A., Comstock, C., Witkiewicz, A., Musgrove, E., Rui, H., Lemarchand, L., Setiawan, V., Haiman, C., Knudsen, K., Sutherland, R., Knudsen, E. (2009), Cyclin D1b protein expression in breast cancer is independent of cyclin D1a and associated with poor disease outcome. Oncogene. 28(15), 1812-1820. [Abstract]
  • Zardawi, S., O'Toole, S., Sutherland, R., Musgrove, E. (2009), Dysregulation of Hedgehog, Wnt and Notch signalling pathways in breast cancer. Histology and histopathology. 24(3), 385-398. [Abstract]
  • Tan, E., Yan, M., Campo, L., Han, C., Takano, E., Turley, H., Candiloro, I., Pezzella, F., Gatter, K., Millar, E., O'Toole, S., McNeil, C., Crea, P., Segara, D., Sutherland, R., Harris, A., Fox, S. (2009), The key hypoxia regulated gene CAIX is upregulated in basal-like breast tumours and is associated with resistance to chemotherapy. British journal of cancer. 100(2), 405-11. [Abstract]
  • Millar, E., Anderson, L., McNeil, C., O'Toole, S., Pinese, M., Crea, P., Morey, A., Biankin, A., Henshall, S., Musgrove, E., Sutherland, R., Butt, A. (2009), BAG-1 predicts patient outcome and tamoxifen responsiveness in ER-positive invasive ductal carcinoma of the breast. British Journal of Cancer. 100(1), 123-133. [Abstract]
  • Kitzing, B., O'Toole, S., Waugh, A., Clayton, J., McGill, N., Allman, K. (2009), Hepatobiliary scintigraphy in vasculitis of the gallbladder as a manifestation of polyarteritis nodosa: a case report. Cases Journal. 2, 9300. [Abstract]

2007

   
  • Biankin, S., Collector, M., Biankin, A., Brown, L., Kleeberger, W., Devereux, W., Zahnow, C., Baylin, S., Watkins, D., Sharkis, S., Leach, S. (2007), A histological survey of green fluorescent protein expression in 'green' mice: implications for stem cell research. Pathology. 39(2), 247-251. [Abstract]