Associate Professor Susan McLennan

Principal Research Fellow & Associate Professor
Medicine, Central Clinical School
Bosch Institute

D06 - Blackburn Building
The University of Sydney
NSW 2006 Australia

T: 02 95155185
F: 02 95161273

Research interests

Diabetes and its complications

Current national competitive grants*


Role of Inflammation in Diabetic Cardiomyopathy
Twigg S, King N, McLennan S
NHMRC Project Grants ($476,325 over 3 years)

* Grants administered through the University of Sydney


2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008


  • McGrath, K., Li, X., Whitworth, P., Kasz, R., Tan, J., McLennan, S., Celermajer, D., Barter, P., Rye, K., Heather, A. (2014), High density lipoproteins improve insulin sensitivity in high fat diet fed mice by suppressing hepatic inflammation. Journal of Lipid Research. 55(3), 421-430. [Abstract]
  • Tu, T., Budzinska, M., Maczurek, A., Cheng, R., Di Bartolomeo, A., Warner, F., McCaughan, G., McLennan, S., Shackel, N. (2014), Novel aspects of the liver microenvironment in hepatocellular carcinoma pathogenesis and development. International Journal of Molecular Sciences. 15(6), 9422-9458. [Abstract]
  • Calabro, S., Maczurek, A., Morgan, A., Tu, T., Wen, V., Yee, C., Mridha, A., Lee, M., d'Avigdor, W., Locarnini, S., McCaughan, G., Warner, F., McLennan, S., Shackel, N. (2014), Hepatocyte Produced Matrix Metalloproteinases Are Regulated by CD147 in Liver Fibrogenesis. PloS One. 9(7), e90571. [Abstract]
  • Keane, F., Yao, T., Seelk, S., Gall, M., Chowdhury, S., Poplawski, S., Lai, J., Li, Y., Wu, W., Farrell, P., Vieira de Ribeiro, A., Osborne, B., Yu, D., Seth, D., Rahman, K., Haber, P., Topaloglu, A., Wang, C., Thomson, S., Hennessy, A., Prins, J., Twigg, S., McLennan, S., McCaughan, G., Bachovchin, W., Gorrell, M. (2014), Quantitation of fibroblast activation protein (FAP)-specific protease activity in mouse, baboon and human fluids and organs. FEBS Open Bio. 4, 43-54. [Abstract]


  • Williams, K., Shackel, N., Gorrell, M., McLennan, S., Twigg, S. (2013), Diabetes and Nonalcoholic Fatty Liver Disease: A Pathogenic Duo. Endocrine Reviews. 34(1), 84-129. [Abstract]
  • McLennan, S., Abdollahi, M., Twigg, S. (2013), Connective tissue growth factor, matrix regulation, and diabetic kidney disease. Current Opinion in Nephrology & Hypertension. 22.(1), 85-92. [Abstract]
  • McLennan, S., Warner, F., Shackel, N. (2013), The role of CD147 in Liver Injury - "The truth is in the details". Journal of Hepatology. , 836-837. [Abstract]
  • Tan, J., McLennan, S., Williams, P., Rezaeizadeh, A., Lo, L., Bonner, J., Twigg, S. (2013), Connective tissue growth factor/CCN-2 is upregulated in epididymal and subcutaneous fat depots in a dietary-induced obesity model. American Journal of Physiology. Endocrinology and Metabolism. 304(12), E1291-1302. [Abstract]
  • Boughton, E., McLennan, S. (2013), Biomemetic scaffolds for skin tissue and wound repair. In: Biomimetic Biomaterials: Structure and Applications. (pp.153-180).United Kingdom: Woodhead Publishing Limited.


  • Min, D., Brooks, B., Wong, J., Salomon, R., Bao, W., Harrisberg, B., Twigg, S., Yue, D., McLennan, S. (2012), Alterations in Monocyte CD16 in Association with Diabetes Complications. Mediators of Inflammation. 2012, 649083. [Abstract]
  • Twigg, S., McLennan, S. (2012), Managing diabetes complications in the clinical arena. In: A Modern Epidemic. (pp.353-371).Australia: Sydney University Press.


  • Lo, L., McLennan, S., F Williams, P., Bonner, J., Chowdhury, S., McCaughan, G., Gorrell, M., Yue, D., Twigg, S. (2011), Diabetes is a progression factor for hepatic fibrosis in a high fat fed mouse obesity model of non-alcoholic steatohepatitis. Journal of hepatology. 55(2), 435-44. [Abstract]
  • Wang, X., McLennan, S., Twigg, S. (2011), CCN-2 is up-regulated by and mediates effects of matrix bound advanced glycated end-products in human renal mesangial cells. Journal of cell communication and signaling. 5(3), 193-200. [Abstract]


  • Bao, W., Min, D., Twigg, S., Shackel, N., Warner, F., Yue, D., McLennan, S. (2010), Monocyte CD147 is induced by Advanced Glycation Endproducts (AGEs) and High Glucose Concentration: Possible role in diabetic complications. American journal of physiology. Cell physiology. 299(5), C1212-9. [Abstract]
  • Ban, C., Twigg, S., Franjic, B., Brooks, B., Celermajer, D., Yue, D., McLennan, S. (2010), Serum MMP-7 is increased in diabetic renal disease and diabetic diastolic dysfunction. Diabetes Research and Clinical Practice. 87(3), 335-341. [Abstract]
  • Thomson, S., McLennan, S., Hennessy, A., Boughton, P., Bonner, J., Zoellner, H., Yue, D., Twigg, S. (2010), A novel primate model of delayed wound healing in diabetes: dysregulation of connective tissue growth factor. Diabetologia. 53(3), 572-83. [Abstract]
  • Wang, X., McLennan, S., Allen, T., Twigg, S. (2010), Regulation of pro-inflammatory and pro-fibrotic factors by CCN2/CTGF in H9c2 cardiomyocytes. Journal of Cell Communication and Signaling. 4(1), 15-23. [Abstract]


  • Wang, X., McLennan, S., Allen, T., Tsoutsman, T., Semsarian, C., Twigg, S. (2009), Adverse effects of high glucose and free fatty acid on cardiomyocytes are mediated by connective tissue growth factor. American journal of physiology. Cell physiology. 297(6), C1490-500. [Abstract]
  • Min, D., Lyons, J., Bonner, J., Twigg, S., Yue, D., McLennan, S. (2009), Mesangial cell-derived factors alter monocyte activation and function through inflammatory pathways: possible pathogenic role in diabetic nephropathy. American Journal of Physiology: Renal Physiology. 297(5), F1229-F1237. [Abstract]
  • Wong, J., McLennan, S., Molyneaux, L., Min, D., Twigg, S., Yue, D. (2009), Mitochondrial DNA content in peripheral blood monocytes: relationship with age of diabetes onsetand diabetic complications. Diabetologia. 52(9), 1953-61. [Abstract]
  • Liu, Y., Min, D., Bolton, T., NubĂ©, V., Twigg, S., Yue, D., McLennan, S. (2009), Increased Matrix Metalloproteinase-9 Predicts Poor Wound Healing in Diabetic Foot Ulcers. Diabetes care. 32(1), 117-9. [Abstract]


  • Tan, J., McLennan, S., Song, W., Lo, L., Bonner, J., Williams, P., Twigg, S. (2008), Connective tissue growth factor inhibits adipocyte differentiation. American journal of physiology. Cell physiology. 295(3), C740-51. [Abstract]
  • Brooks, B., Heffernan, S., Thomson, S., McLennan, S., Twigg, S., Yue, D. (2008), The effects of diabetes and aminoguanidine treatment on endothelial function in a primate model of type 1 diabetes. American journal of primatology. 70(8), 796-802. [Abstract]
  • Brooks, B., McLennan, S., Twigg, S., Yue, D. (2008), Detection and characterisation of microcirculatory abnormalities in the skin of diabetic patients with microvascular complications. Diabetes & Vascular Disease Research. 5(1), 30-35. [Abstract]
  • McLennan, S., Min, D., Yue, D. (2008), Matrix metalloproteinases: their role in poor wound healing in diabetes. Wound Practice & Research. 16, 116-120.
  • McLennan, S., Bonner, J., Milne, S., Lo, L., Charlton, A., Kurup, S., Jia, J., Yue, D., Twigg, S. (2008), The anti-inflammatory agent Propolis improves wound healing in a rodent model of experimental diabetes. Wound Repair and Regeneration. 16(5), 706-713. [Abstract]
  • Thomson, S., McLennan, S., Kirwan, P., Heffernan, S., Hennessy, A., Yue, D., Twigg, S. (2008), Renal connective tissue growth factor correlates with glomerular basement membrane thickness and prospective albuminuria in a non-human primate model of diabetes: possible predictive marker for incipient diabetic nephropathy. Journal of diabetes and its complications. 22(4), 284-94. [Abstract]