Professor Tailoi Chan-Ling

Professor of Neurobiology & Visual Science
Anatomy & Histology, School of Medical Sciences
Bosch Institute

F13 - Anderson Stuart Building
The University of Sydney
NSW 2006 Australia

T: +61 2 9351 2596
F: +61 2 9351 6556
E:

Research interests

Dr Chan-Ling has made a sustained contribution to the understanding of glial-vascular biology during normal CNS development as well as key understanding to the disease processes in Retinopathy of Prematurity (the leading cause of infant blindness in the world) animal models of multiple sclerosis, cerebral malaria and inflammation.

International links

United Kingdom. (Department of Opthalmology & Visual Science, Queens University Belfast.) Dr Tom Gardiner - Collaborative studies utilising transmission electron microscopy to characterise changes in pericyte and smooth muscle cell ensheathment of retinal and choroidal blood vessels during normal development, in disease and in aging. Publications arising. Chan-Ling T, Page M, Gardiner T, Baxter L and Hughes S, Desmin Ensheathment ratio (DER) as an indicator of vessel stability: Evidence in normal development and in Retinopathy of prematurity (2004) 165(4) American Journal of Pathology 1301. Hughes S, Gardiner T, Hu P, Baxter E, Rosinova E and Chan-Ling T, Altered pericyte-endothelial relationship during physiological aging: Implications for vessel stability (2006) 27(12) Neurobiology of Aging 1838. E article, available, Nov 2005. http://linkinghub.elsevier.com/retrieve/pii/S0197458005003490 Hughes S, Gardiner T, Baxter L, Chan-Ling T, Changes in pericytes and smooth muscle cells in the kitten model of Retinopathy of Prematurity (ROP): Implications for plus disease (2007) 48 Investigative Ophthalmology and Visual Science 1368-1379..
United States. (Department of Pharmacology & Therapeutics, University of Florida) Professor Maria Grant - Collaborative studies to maximise the repair functions of hematopoietic stem cells in stemming vision loss. Two grants awarded to Professor Chan-Ling (International Science Linkages grant, Department of Education, Science and Technology). Publications arising: Chan-Ling T, Baxter L, Afzal A, Sengupta N, Caballero S, Rosinova E and Grant MB, Hematopoietic stem cells provide repair functions after laser-induced Bruchs membrane rupture model of choroidal neovascularisation (2006) 168 American Journal of Pathology 1031. Chang KH, Chan-Ling T, McFarland EL, Afzal A, Pan H, Baxter LC, Shaw LC, Caballero S, Sengupta N, Calzi SL, Sullivan SM, and Grant MB, IGF Binding Protein-3 Regulates Hematopoietic Stem and Endothelial Precursor Cell Differentiation, Migration and Retinal Development (2007) 104 Proceedings of the National Academy of Sciences (PNAS) 10595 Kielczewski JL, McFarland EL, Jarajapu Y, Afzal A, Calzi S, Chang KH, Lydic T, Shaw LC, Busik J, Hughes J, Cardounel AJ, Wilson K, Lyons TJ, Cai J, Boulton ME, Mames RN, Gardiner T, Chan-Ling T, and Grant MB, Insulin-like growth factor binding protein-3 (IGFBP-3) mediates vascular repair by enhancing nitric oxide generation. (2009) J Circulation Research. Accepted.
United States. (Department of Neurology, University of Washington) Undertook lab visit in January 2008 to gain training in the application of the Helios Gene Gun for complete visualisation of cell morphology. Future visits will provide further experience with HPLC and imaging of ion sensitive dyes with the aim of gaining insights into glial, neuronal and vascular interactions using the rat retinal wholemount preparation. Calcium imaging and hemichannels on human fetal astrocytes. Publication arising: Co-authored a comprehensive review of astrocyte developmental biology and astrocyte function, Ransom and Chan-Ling, In Youmans Neurological Surgery, 2004..
Australia. (Canberra Hospital, Australian National University) Collaborative work with Professor Jane Dahlstrom - Histopathologist. Publications arising: Cellular and molecular mechanisms of formation of the human choroidal and retinal vasculature. Papers arising: Chan-Ling T, Baxter LC, Sterling RA, Dahlstrom J, Bean EG, Hughes S, Human choroidal formation takes place via hematopoietic differentiation, vasculogenesis and angiogenesis Submitted for publication..
United States. (Harkness Eye Institute, Columbia University) Professor John Flynn - Understanding Retinopathy of Prematurity: The Gift of Sight. Professor Chan-Ling currently holds the appointment of Adjunct Professor of Ophthalmic Science(Ophthalmology),Harkness Eye Institute, Columbia University Medical Center New York, USA Publication arising: ROP, Two distinct mechanisms underlying Zone 1 Zone 2 disease (2006) 142 American Journal of Ophthalmology 46.

Publications

2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008

2014

   
  • Braidy, N., Poljak, A., Grant, R., Jayasena, T., Mansour, H., Chan-Ling, T., Guillemin, G., Smythe, G., Sachdev, P. (2014), Mapping NAD(+) metabolism in the brain of ageing Wistar rats: potential targets for influencing brain senescence. Biogerontology. 15, 177¿198. [Abstract]

2013

   
  • Hu, P., Thinschmidt, J., Yan, Y., Hazra, S., Bhatwadekar, A., Caballero, S., Salazar, T., Miyan, J., Li, W., Derbenev, A., Zsombok, A., Tikhonenko, M., Dominguez, J., McGorray, S., Saban, D., Boulton, M., Busik, J., Raizada, M., Chan-Ling, T., Grant, M. (2013), CNS inflammation and bone marrow neuropathy in type 1 diabetes. The American Journal of Pathology. 183(5), 1608-1620. [Abstract]
  • Mansour, H., McColm, J., Cole, L., Weible, M., Korlimbinis, A., Chan-Ling, T. (2013), Connexin 30 expression and frequency of connexin heterogeneity in astrocyte gap junction plaques increase with age in the rat retina. PloS One. 8(3), e57038. [Abstract]

2012

   
  • Kur, J., Newman, E., Chan-Ling, T. (2012), Cellular and physiological mechanisms underlying blood flow regulation in the retina and choroid in health and disease. Progress in Retinal and Eye Research. 31(5), 377-406. [Abstract]
  • Combes, V., Guillemin, G., Chan-Ling, T., Hunt, N., Grau, G. (2012), The crossroads of neuroinflammation in infectious diseases: endothelial cells and astrocytes. Trends in Parasitology. 28(8), 311-319. [Abstract]
  • Jarajapu, Y., Cai, J., Yan, Y., Li Calzi, S., Kielczewski, J., Hu, P., Shaw, L., Firth, S., Chan-Ling, T., Boulton, M., Baxter, R., Grant, M. (2012), Protection of blood retinal barrier and systemic vasculature by insulin-like growth factor binding protein-3. PLoS One. 7(7), e39398. [Abstract]

2011

   
  • Braidy, N., Guillemin, G., Mansour, H., Chan-Ling, T., Grant, R. (2011), Changes in kynurenine pathway metabolism in the brain, liver and kidney of aged female Wistar rats. The FEBS Journal. 278(22), 4425-4434. [Abstract]
  • Ampawong, S., Combes, V., Hunt, N., Radford, J., Chan-Ling, T., Pongponratn, E., Grau, G. (2011), Quantitation of brain edema and localisation of aquaporin 4 expression in relation to susceptibility to experimental cerebral malaria. International Journal of Clinical and Experimental Pathology. 4(6), 566-574. [Abstract]
  • Chan-Ling, T., Dahlstrom, J., Koina, M., McColm, J., Sterling, R., Bean, E., Adamson, S., Hughes, S., Baxter, L. (2011), Evidence of hematopoietic differentiation, vasculogenesis and angiogenesis in the formation of human choroidal blood vessels. Experimental Eye Research. 92(5), 361-376. [Abstract]
  • Kielczewski, J., Hu, P., Shaw, L., Li Calzi, S., Mames, R., Gardiner, T., McFarland, E., Chan-Ling, T., Grant, M. (2011), Novel protective properties of IGFBP-3 result in enhanced pericyte ensheathment, reduced microglial activation, increased microglial apoptosis, and neuronal protection after ischemic retinal injury. The American Journal of Pathology. 178(4), 1517-1528. [Abstract]
  • Hunt, G., Van Nieuwenhuijzen, P., Chan-Ling, T., McGregor, I. (2011), 'When an old rat smells a cat': A decline in defense-related, but not accessory olfactory, Fos expression in aged rats. Neurobiology of aging. 32(4), 737-49. [Abstract]
  • Kielczewski, J., Li Calzi, S., Shaw, L., Cai, J., Qi, X., Ruan, Q., Wu, L., Liu, L., Hu, P., Chan-Ling, T., Mames, R., Firth, S., Baxter, R., Turowski, P., Busik, J., Boulton, M., Grant, M. (2011), Free insulin-like growth factor binding protein-3 (IGFBP-3) reduces retinal vascular permeability in association with a reduction of acid sphingomyelinase (ASMase). Investigative Ophthalmology & Visual Science. 52(11), 8278-8286. [Abstract]
  • Chan-Ling, T., Koina, M., McColm, J., Dahlstrom, J., Bean, E., Adamson, S., Yun, S., Baxter, L. (2011), Role of CD44+ stem cells in mural cell formation in the human choroid: evidence of vascular instability due to limited pericyte ensheathment. Investigative Ophthalmology & Visual Science. 52(1), 399-410. [Abstract]
  • Braidy, N., Guillemin, G., Mansour, H., Chan-Ling, T., Poljak, A., Grant, R. (2011), Age related changes in NAD+ metabolism oxidative stress and sirt1 activity in wistar rats. PloS one. 6(4), e19194. [Abstract]

2010

   
  • Chan-Ling, T. (2010), Development of the Retinal Vasculature. In: Encyclopedia of the Eye. (pp.22-34).United Kingdom, Unit: Elsevier Ltd..

2009

   
  • Howitt, J., Putz, U., Lackovic, J., Doan, A., Dorstyn, L., Cheng, H., Yang, B., Chan-Ling, T., Silke, J., Kumar, S., Tan, S. (2009), Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons. Proceedings of the National Academy of Sciences. 106(36), 15489-15494. [Abstract]
  • Kielczewski, J., Jarajapu, Y., McFarland, E., Cai, J., Afzal, A., Calzi, S., Chang, K., Lydic, T., Shaw, L., Busik, J., Hughes, J., Cardounel, A., Wilson, K., Lyons, T., Boulton, M., Mames, R., Chan-Ling, T., Grant, M. (2009), Insulin-Like Growth Factor Binding Protein-3 Mediates Vascular Repair by Enhancing Nitric Oxide Generation. Circulation Research. 105, 897-905. [Abstract]
  • Chan-Ling, T., Chu, Y., Baxter, L., Weible Ii, M., Hughes, S. (2009), In vivo characterization of astrocyte precursor cells (APCs) and astrocytes in developing rat retinae: Differentiation, proliferation, and apoptosis. Glia. 57(1), 39-53. [Abstract]

2008

   
  • Huang, W., Chamberlain, C., Sarafian, R., Chan-Ling, T. (2008), MHC class II expression by beta2 integrin (CD18)-positive microglia, macrophages and macrophage-like cells in rabbit retina. Neuron glia biology. 4(4), 285-94. [Abstract]
  • Mansour, H., Chamberlain, C., Weible, M., Hughes, S., Chu, Y., Chan-Ling, T. (2008), Aging-related changes in astrocytes in the rat retina: Imbalance between cell proliferation and cell death reduces astrocyte availability. Aging cell. 7(4), 526-40. [Abstract]
  • Kuo, I., Chan-Ling, T., Wojcikiewicz, R., Hill, C. (2008), Limited Intravascular Coupling in the Rodent Brainstem and Retina Supports a Role for Glia in Regional Blood Flow. Journal of Comparative Neurology. 511(6), 773-787. [Abstract]
  • Chan-Ling, T. (2008), Vasculogenesis and Angiogenesis in Formation of the Human Retinal Vasculature. In: Retinal and Choroidal Angiogenesis. (pp.119-138).The Netherlands: Springer Netherlands.