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Associate Professor Tracy Bryan

Unit Head, Cell Biology Research Unit
Medicine, Children's Medical Research Institute

T: +61 2 9687 2800
F: +61 2 9687 2120
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Research interests

Dr Bryan discovered a new mechanism for cell immortalization called ALT and has since established her own laboratory to continue studies into the role of telomeres in human tumours.

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PhD and Masters' project opportunities

Biochemistry and cell biology of the cancer-associated enzyme telomerase   +

+ indicates the opportunity is full and unavailable.

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Keywords

Telomerase; Ageing; Biochemistry

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Publications

2012 | 2011 | 2010 | 2009 | 2008 | 2007

2012

   
  • Conomos, D., Stutz, M., Hills, M., Neumann, A., Bryan, T., Reddel, R., Pickett, H. (2012), Variant repeats are interspersed throughout the telomeres and recruit nuclear receptors in ALT cells. The Journal of Cell Biology. 199(6), 893-906. [Abstract]
  • Stern, J., Zyner, K., Pickett, H., Cohen, S., Bryan, T. (2012), Telomerase Recruitment Requires both TCAB1 and Cajal Bodies Independently. Molecular and Cellular Biology. 32(13), 2384-2395. [Abstract]

2011

   
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  • Bryan, T., Baumann, P. (2011), G-Quadruplexes: From Guanine Gels to Chemotherapeutics. Molecular biotechnology. 49(2), 198-208. [Abstract]
  • Jurczyluk, J., Nouwens, A., Holien, J., Adams, T., Lovrecz, G., Parker, M., Cohen, S., Bryan, T. (2011), Direct involvement of the TEN domain at the active site of human telomerase. Nucleic acids research. 39, 1774-88. [Abstract]

2010

   
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  • Bryan, T., Baumann, P. (2010), G-quadruplexes: from guanine gels to chemotherapeutics. Methods in Molecular Biology. 608, 1-16. [Abstract]

2009

   
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  • Bryan, T. (2009), Telomeres and the End Replication Problem. In: Molecular Themes in DNA Replication. (pp.217-268).Colchester, UK: RSC Publishing.

2008

   
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  • Cao, Y., Bryan, T., Reddel, R. (2008), Increased copy number of the TERT and TERC telomerase subunit genes in cancer cells. Cancer Science. 99(6), 1092-1099. [Abstract]
  • Cao, Y., Huschtscha, L., Nouwens, A., Pickett, H., Neumann, A., Chang, A., Toouli, C., Bryan, T., Reddel, R. (2008), Amplification of telomerase reverse transcriptase gene in human mammary epithelial cells with limiting telomerase RNA expression levels. Cancer research. 68(9), 3115-3123. [Abstract]
  • Finger, S., Bryan, T. (2008), Multiple DNA-binding sites in Tetrahymena telomerase. Nucleic Acids Research. 36(4), 1260-1272. [Abstract]
  • Stern, J., Bryan, T. (2008), Telomerase recruitment to telomeres. Cytogenetic and Genome Research. 122(3-4), 243-254. [Abstract]

2007

   
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  • Bryan, T., Jarstfer, M. (2007), Interrogation of G-quadruplex-protein interactions. Methods (San Diego, Calif.). 43(4), 332-339. [Abstract]
  • Oganesian, L., Graham, M., Robinson, P., Bryan, T. (2007), Telomerase Recognizes G-Quadruplex and Linear DNA as Distinct Substrates. Biochemistry. 46(40), 11279-90. [Abstract]
  • Oganesian, L., Bryan, T. (2007), Physiological relevance of telomeric G-quadruplex formation: a potential drug target. BioEssays : news and reviews in molecular, cellular and developmental biology. 29(2), 155-165. [Abstract]