Dr Thomas Grewal

Senior Lecturer, Pharmaceutical Chemistry; Research Theme Leader, Cardiovascular and Diabetes
Cancer Education Working Group member
Faculty of Pharmacy

A15 - Pharmacy and Bank Building
The University of Sydney
NSW 2006 Australia

T: +61 2 9351 8496

Biographical details

After completing his PhD on gene regulation in Germany in 1993, Associate Professor Thomas Grewal studied lipoprotein receptors during postdoctoral fellowships at the Heart Research Institute (HRI, Sydney) and the Clinical Research Institute (Montreal, Canada). From 1997-2003, Thomas Grewal led a research group at the University Hospital Eppendorf (Hamburg, Germany) and later (2003-2007) at the Centre for Immunology (CFI, St Vincent’s Hospital, Sydney). Thomas Grewal joined the Faculty of Pharmacy in October 2007. His research examines the link between membrane transport and cell signalling, which regulates spatiotemporal signalling in health and disease. Utilising a multi-disciplinal approach involving biochemistry, molecular cell biology, and state-of-the-art microscopy, he has developed an expertise in scaffolding proteins and cellular cholesterol transport, which coordinates the localisation/activity of signaling complexes and receptors.

Research interests

  • Regulation of EGFR/Ras signalling and trafficking.

  • Ras signaling and stimulation of cholesterol efflux in atherosclerosis.

  • Role of Annexin A6 in cholesterol export from late endosomes and caveolae/lipid raft formation.

Teaching areas

Associate Professor Thomas Grewal is currently supervising three PhD and one honours student and is Associate Supervisor of three PhD students. Overall he has supervised 17 MD, 10 Honours, four PhD, four postdoctoral scientists and co-supervised 14 PhD and four honours students. He gives lectures and tutorials focusing on drugs targeting signalling molecules and lipids in cardiovascular disease and cancer. He coordinates lectures/tutorial for fourth year Pharmacy students (BPharm), and as postgraduate coordinator (2010-2011), was involved in student consultation, development of under-/postgraduate student programs and student assessments.


2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008


  • Hoque, M., Rentero, C., Cairns, R., Tebar, F., Enrich, C., Grewal, T. (2014), Annexins - scaffolds modulating PKC localization and signaling. Cellular Signalling. 26(6), 1213-12125. [Abstract]
  • Reverter, M., Rentero, C., Garcia-Melero, A., Hoque, M., Vilà de Muga, S., Álvarez-Guaita, A., Conway, J., Wood, P., Cairns, R., Lykopoulou, L., Grinberg, D., Vilageliu, L., Bosch, M., Heeren, J., Blasi, J., Timpson, P., Pol, A., Tebar, F., Murray, R., Grewal, T., Enrich, C. (2014), Cholesterol Regulates Syntaxin 6 Trafficking at trans-Golgi Network Endosomal Boundaries. Cell Reports. 7(3), 883-897. [Abstract]
  • Tebar, F., Gelebert-Baldrich, M., Hoque, M., Cairns, R., Rentero, C., Pol, A., Grewal, T., Enrich, C. (2014), Annexins and Endosomal Signaling. In: Methods in Enzymology: Vol 535, Endosome Signaling Part B. (pp.56-74).Netherlands: Elsevier Inc..


  • Poeter, M., Radke, S., Koese, M., Hessner, F., Hegemann, A., Musiol, A., Gerke, V., Grewal, T., Rescher, U. (2013), Disruption of the annexin A1/S100A11 complex increases the migration and clonogenic growth by dysregulating epithelial growth factor (EGF) signaling. Biochimica et Biophysica Acta. 1833(7), 1700-1711. [Abstract]
  • Yeung, Y., McDonald, K., Grewal, T., Munoz, L. (2013), Interleukins in glioblastoma pathophysiology: implications for therapy. British Journal of Pharmacology. 168(3), 591-606. [Abstract]
  • Kim, M., Lee, K., Iseli, T., Hoy, A., George, J., Grewal, T., Roufogalis, B. (2013), Compound K modulates fatty acid-induced lipid droplet formation and expression of proteins involved in lipid metabolism in hepatocytes. Liver International. 33, 1583-1593. [Abstract]
  • Koese, M., Rentero, C., Kota, B., Hoque, M., Cairns, R., Wood, P., Vil�� de Muga, S., Reverter, M., Alvarez-Guaita, A., Monastyrskaya, K., Hughes, W., Swarbrick, A., Tebar, F., Daly, R., Enrich, C., Grewal, T. (2013), Annexin A6 is a scaffold for PKCα to promote EGFR inactivation. Oncogene. 32(23), 2858-2872. [Abstract]
  • Mulay, V., Wood, P., Manetsch, M., Darabi, M., Cairns, R., Hoque, M., Chan, K., Reverter, M., Alvarez-Guaita, A., Rye, K., Rentero, C., Heeren, J., Enrich, C., Grewal, T. (2013), Inhibition of Mitogen-Activated Protein Kinase Erk1/2 Promotes Protein Degradation of ATP Binding Cassette Transporters A1 and G1 in CHO and HuH7 Cells. PloS One. 8(4), e62667. [Abstract]
  • Musiol, A., Gran, S., Ehrhardt, C., Ludwig, S., Grewal, T., Gerke, V., Rescher, U. (2013), Annexin A6-balanced late endosomal cholesterol controls influenza a replication and propagation. mBio. 4(6), e00608-e00613. [Abstract]


  • Jiang, L., Salao, K., Li, H., Rybicka, J., Yates, R., Luo, X., Shi, X., Kuffner, T., Tsai, V., Husaini, Y., Wu, L., Brown, D., Grewal, T., Brown, L., Curmi, P., Breit, S. (2012), Intracellular chloride channel protein CLIC1 regulates macrophage function through modulation of phagosomal acidification. Journal of Cell Science. 125(Pt 22), 5479-5488. [Abstract]
  • Yeung, Y., Bryce, N., Adams, S., Braidy, N., Konayagi, M., McDonald, K., Teo, C., Guillemin, G., Grewal, T., Munoz, L. (2012), p38 MAPK inhibitors attenuate pro-inflammatory cytokine production and the invasiveness of human U251 glioblastoma cells. Journal of Neuro-Oncology. 109, 35-44. [Abstract]
  • Roufogalis, B., Grewal, T. (2012), New methodology and approaches to intracellular lipid transport in atherosclerosis and cardiovascular disease. Current Pharmaceutical Biotechnology. 13, 276-277. [Abstract]
  • Mulay, V., Wood, P., Rentero, C., Enrich, C., Grewal, T. (2012), Signal Transduction Pathways Provide Opportunities to Enhance HDL and apoAI-Dependent Reverse Cholesterol Transport. Current Pharmaceutical Biotechnology. 13(2), 352-364. [Abstract]
  • Kim, M., Kung, S., Grewal, T., Roufogalis, B. (2012), Methodologies for Investigating Natural Medicines for the Treatment of Nonalcoholic Fatty Liver Disease (NAFLD). Current Pharmaceutical Biotechnology. 13(2), 278-291. [Abstract]
  • Laatsch, A., Panteli, M., Sornsakrin, M., Hoffzimmer, B., Grewal, T., Heeren, J. (2012), Low density lipoprotein receptor-related protein 1 dependent endosomal trapping and recycling of apolipoprotein E. PloS One. 7(1), e29385. [Abstract]


  • Toh, D., Murray, M., Pern, T., Mulay, V., Grewal, T., Lee, E., Zhou, F. (2011), Functional analysis of pharmacogenetic variants of human organic cation/carnitine transporter 2 (hOCTN2) identified in Singaporean populations. Biochemical pharmacology. 82(11), 1692-9. [Abstract]
  • Reverter, M., Rentero, C., de Muga, S., Alvarez-Guaita, A., Mulay, V., Cairns, R., Wood, P., Monastyrskaya, K., Pol, A., Tebar, F., Blasi, J., Grewal, T., Enrich, C. (2011), Cholesterol transport from late endosomes to the Golgi regulates t-SNARE trafficking, assembly, and function. Molecular Biology of the Cell. 22(21), 4108-4123. [Abstract]
  • Cornely, R., Rentero, C., Enrich, C., Grewal, T., Gaus, K. (2011), Annexin A6 is an organizer of membrane microdomains to regulate receptor localization and signalling. IUBMB life. 63(11), 1009-17. [Abstract]
  • Wood, P., Mulay, V., Darabi, M., Chan, K., Heeren, J., Pol, A., Lambert, G., Rye, K., Enrich, C., Grewal, T. (2011), RAS/MAPK signalling modulates protein stability and cell surface expression of SR-BI. The Journal of biological chemistry. 286(26), 23077-92. [Abstract]
  • Enrich, C., Rentero, C., de Muga, S., Reverter, M., Mulay, V., Wood, P., Koese, M., Grewal, T. (2011), Annexin A6-Linking Ca(2+) signaling with cholesterol transport. Biochimica et biophysica acta. 1813(5), 935-47. [Abstract]
  • Reverter, M., Rentero, C., de Muga, S., Alvarez-Guaita, A., Mulay, V., Cairns, R., Wood, P., Monastyrskaya, K., Pol, A., Tebar, F., Blasi, J., Grewal, T., Enrich, C. (2011), Cholesterol transport from late endosomes to the Golgi regulates t-SNARE trafficking, assembly and function. Molecular Biology of the Cell. 22(21), 4108-4123. [Abstract]
  • Grewal, T., Koese, M., Tebar, F., Enrich, C. (2011), Differential Regulation of RasGAPs in Cancer. Genes & Cancer. 2(3), 288-297. [Abstract]
  • Le Lay, S., Rodriguez, M., Jessup, W., Rentero, C., Li, Q., Cartland, S., Grewal, T., Gaus, K. (2011), Caveolin-1-mediated apolipoprotein A-I membrane binding sites are not required for cholesterol efflux. PloS one. 6(8), e23353. [Abstract]


  • Grewal, T., Koese, M., Rentero, C., Enrich, C. (2010), Annexin A6-regulator of the EGFR/Ras signalling pathway and cholesterol homeostasis. International Journal of Biochemistry & Cell Biology. 42(5), 580-584. [Abstract]


  • Ingelmo-Torres, M., González-Moreno, E., Kassan, A., Hanzal-Bayer, M., Tebar, F., Herms, A., Grewal, T., Hancock, J., Enrich, C., Bosch, M., Gross, S., Parton, R., Pol, A. (2009), Hydrophobic and basic domains target proteins to lipid droplets. Traffic (Copenhagen, Denmark). 10(12), 1785-17801. [Abstract]
  • Moretó, J., Vidal-Quadras, M., Pol, A., Santos, E., Grewal, T., Enrich, C., Tebar, F. (2009), Differential involvement of H- and K-Ras in Raf-1 activation determines the role of calmodulin in MAPK signaling. Cellular signalling. 21(12), 1827-1836. [Abstract]
  • Stogbauer, F., Weigert, J., Neumeier, M., Wanninger, J., Sporrer, D., Weber, M., Schaffler, A., Enrich, C., Wood, P., Grewal, T., Aslanidis, C., Buechler, C. (2009), Annexin A6 is highly abundant in monocytes of obese and type 2 diabetic individuals and is downregulated by adiponectin in vitro. Experimental & molecular medicine. 41(7), 501-507. [Abstract]
  • Monastyrskaya, K., Babiychuk, E., Hostettler, A., Wood, P., Grewal, T., Draeger, A. (2009), Plasma membrane-associated annexin A6 reduces Ca2+ entry by stabilizing the cortical actin cytoskeleton. The Journal of biological chemistry. 284(25), 17227-17242. [Abstract]
  • Ingelmo-Torres, M., Gaus, K., Herms, A., González-Moreno, E., Kassan, A., Bosch, M., Grewal, T., Tebar, F., Enrich, C., Pol, A. (2009), Triton X-100 promotes a cholesterol-dependent condensation of the plasma membrane. The Biochemical journal. 420(3), 373-381. [Abstract]
  • Grewal, T., Enrich, C. (2009), Annexins--modulators of EGF receptor signalling and trafficking. Cellular signalling. 21(6), 847-858. [Abstract]
  • Laatsch, A., Merkel, M., Talmud, P., Grewal, T., Beisiegel, U., Heeren, J. (2009), Insulin stimulates hepatic low density lipoprotein receptor-related protein 1 (LRP1) to increase postprandial lipoprotein clearance. Atherosclerosis. 204(1), 105-111. [Abstract]
  • Vilá de Muga, S., Timpson, P., Cubells, L., Evans, R., Hayes, T., Rentero, C., Hegemann, A., Reverter, M., Leschner, J., Pol, A., Tebar, F., Daly, R., Enrich, C., Grewal, T. (2009), Annexin A6 inhibits Ras signalling in breast cancer cells. Oncogene. 28(3), 363-377. [Abstract]


  • Cubells, L., Vilà de Muga, S., Tebar, F., Bonventre, J., Balsinde, J., Pol, A., Grewal, T., Enrich, C. (2008), Annexin A6-induced inhibition of cytoplasmic phospholipase A2 is linked to caveolin-1 export from the Golgi. The Journal of Biological Chemistry. 283(15), 10174-10183. [Abstract]
  • Lladó, A., Timpson, P., Vilà de Muga, S., Moretó, J., Pol, A., Grewal, T., Daly, R., Enrich, C., Tebar, F. (2008), Protein kinase Cdelta and calmodulin regulate epidermal growth factor receptor recycling from early endosomes through Arp2/3 complex and cortactin. Molecular Biology of the Cell. 19(1), 17-29. [Abstract]
  • Rentero, C., Zech, T., Quinn, C., Engelhardt, K., Williamson, D., Grewal, T., Jessup, W., Harder, T., Gaus, K. (2008), Functional implications of plasma membrane condensation for T cell activation. PloS One. 3(5), e2262,1-e2262,14. [Abstract]