Dr Ulla Simanainen

Research Fellow
Medicine, Concord Clinical School
ANZAC Research Institute

C22 - Concord Hospital
The University of Sydney
NSW 2006 Australia

T: +61 2 9767 9116
F: +61 2 9767 9101

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Themes | Keywords | Publications



Endocrinology; Breast cancer; Reproductive medicine; Andrology; Prostate


2014 | 2013 | 2012 | 2011 | 2010 | 2009


  • Gao, Y., Walters, K., Desai, R., Zhou, H., Handelsman, D., Simanainen, U. (2014), Androgen receptor inactivation resulted in acceleration in pubertal mammary gland growth, upregulation of ERα expression, and Wnt/β-catenin signaling in female mice. Endocrinology. 155(12), 4951-4963. [Abstract]
  • Vignarajan, S., Xie, C., Yao, M., Sun, Y., Simanainen, U., Sved, P., Liu, T., Dong, Q. (2014), Loss of PTEN stabilizes the lipid modifying enzyme cytosolic phospholipase A₂α via AKT in prostate cancer cells. Oncotarget. 5(15), 6289-6299. [Abstract]
  • Zhao, B., Choi, J., Jaehne, M., Gao, Y., Desai, R., Tuckermann, J., Zhou, H., Handelsman, D., Simanainen, U. (2014), Glucocorticoid receptor in prostate epithelia is not required for corticosteroid-induced epithelial hyperproliferation in the mouse prostate. The Prostate. 74(10), 1068-1078. [Abstract]


  • McNamara, K., Nakamura, Y., Sasano, H., Handelsman, D., Simanainen, U. (2013), Prostate epithelial AR inactivation leads to increased intraprostatic androgen synthesis. The Prostate. 73(3), 316-327. [Abstract]
  • Simanainen, U., Gao, Y., Desai, R., Jimenez, M., Spaliviero, J., Keast, J., Handelsman, D. (2013), Evidence for increased tissue androgen sensitivity in neurturin knockout mice. The Journal of Endocrinology. 218(2), 151-163. [Abstract]


  • McNamara, K., Handelsman, D., Simanainen, U. (2012), The mouse as a model to investigate sex steroid metabolism in the normal and pathological prostate. Journal of Steroid Biochemistry and Molecular Biology. 131(3-5), 107-121. [Abstract]
  • Simanainen, U., Gao, Y., Walters, K., Watson, G., Desai, R., Jimenez, M., Handelsman, D. (2012), Androgen Resistance in Female Mice Increases Susceptibility to DMBA-Induced Mammary Tumors. Hormones & Cancer. 3(3), 113-124. [Abstract]
  • Handelsman, D., Simanainen, U., Walters, K., Allan, C. (2012), Estradiol Immunoassays for Mice: Not Fit for Purpose. Endocrinology. , 1501.
  • Walters, K., Middleton, L., Joseph, S., Hazra, R., Jimenez, M., Simanainen, U., Allan, C., Handelsman, D. (2012), Targeted loss of androgen receptor signaling in murine granulosa cells of preantral and antral follicles causes female subfertility. Biology of Reproduction. 87(6), 151. [Abstract]


  • Simanainen, U., McNamara, K., Gao, Y., McPherson, S., Desai, R., Jimenez, M., Handelsman, D. (2011), Anterior prostate epithelial AR inactivation modifies estrogen receptor expression and increases estrogen sensitivity. American journal of physiology. Endocrinology and metabolism. 301(4), E727-35. [Abstract]
  • Simanainen, U., Brogley, M., Gao, Y., Jimenez, M., Harwood, D., Handelsman, D., Robins, D. (2011), Length of the human androgen receptor glutamine tract determines androgen sensitivity in vivo. Molecular and cellular endocrinology. 342(1-2), 81-6. [Abstract]
  • Simanainen, U., Lampinen, A., Henneicke, H., Brennan, T., Heinevetter, U., Harwood, D., McNamara, K., Herrmann, M., Seibel, M., Handelsman, D., Zhou, H. (2011), Long-Term corticosterone treatment induced lobe-specific pathology in mouse prostate. The Prostate. 71, 289-97. [Abstract]
  • Handelsman, D., Allan, C., Walters, K., Simanainen, U. (2011), Genetic models for hormonal regulation of reproduction. Australian Biochemist. 42(1), 4-7.


  • McNamara, K., Harwood, D., Simanainen, U., Walters, K., Jimenez, M., Handelsman, D. (2010), Measurement of sex steroids in murine blood and reproductive tissues by liquid chromatography-tandem mass spectrometry. The Journal of steroid biochemistry and molecular biology. 121(3-5), 611-8. [Abstract]
  • Allan, C., Couse, J., Simanainen, U., Spaliviero, J., Jimenez, M., Rodriguez, K., Korach, K., Handelsman, D. (2010), Estradiol Induction of Spermatogenesis Is Mediated via an Estrogen Receptor-{alpha} Mechanism Involving Neuroendocrine Activation of Follicle-Stimulating Hormone Secretion. Endocrinology. 151(6), 2800-10. [Abstract]
  • Finnilä, M., Zioupos, P., Herlin, M., Miettinen, H., Simanainen, U., Håkansson, H., Tuukkanen, J., Viluksela, M., Jämsä, T. (2010), Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on bone material properties. Journal of Biomechanics. 43(6), 1097-1103. [Abstract]
  • Walters, K., Simanainen, U., Handelsman, D. (2010), Molecular insights into androgen actions in male and female reproductive function from androgen receptor knockout models. Human reproduction update. 16(5), 543-58. [Abstract]


  • Simanainen, U., McNamara, K., Gao, Y., Handelsman, D. (2009), Androgen sensitivity of prostate epithelium is enhanced by postnatal androgen receptor inactivation. American Journal of Physiology: Endocrinology and Metabolism. 296(6), E1335-E1343. [Abstract]