Dr Yuyan Chen

Senior Lecturer
Paediatrics & Child Health, Children's Hospital, Westmead

C29 - Children's Hospital Westmead
The University of Sydney
NSW 2006 Australia

T: +61 2 9845 3114

Research interests

Yuyan Chen's current research interests are to understand the roles of Tumor Protein PD52 (TPD52) in tumorigenesis; the molecular mechanisms by which TPD52 is involved in cancer development/ progression, with a focus on TPD52 involvement in the cellular response to DNA damage.


Genetics; Breast cancer; Biochemistry; Cell biology; Cancer


2014 | 2013 | 2012 | 2011 | 2009


  • Byrne, J., Frost, S., Chen, Y., Bright, R. (2014), Tumor protein D52 (TPD52) and cancer-oncogene understudy or understudied oncogene?. Tumour Biology. 35(8), 7369-7382. [Abstract]
  • Shahheydari, H., Frost, S., Smith, B., Groblewski, G., Chen, Y., Byrne, J. (2014), Identification of PLP2 and RAB5C as novel TPD52 binding partners through yeast two-hybrid screening. Molecular Biology Reports. 41, 4565¿4572. [Abstract]
  • Takita, J., Chen, Y., Kato, M., Ohki, K., Sato, Y., Ohta, S., Sugita, K., Nishimura, R., Hoshino, N., Seki, M., Sanada, M., Oka, A., Hayashi, Y., Ogawa, S. (2014), Genome-wide approach to identify second gene targets for malignant rhabdoid tumors using high-density oligonucleotide microarrays. Cancer science. 105(3), 258-264. [Abstract]


  • Chen, Y., Kamili, A., Hardy, J., Groblewski, G., Khanna, K., Byrne, J. (2013), Tumor protein D52 represents a negative regulator of ATM protein levels. Cell Cycle. 12(18), 3083-3097. [Abstract]


  • Byrne, J., Chen, Y., Martin La Rotta, N., Peters, G. (2012), Challenges in Identifying Candidate Amplification Targets in Human Cancers: Chromosome 8q21 as a Case Study. Genes & Cancer. 3(2), 87-101. [Abstract]


  • Takita, J., Chen, Y., Okubo, J., Sanada, M., Adachi, M., Ohki, K., Nishimura, R., Hanada, R., Igarashi, T., Hayashi, Y., Ogawa, S. (2011), Aberrations of NEGR1 on 1p31 and MYEOV on 11q13 in neuroblastoma. Cancer Science. 102(9), 1645-1650. [Abstract]


  • Kato, M., Takita, J., Takahashi, K., Mimaki, M., Chen, Y., Koh, K., Ida, K., Oka, A., Mizuguchi, M., Ogawa, S., Igarashi, T. (2009), Hepatoblastoma in a patient with sotos syndrome. Journal of Pediatrics. 155(6), 937-939. [Abstract]
  • Kato, M., Sanada, M., Kato, I., Sato, Y., Takita, J., Takeuchi, K., Niwa, A., Chen, Y., Nakazaki, K., Nomoto, J., Asakura, Y., Muto, S., Tamura, A., Iio, M., Akatsuka, Y., Hayashi, Y., Mori, H., Igarashi, T., Kurokawa, M., Chiba, S., Mori, S., Ishikawa, Y., Okamoto, K., Tobinai, K., Nakagama, H., Nakahata, T., Yoshino, T., Kobayashi, Y., Ogawa, S. (2009), Frequent inactivation of A20 in B-cell lymphomas. Nature. 459(7247), 712-716. [Abstract]