Recent Cancer Council NSW grant outcomes

2013

A/Prof Janette Vardy
University of Sydney
Evaluation of a Web-based Cognitive Rehabilitation Programme in Cancer Survivors with Self-reported Cognitive Impairment

A/Prof Deborah Marsh
University of Sydney
Monoubiquitinated histone H2B –marking key pathways in ovarian cancer

Prof Markus Seibel
University of Sydney
Novel Cytoplasmic Functions of the Vitamin D Receptor in Bone Metastases

Dr Elena Shklovskaya
University of Sydney
Role of dendritic cell subsets in regulating CD4 T cell memory responses in inflammation and cancer

Dr Linda Bendall
University of Sydney
Sphingosine Kinases as Potential Therapeutic Targets for Acute Lymphoblastic Leukemia

Prof Christine Clarke
University of Sydney
Determinants of genomic binding of the progesterone receptor in endocrine target cells

Dr Nickolas Haass
University of Sydney
Effect of three-dimensional tumour organisation on the sensitivity of individual melanoma cells to endoplasmic reticulum stress

A/Prof Tim Price
University of Sydney
PETACC-6: Preoperative chemoradiotherapy and postoperative chemotherapy with capecitabine and oxaliplatin vs. capecitabine alone in locally advanced rectal cancer

2012

Project grants

A/Prof Tracy Bryan
Children’s Medical Research Institute, Wake Forest University
Involvement of helicase DHX36 in human telomere maintenance

Dr Scott Cohen
Children’s Medical Research Institute, St Vincent’s Institute of Medical Research, CSIRO Molecular and Health Technologies
Structure and inhibition of the human telomerase enzyme complex

Dr Sue Firth
Kolling Institute of Medical Research, University of Sydney
IGFBP-3 enhances autophagy to promote breast cancer cell survival during stress

Dr Beric Henderson
Westmead Millenium Institute, Macquarie University
Novel regulation of beta-catenin intracellular transport and its role in cell polarity and migration

Dr Geraldine O’Neill
The Children’s Hospital at Westmead, The University of Erlangen, University of Sydney
A sting in the tail: focal adhesion targeting and mechanotransduction

Innovators Grants

Dr Lionel Hebbard & Prof Jacob George
University of Sydney & Westmead Millennium Institute
Novel molecular targets for treatment of hepatocellular cancer (HCC)

Dr Nicholas Shackel
Centenary Institute & Royal Prince Alfred Hospital
Discovering novel non-invasive diagnostic and prognostic markers in hepatocellular carcinoma

Dr Kathy Willowson
University of Sydney
The role of imagable microspheres in radioembolisation treatment planning for HCC

Prof Michael Murray
University of Sydney
Pharmacogenomic approaches to minimise sorafenib toxicity in patients with liver cancer

2011

New Program Grants

Reddel R
Children’s Medical Research Institute
Alternative lengthening of telomeres: from basic biology to drug discovery
$2,250,000

New Research Project Grants

Baxter R
University of Sydney
Targeting IGFBP-3 signalling pathways as a novel therapeutic approach in triple-negative breast cancer
$119,659

Bryan T
University of Sydney
G-quadruplex stabilisers as cancer therapeutics
$97,508

Chircop M, Sakoff J, McCluskey A, Jones N
University of Sydney
Dynamin as a new drug target for the treatment of glioblastoma
$120,000

Henderson B, Brocardo M, Molloy M
Westmead Millennium Institute for Medical Research
Regulation of APC intracellular dynamics and function
$120,000

Howell V, Gill A
University of Sydney
New opportunities for the study of ovarian cancer through characterisation of mouse models
$97,508

Rasko J, Bailey C
Centenary Institute
Dissecting the multi-component machine that controls chromatin architecture
$119,658

Rasko J, Ritchie W, Holst J
Centenary Institute
The role of small non-coding RNAs (sncRNAs) in alternative splicing
$120,000

Innovator Grants

George J, Hebbard L
University of Sydney
Novel molecular targets for treatment of hepatocellular cancer (HCC)
$100,000

Grau G, Suter C
University of Sydney
Deep sequencing of glioma-derived microparticles
$100,000

Murray M
University of Sydney
Pharmacogenomic approaches to minimise sorafenib toxicity in patients with liver cancer
$97,730

Shackel N
University of Sydney
Discovering novel non-invasive diagnostic and prognostic markers in hepatocellular carcinoma
$100,000

Willowson K
The role of imageable microspheres in radioembolisation treatment planning for HCC
University of Sydney
$3,217

2010

Bendall L
Westmead Millennium Institute
The role of sphingosine-1-phosphate in haematopoietic stem cell egress from the bone marrow

deFazio A
Westmead Millennium Institute
Pathways of malignant progression in ovarian cancer

Lyons G
University of Sydney
Restoring epithelial differentiation to squamous cell carcinomas

2009

New Project Grants

Bebawy M
University of Sydney
Microparticle-mediated transfer of p-glycoprotein in conferring multi-drug resistance in cancer

Byrne J
University of Sydney
The molecular basis of cell transformation produced by tpd52 over-expression

Chen S
Westmead Hospital
Randomised trial of diagnostic strategies for invasive aspergillosis in at-risk haematology patients: funding extension

Fabbro M
University of Sydney
Dynamin inhibitors as new anti-cancer drugs

Goldstein D
University of Sydney
Lap07: randomised multicentre phase iiistudy in patients with locally advanced adenocarinoma of the pancreas: gemcitabine – with or without chemoradiotherapy and with or without erlotinib

Gottlieb D
University of Sydney
Adoptive immunotherapy for the prevention of varicella-zoster virus reactivation post stem cell transplant

Hart D
Molecular and Microbial Sciences
University of Sydney
RNA loading of tumor associated antigens and the activation of blood dendritic cells for prostate cancer immunotherapy

Jolly C
University of Sydney
Understanding aid-induced cancer: unravelling complex mutation and repair pathways

McDonald K
University of Sydney
The role of iqgap1 in actively migrating glioma cells and its regulation by mir-124

Murray M
University of Sydney
Development of personalised dosage protocols for tyrosine kinase inhibitors in oncology patients

Naylor M
Faculty of Veterinary Science
University of Sydney
Role of beta1 integrin in prostate development and carcinogenesis

O’Neill G
University of Sydney
The signalling switch function of the pro-metastatic, adhesion adaptor protein hef1

Young J
University of Sydney
Quality of life outcomes and cost effectiveness of pelvic exenteration for people with advanced rectal cancer

New Innovator Grants

Xue A and Smith R
Kolling Institute
Discovery of prognostic serum biomarkers for pancreatic cancer

Richardson D
University of Sydney
Development of novel and potent anti-tumour agents for the treatment of pancreatic cancer

2008

New Strategic Research Partnership Grants

George J
Westmead Hospital
Epidemiology, prevention and management of liver cancer in NSW

New Projects

Armstrong B
School of Public Health
Prostate specific antigen, sun and vitamin D

Boyer M
Central Clinical School
Trialling adding nitroglycerin to first line chemotherapy in advanced non-small call lung cancer

Clifton-Bligh R
Kolling Institute of Medical Research
The PPAR gene and thyroid cancer

Crossley M
School of Molecular and Microbial Sciences
Gene regulatory proteins associated with lymphoma

Damian D
Department of Dermatology, Royal Prince Alfred Hospital
Nicotinamide protection from skin cancer development

Reeve V
Faculty of Veterinary Science
Oestrogen protection from ultraviolet radiation and skin cancer

Suchowerska N
Department of Radiation Oncology, Royal Prince Alfred Hospital
A new radiobiological model for radiotherapy

Trevena L
School of Public Health
Preventing cervical cancer: a web-based toolkit for young women