High Expression System For Human Lysyl Oxidase
An over expression system that provides for the efficient production of large amounts of the human lysyl oxidase protein.
Lysyl oxidase is needed in vivo to cross-link elastin and collagen containing tissues. Our technology provides a soluble form of the human lysyl oxidase protein.
Lysyl oxidase cannot be easily accessed from mammalian tissues and is not normally soluble in aqueous solutions. We have solved these yield and solubility problems.
This invention relates to synthetic polynucleotides which encode lysyl oxidase, lysyl oxidase like molecules or variants of these species.
The synthetic polynucleotides of the invention permit the expression of functional lysyl oxidase, lysyl oxidase like molecules or variants of these species, typically in good yield.
The invention also relates to recombinant DNA molecules containing these, synthetic polynucleotides, to cells containing them and to uses of the expression products.
The lysyl oxidase can be used as component in a collagen or elastin based formulation, such as for wound repair or cosmetic uses.
- Professor Anthony Weiss