Rapid Tests for Disease Diagnoses

Ref: 12112
A fast and accurate pathology test that can be used to indicate the presence of certain specific diseases from a drop of biological fluid (such as blood) before clinical signs are apparent, or to differentiate diseases with similar clinical symptoms.specific diseases before clinical signs are apparent, or to differentiate diseases with similar clinical symptoms.

Key advantages
  • Early-stage medical diagnostics for diseases before clinical signs are apparent and for which there are currently no diagnostic methods.
  • Diagnostics for high specificity and differentiation of diseases with similar clinical symptoms for which there are no simple diagnostics
  • Identify non-responders who can then be put on alternative treatment

Background

The successful treatment of many life-threatening or debilitating illnesses requires an early diagnosis but, for many diseases, the diagnosis comes at a stage when treatment is less than optimal with serious consequences for the patient.

Similarly, there are many serious diseases caused by pathogens that may have clinical signs and for which there is no simple and rapid test to aid in differentiating this disease.

If the incorrect treatment is used before diagnosis, the patient may die or suffer permanent damage; similarly, some of the treatments that are used to treat serious pathogenic diseases have an unfavourable side-effect profile and, therefore, should only be used if a diagnosis has been made.

However, the serious nature of certain pathogenic diseases requires that quick accurate and cheap diagnoses to maximise the treatment outcomes.

The invention

The invention involves objective techniques for the rapid, early and accurate determination of the underlying biomedical markers for a range of diseases from a single drop of blood or other biological fluids using various spectroscopic techniques.

The invention aims to provide such objective diagnosis for differentiation of diseases for which there are currently no effective diagnoses or for which early diagnosis is essential to provide effective treatment.

The aim is also to provide complete device technology (hardware and software), which will require minimal training for people in remote communities or hospital settings to produce reliable results.

Applications

As described previously, the main potential for the technology lies in its application for new pathology tests for a variety of diseases in a hospital setting or in remote clinics. In addition, the technology can be used to monitor the effectiveness of treatments and to aid in the design of new drugs by using blood biochemistry to monitor the efficacy of the treatment.

Principal inventors

  • Professor Peter Lay
  • Professor Nick Hunt

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