Molecular Biology & Biochemistry- Genes (BCHM3071)

UNIT OF STUDY

This unit of study is designed to provide a comprehensive coverage of the activity of genes in living organisms, with a focus on eukaryotic and particularly human systems. The lecture component covers the arrangement and structure of genes, how genes are expressed, promoter activity and enhancer action. This leads into discussions on the biochemical basis of differentiation of eukaryotic cells, the molecular basis of imprinting, epigenetics, and the role of RNA in gene expression. Additionally, the course discusses the effects of damage to the genome and mechanisms of DNA repair. The modern techniques for manipulating and analysing macromolecules such as DNA and proteins and their relevance to medical and biotechnological applications are discussed. Techniques such as the generation of gene knockout and transgenic mice are discussed as well as genomic methods of analysing gene expression patterns. Particular emphasis is placed on how modern molecular biology and biochemical methods have led to our current understanding of the structure and functions of genes within the human genome. The practical course is designed to complement the lecture course and will provide students with experience in a wide range of techniques used in molecular biology laboratories.

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Further unit of study information

Classes

Two 1-hour lectures per week and one 6-hour practical per fortnight.

Assessment

One 2.5-hour exam, practical work (100%)

Textbooks

Lewin, B. Genes X. 10th edition. Jones & Bartlett. 2011.

Faculty/department permission required?

No

Unit of study rules

Prerequisites and assumed knowledge

(MBLG 1001/1901) and 12 CP of Intermediate BCHM/MBLG units (taken from MBLG2071/2971 or BCHM2071/2971 or BCHM2072/2972). For BMedSc: (18 credit points of BMED including BMED2401, BMED2405 and one of MBLG2071/2971 or BCHM2071/2971) or (BMED2801 and BMED280

Prohibitions

BCHM3001, BCHM3901, BCHM3971

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Cross-institutional study

If you are from another Australian tertiary institution you may be permitted to underake cross-institutional study in one or more units of study at the University of Sydney.

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