Mol Biology & Biochemistry- Proteins (BCHM3081)

UNIT OF STUDY

This unit of study is designed to provide a comprehensive coverage of the functions of proteins in living organisms, with a focus on eukaryotic and particularly human systems. Its lecture component deals with how proteins adopt their biologically active forms, including discussions of protein structure, protein folding and how recombinant DNA technology can be used to design novel proteins with potential medical or biotechnology applications. Particular emphasis is placed on how modern molecular biology and biochemical methods have led to our current understanding of the structure and functions of proteins. It also covers physiologically and medically important aspects of proteins in living systems, including the roles of chaperones in protein folding inside cells, the pathological consequences of misfolding of proteins, how proteins are sorted to different cellular compartments and how the biological activities of proteins can be controlled by regulated protein degradation. The practical course is designed to complement the lecture course and will provide students with experience in a wide range of techniques used in molecular biology and protein biochemistry laboratories.

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Further unit of study information

Classes

Two 2 hour lectures per week and one 6 hour practical per fortnight.

Assessment

One 2.5 hour exam, practical work (100%)

Textbooks

Williamson M. How Proteins Work. Garland. 2011.

Faculty/department permission required?

No

Unit of study rules

Prerequisites and assumed knowledge

(MBLG1001/1901) and 12 CP of Intermediate BCHM/MBLG units (taken from MBLG2071/2971 or BCHM2071/2971 or BCHM2072/2972). For BMedSc: (18 credit points of BMED including BMED2401 and BMED2405 and one of MBLG2071/2971 or BCHM2071/2971) or (BMED2801 and BMED2

Prohibitions

BCHM3981, BCHM3001, BCHM3901

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Cross-institutional study

If you are from another Australian tertiary institution you may be permitted to underake cross-institutional study in one or more units of study at the University of Sydney.

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