Molecular Biology & Biochem- Genes (Adv) (BCHM3971)

UNIT OF STUDY

This unit of study is designed to provide a comprehensive coverage of the activity of genes in living organisms, with a focus on eukaryotic and particularly human systems. The lecture component covers the arrangement and structure of genes, how genes are expressed, promoter activity and enhancer action. This leads into discussions on the biochemical basis of differentiation of eukaryotic cells, the molecular basis of imprinting, epigenetics, and the role of RNA in gene expression. Additionally, the course discusses the effects of damage to the genome and mechanisms of DNA repair. The modern techniques for manipulating and analysing macromolecules such as DNA and proteins and their relevance to medical and biotechnological applications are discussed. Techniques such as the generation of gene knockout and transgenic mice are discussed as well as genomic methods of analysing gene expression patterns. Particular emphasis is placed on how modern molecular biology and biochemical methods have led to our current understanding of the structure and functions of genes within the human genome. The practical course is designed to complement the lecture course and will provide students with experience in a wide range of techniques used in molecular biology laboratories. The lecture component of this unit of study is the same as BCHM3071. Qualified students will attend seminars/practical classes in which more sophisticated topics in gene expression and manipulation will be covered.

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Further unit of study information

Classes

Two 1-hour lectures per week and one 6-hour practical per fortnight.

Assessment

One 2.5-hour exam, practical work (100%)

Textbooks

Lewin, B. Genes X. 10th edition. Jones & Bartlett. 2011.

Faculty/department permission required?

No

Unit of study rules

Prerequisites and assumed knowledge

(MBLG1001/1901) and Distinction in 12 CP of Intermediate BCHM/MBLG units (taken from MBLG2071/2971 or BCHM2071/2971 or BCHM2072/2972). For BMedSc: (18 credit points of BMED including BMED2401 and Distinction in BMED2405 and one of MBLG2071/2971 or BCHM207

Prohibitions

BCHM3901, BCHM3001, BCHM3071

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