Proteomics and Functional Genomics (Adv) (BCHM3992)
UNIT OF STUDY
This unit of study will focus on the high throughput methods for the analysis of gene structure and function (genomics) and the analysis of proteins (proteomics) which are at the forefront of discovery in the biomedical sciences. The course will concentrate on the hierarchy of gene-protein-structure-function through an examination of modern technologies built on the concepts of genomics versus molecular biology, and proteomics versus biochemistry. Technologies to be examined include DNA sequencing, nucleic acid and protein microarrays, two-dimensional gel electrophoresis of proteins, uses of mass spectrometry for high throughput protein identification, isotope tagging for quantitative proteomics, high-performance liquid chromatography, high-throughput functional assays, affinity chromatography and modern methods for database analysis. Particular emphasis will be placed on how these technologies can provide insight into the molecular basis of changes in cellular function under both physiological and pathological conditions as well as how they can be applied to biotechnology for the discovery of biomarkers, diagnostics, and therapeutics. The practical component is designed to complement the lecture course and will provide students with experience in a wide range of techniques used in proteomics and genomics.
The lecture component of this unit of study is the same as BCHM3092. Qualified students will attend seminars/practical classes in which more sophisticated topics in proteomics and genomics will be covered.
Further unit of study information
Two 1-hour lectures per week and one 3-hour practical per fortnight.
One 2.5-hour exam, practical work (100%)
Kraj A and Silberring J Proteomics Introduction to Methods and Applications Wiley 2008
Faculty/department permission required?
Unit of study rules
Prerequisites and assumed knowledge
(MBLG1001 or MBLG1901) and Disctinction level in 12 credit points of (MBLG2071 or MBLG2971 or BCHM2071 or BCHM2971 or BCHM2072 or BCHM2972). For BMedSc: (BMED2401 and Disctinction level in BMED2405, and one of (MBLG2071 or MBLG2971 or BCHM2071 or BCHM2971) or (Distinction average in BMED2801 and BMED2802 and BMED2804))
BCHM3092 or BCHM3098
Study this unit outside a degree
If you wish to undertake one or more units of study (subjects) for your own interest but not towards a degree, you may enrol in single units as a non-award student.
If you are from another Australian tertiary institution you may be permitted to underake cross-institutional study in one or more units of study at the University of Sydney.