Microbes, Infection and Immunity (BMED2404)

UNIT OF STUDY

This unit of study begins by introducing the concepts of disease transmission, pathogenicity and virulence mechanisms of microbes. For a full understanding of the process of infection, the structure and function of pathogenic microorganisms is examined. How the body deals with injury and infection is discussed by exploring barriers to infection and host response once those barriers are breached. The body's response to such physical damage is dealt with in a series of lectures on wound healing, clotting and inflammation, and is complemented by discussion of the pharmacological basis of anti-inflammatory drugs. This is followed by a comprehensive discussion of molecular and cellular immune responses to pathogen invasion. In particular, this gives students an appreciation of the processing of antigens, the structure, production and diversity of antibodies, the operation of the complement system and mechanisms for recognition and destruction of invading microbes. The unit concludes with an overview of microbial diseases, the characteristics of causative agents, pathogenesis and symptoms as well as treatment and control and culminates with exploring current issues of antibiotic resistance, important emerging infections and vaccination strategies.

Practical classes illustrate and underpin the lecture content. Students will investigate normal flora, host defences and medically important microbes and will obtain experience in, and an understanding of, a range of techniques in bacteriology. In these practical sessions experience will be gained handling live, potentially pathogenic microbes.

Further unit of study information

Classes

2 lec & 1 prac/wk, 2 tut

Assessment

One 2hr theory exam (60%), in-semester assessments (40%)

Textbooks

Prescott's Microbiology Willey JM, Sherwood LM and Woolverton CJ McGraw-Hill, 9th Edition, 2014; Basic Immunology: Functions and Disorders of the Immune System. Abass AK and Lichtman AH WB Saunders, 4th Edition, 2013; Robbins Basic Pathology Kumar V, Cotran KS and Robbins SL Saunders, Philadelphia, 9th Edition, 2012

Faculty/department permission required?

No

Unit of study rules

Prerequisites and assumed knowledge

42 credit points of Junior Bachelor of Medical Science units of study

Prohibitions

PHSI2005, ANAT2010, ANAT2008, MICR2022, MICR2021, BMED2807, BIOL2016, PHSI2905, BIOL2006, PHSI2006, NUTR2912, NUTR2911, IMMU2101, BCHM2972, BIOL2906, PHSI2906, MICR2921, BIOL2916, BCHM2072, PCOL2011, MICR2922

Study this unit outside a degree

Non-award/non-degree study

If you wish to undertake one or more units of study (subjects) for your own interest but not towards a degree, you may enrol in single units as a non-award student.

Cross-institutional study

If you are from another Australian tertiary institution you may be permitted to underake cross-institutional study in one or more units of study at the University of Sydney.