Advanced Trial Design (CLTR5004)


Candidates will be taught skills to design and interpret equivalence trials, non-inferiority trials and cluster randomised trials. Specialised designs including enrichment and discontinuation designs will be discussed and special aspects relating to cross-over studies will be taught. Techniques to validly incorporate composite, co-primary and surrogate endpoints will be covered. Distinctions between event and chronological time directed outcomes will be discussed. Skills to incorporate sub-studies into clinical research projects will be covered in this unit.

Further unit of study information


discussion groups and problem based learning


2x quizzes (2x10%), 2x assessments (2x40%)


Recommended reading: Interpreting and Reporting of Clinical Trials: a guide to the Consort statement.

Faculty/department permission required?


Unit of study rules

Prerequisites and assumed knowledge

CLTR5001 and CLTR5007

Study this unit outside a degree

Non-award/non-degree study

If you wish to undertake one or more units of study (subjects) for your own interest but not towards a degree, you may enrol in single units as a non-award student.

Cross-institutional study

If you are from another Australian tertiary institution you may be permitted to underake cross-institutional study in one or more units of study at the University of Sydney.