Drug Discovery and Design B (PHAR2821)


This unit of study covers drug design; physicochemical properties of drugs and how this determines the interactions of small molecules (drugs) with biological macromolecules (enzymes and receptors). All stages in the process of drug design and development will be investigated, including computational drug design and the required mathematics for computation and statistical treatment; role of stereochemistry in drug action, structure-activity relationships and molecular modelling; drug metabolism, bioactivation and inactivation; advanced analytical methods for the identification of drugs, their metabolites and degradation products; sources of drugs; discovery of new small molecules as leads for drug development. Workshops consist of the Stereochemistry/Ligand-Based Drug Design molecular modelling workshop, drug action workshop and drug metabolism problem-based learning workshop.

Our courses that offer this unit of study

Further unit of study information


3 x lectures/wk


2hr exam (55%), workshops and quizzes (45%)


G L Patrick (2009) An Introduction to Medicinal Chemistry, 4th Edition, Oxford University Press

Faculty/department permission required?


Unit of study rules


PHAR2811 and PCOL2605

Study this unit outside a degree

Non-award/non-degree study

If you wish to undertake one or more units of study (subjects) for your own interest but not towards a degree, you may enrol in single units as a non-award student.

Cross-institutional study

If you are from another Australian tertiary institution you may be permitted to underake cross-institutional study in one or more units of study at the University of Sydney.