Dr Babak Sarrafpour

Lecturer
Discipline of Oral Pathology

C12 - United Dental Hospital
The University of Sydney

Telephone +61 2 8890 7401
Fax +61 2 8890 7599

Biographical details

Dr Babak Sarrafpour is an overseas trained oral and maxillofacial pathologist and dentist who has had several years experience in dental clinics and academia prior to moving to Australia.

Dr Sarrafpour completed his PhD degree at The University of Sydney in 2013 studying the biomechanical and biological aspects of tooth movement under the supervisor of Prof Hans Zoellner. They established a new biomechanics based theory for tooth eruption by using advanced computer modelling with 3D finite element analysis. With this research project, they proposed a mechanosensory role for soft tissue dental follicle during tooth eruption and also developed a novel analytical method that relates tension or compression as seen in soft tissues in finite element analysis, to the biological response in adjacent bone.

In early 2016, Dr Sarrafpour returned to the faculty after his postdoctoral fellowship in New York and now serves as a lecturer in Discipline of Oral Pathology at The University of Sydney. He has been involved in teaching and coordinating oral biology and pathology courses based on Clinico-Pathological Enquiry Based Learning (CPEBL) model for DMD and BOH students at The University of Sydney. Dr Sarrafpour and Prof Zoellner have recently developed a novel approach to the CPEBL teaching sessions, using online eNotebooks to encourage students to develop their own learning portfolio with interactive self-assessment using Smart Sparrow platform.

Research interests

Dr Babak Sarrafpour’s research focuses on the role of mechanical stress in tooth development and oral and maxillofacial abnormities. He has investigated the role of functional bone strain for cyst expansion and cortication using a three-dimensional finite element analysis (FEA) model of a simulated cyst in the mandible. This study has shown that predominant compression of the soft tissue capsule surrounding bony cysts contributes to cyst expansion. Furthermore, it was found that functional stress becomes concentrated in the bone immediately adjacent to the soft tissue cyst capsule, with the effect of driving bone formation and cortication, a thickening of bone seen in radiographs but until Dr Sarrafpour’s work was unexplained.

Dr Sarrafpour is also conducting studies using high resolution FEA models to investigate: the potential role for parafunctional occlusal loading in maxillofacial disorders; the possible function for endosteum in bone remodelling; and the mechanics of the dentinoenamel junction.In a multidisciplinary collaboration, he has also been involved in development of an experimental system to stimulate cultured cells with mechanical forces.

Current projects

- A method for investigating the cellular response to cyclic tension or compression in three- dimensional culture

- Development Of Online Adaptive Exercises In Oral Pathobiology Using ENotebooks and Smart Sparrow

- Parafunctional occlusal loading account for mandibular tori: A 3D Finite Element Analysis Study

Awards and honours

· 2016- New South Wales Fresh Science Nominee

· 2014-2015: Postdoctoral Fellowship, New York, USA

· 2009-2013: Faculty Scholarship for International students, University of Sydney, Australia

In the media

Keywords

Finite Element Analysis; Oral Pathology; Oral tissue mechanics; 3D Computational Modeling

Selected grants

2017

  • Development Of Online Adaptive Exercises In Oral Pathobiology Using The Smart Sparrow Platform; Sarrafpour B, Zoellner H, Schifter M, Sukumar S; DVC Education/Small Educational Innovation Grant.

2014

  • The response of dental follicle to mechanical stress; Sarrafpour B, Zoellner H, Kelly E; Australian Dental Association Inc/Research Support.

Selected publications

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Journals

  • Austin, C., Smith, T., Mostofi Zadeh Farahani, R., Hinde, K., Carter, E., Lee, J., Lay, P., Kennedy, B., Sarrafpour, B., Wright, R., Arora, M., et al (2016). Uncovering system-specific stress signatures in primate teeth with multimodal imaging. Scientific Reports, 6, 1-11. [More Information]
  • Austin, C., Smith, T., Mostofi Zadeh Farahani, R., Hinde, K., Carter, E., Lee, J., Lay, P., Kennedy, B., Sarrafpour, B., Wright, R., Arora, M., et al (2016). Uncovering system-specific stress signatures in primate teeth with multimodal imaging. Scientific Reports, 6, 1-11. [More Information]
  • Arora, M., Austin, C., Sarrafpour, B., Hernandez-avila, M., Hu, H., Wright, R., Tellez-Rojo, M. (2014). Determining prenatal, early childhood and cumulative long-term lead exposure using micro-spatial deciduous dentine levels. PloS One, 9(5), 1-8. [More Information]
  • Xie, K., Wang, Y., Zhao, Y., Chang, L., Wang, G., Chen, Z., Cao, Y., Liao, X., Lavernia, E., Valiev, R., Sarrafpour, B., Zoellner, H., Ringer, S. (2013). Nanocrystalline B-Ti alloy with high hardness, low Young's modulus and excellent in vitro biocompatibility for biomedical applications. Materials Science and Engineering C, 33(6), 3530-3536. [More Information]
  • Sarrafpour, B., Swain, M., Li, Q., Zoellner, H. (2013). Tooth Eruption Results from Bone Remodelling Driven by Bite Forces Sensed by Soft Tissue Dental Follicles: A Finite Element Analysis. PloS One, 8(3), 1-18. [More Information]
  • Mostofi Zadeh Farahani, R., Sarrafpour, B., Simonian, M., Li, Q., Hunter, N. (2012). Directed glia-assisted angiogenesis in a mature neurosensory structure: Pericytes mediate an adaptive response in human dental pulp that maintains blood-barrier function. The Journal of Comparative Neurology, 520(17), 3803-3826. [More Information]
  • Sarrafpour, B., Rungsiyakull, C., Swain, M., Li, Q., Zoellner, H. (2012). Finite element analysis suggests functional bone strain accounts for continuous post-eruptive emergence of teeth. Archives of Oral Biology, 57(8), 1070-1078. [More Information]

2016

  • Austin, C., Smith, T., Mostofi Zadeh Farahani, R., Hinde, K., Carter, E., Lee, J., Lay, P., Kennedy, B., Sarrafpour, B., Wright, R., Arora, M., et al (2016). Uncovering system-specific stress signatures in primate teeth with multimodal imaging. Scientific Reports, 6, 1-11. [More Information]
  • Austin, C., Smith, T., Mostofi Zadeh Farahani, R., Hinde, K., Carter, E., Lee, J., Lay, P., Kennedy, B., Sarrafpour, B., Wright, R., Arora, M., et al (2016). Uncovering system-specific stress signatures in primate teeth with multimodal imaging. Scientific Reports, 6, 1-11. [More Information]

2014

  • Arora, M., Austin, C., Sarrafpour, B., Hernandez-avila, M., Hu, H., Wright, R., Tellez-Rojo, M. (2014). Determining prenatal, early childhood and cumulative long-term lead exposure using micro-spatial deciduous dentine levels. PloS One, 9(5), 1-8. [More Information]

2013

  • Xie, K., Wang, Y., Zhao, Y., Chang, L., Wang, G., Chen, Z., Cao, Y., Liao, X., Lavernia, E., Valiev, R., Sarrafpour, B., Zoellner, H., Ringer, S. (2013). Nanocrystalline B-Ti alloy with high hardness, low Young's modulus and excellent in vitro biocompatibility for biomedical applications. Materials Science and Engineering C, 33(6), 3530-3536. [More Information]
  • Sarrafpour, B., Swain, M., Li, Q., Zoellner, H. (2013). Tooth Eruption Results from Bone Remodelling Driven by Bite Forces Sensed by Soft Tissue Dental Follicles: A Finite Element Analysis. PloS One, 8(3), 1-18. [More Information]

2012

  • Mostofi Zadeh Farahani, R., Sarrafpour, B., Simonian, M., Li, Q., Hunter, N. (2012). Directed glia-assisted angiogenesis in a mature neurosensory structure: Pericytes mediate an adaptive response in human dental pulp that maintains blood-barrier function. The Journal of Comparative Neurology, 520(17), 3803-3826. [More Information]
  • Sarrafpour, B., Rungsiyakull, C., Swain, M., Li, Q., Zoellner, H. (2012). Finite element analysis suggests functional bone strain accounts for continuous post-eruptive emergence of teeth. Archives of Oral Biology, 57(8), 1070-1078. [More Information]

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