Mr Jinlong Gao

Dr

C24 - Westmead Hospital
The University of Sydney

Telephone 61 2 9845 8766
Fax 61 2 9845 7599

Curriculum vitae Curriculum vitae

Biographical details

Bachelor of Dental Science, Sun Yat-sen University, China, 2007

Doctor of Philosophy, The University of Sydney, 2011, thesis title: “Characterisation of Novel Haem Binding Proteins in the Oral Pathogen Porphyromonas gingivalis”. Supervisor: Professor Neil Hunter, Dr Ky-Anh Nguyen.

Upon completing the PhD, he took up a research fellow position at Institute of Dental Research, Westmead Millennium Institute. Currently, he is offered a combined teaching and research position with the Faculty of Dentistry, The University of Sydney.

Research interests

Iron is essential for the survival of all bacteria and many pathogenic bacteria have developed sophisticated mechanisms by which they utilize the host haem containing proteins as a source of iron. The ability of periodontal pathogens, such as Porphyromonas gingivalis, to acquire haem is in part linked to their virulence. Utilizing a number of approaches we seek to understand the molecular mechanisms by which pathogenic bacteria acquire haem. These studies have led to the functional and structural characterisation of several proteins involved in haem uptake and degradation.

We were the first to discovered and functionally characterize the haemophore HusA in the oral pathogen P. gingivalis. HusA plays a critical role in the capacity of P. gingivalis to grow under haem limitation which is a physiologically relevant situation. We also characterized the DNA protective protein Dps in P. gingivalis binds haem and protects P gingivalis cells against DNA damage induced by radicals generated by haem and iron through Fenton reaction. These studies will provide new targets for control of infection by P. gingivalis and eventually lead to the rational design of potential therapeutic agents.

Current projects

1. Characterization of a novel haemophore-dependent haem uptake pathway in the oral pathogen Porphyromonas gingivalis

2. Exploring the roles of DNA-protective protein Dps in the resistance to oxidative stresses induced by haem or iron in anaerobes

3. Understanding the haem utilization in black-pigmented Bacteriodetes

Associations

Member of International Association of Dental Research

Awards and honours

Bela Schwartz fellowship, Bela Schwartz Foundation, The University of Sydney, 2009-2011

Chinese Government Award for Outstanding Chinese Students Study Abroad, Chinese Scholarship Council, 2010

Award of Colgate Travel Grant for IADR/PAPF, 2009

RG Schamschula Prize, The Faculty of Dentistry, The University of Sydney, 2008

International Research Vernick Fee Scholarship, Faculty of Dentistry, The University of Sydney, 2008, 2009

NSW Dental Board Postgraduate Award, 2007, 2008, 2009

Keywords

Microbiology; Protein Chemistry; Protein Function

Selected grants

2013

  • Characterize a haemophore receptor HusB in the hus haem uptake pathway in Porphyromonas gingivalis; Gao J; Australian Dental Research Foundation/Research Support.

Selected publications

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Journals

  • Zhou, X., Gao, J., Hunter, N., Potempa, J., Nguyen, K. (2013). Sequence-independent processing site of the C-terminal domain (CTD) influences maturation of the RgpB protease from Porphyromonas gingivalis. Molecular Microbiology, 89(5), 903-917. [More Information]
  • Gu, H., Fan, D., Gao, J., Zou, W., Peng, Z., Zhao, Z., Ling, J., LeGeros, R. (2012). Effect of ZnCl2 on plaque growth and biofilm vitality. Archives of Oral Biology, 57(4), 369-375. [More Information]
  • Gao, J., Lu, Y., Browne, G., Yap, B., Trewhella, J., Hunter, N., Nguyen, K. (2012). The role of heme-binding by DNA-protective protein from starved-cells (Dps) in the tolerance of Porphyromonas gingivalis to heme toxicity. Journal of Biological Chemistry, 287(50), 42243-42258. [More Information]
  • Gao, J., Nguyen, K., Hunter, N. (2010). Characterization of a hemophore-like protein from Porphyromonas gingivalis. Journal of Biological Chemistry, DOI:10.1074/jbc.M110.163535, 1-22. [More Information]
  • Gao, J., Nguyen, K., Hunter, N. (2009). A novel haem uptake in Porphyromonas gingivalis. Journal of Dental Research.
  • Zou, W., Gao, J., Jones, A., Hunter, N., Swain, M. (2009). Characterization of a novel calibration method for mineral density determination of dentine by x-ray micro-tomography. The Analyst, 134(1), 72-79.
  • Gao, J., Xie, H., Nguyen, K., Hunter, N. (2008). Detection and characterization of novel outer membrane proteins involved in heme binding by Porphyromonas gingivalis. Journal of Biotechnology, 136, S88. [More Information]

2013

  • Zhou, X., Gao, J., Hunter, N., Potempa, J., Nguyen, K. (2013). Sequence-independent processing site of the C-terminal domain (CTD) influences maturation of the RgpB protease from Porphyromonas gingivalis. Molecular Microbiology, 89(5), 903-917. [More Information]

2012

  • Gu, H., Fan, D., Gao, J., Zou, W., Peng, Z., Zhao, Z., Ling, J., LeGeros, R. (2012). Effect of ZnCl2 on plaque growth and biofilm vitality. Archives of Oral Biology, 57(4), 369-375. [More Information]
  • Gao, J., Lu, Y., Browne, G., Yap, B., Trewhella, J., Hunter, N., Nguyen, K. (2012). The role of heme-binding by DNA-protective protein from starved-cells (Dps) in the tolerance of Porphyromonas gingivalis to heme toxicity. Journal of Biological Chemistry, 287(50), 42243-42258. [More Information]

2010

  • Gao, J., Nguyen, K., Hunter, N. (2010). Characterization of a hemophore-like protein from Porphyromonas gingivalis. Journal of Biological Chemistry, DOI:10.1074/jbc.M110.163535, 1-22. [More Information]

2009

  • Gao, J., Nguyen, K., Hunter, N. (2009). A novel haem uptake in Porphyromonas gingivalis. Journal of Dental Research.
  • Zou, W., Gao, J., Jones, A., Hunter, N., Swain, M. (2009). Characterization of a novel calibration method for mineral density determination of dentine by x-ray micro-tomography. The Analyst, 134(1), 72-79.

2008

  • Gao, J., Xie, H., Nguyen, K., Hunter, N. (2008). Detection and characterization of novel outer membrane proteins involved in heme binding by Porphyromonas gingivalis. Journal of Biotechnology, 136, S88. [More Information]

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