Mr Jinlong Gao
C24 - Westmead Hospital
The University of Sydney
|Telephone||61 2 9845 8766|
|Fax||61 2 9845 7599|
|Curriculum vitae||Curriculum vitae|
Bachelor of Dental Science, Sun Yat-sen University, China, 2007
Doctor of Philosophy, The University of Sydney, 2011, thesis title: “Characterisation of Novel Haem Binding Proteins in the Oral Pathogen Porphyromonas gingivalis”. Supervisor: Professor Neil Hunter, Dr Ky-Anh Nguyen.
Upon completing the PhD, he took up a research fellow position at Institute of Dental Research, Westmead Millennium Institute. Currently, he is offered a combined teaching and research position with the Faculty of Dentistry, The University of Sydney.
Iron is essential for the survival of all bacteria and many pathogenic bacteria have developed sophisticated mechanisms by which they utilize the host haem containing proteins as a source of iron. The ability of periodontal pathogens, such as Porphyromonas gingivalis, to acquire haem is in part linked to their virulence. Utilizing a number of approaches we seek to understand the molecular mechanisms by which pathogenic bacteria acquire haem. These studies have led to the functional and structural characterisation of several proteins involved in haem uptake and degradation.
We were the first to discovered and functionally characterize the haemophore HusA in the oral pathogen P. gingivalis. HusA plays a critical role in the capacity of P. gingivalis to grow under haem limitation which is a physiologically relevant situation. We also characterized the DNA protective protein Dps in P. gingivalis binds haem and protects P gingivalis cells against DNA damage induced by radicals generated by haem and iron through Fenton reaction. These studies will provide new targets for control of infection by P. gingivalis and eventually lead to the rational design of potential therapeutic agents.
1. Characterization of a novel haemophore-dependent haem uptake pathway in the oral pathogen Porphyromonas gingivalis
2. Exploring the roles of DNA-protective protein Dps in the resistance to oxidative stresses induced by haem or iron in anaerobes
3. Understanding the haem utilization in black-pigmented Bacteriodetes
Member of International Association of Dental Research
Awards and honours
Bela Schwartz fellowship, Bela Schwartz Foundation, The University of Sydney, 2009-2011
Chinese Government Award for Outstanding Chinese Students Study Abroad, Chinese Scholarship Council, 2010
Award of Colgate Travel Grant for IADR/PAPF, 2009
RG Schamschula Prize, The Faculty of Dentistry, The University of Sydney, 2008
International Research Vernick Fee Scholarship, Faculty of Dentistry, The University of Sydney, 2008, 2009
NSW Dental Board Postgraduate Award, 2007, 2008, 2009
Microbiology; Protein Chemistry; Protein Function
- Characterize a haemophore receptor HusB in the hus haem uptake pathway in Porphyromonas gingivalis; Gao J; Australian Dental Research Foundation/Research Support.