Ms Munira Xaymardan

Senior Lecturer, Faculty of Dentistry

C12 - United Dental Hospital
The University of Sydney

Telephone 61 2 9351 8321
Fax 61 2 9351 8333

Website University of Sydney

Biographical details

Munira Xaymardan is a senior lecturer in the Faculty of Dentistry and Theme Head of Life Sciences unit of study. Dr. Xaymardan graduated from the Dental Faculty of Shanghai Jiao Tong (former 2nd Medical) University. She completed Ph.D. program at the University of Sydney and has had successful postdoctoral careers at the Cornell University (USA) and University of Toronto (Canada).

Research interests

Dr. Xaymardan's research interest has been in the areas of wound healing, tissue specific and circulating stem cells and their role in adult muscle regeneration. Particularly, she has been interested in the role of the platelet-derived growth factor receptor alpha in the cardiac homeostasis, injury and more recently in the cardiac development.

Current projects

1) PDGF modulation of the endogenous adult cardiac stem cells

2) PDGFRa positive cardiac interstitial cells: chracterisation and differentiation in homeostasis, development and injury

3) Role of masticatory muscle progenitors in cardiac repair

Associations

· International Society of Stem Cell Research

· Australian Dental Association

· Australian Stem Cell Network

Awards and honours

1. Canadian Heart and Stroke Foundation postdoctoral fellowship (2008-9)

2. Presented in the book of Kazakhstan president's list of Outstanding Expatriate Kazakh Scientists

3. Banting and Best Postdoctoral Fellowship. Canada (2004-6)

4. Travel Award for International Stem Cell Conference (2007). Australian Stem Cell Center

5. Travel award for Keystone Symposium (2004), Keystone, Colorado, USA

6. New Investigator Award, American Heart Association (2003). Salt Lake City, USA

7. Ausaid PhD scholarship (1996-2000).

8. US Patent, ?Protection of Myocardium.. Co-inventor: Dr. Jay Edelberg (2007-).

Keywords

Platelet derived growth factor; Cardiovascular diseases; Regeneration medicine/Tissue engineering; Dentistry; Stem cells

Honours project opportunities

  • Role of Platelet Derived Growth factor Receptor Alpha cells in Tooth Development

Selected grants

2011

  • Development prospective research skills in the year 1-2- Doctor of Medical Dentistry Students; Xaymardan M; University of Sydney/Strategic Development Grant.

2010

  • Major Equipment Grant; Xaymardan M; University of New South Wales/Research Support.
  • Rebecca Cooper Foundation Grant; Xaymardan M; Rebecca Cooper Foundation/Rebecca Cooper Foundation.

Selected publications

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Book Chapters

  • Xaymardan, M., Cimini, M., Weisel, R., Li, R. (2010). Bone Marrow Stem Cell: Properties and pluripotency. In Anthony Atala (Eds.), Foundations of Regenerative Medicine: Clinical and Therapeutic Applications, (pp. 166-181). United States of America: Elsevier.
  • Xaymardan, M., Cimini, M., Weisel, R., Li, R. (2008). Bone Marrow Stem Cell: Properties and pluripotency. In Anthony Atala (Eds.), Principles of Regenerative Medicine, (pp. 268-283). United States of America: Elsevier.
  • Xaymardan, M., Cimini, M., Weisel, R., Li, R. (2008). Bone Marrow Stem Cells: Properties and Pluripotency. In Anthony Atala (Eds.), Foundations of Regenerative Medicine: Clinical and Therapeutic Applications, (pp. 268-283). United States of America: Elsevier.

Journals

  • David, M., Kelly, E., Cheung, I., Xaymardan, M., Moore, M., Zoellner, H. (2014). SAOS-2 Osteosarcoma Cells Bind Fibroblasts via ICAM-1 and This Is Increased by Tumour Necrosis Facotr-a. PloS One, 9(6), e101202.
  • David, M., Kelly, E., Cheung, I., Xaymardan, M., Moore, M., Zoellner, H. (2014). SAOS-2 Osteosarcoma Cells Bind Fibroblasts via ICAM-1 and This Is Increased by Tumour Necrosis Factor-α. PloS One, 9(6), e101202. [More Information]
  • Xaymardan, M., Sun, Z., Hatta, K., Tsukashita, M., Konecny, F., Weisel, R., Li, R. (2012). Uterine cells are recruited to the infarcted heart and improve cardiac outcomes in female rats. Journal of Molecular and Cellular Cardiology, 52(6), 1265-1273. [More Information]
  • Chong, J., Chandrakanthan, V., Xaymardan, M., Asli, N., Li, J., Ahmed, I., Heffernan, C., Menon, M., Scarlett, C., Rashidianfar, A., Zoellner, H., et al (2011). Adult Cardiac-Resident MSC-like Stem Cells with a Proepicardial Origin. Cell Stem Cell, 9(6), 527-540. [More Information]
  • Bolitho (nee Donald), C., Xaymardan, M., Lynch, G., Zoellner, H. (2010). Vascularity during wound maturation correlates with fragmentation of serum albumin but not ceruloplasmin, transferrin, or haptoglobin. Wound Repair and Regeneration, 18, 211-222. [More Information]
  • Xaymardan, M., Cimini, M., Fazel, S., Weisel, R., Lu, W., Martin, U., Harvey, R., Li, R. (2009). c-Kit function is necessary for in vitro myogenic differentiation of bone marrow hematopoietic cells. Stem Cells: the international journal of cell differentiation and proliferation, 27(8), 1911-1920. [More Information]
  • Xaymardan, M., Cimini, M., Fazel, S., Weisel, R., Lu, W., Martin, U., Harvey, R., Li, R. (2009). c-Kit function is necessary for in vitro myogenic differentiation of bone marrow hematopoietic cells. Stem Cells, 27(8), 1911-1920. [More Information]
  • Ahmed, I., Chandrathanan, V., Xaymardan, M., Prall, O., Nasr-Esfahani, S., Harvey, R. (2008). In vitro characterization of adult cardiac progenitors and flux after ischemic injury. Journal Of Heart And Lung Transplantation, 27(2), S213-S213.
  • Cimini, M., Fazel, S., Zhuo, S., Xaymardan, M., Fujii, H., Weisel, R., Li, R. (2007). c-Kit Dysfunction Impairs Myocardial Healing After Infarction. Circulation (Baltimore), 116. [More Information]
  • Cai, D., Holm, J., Duignan, I., Zheng, J., Xaymardan, M., Chin, A., Ballard, V., Bella, J., Edelberg, J. (2006). BDNF-mediated enhancement of inflammation and injury in the aging heart. Physiological Genomics, 24(3), 191-197.
  • Cimini, M., Fazel, S., Sun, Z., Xaymardan, M., Weisel, R., Li, R. (2006). Left Decreased myofibrobst accumulation predispose cKit-deficient (Kit(W)/Kit(W-v)) mice to LV dilation. Circulation, 114(18), 566-566.
  • Ballard, V., Xaymardan, M., Chin, A., Dulgnan, I., Holm, J., Edelberg, J. (2006). Restoration of cardiac angiogenesis in aging female mice: identification of a novel estrogen-tenascin-C inductive pathway. The FASEB Journal, 20(Suppl), A31-A31.
  • Cai, D., Holm, J., Duignan, I., Zheng, J., Xaymardan, M., Chin, A., Ballard, V., Bella, J., Edelberg, J. (2005). BDNF-mediated enhancement of inflammation andinjury in the aging heart. Physiological Genomics, 24(3), 191-197. [More Information]
  • Xaymardan, M., Gibbins, J., Zoellner, H. (2002). Adipogenic healing in adult mice by implantation of hollow devices in muscle. Anatomical Record - Advances in Integrative Anatomy and Evolutionary Biology, 267(1), 28-36. [More Information]

Conferences

  • Xaymardan, M., Asli, N., Chandrathanan, V., Chong, J., Harvey, R. (2010). In vivo Regulation and Differentiation of PDGFRa+ Adult Murine Endogenous Cardiac Stem Cells. 2010 Australian Stem Cell Centre Stream 4 Symposium.
  • Xaymardan, M., Asli, N., Chandrathanan, V., Chong, J., Harvey, R. (2010). Regulation and Differentiation of PDGFRa+ Adult Murine Endogenous Cardiac Stem Cells. St Vincent's Hospital Research Symposium.
  • Xaymardan, M., Asli, N., Chandrathanan, V., Chong, J., Harvey, R. (2010). Regulation and Differentiation of PDGFRa+ Adult Murine Endogenous Cardiac Stem Cells. 2010 Australian Stem Cell Conference.
  • Xaymardan, M., Asli, N., Chandrathanan, V., Chong, J., Harvey, R. (2010). Regulation and Differentiation of PDGFRa+ Adult Murine Endogenous Cardiac Stem Cells. 8th Annual Meeting of International Society for Stem Cell Research.
  • Xaymardan, M., Chandrathanan, V., Kollar, K., Harvey, R. (2007). Distribution and Therapeutic Potential of PDGFR-alpha Stem Cell in the Adult Heart. 2007 International Stem Cell Conference.
  • Cimini, M., Fazel, S., Sun, Z., Seneviratne, C., Xaymardan, M., Weisel, R., Li, R. (2006). Left Ventricular Dilatation after Myocardial Infarction Results From Inadequate Myobiroblast Proliferation. 2006 American Heart Association Conference.
  • Xaymardan, M., Weisel, R., Li, R. (2006). Spontaneous in Vitro Cardiomyocyte Differentiation of Bone Marrow Cells in Aging Mice. Canadian Cardiovascular Society Consensus Conference 2006.
  • Xaymardan, M., Xiao, C., Lewis, G. (2005). Endothelial, Lipase (EL) Does not Preferentially Enhance the Clearance of Triglyceride (TG)-Enriched vs Native HDL apo A-I. American Diabetes Association 2005.
  • Cimini, M., Fazel, S., Sun, Z., Seneviratne, C., Xaymardan, M., Weisel, R., Li, R. (2005). Left Ventricular Dilatation after Myocardial Infarction Results From Inadequate Myobiroblast Proliferation. Canadian Cardiovascular Society Consensus Conference 2005.
  • Hao, L., Xaymardan, M., Gibbins, J., Zoellner, H. (2004). Expression Of Leptin Mrna, Increase In Cell Size And The Effect Of Auto-Transplantation In Adipogenic Wound Tissue. Fourth International Conference of Biological Mechanisms of Tooth Movement and Craniofacial Adaptation, Bangkok: Amarin Printing & Publishing.

2014

  • David, M., Kelly, E., Cheung, I., Xaymardan, M., Moore, M., Zoellner, H. (2014). SAOS-2 Osteosarcoma Cells Bind Fibroblasts via ICAM-1 and This Is Increased by Tumour Necrosis Facotr-a. PloS One, 9(6), e101202.
  • David, M., Kelly, E., Cheung, I., Xaymardan, M., Moore, M., Zoellner, H. (2014). SAOS-2 Osteosarcoma Cells Bind Fibroblasts via ICAM-1 and This Is Increased by Tumour Necrosis Factor-α. PloS One, 9(6), e101202. [More Information]

2012

  • Xaymardan, M., Sun, Z., Hatta, K., Tsukashita, M., Konecny, F., Weisel, R., Li, R. (2012). Uterine cells are recruited to the infarcted heart and improve cardiac outcomes in female rats. Journal of Molecular and Cellular Cardiology, 52(6), 1265-1273. [More Information]

2011

  • Chong, J., Chandrakanthan, V., Xaymardan, M., Asli, N., Li, J., Ahmed, I., Heffernan, C., Menon, M., Scarlett, C., Rashidianfar, A., Zoellner, H., et al (2011). Adult Cardiac-Resident MSC-like Stem Cells with a Proepicardial Origin. Cell Stem Cell, 9(6), 527-540. [More Information]

2010

  • Xaymardan, M., Cimini, M., Weisel, R., Li, R. (2010). Bone Marrow Stem Cell: Properties and pluripotency. In Anthony Atala (Eds.), Foundations of Regenerative Medicine: Clinical and Therapeutic Applications, (pp. 166-181). United States of America: Elsevier.
  • Xaymardan, M., Asli, N., Chandrathanan, V., Chong, J., Harvey, R. (2010). In vivo Regulation and Differentiation of PDGFRa+ Adult Murine Endogenous Cardiac Stem Cells. 2010 Australian Stem Cell Centre Stream 4 Symposium.
  • Xaymardan, M., Asli, N., Chandrathanan, V., Chong, J., Harvey, R. (2010). Regulation and Differentiation of PDGFRa+ Adult Murine Endogenous Cardiac Stem Cells. St Vincent's Hospital Research Symposium.
  • Xaymardan, M., Asli, N., Chandrathanan, V., Chong, J., Harvey, R. (2010). Regulation and Differentiation of PDGFRa+ Adult Murine Endogenous Cardiac Stem Cells. 2010 Australian Stem Cell Conference.
  • Xaymardan, M., Asli, N., Chandrathanan, V., Chong, J., Harvey, R. (2010). Regulation and Differentiation of PDGFRa+ Adult Murine Endogenous Cardiac Stem Cells. 8th Annual Meeting of International Society for Stem Cell Research.
  • Bolitho (nee Donald), C., Xaymardan, M., Lynch, G., Zoellner, H. (2010). Vascularity during wound maturation correlates with fragmentation of serum albumin but not ceruloplasmin, transferrin, or haptoglobin. Wound Repair and Regeneration, 18, 211-222. [More Information]

2009

  • Xaymardan, M., Cimini, M., Fazel, S., Weisel, R., Lu, W., Martin, U., Harvey, R., Li, R. (2009). c-Kit function is necessary for in vitro myogenic differentiation of bone marrow hematopoietic cells. Stem Cells: the international journal of cell differentiation and proliferation, 27(8), 1911-1920. [More Information]
  • Xaymardan, M., Cimini, M., Fazel, S., Weisel, R., Lu, W., Martin, U., Harvey, R., Li, R. (2009). c-Kit function is necessary for in vitro myogenic differentiation of bone marrow hematopoietic cells. Stem Cells, 27(8), 1911-1920. [More Information]

2008

  • Xaymardan, M., Cimini, M., Weisel, R., Li, R. (2008). Bone Marrow Stem Cell: Properties and pluripotency. In Anthony Atala (Eds.), Principles of Regenerative Medicine, (pp. 268-283). United States of America: Elsevier.
  • Xaymardan, M., Cimini, M., Weisel, R., Li, R. (2008). Bone Marrow Stem Cells: Properties and Pluripotency. In Anthony Atala (Eds.), Foundations of Regenerative Medicine: Clinical and Therapeutic Applications, (pp. 268-283). United States of America: Elsevier.
  • Ahmed, I., Chandrathanan, V., Xaymardan, M., Prall, O., Nasr-Esfahani, S., Harvey, R. (2008). In vitro characterization of adult cardiac progenitors and flux after ischemic injury. Journal Of Heart And Lung Transplantation, 27(2), S213-S213.

2007

  • Cimini, M., Fazel, S., Zhuo, S., Xaymardan, M., Fujii, H., Weisel, R., Li, R. (2007). c-Kit Dysfunction Impairs Myocardial Healing After Infarction. Circulation (Baltimore), 116. [More Information]
  • Xaymardan, M., Chandrathanan, V., Kollar, K., Harvey, R. (2007). Distribution and Therapeutic Potential of PDGFR-alpha Stem Cell in the Adult Heart. 2007 International Stem Cell Conference.

2006

  • Cai, D., Holm, J., Duignan, I., Zheng, J., Xaymardan, M., Chin, A., Ballard, V., Bella, J., Edelberg, J. (2006). BDNF-mediated enhancement of inflammation and injury in the aging heart. Physiological Genomics, 24(3), 191-197.
  • Cimini, M., Fazel, S., Sun, Z., Xaymardan, M., Weisel, R., Li, R. (2006). Left Decreased myofibrobst accumulation predispose cKit-deficient (Kit(W)/Kit(W-v)) mice to LV dilation. Circulation, 114(18), 566-566.
  • Cimini, M., Fazel, S., Sun, Z., Seneviratne, C., Xaymardan, M., Weisel, R., Li, R. (2006). Left Ventricular Dilatation after Myocardial Infarction Results From Inadequate Myobiroblast Proliferation. 2006 American Heart Association Conference.
  • Ballard, V., Xaymardan, M., Chin, A., Dulgnan, I., Holm, J., Edelberg, J. (2006). Restoration of cardiac angiogenesis in aging female mice: identification of a novel estrogen-tenascin-C inductive pathway. The FASEB Journal, 20(Suppl), A31-A31.
  • Xaymardan, M., Weisel, R., Li, R. (2006). Spontaneous in Vitro Cardiomyocyte Differentiation of Bone Marrow Cells in Aging Mice. Canadian Cardiovascular Society Consensus Conference 2006.

2005

  • Cai, D., Holm, J., Duignan, I., Zheng, J., Xaymardan, M., Chin, A., Ballard, V., Bella, J., Edelberg, J. (2005). BDNF-mediated enhancement of inflammation andinjury in the aging heart. Physiological Genomics, 24(3), 191-197. [More Information]
  • Xaymardan, M., Xiao, C., Lewis, G. (2005). Endothelial, Lipase (EL) Does not Preferentially Enhance the Clearance of Triglyceride (TG)-Enriched vs Native HDL apo A-I. American Diabetes Association 2005.
  • Cimini, M., Fazel, S., Sun, Z., Seneviratne, C., Xaymardan, M., Weisel, R., Li, R. (2005). Left Ventricular Dilatation after Myocardial Infarction Results From Inadequate Myobiroblast Proliferation. Canadian Cardiovascular Society Consensus Conference 2005.

2004

  • Hao, L., Xaymardan, M., Gibbins, J., Zoellner, H. (2004). Expression Of Leptin Mrna, Increase In Cell Size And The Effect Of Auto-Transplantation In Adipogenic Wound Tissue. Fourth International Conference of Biological Mechanisms of Tooth Movement and Craniofacial Adaptation, Bangkok: Amarin Printing & Publishing.

2002

  • Xaymardan, M., Gibbins, J., Zoellner, H. (2002). Adipogenic healing in adult mice by implantation of hollow devices in muscle. Anatomical Record - Advances in Integrative Anatomy and Evolutionary Biology, 267(1), 28-36. [More Information]

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