Professor Neil Hunter

Associate Dean (Research)

C24 - Westmead Hospital
The University of Sydney

Telephone +61 2 98458762
Fax +61 2 98457599

Website University of Sydney
Westmead Millenium Institute
Google Scholar
Curriculum vitae Curriculum vitae

Biographical details

Neil Hunter is the Associate Dean (Research), Faculty of Dentistry, University of Sydney and an Adjunct Professor of the Cooperative Research Centre for Eye Research and Technology, University of NSW.

He is a member of the Oral Health Executive and a founding Fellow of the Faculty of Oral Pathology, The Royal College of Pathologists of Australasia.

Research interests

Neil's early work laid the basis for a model of relapsing arthritis. More recently, he has contributed to understanding of the characteristic morphological changes of the destructive inflammation of the supporting tissues of the teeth. Investigations of chronic infection have been enhanced by the development of quantitative molecular probe analysis of bacterial populations.

This approach has enabled the dissection of the microflora causally related to the major oral infections and provided novel approaches to the diagnosis of infection.

Teaching and supervision

Neil Hunter teaches in the Life Science stream of the DMD, BDent and BOH graduate programs. He also supervises both PhD and MPhil candidates.

Keywords

Infection and immunity; Porphyromonas gingivalis; Chronic disease

Selected grants

2013

  • The inflammasome of atal epithelium; Hunter N; DVC Research/Bridging Support Grant.
  • Acidogenicity of bacterial consortia within carious dentine; Kianoush N, Hunter N; Australian Dental Research Foundation/Research Support.
  • Towards selective removal of Porphyromonas gingivalis from the dental plaque; Dingsdag S, Hunter N; Australian Dental Research Foundation/Research Support.

2012

  • Acidogenicity of bacterial consortia within carious dentine; Kianoush N, Hunter N; Australian Dental Research Foundation/Research Support.

2011

  • Acidogenicity of bacterial consortia within carious dentine; Kianoush N, Hunter N; Dental Board of NSW/Research Support.
  • Dental pulp microvasculature in reactionary dentinogenesis; Mostofi Zadeh Farahani R, Hunter N; Dental Board of NSW/Research Support.
  • The study of relationship between bacteria and matrix metalloproteinase-2 (MMP-2) in mature human carious dentin; Charadram N, Swain M, Hunter N, Kianoush N; Australian Dental Research Foundation/Research Support.
  • Acidogenicity of bacterial consortia within carious dentine; Kianoush N, Hunter N; Australian Dental Research Foundation/Research Support.
  • Characterisation of HusA, a novel haemophore-like protein in Porphyromonas gingivalis; Hunter N; DVC Research/Bridging Support Grant.

2010

  • The interaction of odontoblasts and dentric pulp cells in healthy and carious human teeth; Mostofi Zadeh Farahani R, Hunter N; Australian Dental Research Foundation/Research Support.
  • The significance of binding of blood group antigens by the lysine gingipain of Porphyromanos gingivalis; Hunter N; DVC Research/Bridging Support Grant.

2009

  • Accuracy of µCT-based quantification of calcified tissue mineralization; Zou W, Swain M, Hunter N; Australian Dental Research Foundation/Research Support.
  • Growth factor expression in reactionary dentinogenesis; Mostofi Zadeh Farahani R, Hunter N; Dental Board of NSW/Research Support.
  • Immune responses to biotype specific regions of the lysine gingipain (Kgp) of Porphyromonas gingivalis in patients with periodontitis; Nadkarni M, Hunter N; Australian Dental Research Foundation/Research Support.
  • Regulation of the permeability of oral epithelia by CD24; Hunter N; DVC Research/Bridging Support Grant.
  • Binding of blood group antigens mediated by the Lys-gingipain of porphyromonas gingivalis; Hunter N; DVC Research/Bridging Support Grant.

2008

  • Microbial indicators for the conservative therapy of dentinal caries; Hunter N, Martin E, Nadkarni M, Swain M, Zoellner H, Jacques N; National Health and Medical Research Council (NHMRC)/Project Grants.

2006

  • Stability and structure of the interface between a metallic glass and its congruent crystal phases; Xie H, Hunter N; Australian Dental Research Foundation/Project Support.
  • The presence of advanced glycation end products in periodontal disease in diabetic and non-diabetic subjects: a potential mechanism for the pathogenesis of periodontal disease; Yu H, Hunter N, Chapple C, Yu H; Australian Dental Research Foundation/Project Support.
  • Immunity to lys-gingipain domains in chronic periodontitis; Nadkarni M, Hunter N; Australian Dental Research Foundation/Project Support.
  • Local Production Of Auto-Antibodies In Chronic Periodontitis; Ye P, Hunter N; Australian Dental Research Foundation/Project Support.

2005

  • The presence of advanced glycation end products in periodontal disease in diabetic and non-diabetic subjects: a potential mechanism for the pathogenesis of periodontal disease.; Daly C, Yu H, Yu H, Hunter N; Dental Board of NSW/Research and Education Grants.
  • Synthesis and evaluation of anti-microbial porphyrin adducts for the targeted inhibition of Porphyromonas gingivalis; Crossley M, Collyer C, Hunter N, Hunter N; Australian Research Council (ARC)/Linkage Projects (LP).

2003

  • Molecular epidemiology of infection in aboriginal communities; Hunter N, Jacques N, Nadkarni M, Martin E, Chapple C, Willcox M; National Health and Medical Research Council (NHMRC)/Strategic Research Development Committee (SDRC): Oral Health Research Grant.

Selected publications

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Journals

  • Kianoush, N., Adler, C., Nguyen, K., Browne, G., Simonian, M., Hunter, N. (2014). Bacterial Profile of Dentine Caries and the Impact of pH on Bacterial Population Diversity. PLoS One, 9(3), 1-10. [More Information]
  • Nadkarni, M., Chen, Z., Wilkins, M., Hunter, N. (2014). Comparative Genome Analysis of Lactobacillus rhamnosus Clinical Isolates from Initial Stages of Dental Pulp Infection: Identification of a New Exopolysaccharide Cluster. PLoS One, 9(3), e90643. [More Information]
  • Ye, P., Yu, H., Simonian, M., Hunter, N. (2014). Expression patterns of tight junction components induced by CD24 in an oral epithelial cell-culture model correlated to affected periodontal tissues. Journal of Periodontal Research, 49(2), 253-259. [More Information]
  • Kianoush, N., Nguyen, K., Browne, G., Simonian, M., Hunter, N. (2014). pH gradient and distribution of streptococci, lactobacilli, prevotellae, and fusobacteria in carious dentine. Clinical Oral Investigations, 18(2), 659-669. [More Information]
  • Ye, P., Harty, D., Commandeur, Z., Hunter, N. (2013). Binding of Streptococcus gordonii to oral epithelial monolayers increases paracellular barrier function. Microbial Pathogenesis, 56, 53-59. [More Information]
  • Chen, Z., Wilkins, M., Hunter, N., Nadkarni, M. (2013). Draft genome sequences of two clinical isolates of Lactobacillus rhamnosus initial stages of dental pulp infection. Genome Announcements, 1(1), e00073-12. [More Information]
  • Zhou, X., Gao, J., Hunter, N., Potempa, J., Nguyen, K. (2013). Sequence-independent processing site of the C-terminal domain (CTD) influences maturation of the RgpB protease from Porphyromonas gingivalis. Molecular Microbiology, 89(5), 903-917. [More Information]
  • Charadram, N., Austin, C., Trimby, P., Simonian, M., Swain, M., Hunter, N. (2013). Structural analysis of reactionary dentin formed in response to polymicrobial invasion. Journal of Structural Biology, 181(3), 207-222. [More Information]
  • Mostofi Zadeh Farahani, R., Sarrafpour, B., Simonian, M., Li, Q., Hunter, N. (2012). Directed glia-assisted angiogenesis in a mature neurosensory structure: Pericytes mediate an adaptive response in human dental pulp that maintains blood-barrier function. The Journal of Comparative Neurology, 520(17), 3803-3826. [More Information]
  • Nadkarni, M., Browne, G., Chhour, K., Byun, R., Nguyen, K., Chapple, C., Jacques, N., Hunter, N. (2012). Pattern of distribution of Prevotella species/phylotypes associated with healthy gingiva and periodontal disease. European Journal of Clinical Microbiology and Infectious Diseases, 31(11), 2989-2999. [More Information]
  • Charadram, N., Mostofi Zadeh Farahani, R., Harty, D., Rathsam, C., Swain, M., Hunter, N. (2012). Regulation of reactionary dentin formation by odontoblasts in response to polymicrobial invasion of dentin matrix. Bone, 50(1), 265-275. [More Information]
  • Harty, D., Mostofi Zadeh Farahani, R., Simonian, M., Hunter, L., Hunter, N. (2012). Streptococcus gordonii FSS2 Challisin affects fibrin clot formation by digestion of the aC region and cleavage of the N-terminal region of the BB chains of fibrinogen. Thrombosis and Haemostasis, 108(2), 236-246. [More Information]
  • Yun, P., Li, N., Collyer, C., Hunter, N. (2012). The K1K2 Region of Lys-Gingipain of Porphyromonas gingivalis Blocks Induction of HLA Expression by Gamma Interferon. Infection and Immunity, 80(10), 3733-3741. [More Information]
  • Gao, J., Lu, Y., Browne, G., Yap, B., Trewhella, J., Hunter, N., Nguyen, K. (2012). The role of heme-binding by DNA-protective protein from starved-cells (Dps) in the tolerance of Porphyromonas gingivalis to heme toxicity. Journal of Biological Chemistry, 287(50), 42243-42258. [More Information]
  • Zou, W., Hunter, N., Swain, M. (2011). Application of Polychromatic muCT for Mineral Density Determination. Journal of Dental Research, 90(1), 18-30. [More Information]
  • Mostofi Zadeh Farahani, R., Simonian, M., Hunter, N. (2011). Blueprint of an Ancestral Neurosensory Organ Revealed in Glial Networks in Human Dental Pulp. The Journal of Comparative Neurology, 519(16), 3306-3326. [More Information]
  • Harty, D., Hunter, N. (2011). Carboxypeptidase activity common to viridans group steptococci cleaves angiotensin I to angiotensin II: an activity homologous to angiotensin-converting enzyme (ACE). Microbiology, 157(7), 2143-2151. [More Information]
  • Ye, P., Yu, H., Simonian, M., Hunter, N. (2011). Ligation of CD24 expressed by oral eipithelial cells induced kinase dependent decrease in paracellular permeability mediated by tight junction proteins. Biochemical and Biophysical Research Communications, 412(1), 165-169. [More Information]
  • Li, N., Yun, P., Jeffries, C., Langley, D., Gamsjaeger, R., Church, W., Hunter, N., Collyer, C. (2011). The modular structure of haemagglutinin/adhesin regions in gingipains of Porphyromonas gingivalis. Molecular Microbiology, 81(5), 1358-1373. [More Information]
  • Mostofi Zadeh Farahani, R., Nguyen, K., Simonian, M., Hunter, N. (2010). Adaptive calcified matrix response of dental pulp to bacterial invasion in associated with establishment of a network of Glial Fibrillary Acidic Protein+/Glutamine Synthetase+ Cells. The American Journal of Pathology: cellular and molecular biology of disease, 177(4), 1901-1914. [More Information]
  • Gao, J., Nguyen, K., Hunter, N. (2010). Characterization of a hemophore-like protein from Porphyromonas gingivalis. Journal of Biological Chemistry, DOI:10.1074/jbc.M110.163535, 1-22. [More Information]
  • Nadkarni, M., Simonian, M., Harty, D., Zoellner, H., Jacques, N., Hunter, N. (2010). Lactobacilli Are Prominent in the Initial Stages of Polymicrobial Infection of Dental Pulp. Journal of Clinical Microbiology, 48(5), 1732-1740. [More Information]
  • Li, N., Yun, P., Nadkarni, M., Nazila, B., Nguyen, K., Lee, M., Hunter, N., Collyer, C. (2010). Structure determination and analysis of a haemolytic gingipain adhesin domain from Porphyromonas gingivalis. Molecular Microbiology, 76(4), 861-873. [More Information]
  • Gao, J., Nguyen, K., Hunter, N. (2009). A novel haem uptake in Porphyromonas gingivalis. Journal of Dental Research.
  • Ye, P., Nadkarni, M., Simonian, M., Hunter, N. (2009). CD24 regulated gene expression and distribution of tight junction proteins is associated with altered barrier function in oral epithelial monolayers. BMC Cell Biology, 10, 1-16. [More Information]
  • Zou, W., Gao, J., Jones, A., Hunter, N., Swain, M. (2009). Characterization of a novel calibration method for mineral density determination of dentine by x-ray micro-tomography. The Analyst, 134(1), 72-79.
  • Nadkarni, M., Chhour, K., Browne, G., Jacques, N., Hunter, N. (2009). Lysine gingipain (kgp) biovars of Porphyromonas gingivalis exhibit differential distribution on oral mucosal sites. Journal of Clinical Microbiology, 47(10), 3350-3352. [More Information]
  • Nadkarni, M., Martin, E., Hunter, N., Jacques, N. (2009). Methods for optimizing DNA extraction before quantifying oral bacterial numbers by real-time PCR. FEMS Microbiology Letters, 296, 45-51. [More Information]
  • Yap, B., Simpkins, G., Collyer, C., Hunter, N., Crossley, M. (2009). Porphyrin-linked nitroimidazole antibiotics targeting: Prophyromonas gingivalis. Organic and Biomolecular Chemistry, 7(14), 2855-2863. [More Information]
  • Nguyen, K., Zylicz, J., Szczesny, P., Sroka, A., Hunter, N., Potempa, J. (2009). Verification of a topology model of PorT as an integral outer-membrane protein in Porphyromonas gingivalis. Microbiology, 155(2), 328-337. [More Information]
  • Gao, J., Xie, H., Nguyen, K., Hunter, N. (2008). Detection and characterization of novel outer membrane proteins involved in heme binding by Porphyromonas gingivalis. Journal of Biotechnology, 136, S88-S88. [More Information]
  • Smith-Vaughan, H., Byun, R., Halpin, S., Nadkarni, M., Jacques, N., Hunter, N., Morris, P., Leach, A. (2008). Interventions for prevention of otitis media may be most effective if implemented in the first weeks of life. International Journal of Pediatric Otorhinolaryngology, 72, 57-61. [More Information]
  • Langley, D., Harty, D., Jacques, N., Hunter, N., Guss, M., Collyer, C. (2008). Structure of N-acetyl-B-D-glucosaminidase (GcnA) from the Endocarditis Pathogen Streptococcus gordonii and its Complex with the Mechanism-based Inhibitor NAG-thiazoline. Journal of Molecular Biology, 377, 104-116. [More Information]
  • Yun, P., DeCarlo, A., Hunter, N. (2007). Blockade of protese-activated receptors on T cells corelated with altered proteloysis of CD27 by gingipains of porphyromonas gingivalis. Clinical and Experimental Immunology, 150(2), 217-229. [More Information]
  • Fong, M., Darendeliler, M., Hunter, N., Shen, G. (2007). Epithelial cells in PDL are critical in resuming the integral relation between tooth root and supporting bone after trauma - A transplantation experiment. Archives of Oral Biology, 52(2), 182-188. [More Information]
  • Byun, R., Carlier, J., Jacques, N., Marchandin, H., Hunter, N. (2007). Veillonella denticariosi sp. nov., isolated from human carious dentine. International Journal of Systematic and Evolutionary Microbiology, 57(12), 2844-2848. [More Information]
  • Yun, P., DeCarlo, A., Hunter, N. (2006). Gingipains of porphyromonas gingivalis modulate leukocyte adhesion molecule expression induced in human endothelial cells by ligation of CD99. Infection and Immunity, 74(3), 1661-1672. [More Information]
  • Smith-Vaughan, H., Byun, R., Nadkarni, M., Jacques, N., Hunter, N., Halpin, S., Morris, P., Leach, A. (2006). Measuring nasal bacterial load and its association with otitis media. B M C Ear Nose and Throat Disorders, 6(1), 10. [More Information]
  • Ye, P., Nadkarni, M., Hunter, N. (2006). Regulation of E-cadherin and TGF-β3 expression by CD24 in cultured oral epithelial cells. Biochemical and Biophysical Research Communications, 349(1), 229-235. [More Information]
  • Yun, P., DeCarlo, A., Chapple, C., Collyer, C., Hunter, N. (2005). Binding of Porphyromonas gingivalis gingipains to human CD4(+) T cells preferentially down-regulates surface CD2 and CD4 with little affect on co-stimulatory molecule expression. Microbial Pathogenesis, 38(2-3), 85-96. [More Information]
  • Yun, P., DeCarlo, A., Chapple, C., Hunter, N. (2005). Functional implication of the hydrolysis of platelet endothelial cell adhesion molecule 1 (CD31) by gingipains of porphyromonas gingivalis for the pathology periodontal disease. Infection and Immunity, 73(3), 1386-1398. [More Information]
  • Ye, P., Simonian, M., Nadkarni, M., DeCarlo, A., Chapple, C., Hunter, N. (2005). Identification of epithelial auto-antigens associated with periodontal disease. Clinical and Experimental Immunology, 139(2), 328-337. [More Information]
  • Chhour, K., Nadkarni, M., Byun, R., Martin, E., Jacques, N., Hunter, N. (2005). Molecular Analysis of Microbial Diversity in Advanced Caries. Journal of Clinical Microbiology, 43(2), 843-849. [More Information]
  • Nadkarni, M., Caldon, E., Chhour, K., Fisher, I., Martin, E., Jacques, N., Hunter, N. (2004). Carious Dentine Provides a Habitat for a Complex Array of Novel Prevotella-Like Organisms. Journal of Clinical Microbiology, 42(11), 5238-5244.
  • Harty, D., Chen, Y., Simpson, C., Berg, T., Cook, S., Mayo, J., Hunter, N., Jacques, N. (2004). Characterisation Of A Novel Homodimeric N-Acetyl-B-D-Glucosaminidase From Streptococcus Gordonii. Biochemical and Biophysical Research Communications, 319(2), 439-447. [More Information]
  • Langley, D., Harty, D., Graham, S., Guss, M., Hunter, N., Collyer, C. (2004). Crystallization Of Gcna, An N-Acetyl-β-D-Glucosaminidase, From Streptococcus Gordonii. Acta Crystallographica. Section D: Biological Crystallography, D60, 1910-1911.
  • Nadkarni, M., Nguyen, K., Chapple, C., DeCarlo, A., Jacques, N., Hunter, N. (2004). Distribution Of Porphyromonas Gingivalis Biotypes Defined By Alleles Of The Kgp (Lys-Gingipain) Gene. Journal of Clinical Microbiology, 42(8), 3873-3876.
  • Nguyen, K., DeCarlo, A., Paramaesvaran, M., Collyer, C., Langley, D., Hunter, N. (2004). Humoral Responses To Porphyromonas gingivalis Gingipain Adhesin Domains In Subjects With Chronic Periodontitis. Infection and Immunity, 72(3), 1374-1382.
  • Byun, R., Nadkarni, M., Chhour, K., Martin, E., Jacques, N., Hunter, N. (2004). Quantitative Analysis Of Diverse Lactobacillus Species Present In Advanced Dental Caries. Journal of Clinical Microbiology, 42(7), 3128-3136.
  • DeCarlo, A., Nadkarni, M., Paramaesvaran, M., Yun, P., Collyer, C., Hunter, N. (2004). Serum Antibodies Against The Hemoglobin-Binding Domain (HA2) Of Porphyromonas Gingivalis. Journal of Periodontal Research, 39(4), 228-235.
  • Ye, P., Simonian, M., Chapple, C., Gibbins, J., Kumar, R., Hunter, N. (2003). Differential expression of transforming growth factors-beta1, -beta2, -beta3 and the type I, II, II receptors in the linng epithelia of inflamed gingiva. Pathology, 35(5), 384-392.
  • Paramaesvaran, M., Nguyen, K., Caldon, E., McDonald, J., Najdi, S., Gonzaga, G., Langley, D., DeCarlo, A., Hunter, N., Crossley, M., Collyer, C. (2003). Porphyrin-mediated cell surface heme capture from hemoglobin by Porphyromanas gingivalis. Journal of Bacteriology, 185(8), 2528-2537.
  • Ye, P., Harty, D., Chapple, C., Nadkarni, M., DeCarlo, A., Hunter, N. (2003). Streptococci and Actinomyces induce antibodies which cross react with epithelial antigens in periodontitis. Clinical and Experimental Immunology, 131(3), 468-476.
  • Nadkarni, M., Martin, E., Jacques, N., Hunter, N. (2002). Determination of bacterial load by real-time PCR using a broad-range (universal) probe and primers set. Microbiology, 148(1), 257-266.
  • Zoellner, H., Chapple, C., Hunter, N. (2002). Microvasculature in gingivitis and chronic periodontitis: disruption of vascular networks with protracted inflammation. Microscopy Research and Technique, 56(1), 15-31. [More Information]
  • Yun, P., DeCarlo, A., Collyer, C., Hunter, N. (2002). Modulation of an interleukin-12 and interferon gamma synergistic feedback regulatory cycle of T-cell/monocyte co-cultures by Porphyromonas gingivalis lipopolysaccharide in the absence or presence of cysteine proteinases. Infection and Immunity, 70(10), 5695-5705.
  • Martin, E., Nadkarni, M., Jacques, N., Hunter, N. (2002). Quantitative microbiological study of human carious dentine by culture and real-time PCR: association of anaerobes with histopathological changes in chronic pulpitis. Journal of Clinical Microbiology, 40(5), 1698-1704.
  • Hunter, N., Nguyen, K., McDonald, J., Quinn, M., Langley, D., Crossley, M., Collyer, C. (2002). Structural requirements for recognition of essential porphyrin by Porphyromonas gingivalis. Journal of Porphyrins and Phthalocyanines, 6(12), 774-782.

Patents

  • Hunter, N., Collyer, C., De Carlo, A. (2010). Prophylaxis And Treatment Of P. Gingivalis Infection. Patent No. 1189630, 60043936.4-08. Germany.
  • Hunter, N., Collyer, C., DeCarlo, A. (2008). A Method Of Prophylaxis And Treatment And Agents Useful For Same. Patent No. 515853, 7319086, 781704. New Zealand.
  • Martin, E., Hunter, N., Jacques, N., Nadkarni, M. (2007). A Method of Detecting Microorganisms. Patent No. 1311706, 2001276180, 7244480. Austria, Belgium, Cyprus, Denmark, Finland, France, Germany, Greece, Ireland, Italy, Luxembourg, Monaco, Netherlands, Portugal, Spain, Sweden, Switzerland, Turkey, United Kingdom.

Reference Works

  • Nadkarni, M., Martin, E., Jacques, N., Hunter, N. (2009). Caries. Encyclopedia of Molecular Mechanisms of Disease. (Vol. 1, pp. 279-280). Berlin: Springer.

2014

  • Kianoush, N., Adler, C., Nguyen, K., Browne, G., Simonian, M., Hunter, N. (2014). Bacterial Profile of Dentine Caries and the Impact of pH on Bacterial Population Diversity. PLoS One, 9(3), 1-10. [More Information]
  • Nadkarni, M., Chen, Z., Wilkins, M., Hunter, N. (2014). Comparative Genome Analysis of Lactobacillus rhamnosus Clinical Isolates from Initial Stages of Dental Pulp Infection: Identification of a New Exopolysaccharide Cluster. PLoS One, 9(3), e90643. [More Information]
  • Ye, P., Yu, H., Simonian, M., Hunter, N. (2014). Expression patterns of tight junction components induced by CD24 in an oral epithelial cell-culture model correlated to affected periodontal tissues. Journal of Periodontal Research, 49(2), 253-259. [More Information]
  • Kianoush, N., Nguyen, K., Browne, G., Simonian, M., Hunter, N. (2014). pH gradient and distribution of streptococci, lactobacilli, prevotellae, and fusobacteria in carious dentine. Clinical Oral Investigations, 18(2), 659-669. [More Information]

2013

  • Ye, P., Harty, D., Commandeur, Z., Hunter, N. (2013). Binding of Streptococcus gordonii to oral epithelial monolayers increases paracellular barrier function. Microbial Pathogenesis, 56, 53-59. [More Information]
  • Chen, Z., Wilkins, M., Hunter, N., Nadkarni, M. (2013). Draft genome sequences of two clinical isolates of Lactobacillus rhamnosus initial stages of dental pulp infection. Genome Announcements, 1(1), e00073-12. [More Information]
  • Zhou, X., Gao, J., Hunter, N., Potempa, J., Nguyen, K. (2013). Sequence-independent processing site of the C-terminal domain (CTD) influences maturation of the RgpB protease from Porphyromonas gingivalis. Molecular Microbiology, 89(5), 903-917. [More Information]
  • Charadram, N., Austin, C., Trimby, P., Simonian, M., Swain, M., Hunter, N. (2013). Structural analysis of reactionary dentin formed in response to polymicrobial invasion. Journal of Structural Biology, 181(3), 207-222. [More Information]

2012

  • Mostofi Zadeh Farahani, R., Sarrafpour, B., Simonian, M., Li, Q., Hunter, N. (2012). Directed glia-assisted angiogenesis in a mature neurosensory structure: Pericytes mediate an adaptive response in human dental pulp that maintains blood-barrier function. The Journal of Comparative Neurology, 520(17), 3803-3826. [More Information]
  • Nadkarni, M., Browne, G., Chhour, K., Byun, R., Nguyen, K., Chapple, C., Jacques, N., Hunter, N. (2012). Pattern of distribution of Prevotella species/phylotypes associated with healthy gingiva and periodontal disease. European Journal of Clinical Microbiology and Infectious Diseases, 31(11), 2989-2999. [More Information]
  • Charadram, N., Mostofi Zadeh Farahani, R., Harty, D., Rathsam, C., Swain, M., Hunter, N. (2012). Regulation of reactionary dentin formation by odontoblasts in response to polymicrobial invasion of dentin matrix. Bone, 50(1), 265-275. [More Information]
  • Harty, D., Mostofi Zadeh Farahani, R., Simonian, M., Hunter, L., Hunter, N. (2012). Streptococcus gordonii FSS2 Challisin affects fibrin clot formation by digestion of the aC region and cleavage of the N-terminal region of the BB chains of fibrinogen. Thrombosis and Haemostasis, 108(2), 236-246. [More Information]
  • Yun, P., Li, N., Collyer, C., Hunter, N. (2012). The K1K2 Region of Lys-Gingipain of Porphyromonas gingivalis Blocks Induction of HLA Expression by Gamma Interferon. Infection and Immunity, 80(10), 3733-3741. [More Information]
  • Gao, J., Lu, Y., Browne, G., Yap, B., Trewhella, J., Hunter, N., Nguyen, K. (2012). The role of heme-binding by DNA-protective protein from starved-cells (Dps) in the tolerance of Porphyromonas gingivalis to heme toxicity. Journal of Biological Chemistry, 287(50), 42243-42258. [More Information]

2011

  • Zou, W., Hunter, N., Swain, M. (2011). Application of Polychromatic muCT for Mineral Density Determination. Journal of Dental Research, 90(1), 18-30. [More Information]
  • Mostofi Zadeh Farahani, R., Simonian, M., Hunter, N. (2011). Blueprint of an Ancestral Neurosensory Organ Revealed in Glial Networks in Human Dental Pulp. The Journal of Comparative Neurology, 519(16), 3306-3326. [More Information]
  • Harty, D., Hunter, N. (2011). Carboxypeptidase activity common to viridans group steptococci cleaves angiotensin I to angiotensin II: an activity homologous to angiotensin-converting enzyme (ACE). Microbiology, 157(7), 2143-2151. [More Information]
  • Ye, P., Yu, H., Simonian, M., Hunter, N. (2011). Ligation of CD24 expressed by oral eipithelial cells induced kinase dependent decrease in paracellular permeability mediated by tight junction proteins. Biochemical and Biophysical Research Communications, 412(1), 165-169. [More Information]
  • Li, N., Yun, P., Jeffries, C., Langley, D., Gamsjaeger, R., Church, W., Hunter, N., Collyer, C. (2011). The modular structure of haemagglutinin/adhesin regions in gingipains of Porphyromonas gingivalis. Molecular Microbiology, 81(5), 1358-1373. [More Information]

2010

  • Mostofi Zadeh Farahani, R., Nguyen, K., Simonian, M., Hunter, N. (2010). Adaptive calcified matrix response of dental pulp to bacterial invasion in associated with establishment of a network of Glial Fibrillary Acidic Protein+/Glutamine Synthetase+ Cells. The American Journal of Pathology: cellular and molecular biology of disease, 177(4), 1901-1914. [More Information]
  • Gao, J., Nguyen, K., Hunter, N. (2010). Characterization of a hemophore-like protein from Porphyromonas gingivalis. Journal of Biological Chemistry, DOI:10.1074/jbc.M110.163535, 1-22. [More Information]
  • Nadkarni, M., Simonian, M., Harty, D., Zoellner, H., Jacques, N., Hunter, N. (2010). Lactobacilli Are Prominent in the Initial Stages of Polymicrobial Infection of Dental Pulp. Journal of Clinical Microbiology, 48(5), 1732-1740. [More Information]
  • Hunter, N., Collyer, C., De Carlo, A. (2010). Prophylaxis And Treatment Of P. Gingivalis Infection. Patent No. 1189630, 60043936.4-08. Germany.
  • Li, N., Yun, P., Nadkarni, M., Nazila, B., Nguyen, K., Lee, M., Hunter, N., Collyer, C. (2010). Structure determination and analysis of a haemolytic gingipain adhesin domain from Porphyromonas gingivalis. Molecular Microbiology, 76(4), 861-873. [More Information]

2009

  • Gao, J., Nguyen, K., Hunter, N. (2009). A novel haem uptake in Porphyromonas gingivalis. Journal of Dental Research.
  • Nadkarni, M., Martin, E., Jacques, N., Hunter, N. (2009). Caries. Encyclopedia of Molecular Mechanisms of Disease. (Vol. 1, pp. 279-280). Berlin: Springer.
  • Ye, P., Nadkarni, M., Simonian, M., Hunter, N. (2009). CD24 regulated gene expression and distribution of tight junction proteins is associated with altered barrier function in oral epithelial monolayers. BMC Cell Biology, 10, 1-16. [More Information]
  • Zou, W., Gao, J., Jones, A., Hunter, N., Swain, M. (2009). Characterization of a novel calibration method for mineral density determination of dentine by x-ray micro-tomography. The Analyst, 134(1), 72-79.
  • Nadkarni, M., Chhour, K., Browne, G., Jacques, N., Hunter, N. (2009). Lysine gingipain (kgp) biovars of Porphyromonas gingivalis exhibit differential distribution on oral mucosal sites. Journal of Clinical Microbiology, 47(10), 3350-3352. [More Information]
  • Nadkarni, M., Martin, E., Hunter, N., Jacques, N. (2009). Methods for optimizing DNA extraction before quantifying oral bacterial numbers by real-time PCR. FEMS Microbiology Letters, 296, 45-51. [More Information]
  • Yap, B., Simpkins, G., Collyer, C., Hunter, N., Crossley, M. (2009). Porphyrin-linked nitroimidazole antibiotics targeting: Prophyromonas gingivalis. Organic and Biomolecular Chemistry, 7(14), 2855-2863. [More Information]
  • Nguyen, K., Zylicz, J., Szczesny, P., Sroka, A., Hunter, N., Potempa, J. (2009). Verification of a topology model of PorT as an integral outer-membrane protein in Porphyromonas gingivalis. Microbiology, 155(2), 328-337. [More Information]

2008

  • Hunter, N., Collyer, C., DeCarlo, A. (2008). A Method Of Prophylaxis And Treatment And Agents Useful For Same. Patent No. 515853, 7319086, 781704. New Zealand.
  • Gao, J., Xie, H., Nguyen, K., Hunter, N. (2008). Detection and characterization of novel outer membrane proteins involved in heme binding by Porphyromonas gingivalis. Journal of Biotechnology, 136, S88-S88. [More Information]
  • Smith-Vaughan, H., Byun, R., Halpin, S., Nadkarni, M., Jacques, N., Hunter, N., Morris, P., Leach, A. (2008). Interventions for prevention of otitis media may be most effective if implemented in the first weeks of life. International Journal of Pediatric Otorhinolaryngology, 72, 57-61. [More Information]
  • Langley, D., Harty, D., Jacques, N., Hunter, N., Guss, M., Collyer, C. (2008). Structure of N-acetyl-B-D-glucosaminidase (GcnA) from the Endocarditis Pathogen Streptococcus gordonii and its Complex with the Mechanism-based Inhibitor NAG-thiazoline. Journal of Molecular Biology, 377, 104-116. [More Information]

2007

  • Martin, E., Hunter, N., Jacques, N., Nadkarni, M. (2007). A Method of Detecting Microorganisms. Patent No. 1311706, 2001276180, 7244480. Austria, Belgium, Cyprus, Denmark, Finland, France, Germany, Greece, Ireland, Italy, Luxembourg, Monaco, Netherlands, Portugal, Spain, Sweden, Switzerland, Turkey, United Kingdom.
  • Yun, P., DeCarlo, A., Hunter, N. (2007). Blockade of protese-activated receptors on T cells corelated with altered proteloysis of CD27 by gingipains of porphyromonas gingivalis. Clinical and Experimental Immunology, 150(2), 217-229. [More Information]
  • Fong, M., Darendeliler, M., Hunter, N., Shen, G. (2007). Epithelial cells in PDL are critical in resuming the integral relation between tooth root and supporting bone after trauma - A transplantation experiment. Archives of Oral Biology, 52(2), 182-188. [More Information]
  • Byun, R., Carlier, J., Jacques, N., Marchandin, H., Hunter, N. (2007). Veillonella denticariosi sp. nov., isolated from human carious dentine. International Journal of Systematic and Evolutionary Microbiology, 57(12), 2844-2848. [More Information]

2006

  • Yun, P., DeCarlo, A., Hunter, N. (2006). Gingipains of porphyromonas gingivalis modulate leukocyte adhesion molecule expression induced in human endothelial cells by ligation of CD99. Infection and Immunity, 74(3), 1661-1672. [More Information]
  • Smith-Vaughan, H., Byun, R., Nadkarni, M., Jacques, N., Hunter, N., Halpin, S., Morris, P., Leach, A. (2006). Measuring nasal bacterial load and its association with otitis media. B M C Ear Nose and Throat Disorders, 6(1), 10. [More Information]
  • Ye, P., Nadkarni, M., Hunter, N. (2006). Regulation of E-cadherin and TGF-β3 expression by CD24 in cultured oral epithelial cells. Biochemical and Biophysical Research Communications, 349(1), 229-235. [More Information]

2005

  • Yun, P., DeCarlo, A., Chapple, C., Collyer, C., Hunter, N. (2005). Binding of Porphyromonas gingivalis gingipains to human CD4(+) T cells preferentially down-regulates surface CD2 and CD4 with little affect on co-stimulatory molecule expression. Microbial Pathogenesis, 38(2-3), 85-96. [More Information]
  • Yun, P., DeCarlo, A., Chapple, C., Hunter, N. (2005). Functional implication of the hydrolysis of platelet endothelial cell adhesion molecule 1 (CD31) by gingipains of porphyromonas gingivalis for the pathology periodontal disease. Infection and Immunity, 73(3), 1386-1398. [More Information]
  • Ye, P., Simonian, M., Nadkarni, M., DeCarlo, A., Chapple, C., Hunter, N. (2005). Identification of epithelial auto-antigens associated with periodontal disease. Clinical and Experimental Immunology, 139(2), 328-337. [More Information]
  • Chhour, K., Nadkarni, M., Byun, R., Martin, E., Jacques, N., Hunter, N. (2005). Molecular Analysis of Microbial Diversity in Advanced Caries. Journal of Clinical Microbiology, 43(2), 843-849. [More Information]

2004

  • Nadkarni, M., Caldon, E., Chhour, K., Fisher, I., Martin, E., Jacques, N., Hunter, N. (2004). Carious Dentine Provides a Habitat for a Complex Array of Novel Prevotella-Like Organisms. Journal of Clinical Microbiology, 42(11), 5238-5244.
  • Harty, D., Chen, Y., Simpson, C., Berg, T., Cook, S., Mayo, J., Hunter, N., Jacques, N. (2004). Characterisation Of A Novel Homodimeric N-Acetyl-B-D-Glucosaminidase From Streptococcus Gordonii. Biochemical and Biophysical Research Communications, 319(2), 439-447. [More Information]
  • Langley, D., Harty, D., Graham, S., Guss, M., Hunter, N., Collyer, C. (2004). Crystallization Of Gcna, An N-Acetyl-β-D-Glucosaminidase, From Streptococcus Gordonii. Acta Crystallographica. Section D: Biological Crystallography, D60, 1910-1911.
  • Nadkarni, M., Nguyen, K., Chapple, C., DeCarlo, A., Jacques, N., Hunter, N. (2004). Distribution Of Porphyromonas Gingivalis Biotypes Defined By Alleles Of The Kgp (Lys-Gingipain) Gene. Journal of Clinical Microbiology, 42(8), 3873-3876.
  • Nguyen, K., DeCarlo, A., Paramaesvaran, M., Collyer, C., Langley, D., Hunter, N. (2004). Humoral Responses To Porphyromonas gingivalis Gingipain Adhesin Domains In Subjects With Chronic Periodontitis. Infection and Immunity, 72(3), 1374-1382.
  • Byun, R., Nadkarni, M., Chhour, K., Martin, E., Jacques, N., Hunter, N. (2004). Quantitative Analysis Of Diverse Lactobacillus Species Present In Advanced Dental Caries. Journal of Clinical Microbiology, 42(7), 3128-3136.
  • DeCarlo, A., Nadkarni, M., Paramaesvaran, M., Yun, P., Collyer, C., Hunter, N. (2004). Serum Antibodies Against The Hemoglobin-Binding Domain (HA2) Of Porphyromonas Gingivalis. Journal of Periodontal Research, 39(4), 228-235.

2003

  • Ye, P., Simonian, M., Chapple, C., Gibbins, J., Kumar, R., Hunter, N. (2003). Differential expression of transforming growth factors-beta1, -beta2, -beta3 and the type I, II, II receptors in the linng epithelia of inflamed gingiva. Pathology, 35(5), 384-392.
  • Paramaesvaran, M., Nguyen, K., Caldon, E., McDonald, J., Najdi, S., Gonzaga, G., Langley, D., DeCarlo, A., Hunter, N., Crossley, M., Collyer, C. (2003). Porphyrin-mediated cell surface heme capture from hemoglobin by Porphyromanas gingivalis. Journal of Bacteriology, 185(8), 2528-2537.
  • Ye, P., Harty, D., Chapple, C., Nadkarni, M., DeCarlo, A., Hunter, N. (2003). Streptococci and Actinomyces induce antibodies which cross react with epithelial antigens in periodontitis. Clinical and Experimental Immunology, 131(3), 468-476.

2002

  • Nadkarni, M., Martin, E., Jacques, N., Hunter, N. (2002). Determination of bacterial load by real-time PCR using a broad-range (universal) probe and primers set. Microbiology, 148(1), 257-266.
  • Zoellner, H., Chapple, C., Hunter, N. (2002). Microvasculature in gingivitis and chronic periodontitis: disruption of vascular networks with protracted inflammation. Microscopy Research and Technique, 56(1), 15-31. [More Information]
  • Yun, P., DeCarlo, A., Collyer, C., Hunter, N. (2002). Modulation of an interleukin-12 and interferon gamma synergistic feedback regulatory cycle of T-cell/monocyte co-cultures by Porphyromonas gingivalis lipopolysaccharide in the absence or presence of cysteine proteinases. Infection and Immunity, 70(10), 5695-5705.
  • Martin, E., Nadkarni, M., Jacques, N., Hunter, N. (2002). Quantitative microbiological study of human carious dentine by culture and real-time PCR: association of anaerobes with histopathological changes in chronic pulpitis. Journal of Clinical Microbiology, 40(5), 1698-1704.
  • Hunter, N., Nguyen, K., McDonald, J., Quinn, M., Langley, D., Crossley, M., Collyer, C. (2002). Structural requirements for recognition of essential porphyrin by Porphyromonas gingivalis. Journal of Porphyrins and Phthalocyanines, 6(12), 774-782.

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